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1F I N A L P R O G R A M M E
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
2
C O M M I T T E E SOrganizing Committee
ChairJesús Pérez-Gil, UCM
Co-ChairJuan Manuel Parrondo, UCM
Jorge Alegre, CNICSaúl Ares, UCIIILaura Arriaga, UCMAntonio Cruz, UCMMercedes Echaide, UCMBegoña García Álvarez, UCMLucía García Ortega, UCMJuan Hermoso, IQFR-CSICFrancisco Monroy, UCMGermán Rivas, CIB-CSICJosé María Valpuesta, CNB-CSICMarisela Vélez, ICPQ-CSIC
Scientific Committee
ChairJesús Pérez-Gil, Madrid
Ana Azuaga, GranadaMark Baldus, UtrechtFrançoise Brochard, ParisChristian Eggelin, OxfordAntonio Ferrer-Montiel, ElcheVadim Frolov, BilbaoMaria Garcia-Parajo, BarcelonaJordi Garcia-Ojalvo, BarcelonaRamin Golestanian, OxfordStephan Grill, DresdenJuan Hermoso, MadridHerbert Levine, HoustonAndrea Liu, PennsylvaniaJuan Manuel Parrondo, MadridManuela Pereira, LisbonSriram Ramaswamy, BengaluruFelix Ritort, BarcelonaClaudia Steinem, GottingenMasaki Sasai, NagoyaIlpo Vattulainen, Helsinki
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
3
EBSA Council
President Prof. Anthony Watts, UK
Vice President Prof. Jesus Perez-Gil, Spain
Past President Prof. Helmut Grubmüller, Germany
Secretary Prof. John M. Seddon, UK
Treasurer Prof. Anthony J. Wilkinson, UK
EBJ Editor Prof. Robert Gilbert, UK
Member Prof. José L. Carrascosa, Spain
Member Prof. Jacqueline Cherfils, France
Member Prof. André Matagne, Belgium
Member Prof. Pavol Miskovsky, Slovakia
Member Prof. Mauro Dalla Serra, Italy
Co-opted member Prof. László Mátyus, Hungary
Co-opted member Prof. Pierre-Emmanuel Milhiet, France
Co-opted member Elena Pohl, Austria
Co-opted member Prof. Ilpo Vattulainen, Finland
C6 IUPAP ComissionOfficers
Chair Ramin Golestanian, Germany (2011) (2014) (2017)
Vice-Chair Jeff Gore, USA (2017)
Secretary Masaki Sasai, Japan (2014) (2017)
MembersMing Li, China (2014) (2017)Françoise Brochard Wyart, France (2014) (2017)Suliana Manley, Switzerland (2017)Hans-Joachim Galla, Germany (2017)Vladimir Nekorkin, Russia (2017)Mohammad Reza Ejtehadi, Iran (2017)Bryan Trevor Sewell, South Africa (2014) (2017)Debashish Chowdhury, India (2017)Juan Manuel Rodríguez Parrondo, Spain (2017)Joanna Trylska, Poland (2017)Marcia Barbosa, Brazil (2017)
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
4
G E N E R A L I N F O R M A T I O N Technical Secretariat
VIAJES PACÍFICO S.A. Calle Castello, 128- 7ª planta - 28006; MadridPh. +34 91 383 60 00 ebsa2019@pacifico-meetings.com
Venue
IFEMA Palacio Municipal de Congresos de MadridIFEMA Municipal Conference Centre
Av. de la Capital de España Madrid, s/n28042 Madrid (Spain)www.ifema.es/convencionesycongresos_01/IFEMAPalacioMunicipal/index.htm
Language
The official language of the congress is English. No simultaneous translation will be provided.
Wifi
NETWORK: EBSA_2019PASSWORD: madrid19
Poster Session
» All posters will be presented in paper format » Posters should be 90 cm (width) x 120 cm (height) Portrait type, and they should
be displayed by the authors in the poster area at the slot corresponding to the code number provided in the confirmation letter.
Presenting authors are expected to be in front of their posters one of the day of the block session they have been assigned, (during the poster session slot) as follows:
» Sunday Poster Session: Sunday 21st July, from 12:45 to 15:00h. Authors with odd poster numbers (ex: P-001, P-003, P-005…)
» Monday Poster Session: Monday 22nd July, from 12:45 to 15:00h. Authors with even poster numbers (ex: P-002, P-004, P-006...)
» Tuesday Poster Session: Tuesday 23rd July, from 12:45 to 15:00h. Authors with odd poster numbers (ex: P-401, P-403, P-405…)
» Wednesday Poster Session: Wednesday 24th July, from 12:45 to 15:00h. Authors with even poster numbers (ex: P-402, P-404, P-406...)
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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Setting-up and taking down times: » The posters should be fixed on the corresponding board on
Sunday 21st from 10:00h, and must be removed on Monday 22nd before 20:00h.Tuesday 23rd from 10:00h, and must be removed on Wednesday 24th before 20:00h.
Fixing tape to set up the posters will be provided by the organization.The Technical Secretariat is not responsible for those posters that will not be removed at the end of the Congress
Congress badges
All participants, accompanying persons and exhibitors must wear the Congress identification badges. Entrance to meeting rooms, posters and exhibition area will not be allowed to any person without badge.
Certificate of Attendance
A certificate of attendance will be sent by email to each delegate at the end of the congress sessions. For special requirements, please ask to the Technical Secretariat.
Liability
Upon registration, participants agree that neither the Organizing Committee nor the Technical Secretariat assume any liability. Participants should, therefore, organize their own health and travel insurance.
Rooms directory
AUDITORIUM
EXHIBITION & POSTERSAREA / COFFEE BREAKS
ENTRANCE RIGHT SIDELEFT SIDE
2nd FLOOR
3rd FLOOR
1st FLOOR
GROUND FLOORHALL CAFETERIA
LUNCH AREAHALL ESTRASBURGOLUNCH AREA
ROMAREIJKIAVIK
DUBLIN
MADRIDPARIS
MÓNACOBONN
PREVIEW ROOM-LUXEMBURGO
2nd FLOOR
3rd FLOOR
1st FLOOR
GROUND FLOOR
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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C L O S E D A N D O P E N M E E T I N G SMEETING CLOSED/ OPEN DAY TIME ROOM
First EBSA EC meeting closed Saturday 20th
July 15:00-17:00 Room Monaco- 1st floor left side
SBE Meeting open Sunday 21st July 14:00 -15:00 Room Monaco- 1st floor left side
Nanotemper workshop open Monday 22nd July 14:00 -15:00 Room Paris -
1st floor left side
SEBM National Assembly open Monday 22nd July 19:15-20:15 Room Madrid -
1st floor left side
SFB (Société Française de Biophysique)
National Assembly
open Monday 22nd July 19:15-20:15 Room Roma- 2nd floor left side
SBfP (Sociedade
Portuguesa de Biofísica) National
Assembly
open Monday 22nd July 19:15-20:15 Room Paris- 1st floor left side
EBSA Presidents’ meeting closed Monday 22nd July 13:00 -15:00 Room Berlin-
1st floor left side
CPL meeting closed Tuesday 23rd July 13:00-15:00 Room Monaco- 1st floor left side
ERC Information open Tuesday 23rd July 14:00-15:00 Room Paris - 1st floor left side
EBSA General Assembly closed Tuesday 23rd July 19:00-20:00 Room Paris-
1st floor left side
Second EBSA EC meeting closed Wednesday 24th
July 14:00-15:00 Room Monaco- 1st floor left side
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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E B S A D E T A I L E D P R O G R A MS a t u r d a y 2 0 J u ly AUDITORIUM
17:30 WELCOME ADDRESS
18:00 PLENARY LECTURE Harnessing evolution to create new medicines Sir Gregory Paul Winter Chair: Anthony Watts, President of EBSA, UK
S u n d a y 2 1 J u lyAUDITORIUM
09:00 PLENARY LECTURE Eukaryotic organelles: deciphering their interdependency, structure and dynamics with new imaging technologies Jennifer Lippincott-Schwartz, USA Chair: María García-Parajo, Spain
10:00-12:45 PROTEIN FOLDING Chairs: Ana Azuaga, Spain Jacqueline Cherfils, France
Invited speakers
10:00 Understanding alpha-synuclein amyloid self-assembly and its associated toxicity Nunilo Cremades, Spain
10:30 Dodging the crisis of folding proteins with non-trivial topology - new challenges Joanna Sulkowska, Powland
11:00 – 11: 30 COFFEE BREAK
11:30 The structural determinants of the toxicity of misfolded protein oligomers associated with neurodegenerative diseases Fabrizio Chiti, Italy
Short Talks
12:00 Prion soft amyloid core driven self-assembly of globular proteins into bioactive nanofibrils Weiqiang Wang, Spain
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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12:15 Unravelling the details of the conformational cycle of the Hsp90 chaperone Katarzyna Tych, Germany
12:30 Strategically positioned slow codons support protein folding Michal Perach, Israel
MADRID
10:00-12:45 DNA ARCHITECTURE AND GENE REGULATION Chairs: Masaki Sasai, Japan Helmut Schiessel, Netherlands
Invited speakers
10:00 DNA release from histones in nucleosome core particles: measurements and models Lois Pollack, USA
10:30 Gene control with a “twist”: Exploring the dynamic chromatin landscape Beat Fierz, Switzerland
11:00- 11:30 COFFEE BREAK
11:30 Chromosome organization in living human cells revealed by single nucleosome imaging Kazuhiro Maeshima, Japan
Short Talks
12:00 Non-specific action of polyamines leads to specific changes in structure and function of DNA Takashi Nishio, Japan
12:15 Simulating the binding of pioneer transcription factors to the nucleosome Jan Huertas, Germany
12:30 Dependence of DNA persistence length on ionic strength and ion type Catherine Tardin, France
S u n d a y 2 1 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
9
S u n d a y 2 1 J u ly
ROMA
10:00-12:45 MECHANOBIOLOGY Chairs: Malgorzata Lekka, Poland Pere Roca-Cusachs, Spain
Invited speakers
10:00 Mechanically and biochemically induced pathways regulating integrin-dependent cell adhesion Nico Strohmeyer, Switzerland
10:30 Molecular to cellular mechanics at short timescales Felix Rico, France
11:00- 11:30 COFFEE BREAK
11:30 Mechanosensitive actomyosin network dynamics and migration plasticity in 3D environments Verena Ruprecht, Spain
Short Talks
12:00 Activation of human aortic valve interstitial cells by local stiffness in calcific aortic valve disease Loredana Casalis, Italy
12:15 Role of Rab8A and Caveolin-1 in the interplay between cell mechanotransduction and cholesterol trafficking Giulio Fulgoni, Spain
12:30 The mechanical work of vinculin binding to talin regulates vinculin activation Rafael Tapia Rojo, USA
PARIS
10:00-12:45 BIOPHYSICS OF CYTOSKELETON Chairs: Marisela Velez, Spain Andreas Janshoff, Germany
Invited speakers
10:00 Mind the gap: polyampholytes meet the neuronal skeleton Roy Beck, Israel
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
10
10:30 Reconstitution of basic mitotic spindles in cell-like confinement Marleen Dogterom, the Netherlands
11:00 – 11:30 COFFEE BREAK
11:30 The spindle is a composite of two permeating polar gels Jan Brugués, Germany
Short Talks
12:00 Structure dissection of a contractile phage tail tube Birgit Habenstein, France
12:15 Ultrafast tracking reveals the function of structural domains of single proteins Kristýna Holanová, Czech Republic
12:30 Nucleotide and osmolyte induced folding of FtsZ from staphylococcus aureus Sonia Huecas, Spain 12:45-14:30 LUNCH AND POSTER SESSION
AUDITORIUM
14:30 PLENARY LECTURE Shaping membranes with proteins and cytoskeleton: deciphering mechanisms with reconstituted systems Patricia Bassereau, France Chair: John Seddon, UK
15:15 AVANTI-EBSA MEMBRANE BIOPHYSICS AWARD Control of organelle dynamics by membrane curvature and lipid unsaturation Bruno Antonny, France Chair: Anthony Watts, President of EBSA
16:00-16:30 EBSA YOUNG INVESTIGATOR AWARD Sensing the matrix: transducing mechanical signals from integrins to the nucleus. Pere Roca-Cusachs, Spain Chair: Anthony Watts, President of EBSA
16:30 – 17:00 COFFEE BREAK
S u n d a y 2 1 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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17:00-19:15 MEMBRANE STRUCTURE AND DYNAMICS Chairs: Claudia Steinem, Germany Felix Goñi, Spain
Invited speakers
17:00 Lessons learned from complex mimics of biological membranes Georg Pabst, Austria
17:30 Regulating the dynamic interactions between herpes simplex viruses and cell-surface glycosaminoglycans Marta Bally, Sweden
18:00 IQGAP1 links phosphoinositide signaling to the cytoskeleton and promotes cytoskeletal reorganization Arne Gericke, USA
Short Talks
18:30 Adsorption kinetics of pulmonary surfactant complexes purified from bronchoalveolar lavages of porcine lungs and human amniotic fluid José Carlos Castillo-Sánchez, Spain
18:45 Microfluidic platforms for the handling, manipulation, and analysis of model cells Tom Robinson, Germany
19:00 Quantified efficiency of membrane leakage events relates to antimicrobial selectivity Maria Hoernke, Germany
MADRID
17:00-19:15 CELLULAR PROLIFERATION Chair: Juan M. R. Parrondo, Spain
Invited speakers
17:00 Dynamics of bacterial swarms and biofilms Knut Drescher, Germany
17:30 Biophysical concepts applied to tumor progression Herbert Levine, USA
18:00 How molecular forces shape bacterial biofilms Berenike Maier, Germany
S u n d a y 2 1 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
12
Short Talks
18:30 A nonequilibrium phase transition theory for the formation of diverse homeostasis and the emergence of systematic aging in multicellular systems Yuting Lou, Japan
18:45 Molecular architecture of bacterial amyloids in Bacillus biofilms Nadia El Mammeri, France
19:00 Microviscosity of bacterial biofilm matrix characterized by fluorescence correlation spectroscopy and single particle tracking Valentin Dunsing, Germany
ROMA
17:00-19:15 TRAFFICKING AND SIGNALLING Chair: Carlo Manzo, Spain
Invited speakers
17:00 Systematic superresolution analysis of endocytosis reveals an actin nucleation nano-template that drives efficient vesicle formation Jonas Ries, Germany
17:30 Shedding new light on the nanoscale organization of GPCR signalling Davide Calebiro, UK
18:00 Cryo-EM structural analysis of focal adhesion machinery Naoko Mizuno, Germany
Short Talks
18:30 TANGO1 regulates membrane tension to mediate collagen export from the endoplasmic reticulum Felix Campelo, Spain
18:45 Facile membrane flow and tension equilibration at a presynaptic nerve terminal Erdem Karatekin, USA
19:00 Allosteric regulation of small GTPases at the surface of membranes Jacqueline Cherfils, France
S u n d a y 2 1 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
13
PARIS
17:00-19:15 NON-EQUILIBRIUM PHYSICS Chairs: Jeff Gore, USA a Udo Seifert, Germany
Invited speakers
17:00 How rotating ATP synthases can modulate membrane structure Ivan Lopez-Montero, Spain (Premio Enrique Pérez-Paya SBE)
17:30 Quantifying and modelling active motion in biological systems Timo Betz, Germany
18:00 Dynamics of nanoparticle and virus uptake at cell membranes Ulrich Schwarz, Germany
Short Talks
18:30 Non-equilibrium processes in proteins triggered by light: excited states molecular dynamics perspective Wieslaw Nowak, Poland
18:45 1/f noise in ion channels formed by the Classical Swine Fever Virus (CSFV) p7 protein Antonio Alcaraz, Spain
19:00 Biophysical models of mRNA translation applied to ribosome profiling data Juraj Szavits-Nossan, UK
S u n d a y 2 1 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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M o n d a y 2 2 J u ly
AUDITORIUM
09:00 PLENARY LECTURE Overcoming the multiscale simulation challenge for biomolecular systems Gregory Voth, USA Chair: Ilpo Vattulainen, Finland
10:00-12:45 BIOMOLECULAR SIMULATION I Chairs: Claudio Soares, Portugal Ilpo Vattulainen, Finland
Invited speakers
10:00 Deep learning for molecular biophysics Frank Noe, Germany
10:30 Sculpting cell membranes by protein nanomachines Andela Saric, UK
11:00 – 11:30 COFFEE BREAK
11:30 Pentameric ligand-gated ion channels: new crystal structures and MD simulations Marc Delarue, France
Short Talks
12:00 Automated cryo-EM structure refinement using correlation-driven molecular dynamics Maxim Igaev, Germany
12:15 Aβ peptides and β-sheet breakers. A coarse grained molecular dynamics approach using GO-Martini Aishwarya Dhar, Italy
12:30 Effect of pH on the influenza fusion peptide structure and activity: A constant-pH molecular dynamics approach Diana Lousa, Portugal
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
15
MADRID
10:00-12:45 MACROMOLECULAR COMPLEXES Chairs: Tony Wilkinson, UK Irene Diaz-Moreno, Spain
Invited speakers
10:00 Recent insights into the peptide-loading complex machinery Simon Trowitzch, Germany
10:30 LUBAC and linear ubiquitin chains: novel tools to study immune signalling Katrin Rittinger, UK
11:00 – 11:30 COFFEE BREAK
11:30 Analysing cryoEM data quality in the post resolution revolution era: Validity criteria José M. Carazo, Spain Short Talks
12:00 Histone tails in nucleosome: fuzzy interaction with DNA Sevastyan Rabdano, Russia
12:15 New protein-protein interaction modulators for the therapeutic regulation of synapse dysfunction in neurodevelopmental disorders and neurodegeneration María José Sánchez, Spain
12:30 Structural characterisation of tissue-derived, disease-associated polymers of alpha-1-antitrypsin using conformation-selective antibodies and single-particle reconstructions from electron microscopy images James Irving, UK
ROMA
10:00-12:45 BIOPHYSICS OF MEMBRANE OXIDATION Chairs: Manuel Prieto, Portugal Rosangela Itri, Brazil
M o n d a y 2 2 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
16
Invited speakers
10:00 Photosensitized oxidation of lipid membranes: yields and rates of chemical and physical changes Mauricio da Silva, Brazil
10:30 Achievements, challenges and hopes in the biophysical analysis of oxidized (phospho)lipids Ana Reis, Portugal
11:00-11:30 COFFEE BREAK
11:30 Oxysterols and truncated oxidized phospholipids in model membranes Martin Hof, Czech Republic
Short Talks
12:00 Lipids as substrates and dynamic activators: pro-apoptotic lipid peroxidation at the mitochondrial membrane surface Patrick Van Der Wel, Netherlands
12:15 The effect of oxidized cholesterol on model red blood cell membranes Paul Smith, UK
12:30 Lipid curvature modulates function of mitochondrial membrane proteins Olga Jovanovic, Austria
PARIS
10:00-12:45 EVOLUTIONARY DYNAMICS Chairs: Susanna Manrubia, Spain Liedewij Laan, Netherlands
Invited speakers
10:00 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut Isabel Gordo, Portugal
10:30 Evolutionary biology of cell division: integrating quantitative genetics and cellular biophysics Daniel Needelman, USA
11:00- 11:30 COFFEE BREAK
M o n d a y 2 2 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
17
M o n d a y 2 2 J u ly
11:30 Universal properties of genotype-phenotype maps Sebastian Ahnert, UK
Short Talks
12:00 ScarTrace: CRISPR/Cas9-mediated clonal tracing in zebrafish embryonic development and regeneration Anna Alemany, Netherlands (Premio Antalgenics SBE)
12:15 Rare beneficial mutations cannot halt Muller’s ratchet in spatial populations Su-Chan Park, South Korea
12:30 Exploring phenotypic variability of bacteria using microfluidic cell traps Ágnes Ábrahám, Hungary
12:45-15:00 LUNCH AND POSTER SESSION
13:00-15:00 MEETING OF EBSA Presidents
AUDITORIUM
15:00 PLENARY LECTURE Cryo-EM to visualize structure and dynamics of complex biological macromolecular assemblies Eva Nogales, USA Chair: Jose Carrascosa, Madrid
15:45 IUPAP Young Scientist Prize in Biological Physics 2019 Bacterial collective behaviors Knut Drescher, Germany Chair: Ramin Golestanian, Chair C6-IUPAP
16:00 IUPAP Young Scientist Prize in Biological Physics 2018 Thermodynamics of biological active matter Nikta Fakhari, USA Chair: Jeff Gore, Vice-Chair C6-IUPAP
16:30-19:15 PROTEIN STRUCTURE AND FUNCTION Chairs: Mark Baldus, Netherlands Juan Hermoso, Spain
Invited speakers
16:30 Unraveling the role of SepF in the early actinobacterial divisome Pedro Alzari, France
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
18
17:00 Molecular basis for the extra-mitochondrial roles of cytochrome C in cell life and death Miguel Angel de la Rosa, Spain
17:30- 18:00 COFFEE BREAK
18:00 Atomistic simulation of biomolecular function: ribosomal translation and ligand binding heterogeneity Helmut Grubmueller, Germany
Short Talks
18:30 Campylobacter jejuni Tlp3 dCache sensing domain specifically recognises hydrophobic amino acids Mohammad Firoz Khan, Australia
18:45 Dynamics of intrinsically disordered and unfolded proteins: investigations using neutron spin-echo spectroscopy Andreas Stadler, Germany
19:00 Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor Albert Escobedo, Spain
MADRID
16:30-19:15 CELL MEMBRANE BIOPHYSICS (CPL Symposium) Chairs: Pierre Emmanuel Milhiet, France Gemma Fabries, Spain
Invited speakers
16:30 Cholesterol modulation of nicotinic acetylcholine receptor single molecule and nanocluster trajectories Francisco Barrantes, Argentina
17:00 Morphology of membrane contact sites contributes to the regulation of the phosphatidylinositol cycle Richard Epand, Canada
17:30 – 18:00 COFFEE BREAK
18:00 Redox lipidomics deciphers phospholipid signals of programmed cell death Edgard Koijmann, USA
M o n d a y 2 2 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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Short Talks
18:30 Linking structure, stability and function in the anti-measles virus action of tocopherol-derivatized peptide nanoparticles Tiago N. Figueira, Portugal (Prize SBfP)
18:45 Antimicrobial peptides impair bacteria cell structure within seconds Enrico F. Semeraro, Austria
19:00 Elucidating the nanoscale architecture of the plasma membrane with super-resolution spectroscopy Erdinc Sezgin, UK
ROMA
16:30-19:15 NEW FRONTIERS IN BIOIMAGING Chairs: Laszlo Matyus, Hungary Silvia Caponi, Italy
Invited speakers
16:30 Faster and gentler optical nanoscopy for brain cell imaging Ilaria Testa, Sweden
17:00 The mesolens: a new instrument for 3d optical imaging of large biological specimens with sub-cellular resolution throughout Gail McConnell, UK
17:30 – 18:00 COFFEE BREAK
18:00 Brillouin Microscopy for cell and tissue biomechanics Giuliano Scarcelli, USA
Short Talks
18:30 Wavefront shaping for low background, high resolution STED-FCS in three dimensions Aurélien Barbotin, UK
18:45 High density single particle tracking reveals nano- and meso-scale dynamic organization of plasma membrane receptors in living cells Nicolas Mateos Estevez, Spain
19:00 Photophysics and engineering of transgene labels for optoacoustics Andre C. Stiel, Germany
M o n d a y 2 2 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
20
PARIS
16:30-19:15 GENE NETWORK DYNAMICS AND SIGNALING Chairs: Marta Ibañez, Spain Jan Brugues, Germany
Invited speakers
16:30 Stochastic Turing patterns in the development of a one-dimensional organism Joel Stavans, Israel
17:00 Human time vs. mouse time: in vitro segmentation clock as a model system Miki Ebisuya, Spain
17:30- 18:00 COFFEE BREAK
18:00 Distinguishing dormant from dead by triggering life in spores Hyun Youk, Netherlands
Short Talks
18:30 A nonequilibrium phase transition theory for the formation of diverse homeostasis and the emergence of systematic aging in multicellular systems Yuting Lou, Japan
18:45 Post-transcriptional regulation, noise and spatial transcript localization of small RNA-controlled genes in an Escherichia coli stress response network Rinat Arbel-Goren, Israel
19:00 Modeling cytoneme guidance for Hedgehog signaling Adrián Aguirre-Tamaral, Spain
19:15-20:15 NATIONAL ASSEMBLIES
M o n d a y 2 2 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
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T u e s d a y 2 3 J u ly
AUDITORIUM
09:00 PLENARY LECTURE 6Titin folding powers muscle contraction
Julio Fernández, USA Chair: Jorge Alegre-Cebollada, Spain
10:00-12:45 MECHANISMS OF MEMBRANE PROTEINS Chairs: Elena Pohl, Austria Antonio Ferrer, Spain
Invited speakers
10:00 Factors affecting ion permeation through K+-Channels Carmen Domene, UK
10:30 The first human lacking functional TRPV1 channel: Implications on TRPV1 functions in nociception Baruk Minke, Israel
11:00-11:30 COFFEE BREAK
11:30 Optoelectrical dynamics of BK channel activation Teresa Giraldez, Spain
Short Talks
12:00 Structural insight into TRPV5 channel function and modulation Jenny Van Der Wijst, Netherlands
12:15 Biophysical insights into membrane fission mediated by ESCRT III Vasil Georgiev, Germany
12:30 Ion transport, interfacial effects and scaling behavior in protein channels Vicente Aguilella, Spain
MADRID
10:00-12:45 SINGLE MOLECULE BIOPHYSICS Chairs: Nuno Santos, Portugal David Rueda, UK
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
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Invited speakers
10:00 The mechanical stability of proteins regulates their translocation rate into the cell nucleus Sergi Garcia-Manyes, UK10:30 Mechanosensitive states of the giant muscle protein titin Miklos Kellermayer, Hungary
11:00 – 11:30 COFFE BREAK
11:30 Single-molecule live-cell imaging of mRNA life cycle María Carmo-Fonseca, UK
Short Talks
12:00 ParB dynamics and the critical role of the C-terminal domain in DNA condensation unveiled by combined magnetic tweezers and TIRF microscopy Julene Madariaga-Marcos, Spain
12:15 A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy Gabriel Zoldak, Slovakia
12:30 Single-molecule dissection of the dihydrofolate reductase reaction revealed multiple conformers leading to a catalytic product release Nicole Galenkamp, Netherlands
ROMA
10:00-12:45 BIOPHYSICS OF IMMUNE RESPONSE Chairs: Jean Marie Ruysschaert, Belgium Mario Castro, Spain
Invited speakers
10:00 Membrane sensing and remodelling during the immune synapse. A spatiotemporal adaptive tale of lipid packing dynamics and collective assembly Jorge Bernardino de la Serna, Spain
10:30 Mechanosensing via immunoreceptors Cheng Zhu, USA
11:00 – 11:30 COFFEE BREAK
T u e s d a y 2 3 J u ly
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MADRID20-24 JULY 2019
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T u e s d a y 2 3 J u ly
11:30 The role of oligomeric scaffolds in inflammatory signal transduction through Toll-like receptors and MyD88 Nick Gay, UK
Short Talks
12:00 Insights into the molecular mechanism of lipids/Toll-Like receptors interaction Malvina Pizzuto, Spain
12:15 Super-resolution microscopy analysis of molecular interactions between epithelial cells and tissue-resident T cells in mouse epidermis Dmitry Ushakov, UK
12:30 Shape matters: Towards a molecular understanding of the innate immune response to microbial lipids Andra Schromm, Germany
12:45-15:00 LUNCH AND POSTER SESSION
AUDITORIUM
15:00-16:15 NEW AND NOTABLE Chairs: Anthony Watts, UK Maria Garcia-Parajo, Spain
15:00 A molecular mechanism for transthyretin amyloidogenesis Trevor Forsyth, France
15:25 Cryo-EM of helical polymers at near atomic resolution yields surprises: from microbial nanowires to indestructible pili Edward H. Egelman, USA
15:50 To spread or not to spread: the mechanosensitive dilemma of T cells Kheya Senguptaa, France
16:15-19:00 BIOMOLECULAR SIMULATION II Chairs: Claudio Soares, Portugal Ilpo Vattulainen, Finland Invited speakers
16:15 Advances in multiscale simulation of DNA Modesto Orozco, Spain
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
24
16:45 Nanoparticle-bio interactions: the role of interface composition, conformation and softness Giulia Rossi, Italy
17:15 – 17: 45 COFFEE BREAK
17:45 Lipid regulation of structure, dynamics, energetics, and function of membrane proteins Emad Tajkhorshid, USA
Short Talks
18:15 The catalytic mechanism of MB-COMT: new drug design paradigm? Alex Bunker, Finland
18:30 Combining theoretical and experimental approaches to understand the mechanism of antibiotic permeation: implications on the fight against bacterial resistance Carla F. Sousa, Portugal
18:45 Exploring conformational transitions and free energy profiles of proton coupled oligopeptide transport Mariana Batista, Brazil
MADRID
16:15-19:00 LIVE IMAGING AND OPTICAL MICROSCOPY Chair: Susanne Fenz, Germany
Invited speakers
16:15 Faster and better: taking localisation microscopy into live cells Susan Cox, UK
16:45 A Multi Messenger microscope to paint chromatin in cells Alberto Diaspro, Italy
17:15 – 17: 45 COFFEE BREAK
17:45 Looking into the nursery of platelets: Imaging of the bone marrow in vivo, in vitro and in silico Katrin Heinze, Germany
T u e s d a y 2 3 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
25
Short Talks
18:15 Strong cytoskeleton activity on millisecond timescales upon particle binding revealed by ROCS microscopy Felix Jünger, Germany
18:30 Multiplexed single-molecule fluorescence imaging by FRET PAINT Nina Deußner-Helfmann, Germany
18:45 In vivo single-molecule imaging of DNA gyrase Ji-Eun Lee, UK
ROMA
16:15-19:00 ACTIVE MATTER AND BIOLOGICAL SELF-ORGANIZATION Chairs: Sriram Ramaswamy, India Ramin Golestanian, Germany
Invited speakers
16:15 Active polymers and membranes Gerhard Gompper, Germany
16:45 The microtubule/kinesin system: A versatile realization of an active nematic Francesc Sagues, Spain
17:15 – 17: 45 COFFEE BREAK
17:45 Spontaneous tension cable generation and convergence-extension flows in the gastrulating chick embryo Silke Henkes, UK
Short Talks
18:15 Design principles for robust self-assembly of multiple biological structures from limited resources Deb Sankar Banerjee, UK
18:30 Active phase separation in mixtures of chemically-interacting particles Jaime Agudo-Canalejo, UK
18:45 Self-organization of ciliary beats in bronchial epithelium Simon Gsell, France
T u e s d a y 2 3 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
26
PARIS
14:00-15:00 INFORMATION SESSIONThe European Research Council – Funding for frontier research in Europe
Janne Salo, Research programme officer, European Research Council Executive Agency
Andela Šarić, UK, Starting grantee
Cait MacPhee, UK, Advanced Grant panel chair 2018
16:15- 19:00 IONIC LIQUIDS AND BIOMOLECULES Chairs: Hans-Joachim Galla, Germany Pietro Ballone, Ireland
Invited speakers
16:15 Ionic liquids in bio-systems: from model biomembranes to living cells Antonio Benedetto, Ireland
16:45 Aqueous ionic liquids: consequences for biological stabilities Jens Smiatek, Germany
17:15 – 17: 45 COFFEE BREAK
17:45 Studying fundamental role of ionic interactions to connect structure and properties of ionic liquids with biological activity Valentine Ananikov, Russia
Short Talks
18:15 Probing the effect of a room temperature ionic liquid on self assembled structure of phospholipid membranes Saheli Mitra, India
18:30 The effect of imidazolium-based ionic liquids on human insulin aggregation/amyloid fibrillization Vladimir Vanik, Slovakia
18:45 Effect of Ionic Liquids on the mechanoelasticity of biomembranes: from model phospholipid bilayers to living cells Pallavi Kumari, Ireland
19:00-20:00 EBSA GENERAL ASSEMBLY
T u e s d a y 2 3 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
27
W e d n e s d a y 2 4 J u ly
AUDITORIUM
09:00 PLENARY LECTURE Nonequilibrium stresses and fluxes: compositional organization at the cell surface and organelle morphodynamics Madan Rao, India Chair: Juan M. R. Parrondo, Spain
10:00-12:45 LIPID AND LIPIDOME Chairs: John Seddon, UK Francisco Monroy, Spain
Invited speakers
10:00 Membrane remodeling by the amyloidogenic peptide IAPP: surface crowing relevance Manuel Prieto, Portugal
10:30 How the globoside Gb3 partitions in phase-separated membranes Claudia Steinem, Germany
11:00 – 11: 30 COFFEE BREAK
11:30 Curvature rigidity of asymmetric and differentially stressed membranes Markus Deserno, USA
Short Talks
12:00 Formation of membrane domains: insight from simulations on different scales Andreas Heuer, Germany
12:15 Monte Carlo and molecular dynamics simulations to explain biomembrane meso-patterning by a composition-curvature coupling mechanism Julie Cornet, France
12:30 Biophysical properties of 1-deoxyceramides in ordered and disordered bilayers Felix M Goñi, Spain
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
28
MADRID
10:00-12:45 BIG DATA IN BIOPHYSICS Chairs: Remy Monasson, France Alfonso Valencia, Spain
Invited speakers
10:00 A systems approach to understanding the allosteric mechanism of pyruvate kinase M2 Franca Fraternali, UK
10:30 Statistical mechanics of protein evolution: From models to algorithms Ugo Bastolla, Spain
11:00 – 11: 30 COFFEE BREAK
11:30 Combining imaging and gene expression data in mathematical models for immuno-oncology Vera Pancaldi, France
Short Talks
12:00 Real-time dynamic changes in serum metabolome during the anticancer treatment by means of NMR-based metabolomics Lukasz Boguszewicz, Poland
12:15 Decrypting interaction fingerprints in protein molecular surfaces Bruno Correia, Switzerland
12:30 Bayesian inference and machine learning approaches to determine protein copy number from localization microscopy Carlo Manzo, Spain
ROMA
10:00-12:45 INSTRUCT-ERIC: INTEGRATING ACCESS TO BIOPHYSICS AND STRUCTURAL BIOLOGY IN EUROPE Chair: Ray Owens, UK
Invited speakers
10:00 Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity Rob Gilbert, UK
W e d n e s d a y 2 4 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
29
W e d n e s d a y 2 4 J u ly
10:30 NMR-based hybrid approaches for cellular structural biology Marc Baldus, Netherlands
11:00 – 11: 30 COFFEE BREAK
11:30 Towards High Throughput cryoEM data acquisition and processing, assuring reproducibility Jose-Maria Carazo, Spain
Short Talks
12:00 Access to structural biology and biophysics technologies through Instruct-ERIC Naomi Gray, UK
12:15 Crystal structures of bacteriophage receptor binding proteins Mark J. Van Raaij, Spain
12:30 The Cryo-EM structure of a non-toxic greek key oligomer of alpha synuclein Ritobrita Chakraborty, India
PARIS
10:00-12:45 LIQUID-LIQUID PHASE SEPARATION IN BIOLOGICAL SYSTEMS Chair: Mauro della Serra, Italy
Invited speakers
10:00 Bacterial division protein phase-separated condensates: biochemical and functional consequences German Rivas, Spain (Bruker Manuel Rico SBE Prize)
10:30 Light controlled cytoplasmic transport to probe cellular organization Mortiz Kreysing, Germany
11:00 – 11: 30 COFFEE BREAK
11:30 Multivalency of proteins in cellular phase separation Samuel Safran, Israel
Short Talks
12:00 General sol to gel transition of liquid-liquid phase separated protein under shear Yi Shen, UK
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
30
12:15 Recapitulation of nucleocytoplasmic transport with phase separation of engineered protein repeats Sheung Chun Ng, Germany
12:30 Protein phase transition: from biology towards new dynamic protein materials Paolo Arosio, Switzerland
12:45-15:00 LUNCH AND POSTER SESSION
14:00-15:00 EBSA EC SECOND MEETING
AUDITORIUM
15:00-17:45 MOLECULAR MOTORS Chairs: Christoph Schmidt, USA José Carrascosa, Spain
Invited speakers
15:00 Cooperative functions of molecular motor assemblies Shin’Ichi Ishiwata, Japan
15:30 A molecular hurdle race: How does DNA polymerase deal with SSBs stably bound to the template? Borja Ibarra, Spain
16:00 – 16:30 COFFEE BREAK
16:30 A ratchet mechanism governs load adaptation by branched actin networks Peter Bieling, Germany
Short Talks
17:00 Kinesin-2 stepping reflects its heteromeric nature Willi L. Stepp, Germany
17:15 Reverse stroke of cardiac myosin revealed by single molecule microscopy is essential for heart function Yongtae Hwang, Japan
17:30 Artificial assembly of the bacterial flagella motor on DNA scaffolds Sophie Hertel, Australia
W e d n e s d a y 2 4 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
31
MADRID
15:00-17:45 TISSUE BIOPHYSICS AND MORPHOGENESIS Chair: Françoise Brochard-Wyart, France
Invited speakers
15:00 Forming, watching and stressing organoids Pierre Nassoy, France
15:30 Physics of epithelial folds and flows Guillaume Salbreux, UK
16:00 – 16:30 COFFEE BREAK
16:30 Bacterial colonies as active droplets - from single cells to continuum theory Vasily Zaburdaev, Germany
Short Talks
17:00 Biomimetic emulsions probe the mechanics of tissues Lea-Laetitia Pontani, France
17:15 Mechano-transduction and coordination of epithelial cells during Drosophila morphogenesis Matthias Häring, Germany
17:30 A hydraulic instability underlies oocyte size selection in C. elegans Arghyadip Mukherjee, Germany
ROMA
15:00-17:45 EMERGING BREAKTHROUGH MOLECULAR-SCALE BIOPHYSICS METHODOLOGIES (ARBRE-MOBIEU COST Action) Chairs: Patrick England, France Isabel Alves, France
Invited speakers
15:00 Adventures with dynamic and disordered systems Perdita Barran, UK
15:30 Access to atomic resolution structural information of homo repeats: The huntingtin case Pau Bernado, France
16:00 – 16:30 COFFEE BREAK
W e d n e s d a y 2 4 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
32
16:30 Investigating the bacterial translocon at the single molecule level Peter Hinterdorfer, Austria
Short Talks
17:00 Correlative μ-Brillouin and μ-Raman spectroscopy: emerging tool for simultaneous mechanical and chemical analysis of cells and tissues Silvia Caponi, Italy
17:15 Revisiting the structure-function relationship with mass photometry Gavin Young, UK
17:30 Hierarchical micro- and nanostructured surface architectures for label-free spectroscopic and microscopic protein interrogation Julia Flesch, Germany
AUDITORIUM
18:00 CLOSING PLENARY LECTUREMINFLUX Nanoscopy: Superresolution post Nobel
Stefan Hell, Germany Chair: Jesús Pérez-Gil, President (Elect) EBSA
19:00 CLOSING CEREMONY
21:00 CONGRESS DINNER
W e d n e s d a y 2 4 J u ly
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
33
E X H B I T I O N F L O O R P L A N - 3 r d F L O O R
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1 Larodan 15 Wyatt 31 Elements
2 Malvern Panalitical 20 Optosigma 33 Refeyn
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6 Dynamic Biosensor 28 IOP Publishing 36 Multichanner
Systems
7 Lumicks 29 Avanti Polar Lipids, Inc 37
Molecular Dimensions
(ANATRACE)
14 Impetux 30 NanoTemper 38 Fluidic Analitics
CATERING AREA
CATERINGAREA
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Larodan makes a comprehensive range of research grade lipids for use as reference standards and reagents with customers all over the world.
Our facilities are located at the Karolinska Institute in Stockholm, Sweden.
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www.larodan.com info@larodan.com
Biophysical Society–IOP SeriesThe official publishing partner of the Biophysical Society
Expand your reach and engagement
Publish your textbook, monograph, review or handbook in this exciting new series. As the Biophysical Society’s own publishing series your book will benefit from exposure to your peers at conferences, member newsletters and much more.
We welcome proposals in all areas of biophysics research, applications, education, methods, computational tools and techniques.
Choose the right publisher for you
Come along to booth 28 on Tuesday 23 July between 2.00–3.00 p.m. for some refreshments and to find out more about this growing book series.
Alternatively e-mail jessica.fricchione@ioppublishing.org for more information.
Benefits of choosing a digital-first publisher
Rapid publication times
Multimedia content
Full-color print copies
No Digital Rights Management
E-reader compatibility
A dedicated, hands on editor
35
Biophysical Society–IOP SeriesThe official publishing partner of the Biophysical Society
Expand your reach and engagement
Publish your textbook, monograph, review or handbook in this exciting new series. As the Biophysical Society’s own publishing series your book will benefit from exposure to your peers at conferences, member newsletters and much more.
We welcome proposals in all areas of biophysics research, applications, education, methods, computational tools and techniques.
Choose the right publisher for you
Come along to booth 28 on Tuesday 23 July between 2.00–3.00 p.m. for some refreshments and to find out more about this growing book series.
Alternatively e-mail jessica.fricchione@ioppublishing.org for more information.
Benefits of choosing a digital-first publisher
Rapid publication times
Multimedia content
Full-color print copies
No Digital Rights Management
E-reader compatibility
A dedicated, hands on editor
O R G A N I Z E R S
S I L V E R
B R O N Z E
E X H I B I T O R S & S P O N S O R S
elements enabling technologies for Life Science
JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress
MADRID20-24 JULY 2019
BIOPHYSICS FOR LIFE AND TECHNOLOGY
36
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