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CURRICULUM VITAE Last name: RENIERS First name: Brigitte Date of birth: 4/10/1972 Place of birth: Uccle (Belgium) Address (private): Sieberg, 27 tel : +32-12-21.37.57 Herderen (Riemst), B-3770 Belgium Main Address (prof): NuTeC / VT-VC Universiteit Hasselt Agoralaan - gebouw H tel: +32-(0)11 292167 3590 Diepenbeek email: [email protected] ; [email protected] Languages : - French (native language) - English (fluent) - Dutch (fluent – B2 – in training for C1) A. Education « Licence en Sciences Physiques » in Free University of Brussels (U.L.B.), Belgium. Obtained with Great Distinction in 1994 Title of the dissertation: "High resolution Rotational study of the vibrational band ν 9 of the trans-glyoxal molecule." in the department of Molecular Physical Chemistry of the Faculty of Sciences of Université Libre de Bruxelles, Belgium. « Agrégation de l'enseignement secondaire supérieur » in Université Libre de Bruxelles, Belgium. Study grant between 15 March 1995 and 31 December 1995 in the department of physical chemistry of the Faculty of Applied Science in Université Libre de Bruxelles, Belgium. Subject: Study of the heat transfer in a layer of porous material using an optical method (the Christiansen effect). M.Sc. in medical physics in the University of Liège, Belgium. - First year : completed with Great Distinction in July 1997 - Second year : completed with Great Distinction in September 1998 Title of the dissertation: "Correlation between calculated dose-volume histograms and perfusion SPECT in the context of lung irradiation. Feasibility study » performed in the Hospital of Jolimont in La Louvière. Supervisors: M lle Hoornaert and M. Merlo Ph.D. in Biomedical Science, orientation Medical Physics in the Catholic University of Louvain, Faculty of Medicine, doctoral school of Clinical research (DCLI), Belgium. February 2005 Title: « The use of low energy photons in brachytherapy: dosimetric and microdosimetric studies around 103 Pd and 125 I”. (full text at http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-02032005- 220655/) Supervisors: Prof S. Vynckier and Prof Y. El Masri Complementary training - Stage in radioprotection, University of Liège, September 1997

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Page 1: CURRICULUM VITAE Last name: RENIERS First …30-31 May 2017, Physikalisch-Technische Bundesanstalt, Braunschweig • B. Reniers F. Verhaegen “microdosimetry for brachytherapy”,

CURRICULUM VITAE Last name: RENIERS First name: Brigitte Date of birth: 4/10/1972 Place of birth: Uccle (Belgium) Address (private): Sieberg, 27 tel : +32-12-21.37.57 Herderen (Riemst), B-3770 Belgium Main Address (prof): NuTeC / VT-VC

Universiteit Hasselt Agoralaan - gebouw H tel: +32-(0)11 292167 3590 Diepenbeek

email: [email protected] ; [email protected] Languages : - French (native language) - English (fluent) - Dutch (fluent – B2 – in training for C1) A. Education • « Licence en Sciences Physiques » in Free University of Brussels (U.L.B.), Belgium. Obtained with Great Distinction in 1994 Title of the dissertation: "High resolution Rotational study of the vibrational band ν9 of the trans-glyoxal molecule." in the department of Molecular Physical Chemistry of the Faculty of Sciences of Université Libre de Bruxelles, Belgium. • « Agrégation de l'enseignement secondaire supérieur » in Université Libre de Bruxelles, Belgium. • Study grant between 15 March 1995 and 31 December 1995 in the department of physical chemistry

of the Faculty of Applied Science in Université Libre de Bruxelles, Belgium. Subject: Study of the heat transfer in a layer of porous material using an optical method (the Christiansen effect). • M.Sc. in medical physics in the University of Liège, Belgium. - First year : completed with Great Distinction in July 1997 - Second year : completed with Great Distinction in September 1998 Title of the dissertation: "Correlation between calculated dose-volume histograms and perfusion SPECT in the context of lung irradiation. Feasibility study » performed in the Hospital of Jolimont in La Louvière. Supervisors: Mlle Hoornaert and M. Merlo • Ph.D. in Biomedical Science, orientation Medical Physics in the Catholic University of Louvain,

Faculty of Medicine, doctoral school of Clinical research (DCLI), Belgium. February 2005 Title: « The use of low energy photons in brachytherapy: dosimetric and microdosimetric studies around 103Pd and 125I”. (full text at http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-02032005-220655/) Supervisors: Prof S. Vynckier and Prof Y. El Masri Complementary training - Stage in radioprotection, University of Liège, September 1997

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Brigitte Reniers 03/04/2019 2

- Training course for the Monte-Carlo code EGSnrc au NRCC: (Ottawa, Canada), March 2000 - Brachytherapy Summerschool AAPM Seattle 2005 - Eclipse Administration and Physics, Varian, Las Vegas, January 2008 - Stralingsbescherming Niveau 3 Diploma, Nijmegen, December 2010. - Eclipse, Brachyvision software (Varian Medical Systems) in Charlottesville, September 2011. Professional certification: Medical Physicist in Belgium (suspended while working out of a hospital) B. Appointments • Jul 2016 – present: Associate professor in Hasselt University. • Dec 2014 – June 2016: 100% project engineer NuTec, responsible the dosimetric audit program

BelDart, UHasselt, Limburg, Diepenbeek • oct 2013 – dec 2014

• 90% project engineer NuTec, responsible the dosimetric BelDart, UHasselt, Limburg, Diepenbeek

• 10% researcher Maastro Clinic, Maastricht, The Netherlands (until dec 5 2014) • February 2013 – oct 2013

• 90% project engineer NuTec, responsible the dosimetric BelDart, Xios Hogeschool Limburg, Diepenbeek

• 10% researcher Maastro Clinic, Maastricht, The Netherlands (until dec 5 2014) • December 2011 – February 2013:

• 80% Researcher in Maastro Clinic, Maastricht, The Netherlands • 20% application specialist for Brachytherapy, Varian Medical Systems.

• September 2011 – December 2011: 50% application specialist for Brachytherapy, Varian Medical Systems.

• September 2008 – September 2011: 50% Medical Physicist in Maastro Clinic. 50% Researcher at the University of Maastricht.

• April 2006 – July 2008: Medical Physicist in the Montreal General Hospital. Head of Brachytherapy since March 2007. Lecturer McGill University.

• Oct. 2003 – March 2006: Medical Physicist in the Maisonneuve-Rosemont Hospital, Montréal • Oct. 2001 –Sep. 2003: Grant of Fonds National pour la Recherche Scientifique « Télévie ».

« Dosimetric and microdosimetric studies around 103Pd and 125I seeds used in brachytherapy ». • Oct. 1999 –Sep. 2001: Grant of Fonds National pour la Recherche Scientifique « Télévie ».

« Dosimetric and microdosimetric studies around 103Pd and 125I seeds used in brachytherapy ». • Oct. 1998 – Sep. 1999: Medical Physicist in the Radiotherapy department of the Cliniques

Universitaires St Luc in Brussels part time brachytherapy, part time development of the quality control in radiotherapy.

C. Awards 1994: « Licence en Sciences Physiques » in Free University of Brussels (U.L.B.), (Belgium): Great

Distinction 1998: M.Sc. in medical physics in the University of Liège (Belgium): Great Distinction 2000: “Young physicist Grant”, Symposium of the Belgian Hospital physicists association, Leuven,

Belgium, December

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2001: “Young student award”, Council on Ionizing Radiation Measurements and Standards (CIRMS), Washington, USA, October

2005: “Financial Assistance for Young Scientists”14th Symposium on Microdosimetry, Venice, Italy, November

2009. Second best poster price at the International Conference on Translational Research (ICTR), Geneva, Switzerland.

D. Teaching 1. Courses

• 1999 and 2000 for the “Group Training on Radiation Protection and Quality Assurance in Radiotherapy” organised by the International Atomic Energy Agency (IAEA) in Brussels, Belgium

• 2004 and 2005 for the “stage de dosimétrie niveau R.V du programme de résidence de Radio-oncologie du département de Radiologie, Médecine Nucléaire et Radio-oncologie de la Faculté de Médecine de l’Université de Montréal”.

• 2006 : McGill Students Lab: dosimetry using solid state detectors • 2007: - McGill Students Lab: - dosimetry using solid state detectors

- treatment planning - Dawson College: - Linac QA - Treatment planning

• 2012-13: Medical nuclear equipment Xios Hogeschool Limburg • 2013-14: Medical nuclear equipment, Universiteit Hasselt Limburg • February 2014: SARA course (Cherne network), Universiteit Hasselt Limburg • March 2014: MANTRA course (Cherne network), Laboratori Nazionali del Sud, Catania, Italy • September 2014: lecture at the Course on Monte Carlo Methods in Radiation Therapy, Oxford, UK. • 2014-15: Medical nuclear equipment, Universiteit Hasselt Limburg • 2015-16:

o Medical nuclear equipment, Universiteit Hasselt Limburg o Medical dosimetry, Universiteit Hasselt Limburg

• 2016-17: o Medical dosimetry o Medical nuclear equipment o Capita selecta nucleaire technology (Lid van het onderwijsteam) o Technology of radiology and radiotherapy

• 2017-2018 o Medical dosimetry o Medical nuclear equipment o Capita selecta nucleaire technology (Lid van het onderwijsteam) o Technology of radiology and radiotherapy

2. Research trainees supervised

a) MSc students: as Supervisor (S) or co-supervisor (CS)

Name Dept Yrs Degree expected/obtained

BERNARD, Sabine (CS) Service de Radio-oncologie, UCL

2003-04 MSc 2004

BERTRAND, Marie-Joelle (S)

Medical Physics Unit, McGill university

2005-08 MSc 2008

LIU, Derek (CS) Medical Physics Unit, McGill university

2006-07 MSc 2007

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b) Stage

c) PhD student

LAGMAGO KAMTA, Gerard (S)

Medical Physics Unit, McGill university

2007-09 MSc 2009

De Jongh Thomas: UHasselt/Jessa Hospital 2014-15 MSc 2015 Stevens Ester Uhasselt/MAASTRO Clinic 2014-15 MSc 2015 VAN DER HEYDEN, Brent (CS)

Uhasselt/MAASTRO Clinic 2015-16 MSc 2016

YALVAC, Burak (CS) Uhasselt/KULeuven Nuclear medicine dept

2015-16 MSc 2016

SEVENOIS, Matthijs Uhasselt/KULeuven radiotherapy dept

2016-2017 MSc 2017

MOMMEN, Stef Uhasselt, SCK-CEN 2016-2017 MSc 2017 SMEULDERS, Jelle Uhasselt, Jessa hospital, Hasselt 2016-2017 MSc 2017 STAUT, Nick Uhasselt, Smart Scientific

Solutions 2018-2019 MSc 2019

VANBUEL, Anna Uhasselt, Jessa hospital, Hasselt

2018-2019 MSc 2019

LAMBRECHTS Christel Uhasselt, UZ Brussel 2018-2019 MSc 2019 LOOTS Hannah Uhasselt, Jessa hospital, Hasselt 2018-2019 MSc 2019 DHAMERS, Lisa Uhasselt, Jessa hospital, Hasselt 2018-2019 MSc 2019 COLSON, Dries Uhasselt 2018-2019 MSc 2019 BOSMANS, Gerben Uhasselt 2018-2019 MSc 2019

Name Dept Yrs Degree expected/obtained

ROSARIO, Tezontl (CS) Maastro Clinic 2010

Name Dept Yrs Degree expected/obtained

LANDRY, Guillaume (CS)

Maastro Clinic 2009-13 PhD 2013

FONSECA Gabriel Paiva (CS)

Maastro Clinic/IPEN-CNEN, Sao Paulo, Brazil

2013-2015 PhD 2015

WHITE, Shane (CS) Maastro Clinic 2011-2015 PhD 2015 DERRIEN, Jonathan NuTeC, Uhasselt 2017-2021 PhD 2021 BIANCHI, Anna NuTeC Uhasselt,

SCK 2017-2021 PhD 2021

REZAEIFAR Behzad NuTeC UHasselt 2018-2022 PhD 2022

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d) postdoc students Name Dept Yrs Degree

expected/obtained FURSTOSS Christophe Medical Physics

Unit, McGill university

2006-08 2008

3. Invited presentations: • “Dosimetric and microdosimetric studies around 103Pd and 125I seeds used in brachytherapy” medical

Physics Unit, McGill, May 2003. • “Heterogeneity corrections for Lung treatment planning” medical Physics Unit, McGill, January 2007. • “Heterogeneity corrections for Lung treatment planning” Workshop “6 MV vs 18 MV and Heterogeneity correction in Lung Cancer” at CARO meeting in Toronto, October 2007. • “Other applications for Cone Beam CT”, Conformal Pre-Operative Endocavitary Treatment for

Locally Advanced Rectal Cancer workshop, Montreal, October 2007. • “Heterogeneity corrections for Lung treatment planning” Hôpital Notre-Dame, Montréal, December

2007. • “Heterogeneity corrections for Lung treatment planning” Association des Radio-Oncologues du

Quebec (AROQ), June 2008. • “Dosimetry and microdosimetry for LDR Brachytherapy” Radiotherapy department, Sunnybrook

Health Sciences Centre, Toronto, February 2010. • F Verhaegen, B Reniers. New insights in brachytherapy physics: Advanced dosimetry & biological

damage assessment. Vienna, Austria, oct 25, 2011. • B. Reniers, F. Verhaegen. New insights in brachytherapy physics: Advanced dosimetry & biological

damage assessment. Princess Margret Hospital, Toronto, Canada, January 2012. • B. Reniers, F. Verhaegen. New insights in brachytherapy physics: Advanced dosimetry & biological

damage assessment. Groote Schuur hospital & Tygerberg hospital, Cape Town, South Africa, February 2012.

• F Verhaegen, G Landry, G Paiva Fonseca, S White, M Plamondon, A Hoffmann, P Visser, D de Haas, L Lutgens, F van Gils, B Reniers. New Developments in Brachytherapy Physics. Seminar at Maastro Clinic, Maastricht, January 30 2013.

• B. Reniers, F. Verhaegen. New insights in brachytherapy physics: Advanced dosimetry & biological damage assessment. Karolinska Hospital, Stockholm, Sweden, May 2013.

• B. Reniers, Dose Calculation Algorithms, Maastro Clinic, Maastricht, November 2013. • B. Reniers, S. White, F. Verhaegen, Effect of metal CT artifact with model-based dose calculation

algorithms for brachytherapy, Webinar for Varian Medical System, August 2014. • B. Reniers, microdosimetry and track structure for low energy photons, Delft University of

Technology, November 2016 • F Verhaegen, G Fonseca, M Bellezzo, S White, G Landry, B Reniers. “Improving clinical brachytherapy:

dosimetry & verification “.Metrology for Brachytherapy: State-of-the-art and beyond, International Workshop, 30-31 May 2017, Physikalisch-Technische Bundesanstalt, Braunschweig

• B. Reniers F. Verhaegen “microdosimetry for brachytherapy”, 1st ESTRO physics worshop, Glasgow, UK.

FONSECA Gabriel Paiva (CS)

Maastro Clinic 2015-2017

2017

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4. Participation at conferences: Oral Presentations

- “Dosimetry of the new InterSource of 103Pd”, ESTRO 2000 (Istanbul, Turkey): September 2000. - “Dosimetry of the new InterSource of 103Pd”, SBPH 2000 (Leuven, Belgium), December 2000. - “Dosimetry of the new InterSource of 103Pd and 125I” ESTRO 2001 (Sevilla, Spain): September 2001. - “Dosimetric study of the new InterSource palladium and iodine seed”, CIRMS, October 2001. - “Dosimetric study of the new InterSource palladium and iodine seed” SBPH (Louvain-La Neuve , Belgium) : December 2001. - “Use of

103Pd and

125I in Brachytherapy”, MCNEG meeting 2002 (Stoke-on-Trent, UK): April 2002.

- “Dosimetric and microdosimetric study of 103Pd and 125I seed sources”, AAPM congress, Montréal, Canada, July 2002. - “Microdosimetric study and cluster analysis of 103Pd and 125I”, World Congress 2003, Sydney, Australia. - “Monte Carlo study of the effect of the tissue composition on the dosimetric data used for low energy photons”, 47th congress of AAPM, 24-28 juillet 2005, Seattle, USA. - “Spectral analysis and Microdosimetric MC study around a novel electronic brachytherapy device” B. Reniers, D. Liu, T. Rusch, F. Verhaegen international workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification (Montreal, Canada): May 2007. - “MonteCarlo study of a novel electronic brachytherapy device: radiation quality effects” B. Reniers, D. Liu, T. Rusch, F. Verhaegen 9th Biennal ESTRO conference 2007 (Barcelona, Spain) - “6MV vs 18MV and heterogeneity correction in Lung Cancer.” CARO meeting octobre 2007, Toronto, Canada. - “Heterogeneity corrections for Lung treatment planning” Association des Radio-Oncologues du Quebec (AROQ), June 2008. - “Introduction of the cone beam CT for 3D image-guided GYN brachytherapy”, 24th annual symposium of the BHPA, Kortrijk, Belgium, Feb 2009. - MCTP2009: Second European Workshop on Monte Carlo Treatment Planning, October 2009 Cardiff, UK. - ESTRO, Maastricht, the Netherlands, September 2009. - ESTRO, London, U.K., May 2011. - ICTR, Geneva, Switzerland, March 2012. - BHPA, Mechelen, Belgium, February 2013 - American Brachytherapy Society, New Orleans, USA, April 2013 - BHPA, Louvain-la-Neuve, Belgium, 2014 - ESTRO, Vienna, Austria, 2014 - BHPA, Antwerpen, Belgium, 2015 E. Other contributions 1. Journals Peer-reviewed Proceedings Advanced workshop on Monte Carlo techniques in radiotherapy delivery and verification (McGill) AAPM Medical Physics Physics in Medicine and Biology Applied radiation and isotopes Brachytherapy

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Physica Medica Radiotherapy and Oncology 2. administrative responsibilities - Head of Brachytherapy from January 2007 until July 2008 3. committees - Committee members of Medical Physics Residency Program from September 2006 until July 2008 4. Thesis examination committees (supervisor in brackets) 2007 Master’s thesis examination committee Margeanu Monica (Dr J. Seuntjens), McGill University, Canada. 2008 Master’s thesis examination committee Luc Serré (Dr W. Abdel Raman), McGill University, Canada. 2010 PhD’s thesis examination committee Magali Edouard, Université de Grenoble, France. 2011 PhD’s thesis examination committee Fadi Abboud, (Prof S. Vynckier) Université Catholique de Louvain, Belgique. 2013 Master’s thesis examination committee Freedom Hliziyo, University of Cape Town, South Africa 2018 Thèse d’habilitation à diriger des recherches, ESRF, Grenoble, France 2018 PhD’s thesis, Solveig Reymond, ESRF, Grenoble, France 5. Professional and/or Learned Societies • ESTRO (European Society for Therapeutic Radiology and Oncology) • AAPM (American Association of Physicists in Medicine) • BHPA (Belgian Hospital Physicists Association) F Clinical Tasks - Clinique Universitaires StLuc (Brussels):

Routine: • Brachytherapy physicist, planning external beam, QA linacs, patient specific measurements, physics support.

Development: • Protocol for linac QA. - Hôpital Maisonneuve-Rosemont (Montreal, Canada): QA linacs, physics support for external beam, planning brachytherapy, patient specific measurements. - Montreal General Hospital (Montreal, Canada):

Routine: • QA linacs, physics support for external beam, QA treatment planning, brachytherapy planning (Nucletron), patient specific measurements, IMRT planning (Corvus treatment system).

Development: • Evaluation of the AAA algorithm (Eclipse, Varian). • Introduction of the use of heterogeneous calculations for lung treatments. Physics support for the transition from dose calculations and prescriptions in water to dose calculations and prescriptions taking into account the presence of heterogeneities using Monte Carlo techniques. • Development of Image Guided Brachytherapy for HDR gynecological treatment using Cone Beam CT images acquired in the treatment room.

- Maastro Clinic (Maastricht, the Netherlands) Routine: • Physics support, QA treatment planning (external and brachytherapy), physics

support for prostate implant (Variseed, Varian). Development: • Introduction of Oncentra Brachy (Nucletron).

• Use of MR for brachytherapy planning.

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• Introduction of HDR for prostate brachytherapy. Evaluation of Brachyvision for prostate and Gynecology.

G Research

1. Past activities: Brachytherapy: • First determination of the dosimetric characteristics of the new Iodine and Palladium

seeds of the IBt company. • Analysis of the effect of the detector size and composition for low energy photons. • Beginning of the analysis of the effect of tissue composition on the dose distribution around low energy photons sources.

• Use of EBT radiochromic films. • Development of Image Guided Brachytherapy for HDR gynecological treatment using

Cone Beam CT images acquired in the treatment room. • Introduction of deformation for dose accumulation between different fractions in

Brachytherapy. • Effect of the metal artifacts on model-based calculation algorithm in brachytherapy.

Microdosimetry: • Theoretical study of the microdosimetric characteristics of low energy photon brachytherapy sources.

• Theoretical study of the microdosimetric parameter for an Electronic Brachytherapy Source (Xoft).

• Study of the influence of the medium on microdosimetry for low energy photons. External beam: • Evaluation of the Monte Carlo algorithm for electron planning in Eclipse (Varian) PET-CT study: study of the evolution of the tumour response to radiation assessed using FDG-PET for lungs and Head and Neck treatment. Beldart2: • development of an audit program for the dynamic treatments in radiotherapy using EPR

dosimetry and EBT3 film dosimetry. • Extension of this audit for head and neck and stereotaxy. Introduction of Monte Carlo for

Beldart. Brachytherapy:

• Participation to the development of a Monte Carlo treatment planning system dedicated to brachytherapy based on 3D images of the patients.

• Development of in-vivo dosimetry for brachytherapy.

2. Current activities: Beldart3: supervision of an audit program for stereotaxic treatments (SRS and SBRT) using EPR

dosimetry and EBT3 film dosimetry. Brachytherapy:

• Participation to the development of a Monte Carlo treatment planning system dedicated to brachytherapy based on 3D images of the patients.

• Development of in-vivo dosimetry for brachytherapy.

3. In Projects: Microdosimetry:

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• Development of a mini microdosimeter with high spatial resolution and usable in the high dose rates used in clinical ion beams. Collaboration with the institute IMO of Hasselt University to develop a chemical vapor deposition (CVD) diamond microdosimeter.

• Radiobiological measurements to determine the biological effectiveness (RBE) of ion beams and low energy photons.

Nanoparticle:

• Study of the dose enhancement effect associated with Gold Nanoparticle using Geant and Geant-DNA for different beams used in radiotherapy.

4. research Grants NCIC (National Cancer Institute of Canada) Title : Monte Carlo Dosimetry for the Optimization and Evaluation of Prostate Brachytherapy Principal Investigator: Luc Beaulieu, Centre hospitalier Universitaire de Québec (CHUQ) Co-investigators : Eric Vigneault (CHUQ), Frank Verhaegen (McGill), Brigitte Reniers (MGH) Funded for 505,000 CAN$ from 10/2006 to 10/2011 RI MUHC (Research Institute of McGill University Health Center) Title: Tissue Equivalent Proportional Counter Principal Investigator: Brigitte Reniers Co-investigator: Frank Verhaegen Funded for 10,000 CAN$ Marie Curie reintegration grant (FP7-PEOPLE-2009_RG) Title : Low Energy Gamma and X-ray therapy Principle Investigator: Brigitte Reniers Funded for 100,000 EUR duration 48 months Received funding from industry (per project) Name project: Image-guided brachytherapy with cone-beam CT imaging Period: 08-11 Project coordinator: F Verhaegen Other participants: Reniers Applicant address: McGill univ. Funded by: Nucletron BV Sum of contract in Euro’s: 65k Sum to person C.V.: 65k Results: none yet Name project: AXXENT Miniature x-ray probe for electronic brachytherapy (equipment donation) Period: 2006-08 Project coordinator: F Verhaegen Other participants: B. Reniers Applicant address: McGill univ Funded by: Xoft Inc Sum of contract in Euro’s: 180k Sum to person C.V.: 180k Results: characterization of novel electronic brachytherapy source

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Name project: Assessment of dose-effect relationship between radiation dose and complications in prostate brachytherapy (Utopia) Period: 2011-14 Project coordinator: F Verhaegen Other participants: F van Gils, W Strijbos, B. Reniers Applicant address: MAASTRO clinic, GROW Funded by: Atrium Medisch Centrum Total sum of contract in Euro’s: 210k Sum to person C.V.: 210k Results: characterization of RadPos detector. (expected: treatment planning software, imaging protocols, outcome studies) Name project: EPID dosimetry for HDR brachytherapy verification Period: 2017-18 Project coordinator: F Verhaegen, Other participants: Gabriel Paiva Fonseca, Mark Podesta, Brigitte Reniers, Bas Nijsten Applicant address: MAASTRO clinic, GROW Funded by: Varian Total sum of contract in Euros: 30k

5. Publications

type Total Peer-reviewed journal papers 48 Publication in Book 3 Abstracts 74 a) Articles in peer-reviewed journals (names of my students are marked with an *) 1) Reniers B., Vynckier S. and Scalliet P., Dosimetric study of the new InterSource125 iodine seed, Med.

Phys. 28: 2285-2288; 2001, IF: 2.313. 2) Reniers B., Vynckier S., Scalliet P., Dosimetric study of a new Palladium seed, Appl Radiat Isot.

57(6): 805-811; 2002, IF: 0.768. 3) Ying H., Serhir L., Mahy P., Reniers B., Gueulette J. , Design of a “cylindrical” brachytherapy

implant container for the irradiation of an intestinal segment in mice, Rad. Res. 158: 123-126; 2003, IF: 3.208.

4) Reniers B., Verhaegen F., Vynckier S., The radial dose function of low-energy brachytherapy seeds in different solid phantoms: comparison between calculations with the EGSnrc and MCNP4C Monte Carlo codes and measurements, Phys Med Biol. 49(8):1569-82; 2004, IF: 2.368.

5) Reniers B., Vynckier S. and Verhaegen F., Theoretical analysis of microdosimetric spectra and cluster formation for 103Pd and 125I photon emitters, Phys Med Biol. 49(16): 3781-95; 2004, IF: 2.368.

6) Verhaegen F. and Reniers B., Microdosimetric Analysis of Various Mammography Spectra: Lineal Energy Distribution and Ionization Cluster Analysis, Rad. Res. 162: 592-599, 2004, IF: 3.228.

7) Lehnert S., Reniers B., Verhaegen F., Relative biological efficiency in terms of tumor response of 125-I implants compared with 60-Co gamma rays, Int. J. Rad. Oncol. Biol. Phys. 63 pp:224-229; 2005, IF: 4.556.

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8) Verhaegen F., Reniers B., Deblois F., Devic S., Seuntjens J., Hristov D., Dosimetric and microdosimetric study of contrast-enhanced radiotherapy with kilovolt x-rays, Phys. Med. Biol. 50 : 3555-3569; 2005, IF: 2.683.

9) Bernard S.*, Reniers B., Scalliet P., Vynckier S., Optimization of a breast implant in Brachytherapy PDR. Validation with Monte Carlo simulation and measurements with TLDs and GafChromic films, Radiother. Oncol. 76(3):326-33; 2005, IF: 3.304.

10) Reniers B., Verhaegen F. The microdosimetry of low energy photons in radiotherapy Radiat Prot Dosimetry 122(1-4):401-3; 2006, IF: 0.490.

11) E. Poon , S. Devic , B. Reniers , T. Vuong¸ V. Verhaegen, Dosimetric characterization of a novel intracavitary mold applicator for 192Ir high dose rate endorectal brachytherapy treatment, Med Phys. 33(12):4515-26; 2006, IF: 3.192

12) Carrier J.F., D'Amours M., Verhaegen F., Reniers B., Martin A.G., Vigneault E., Beaulieu L. Postimplant dosimetry using a monte carlo dose calculation engine: A new clinical standard. Int J Radiat Oncol Biol Phys. 68(4):1190-8; 2007, IF: 4.29.

13) Liu D.*, Poon E., Bazalova M., Reniers B., Evans M., Rusch T., Verhaegen F. Spectroscopic characterization of a novel electronic brachytherapy system. Phys. Med. Biol. 53(1):61-75; 2008, IF: 2.784.

14) Yan X., Poon E., Reniers B., Vuong T., Verhaegen F. Comparison of dose calculation algorithms for colorectal cancer brachytherapy treatment with a shielded applicator. Med. Phys. 35:4824-30; 2008, IF: 3.871.

15) Reniers B., Liu D.*, Rusch T., Verhaegen F. Calculation of relative biological effectiveness of a low-energy electronic brachytherapy source. Phys. Med. Biol. 53:7125-7135; 2008, IF: 2.784.

16) Furstoss C.*, Reniers B., Bertrand M. J.*, Poon E., Carrier J.-F., Keller B. M., Pignol J. P., Beaulieu L., Verhaegen F., Monte Carlo study of LDR seed dosimetry with an application in a clinical brachytherapy breast implant, Med Phys. 36(5):1848-58; 2009, IF: 2.704

17) Al-Halabi H, Portelance L, Duclos M, Reniers B, Bahoric B, Souhami L. Cone Beam CT-Based Three-Dimensional Planning in High-Dose-Rate Brachytherapy For Cervical Cancer. Int J Radiat Oncol Biol Phys 77(4):1092-7; 2009, IF: 4.592

18) Brunet-Benkhoucha M, Verhaegen F, Lassalle S, Béliveau-Nadeau D, Reniers B, Donath D, Taussky D, Carrier JF Clinical implementation of a digital tomosynthesis-based seed reconstruction algorithm for intraoperative postimplant dose evaluation in low dose rate prostate brachytherapy Med Phys. 36(11): 5235-44; 2009, IF: 2.704.

19) Landry G.*, Reniers B., Murrer L., Lutgens L., Bloemen-Van Gurp E., Pignol J.P., Keller B., Beaulieu L., Verhaegen F. Sensitivity of low energy brachytherapy Monte Carlo dose calculations to uncertainties in human tissue composition. Med phys 37: 5188; 2010, IF: 3.07.

20) Afsharpour H., Pignol J.P., Keller B., Carrier J.F., Reniers B., Verhaegen F., Beaulieu L. Influence of breast composition and interseed attenuation in dose calculations for post-implant assessment of permanent breast 103Pd seed implant. Phys Med Biol. 55(16):4547-61; 2010, IF: 3.056

21) Landry G.*, Reniers B., Pignol J.P., Beaulieu L., Verhaegen F., The difference of scoring dose to water or tissues in Monte Carlo dose calculations for low energy brachytherapy photon sources, Med. Phys. 38(3):1526-33; 2011, IF 2.83.

22) van den Bogaard J., Janssen M.H., Janssens G., Buijsen J., Reniers B., Lambin P., Lammering G., Ollers M.C. Residual metabolic tumor activity after chemo-radiotherapy is mainly located in initially high FDG uptake areas in rectal cancer. Radiother Oncol. 99(2):137-41; 2011, IF: 5.58

23) Reniers B., Verhaegen F., Cone beam CT imaging for 3D Image Guided Brachytherapy for gynaecological HDR brachytherapy, Med. Phys. 38(5):2762-2767; 2011, IF:2.83.

24) Landry G.*, Granton P.V., Reniers B., Ollers M.C., Beaulieu L., Wildberger J.E., Verhaegen F. Simulation study on potential accuracy gains from dual energy CT tissue segmentation for low-energy brachytherapy Monte Carlo dose calculations. Phys Med Biol. 56(19):6257-78; 2011, IF 2.829

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25) Afsharpour H, Landry G*, Reniers B, Pignol J-P, Beaulieu L, Verhaegen F. Breast tissue modeling schemes in low energy breast brachytherapy. Phys. Med. Biol. 56, 7045-60, 2011 IF: 2.829

26) Landry G.*, Reniers B, Granton PV, van Rooijen B, Beaulieu L, Wildberger JE, Verhaegen F. Extracting atomic numbers and electron densities from a dual source dual energy CT scanner: Experiments and a simulation model. Radiother Oncol. 100(3):375-9; 2011, IF: 5.58

27) Afsharpour H., Reniers B., Landry G*., Pignol J.P., Keller B.M., Verhaegen F. Consequences of dose heterogeneity on biological efficiency of 103Pd permanent breast seed implants, Phys. Med. Biol., 57(3), pp:809-823, 2012, IF:2.701

28) S White, G Landry*, F van Gils, F Verhaegen, B Reniers. Influence of trace elements in human tissue in low energy photon brachytherapy dosimetry. Phys Med Biol 2012 Jun 7;57(11):3585-96., IF: 2.701

29) Afsharpour H., Landry G.*, D’Amours M., Enger S., Reniers B., Poon E., Carrier J. -F., Verhaegen F., Beaulieu L. ALGEBRA: Heterogeneous dosimetry algorithm based on GEANT4 for brachytherapy Phys Med Biol 2012, Jun 7;57(11):3273-80 ,IF: 2.701

30) Landry G*, Reniers B, Lutgens L, Murrer L, Afsharpour H, de Haas-Kock D, Visser P, van Gils F, Verhaegen F. Dose reduction in LDR brachytherapy by implanted prostate gold fiducial markers. Med Phys, vol. 39 (3) pp. 1410, 2012, IF: 3.042

31) Reniers B., Landry G*., Eichner R., Hallil A.,Verhaegen F. In-vivo dosimetry for gynaecological brachytherapy using a novel position sensitive radiation detector: feasibility study, Med Phys, vol 39, pp 1925, 2012, IF: 2.83.

32) Christel Nomden C, Leeuw A., Van Limbergen E., De Brabandere M., Nulens A., Nout R., Laman M., Ketelaars M., Reniers B., Lutgens L., Jürgenliemk-Schulz I., Multicentre study of MRI-guided brachytherapy treatment planning: Comparison among tandem ovoid applicator users, Radiother Oncol, 107(1), pp:82-7, 2013, IF: 4.52.

33) Fonseca G., Landry G., Reniers B., Hoffmann A., Rubo R., Antunes P.A., Yoriyaz H., Verhaegen F., The contribution from transit dose for 192Ir HDR brachytherapy treatments, Phys. Med. Biol. 59 1831–1844, 2014, IF: 3.012.

34) White S. A., Landry G., Paiva Fonseca G. P., Holt R., Rusch T., Beaulieu L., Verhaegen F., Reniers B., Comparison of TG-43 and TG-186 in breast irradiation using a low energy electronic brachytherapy source, Med Phys, 41(6), 2014, 061701, IF: 3.012.

35) Gaudreault M, Reniers B, Landry G, Verhaegen F, Beaulieu L.Dose perturbation due to catheter materials in high-dose-rate interstitial (192)Ir brachytherapy. Brachytherapy. 2014 Nov-Dec;13(6):627-31. IF: 1.987.

36) G P Fonseca, G Landry, S White, M d’Amours, H Yoriyaz, L Beaulieu, B Reniers, F Verhaegen. The

use of tetrahedral mesh geometries in Monte Carlo simulation of applicator based brachytherapy dose distributions. Phys Med Biol. 59, 5921-35, 2014, IF: 2.922.

37) G.P. Fonseca, B. Reniers, G. Landry, S. White, M. Bellezzo, P.C. Antunes, C.P. de Sales, E. Welteman, H. Yoriyaz, F. Verhaegen, "A medical image-based graphical platform-Features, applications and relevance for brachytherapy," Brachytherapy, 2014, IF: 1.987.

38) Fonseca G P, Viana R. S.; Rubo R. A., de Sales C. P.; Reniers B., Verhaegen F.; Yoriyaz H., HDR 192Ir source speed measurements using a 960 fps video camera Med. Phys., 42(1), pp:412-415, 2015, IF: 3.012.

39) Trani D, Reniers B, Persoon L, Podesta M, Nalbantov G, Leijenaar RT, Granzier M, Yaromina A, Dubois L, Verhaegen F, Lambin P. What Level of Accuracy Is Achievable for Preclinical Dose Painting Studies on a Clinical Irradiation Platform? Radiat Res. 2015 Apr 21. IF: 2.445.

40) Adolfsson E, White S, Landry G, Lund E, Gustafsson H, Verhaegen F, Reniers B, Carlsson Tedgren Å, Carlsson GA. Measurement of absorbed dose to water around an electronic brachytherapy source. Comparison of two dosimetry systems: lithium formate EPR dosimeters and radiochromic EBT2 film. Phys Med Biol. 2015 May 7;60(9):3869-82 IF:2.922.

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41) G Paiva Fonseca, Å Carlsson Tedgren, B Reniers, J Nilsson, M Person, H Yoriyaz, F Verhaegen. Dose specification for 192Ir high dose rate brachytherapy in terms of dose to water in medium and dose to medium in medium. Phys Med Biol 60, 4565-79, 2015. IF: 2.922

42) High dose rate and flattening filter free irradiation can be safely implemented in clinical practice. Dubois L, Biemans R, Reniers B, Bosmans G, Trani D, Podesta M, Kollaard R, Rouschop KM, Theys J, Vooijs M, Pruschy M, Verhaegen F, Lambin P. Int J Radiat Biol. 2015 Jul 1:1-23, IF: 1.687

43) Daniela Trani, Ala Yaromina, Ludwig J. Dubois, Marlies Granzier, Sarah G.J.A. Peeters, Rianne Biemans, Georgi Nalbantov, Natasja G Lieuwes, Brigitte Reniers, Esther G.C. Troost, Frank Verhaegen, and Philippe Lambin, Preclinical assessment of efficacy of radiation dose painting based on intratumoral FDG-PET uptake, clinical cancer research, clin can res. 2015 Dec 15;21(24):5511-8. doi: 10.1158/1078-0432.CCR-15-0290 IF. 8.722

44) Shane White, Brigitte Reniers, Evelyn de Jong, Thomas Rusch, Frank Verhaegen, "A comparison of the relative biological effectiveness of low energy electronic brachytherapy sources in breast tissue: A Monte Carlo study" Phys Med Biol. 2016 Jan 7;61(1):383-99 IF 2.811

45) Brigitte Reniers, G. Janssens, J Orban de Xivry, G. Landry, F Verhaegen. “Dose distribution for gynecological brachytherapy with dose accumulation between insertions: feasibility study.” 2016 Jul-Aug;15(4):504-13. doi: 10.1016/j.brachy.2016.03.003 IF 2.088

46) M Ebert, B Dhal, J Prunster, S McLaren, N Zeps, M House, B Reniers, F Verhaegen, T Corica, C Saunders, D Joseph. Theoretical versus Ex Vivo Assessment of Radiation Damage Repair: An Investigation in Normal Breast Tissue. Rad Res 185, 393-401, 2016. IF 3.022

47) Fonseca GP, Podesta M, Bellezzo M, Van den Bosch MR, Lutgens L, Vanneste BGL, Voncken R, Van Limbergen EJ, Reniers B, Verhaegen F. Online pretreatment verification of high-dose rate brachytherapy using an imaging panel. Phys Med Biol. 2017 Jul 7;62(13):5440-5461.

48) Bellezzo M, Fonseca GP, Verrijssen AS, Voncken R, Van den Bosch MR, Yoriyaz H, Reniers B, Berbée M, Van Limbergen EJ, Verhaegen F. A novel rectal applicator for contact radiotherapy with HDR 192Ir sources. Brachytherapy. 2018 Aug 16. pii: S1538-4721(18)30139-9.

b. Book chapters F. Verhaegen and B. Reniers, “Microdosimetry” in “Review of Radiation Oncology Physics: A handbook

for teachers and students.” Editor Ervin B. Podgorsak (to be published). Pouliot J, Sloboda R, Reniers B. Two-, Three- and Four Dimensional Brachytherapy. In: Comprehensive

Brachytherapy: Physical and Clinical Aspects (Venselaar, Ed). Taylor&Francis, 2012. D. Baltas, B. Reniers, A. Meigooni Experimental dosimetry methods (Venselaar, Ed). Taylor&Francis,

2012. c. Abstracts (1) N. Debbas, M. Cogneau, B. Reniers, S. Vynckier and P. Scalliet 2000 Production of 103Pd radioactive stents – a potential tool to prevent coronary restenosis following percutaneous transluminal coronary angioplasty. Radiother. and Oncol. 56 (suppl. 1):135. (2) B. Reniers, S. Vynckier and P. Scalliet 2000 Dosimetric study of the new InterSource103 palladium seed Radiother. and Oncol. 56 (suppl.):43. (3) B. Reniers, S. Vynckier and P. Scalliet 2000 Dosimetric study of the new interSource Pd-103 seeds Proceedings of the 16th symposium of the BHPA Leuven. (4) B. Reniers, S. Vynckier and P. Scalliet 2001 Dosimetric study of the new InterSource Palladium and Iodine seed. Abstract of the annual AAPM Meeting Med. Phys. 28: 1179. (5) B. Reniers, S. Vynckier and P. Scalliet 2001 “Dosimetry of the new InterSource of 103Pd and 125I. Radiother. and Oncol. 61 (suppl 1) (6) B. Reniers, S. Vynckier and P. Scalliet “Dosimetric study of the new InterSource palladium and iodine seed”, CIRMS, October 2001

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(7) B. Reniers, S. Vynckier and P. Scalliet “Dosimetric study of the new InterSource palladium and iodine seed” Proceedings of the symposium of the Belgian Hospital Physicist Association (Louvain-La Neuve , Belgium), 2001 (8) B. Reniers, F. Verhaegen, S. Vynckier, J. Gueulette. Use of 103Pd and 125I in brachytherapy: dosimetric and microdosimetric study. 8th Annual MCNEGS user group meeting, Stoke, April 22-23, 2002. (9) B. Reniers, F. Verhaegen, S. Vynckier, J. Gueulette. Dosimetric and microdosimetric study of 103Pd and 125I seed sources. 44th Annual Meeting of the American Association of Phyicists in Medicine, Montreal July 14-18, 2002. (10) B. Reniers, S. Vynckier and F. Verhaegen “Microdosimetric study and cluster analysis of 103Pd and 125I”, World Congress 2003, Phys. Med. Biol. 49, Number 16, 21 August 2004 (11) F. Verhaegen, B. Reniers “Monte Carlo simulations and cluster damage analysis for mammography x-ray spectra”, 12th International Congress of Radiation Research, Brisbane, Aug 2003 (12) B. Reniers, S. Vynckier, F.Verhaegen “Comparison between calculations with the EGSnrc and MCNP4C Monte Carlo codes and measurements for the determination of radial function for brachytherapy seeds.” Current Topics in Monte Carlo Treatment Planning, May 3 - 5, 2004, McGill University, Medical Physics Unit, Montreal, Canada. (13) F. Verhaegen, B. Reniers. Cluster Damage Analysis from Monte Carlo Simulations for Mammography X-Rays. Regional Radiation Sciences Meeting, Ottawa, May 12, 2004. (14) B. Reniers, F. Verhaegen “Microdosimetric study and cluster analysis of 103Pd and 125I”, Fourth meeting Regional radiation sciences research group, 3rd November 2004, Montréal. (15) S. Lehnert, B. Reniers, F. Verhaegen. Relative Biological Efficiency in terms of tumor response of 125-I seeds compared to 60-Co gamma rays. Regional Radiation Sciences Meeting, Montreal, October 3, 2004. (16) F Verhaegen, B Reniers, F DeBlois, S Devic, J Seuntjens, and D Hristov SPhoto-Electric Effect with a Vengeance: Dosimetric and Microdosimetric Characterization of Contrast-Enhanced Radiation Therapy Using Kilovolt X-Rays, 47th congress of AAPM, Seattle, SU-FF-T-364: Med. Phys. 32, 2034 (2005) (17) B Reniers Monte Carlo Study of the Effect of the Tissue Composition On the Dosimetric Data Used for Low Energy Photons, 47th congress of AAPM, Seattle, MO-E-T-618-05, Med. Phys. 32, 2069 (2005) (18) B. Reniers, F. Verhaegen “The microdosimetry of low energy photons in radiotherapy”, 14th Symposium on Microdosimetry, Venice, Italy, Novembre 2005 (19) B. Reniers, F. Verhaegen The microdosimetric parameters of low energy photons sources in brachytherapy 27th Annual Meeting of ABS, May 2006, Philadelphia, USA (20) B. Reniers, J-F.Carrier, L. Beaulieu, F. Verhaegen Influence of tissue compositions on dose distributions for 125I and 103Pd seeds 27th Annual Meeting of ABS, May 2006, Philadelphia, USA (21) M. J. Bertrand, B. Reniers, F. Verhaegen “Measured and Calculated Dose Distribution Around 125I Brachytherapy Seeds in a Breast Phantom”, 48th Annual Meeting of AAPM, July 2006, Orlando, USA (22) Bertrand M-J*, Reniers B, Verhaegen F. Utilisation de films Gafchromic EBT en curiethérapie à faible débit de dose pour mesurer des distributions de dose autour de grains d'iode-125 dans un fantôme de sein. 74th Meeting of the Association Francophone pour le Savoir (ACFAS), Montreal, May 15-19, 2006. (23) B. Reniers, M.J. Bertrand, J.F.Carrier, L. Beaulieu, F. Verhaegen “Influence of tissue compositions on dose distributions for 125I and 103Pd seeds” 25th Meeting of ESTRO, October 2006, Leipzig, Germany (24) Beaulieu L, Carrier JF, D'Amours M*, Reniers B, Verhaegen F, A Martin A, Vigneault E. Should Monte Carlo become the standard post-implant dose calculation method? 25th ESTRO Meeting, Leipzig, Oct 8-12, 2006. (25) B. Reniers, D. Liu, T. Rusch, F. Verhaegen “Spectral analysis and Microdosimetric MC study around a novel electronic brachytherapy device” International Workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification, May 2007, Montreal, Canada (26) C. Furstoss, B. Reniers, E. Poon, M. D’Amour, J-F. Carrier, L. Beaulieu, J. Williamson, F. Verhaegen “Monte Carlo iodine brachytherapy dosimetry: study for a clinical application” International Workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification, May 2007, Montreal, Canada (27) E. Poon, B. Reniers, Y. Le, J. Williamson and F. Verhaegen “Dose perturbations due to applicator shielding and patient heterogeneities for 192Ir high dose rate rectal brachytherapy treatment”, International Workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification, May 2007, Montreal, Canada (28) D. Liu, E. Poon, M. Bazalova, B. Reniers, M. Evans, J. Seuntjens, T. Rusch, F. Verhaegen “Geant4 Monte Carlo characterization of novel Electronic Brachytherapy System” International Workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification, May 2007, Montreal, Canada

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(29) Goodfellow D*, Prichindel A*, Bazalova M*, Poon E*, Reniers B, Verhaegen F. Monte Carlo dose calculation accuracy in 192Ir brachytherapy based on CT and cone-beam CT images. Third McGill International Workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification, Montreal May 29 – June 1, 2007. (30) G. Lagmago Kamta and B. Reniers, Evaluation of the Monte Carlo calculation engine of Eclipse treatment planning for electron beams, AAPM, July 2008, Houston, USA (31) Malik Brunet-Benkhoucha, F. Verhaegen, S. Lassalle, D. Béliveau-Nadeau, B. Reniers, D. Donath, D. Taussky, J-F Carrier, Low Dose Rate Prostate Brachytherapy: A Tomosynthesis-Based Intra-Operative Post-Implant Dose Evaluation, AAPM, July 2008, Houston, USA (32) B. Reniers, F. Verhaegen, Introduction of the Cone Beam CT for 3D Image Guided GYN Brachytherapy, AAPM, July 2008, Houston, USA (33) C.Furstoss, X. Yan, B.Reniers, E. Poon, A. Hallil, F. Verhaegen, MOSFET In-Vivo Dosimetry for Colorectal Cancer Patients Treated with Shielded Brachytherapy, AAPM, July 2008, Houston, USA (34) C. Furstoss, E. Poon, B. Reniers, J-F Carrier, J-P Pignol, J. F. Williamson, L. Beaulieu, F. Verhaegen, LDR Brachytherapy Dosimetry: Monte Carlo Code and TG-43 Comparisons, AAPM, July 2008, Houston, USA (35) B. Reniers and F. Verhaegen, Use of the Cone Beam CT for 3D Image Guided GYN Brachytherapy, ESTRO, September 2008, Göteborg, Sweden (36) Furstoss C*, Bertrand M-J*, Poon E*, Reniers B, Carrier J-F, Pignol J-P , Williamson J, Beaulieu L, Verhaegen F. Dosimetric differences between TG-43 and Monte Carlo calculation for breast LDR brachytherapy. 27th ESTRO Meeting, Göteborg, Sept 14-18, 2008. (37) Yan X*, Poon E*, Reniers B, Vuong T, Verhaegen F. Dose calculation algorithms for HDR colorectal cancer brachytherapy treatment with a shielded applicator. 27th ESTRO Meeting, Göteborg, Sept 14-18, 2008. (38) Brunet-Benkhoucha M*, Verhaegen F, Lassalle S, Béliveau-Nadeau D, Reniers B, Donath D, Taussky D, J Carrier. A tomosynthesis-based intraoperative dose evaluation in LDR prostate brachytherapy. 27th ESTRO Meeting, Göteborg, Sept 14-18, 2008. (39) Reniers B., Verhaegen F. Introduction of the cone beam CT for 3D image-guided GYN brachytherapy, 24th annual symposium of the BHPA, Kortrijk, Belgium, Feb 2009. (40) Reniers B., Rusch T., Verhaegen F.. estimation of relative biological effectiveness for a novel electronic brachytherapy x-ray source 3rd International Conference on Translational Research Geneva, Switzerland, march 2009, Radiother. and Oncol. 90 (suppl. 3):S106. (41) Lambin Ph., van Loon J., van Baardewijk A., Aerts H., Petit S., van Elmpt W., Oellers M., Egelmeer A., Reniers B., De ruysscher D. The contribution of PET in lung cancer Radiotherapy: from CT_PET simulation to voxel-control probability, 3rd International Conference on Translational Research Geneva, Switzerland, march 2009, Radiother. and Oncol. 90 (suppl. 3):S5. (42) Poon E, Al-Halabi H, Reniers B, Verhaegen F. Effects of shielded ovoids in HDR 192Ir cervical brachytherapy: A Monte Carlo study using cone-beam CT images. 51st Meeting of the American Association of Physicists in Medicine (AAPM), Anaheim, California, July 26-30, 2009. (43) Afsharpour H, Pignol J-P, Keller B, Carrier J-F, Reniers B, Verhaegen F, Beaulieu L. Toward a more accurate dose calculation using a semiautomatic organ contouring in Monte Carlo post-implant assessment of breast LDR brachytherapy. 51st Meeting of the American Association of Physicists in Medicine (AAPM), Anaheim, California, July 26-30, 2009. (44) Bazalova M, Landry G, Beaulieu L, Reniers B, Verhaegen F. An algorithm for metal streaking artifact reduction in cone beam CT . 51st Meeting of the American Association of Physicists in Medicine (AAPM), Anaheim, California, July 26-30, 2009. (45) Reniers B, Verhaegen F 3D dose distribution for GYN with dose accumulation between insertions: Feasibility study 10th Biennal ESTRO Conference on Physics and Radiation Technology for Clinical Radiotherapy, Maastricht, Aug 2009 (46) Afsharpour H, Reniers B, Verhaegen F, Beaulieu L. The influence of the distance from the source and the source design on the RBE values for brachytherapy seeds. 52nd Annual meeting of the AAPM, Philadelphia, July 18-22, 2010. (47) Afsharpour H, Reniers B, Verhaegen F, Beaulieu L. The sensitivity of BED and TCP parameters to dose heterogeneity in brachytherapy treatments. 52nd Annual meeting of the AAPM, Philadelphia, July 18-22, 2010 (48) Landry G., Reniers B., Pignol J.P., Beaulieu L., Verhaegen F. Dose to medium and water in low energy brachytherapy, ESTRO 2011 (49) Reniers B. Landry G, Eichner R, Bloemen-van Gurp E. Murrer L. Verhaegen F. In vivo dosimetry for gynaecological brachytherapy based on a novel radpos system. ESTRO 2011

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(50) Christel Nomden C, Leeuw A., Van Limbergen E., De Brabandere M., Nulens A., Nout R., Laman M., Ketelaars M., Reniers B., Lutgens L., Jürgenliemk-Schulz I., Multicentre study of MRI-guided brachytherapy treatment planning: Comparison among tandem ovoid applicator users ESTRO 2011 (51) Landry G. Granton P, Reniers B, van Rooien B, Beaulieu L, Wildberger J, Verhaegen F. Evaluating the impact of dual energy CT on LDR brachytherapy dose calculations. AAPM meeting, Vancouver, Jul 31-Aug 4, 2011. (52) B Reniers, G Landry, R Eichner, A Hallil, F Verhaegen. Use of the novel RadPos system for in-vivo dose verification in gynaecological brachytherapy treatment. AAPM meeting, Vancouver, Jul 31-Aug 4, 2011. (53) Reniers B, Landry G, Eichner R, Abdelbasset H, Verhaegen F. In-vivo dosimetry for gynaecological brachytherapy using a novel detector system. ICT conference, Geneva, feb 27-march 2 2012. (54) S White, G Landry, F van Gils, F Verhaegen, B Reniers. Influence of high atomic number elements in human tissue in dosimetry for low energy photon brachytherapy. ESTRO meeting, Barcelona, May 9-13, 2012. (55) G Landry, B Reniers, L Lutgens, L Murrer, H Afsharpour, D de Haas-Kock, P Visser, F van Gils, F Verhaegen. Fiducial markers in combined EBRT-LDR therapy of prostate cancer: influence on LDR dose. ESTRO meeting, Barcelona, May 9-13, 2012. (56) B. Reniers, G. Janssens, Jonathan Orban de Xivry, G. Landry, F Verhaegen. 3D dose distribution for GYN with dose accumulation between insertions: feasibility study. BHPA symposium, Mechelen, Belgium February 2013 (57) S. Lelie, W. Schroeyers, B. Reniers, S Schreurs BELdART-2: Moving towards safer radiotherapy, BHPA symposium, Mechelen, Belgium February 2013 (58) B. Reniers, G. Janssens, Jonathan Orban de Xivry, G. Landry, F Verhaegen. 3D dose distribution for GYN with dose accumulation between insertions: feasibility study. American Brachytherapy Society meeting, New Orleans, April 2013 (59) S. Lelie, W. Schroeyers, B. Reniers, S Schreurs BELdART-2: Moving towards safer radiotherapy, ESTRO, Geneva, April 2013 (60) B. Reniers, G. Janssens, J Orban de Xivry, G. Landry, F Verhaegen. Dose distribution for gynaecological brachytherapy with dose accumulation between insertions: feasibility study. ESTRO, Geneva, April 2013 (61) D. Trani, M. Podesta, B. Reniers, S. Vanhoof, B. Nijstens, S. Peeters, L. Dubois, H. Beijer, F. Verhaegen, P. Lambin Evaluation of the accuracy of Eclipse dose calculations by Gafchromic EBT2 film measurements: towards preclinical “dose painting” studies. ESTRO, Geneva, April 2013 (62) S. White, G. Landry, R. Holt, B. Nelissen, T. Rusch, L. Beaulieu, F. Verhaegen, B. Reniers Comparison of TG-43 and TG-186 in breast irradiation using a low energy electronic brachytherapy source. ESTRO, Geneva, April 2013 (63) G. Landry, B. Reniers, E. Vigneault, L. Beaulieu, J. Wildberger, F. Verhaegen Dual energy CT facilitates LDR brachytherapy seed metal artefact reduction. ESTRO, Geneva, April 2013 (64) S. van der Meer, D Bouvy, B Reniers, D Fontanarosa, F Verhaegen Ultrasound IGRT: Deformable image registration of daily ultrasound images to derive daily CT images ESTRO, Geneva, April 2013. (65) G. Fonseca, B. Reniers, F. Verhaegen, H. Yoriyaz, Heterogeneity impact in a gynecological cancer treatment using a HDR Ir-192 source ESTRO, Geneva, April 2013. (66) L. Dubois, S. Peeters, M. Granzier, N. Lieuwes, R. Biemans, B. Reniers, G. Nalbantov. E. Troost, G. Bosmans, F. Verhaegen, P. Lambin Preclinical Assessment of Efficacy of Intratumoral Fluorodeoxyglucose (FDG) Uptake-Based Radiation Dose Redistribution, ICTR-PHE 2014. (67) B. Reniers, F. Verhaegen, Effect of metal CT artifact with model-based dose calculation algorithms, Symposium of the Belgian Hospital Physicists Association, February 2014. (68) B. Reniers, W. schroeyers, N. Reulens, S. Schreurs. Development of a national audit program for dynamic therapy. , Symposium of the Belgian Hospital Physicists Association, February 2014. (69) B. Reniers F. Verhaegen, Effect of metal CT artifact with model-based dose calculation algorithms, ESTRO, Vienna, April 2014. (70) D. Trani, B. Reniers, L. Persoon, M. Podesta, L. Dubois, F. Verhaegen, P. Lambin Preclinical PET-based dose painting on a clinical linac: methodological developments and dosimetric accuracy, ESTRO, Vienna, April 2014. (71) B. Reniers, W. schroeyers, N. Reulens, S. Schreurs. Development of a national audit program for dynamic therapy. ESTRO, Vienna, April 2014. (72) G. Fonseca, B. Reniers, J. Nilsson, M. Persson, Å. Carlsson Tedgren, H. Yoriyaz..F. Verhaegen, Monte Carlo simulation of HDR Ir-192 brachytherapy cancer treatments, American Brachytherapy Society meeting, April 2014.

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(73) MA Ebert, B Dahl, J Prunster, S McLaren, Zeps N, House M, Reniers B, Verhaegen F, Saunders C, Joseph DJ, Radiation damage and repair in breast tissue – an in vivo assessment of a radiobiological model, Australian Combined Scientific Meeting, Melbourne, Australia, sept 2014. (74) G Fonseca · M Podesta · B Reniers · F Verhaegen MO-AB-BRA-03: Development of Novel Real Time in Vivo EPID Treatment Verification for Brachytherapy, AAPM 2016, Med Phys. 2016 Jun;43(6):3691. doi: 10.1118/1.4957155.