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Source: Intrexon 2015 10-K

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Zika vs.

Dengue Malaria Zika Dengue Malaria

Cases per year 75,000,000 198,000,000 1,500,000 -98% -100%

Deaths per year 22,000 500,000 0 -100% -100%

Deaths + birth defects 22,000 500,000 4,000 -82% -100%

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https://foreignaffairs.house.gov/hearing/subcommittee-hearing-global-zika-epidemic-emerging-americas

Actual Months Estimated

date required date

FDA releases preliminary FONSI Mar-16

+ comment period and compilation 2 May-16

Trial

Preparation phase 1 Jun-16

Rangefinder phase 2 Aug-16

Supression phase 22 May-18

Data aggregation, results computation 12 May-19

FDA review of application and potential approval 3 Aug-19

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Miami city size (sq. mi.) 55.25

x Mosquitoes/hectare 430,000

x Hectares/sq. mi. 259

Mosquitoes required 6,153,168,743

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o

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Still

Date Name Title there? Tenure

10/8/2015 Joseph Vaillancourt Head of Environmental Sector Y

9/28/2015 Corey Huck SVP, Food Sector Y

7/21/2015 Jack Bobo Chief Communications Officer Y

7/21/2015 Joel Liffman SVP, Finance Y

6/2/2015 Olivier Jarry SVP, Consumer Sector N 6 months

12/4/2014 Peter Emtage VP, Synthetic Immunology Y

9/5/2014 Keith Canada VP, UltraVector N 9 months

5/19/2014 Christopher Basta VP, Investor Relations Y

3/17/2014 Samuel Broder VP, Scientif ic and Public Affairs Y3/4/2014 Nir Nimrodi Head of Environmental Sector Y

12/17/2013 Gregory Frost Head of Health Sector N 1 year, 8 months

11/18/2013 Peter Seufer-Wasserthal VP, Business Development for Europe and Asia Y

11/18/2013 Dana Di Fernando Chief Information Officer ?

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Documents

XON Part 1