CURRICULUM VITAE

DR ANDREA PICCIN

MB, MD

University of Medicine, Padua, Italy

Medizinische Fakultät Julius-Maximilians, Würzburg, Germany

MD, Higher Specialist Degree in Haematology

University of Medicine, Verona, Italy

PhD in Haematology

University of Trinity College, Dublin, Ireland

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CONTENT Page

Personal profile: 3

Education 4

Qualifications 5-6

Current position 7-9

Verona University SPR scheme 10-11

Clinical rotations in Haematology 12-13

Other clinical experience 14

Management experiences 14

Grants and scholarships 16

Peer reviewer experience 17-18 Research experience 19-20

Peer reviewed publications 21-30

Publications in preparation 31-32

Abstracts publications 33-41 Posters publications 43-49

Published textbook translations 50 Oral presentation 51-57 Meetings attended: 57-58

Courses attended: 59

Foreign languages: 60

Referees: 61

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PERSONAL PROFILE

NAME: Andrea Piccin

ADDRESS: Via San Quirino 26, 39100 Bolzano, Italy

NATIONALITY: Italian

D.O.B. 24.04.1969

MARITAL STATUS Married

CHILDREN 3

Tel: +39-347-2736692

Work e-mail: andrea.piccin@asbz.it

Private e-mail: apiccin@gmail.com

Irish Register of Medical Number: 379057 Date entered: 14/05/2003 Specialists (Haematology Clinical and Laboratory)

Irish Medical Registration Number: 51004 Date entered: 02/03/2001

Italian Medical Registration Number: 8281 Date entered: 16/07/1997 (Ordine dei Medici di Padova)

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EDUCATIONAL PROFILE

Primary: Scuola Elementare Ardigo’ and Scuola Elementare G.B. Belzoni, Padova, Italy (1975-1980)

Secondary: Scuola Media G.Mameli, Padova, Italy (1980-1983) Liceo Classico Tito Livio, Padova, Italy (1983-1988): High School specializing in classical studies: Ancient Greek, Latin, Philosophy, Ancient History

Tertiary: University of Padova, Faculty of Medicine, Padova, Italy (1989- 1996) Medizinische Fakultät Julius-Maximilians, Würzburg, Germany (1992 - 1993) University of Verona, Specialisation School in Haematology, Italy (1998-2002) University of Dublin, Trinity College, Ireland (2004-2009)

Medizinische Fakultät, Innsbruck Universität, Austria (2013-2014)

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MEDICAL QUALIFICATIONS 1) Medical Degree (Diploma di Laurea in Medicina e Chirurgia), Padua University, Italy. 15/10/1996

2) Italian National Medical Qualifying Exam (Esame di Stato per abilitazione all’ esercizio della professione di medico chirurgo).

15/05/1997 3) 1st MD Thesis "Gene Therapy in Human Medulloblastoma, in Vivo and in Vitro" Paediatric Onco-Haematology Department, Padua University, Italy, 1996 4) Medical-Military Officers Qualification Attended the 125th Course for Medical-Military Officers in Florence and completed the

qualifying exam 18/07/1997 5) Haematology Qualification (Specialista in Ematologia e Malattie degli Organi

Emopoietici). Completed the Higher Specialist Training in Haematology at Verona University, Italy, 21/10/2002.

6) 2nd MD Thesis

“Analysis of conventional and high dose therapy in an analysis of 201 cases of Multiple Myeloma”. Verona University Italy, 2002 7) Diploma in Medical Management Royal College of Surgeon in Ireland and Institute of Public Administration”, Dublin, Ireland, July 2005 8) PhD in Haematology obtained from the University of Dublin, Trinity College, Ireland

on “Sickle cell Anaemia. New insights into its pathophysiology. August 2009

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NON MEDICAL QUALIFICATIONS 9) Awarded title of “Cavaliere della Repubblica Italiana” and medaille from the “Ordine della Stella della Solidarietá italiana” by the Italian President Giorgio Napolitano, Roma, Italy, August 2007 10) Diploma of German language “Kleines deutsches Sprachdiplom”. Goethe Institut Műnchen, Germany 11) Universitary Diploma of bilinguism italian/german

(Zweisprachigkeitsprüfung Stufe A) Provincia Autonoma di Bolzano/Bozen, South Tyrol, Italy, October 2009

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CURRENT POSITION (Consultant Haematologist)

From 16th of February 2009 to the present, I hold the post of consultant haematologist (permanent position) at the Department of Haematology and Bone Marrow Transplant (BMT) Unit, San Maurizio Regional Hospital, Bolzano, Italy. This is a centre of excellence for the treatment of benign and malignant Haematological conditions and a BMT centre of excellence for North Italy It serves the Italian Region of South Tyrol/Alto Adige which has a population of 500.000. The centre is accredited by JACIE, ISO 9001, and participates in multicentre clinical studies in collaboration with - GIMEMA: Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto; - NHLCSG: Non Hodgkin Lymphoma Cooperative Study Group - GITMO: Gruppo Italiano Trapianto di Midollo Osseo - GITIL: Gruppo Italiano Terapie Innovative nei Linfomi - DSMM: Deutsche Studiengruppe Multiples Myelom The medical director of the centre is Professor Sergio Cortelazzo (University of Verona). The Department includes another 11 consultant haematologists, 31 nurses and 11 lab-technicians. The ward has 14 beds; the Day Ward has 10 beds. The centre currently performs approximately 50 autologus and 25 allogeneic bone marrow transplantations per year.

CLINICAL DUTIES IN CURRENT POST:

- The diagnosis and management of patients on the in-patient ward and the day ward, undergoing standard chemotherapy regimes and BMT (autologus and allogeneic). The outpatient clinical follow up of patients with acute leukaemias, lymphomas and other haematological conditions attending the day ward. - Prescription of blood products, management of transfusion reactions, reporting of non conformant, reporting of cases of TACO and TRALI, decision making regarding blood provisions before and during allogeneic transplantation (ABO major and minor). - For patients undergoing BMT my duties include preparation of BMT elegibility, BMT work-up, pre-transplant meetings with transfusion team, organisation of peripheral blood stem cells collections, bone marrow harversting etc. The centre is JACIE accredited all clinical procedures are performed to the highest standards and in accordance with accreditation processes. - I participate on the consultant on call haematology rota which also includes medical cover for neurology and gastroenterology wards. - My clinical duties involve multidisciplinary team working and close

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collaboration with medical colleagues across other medical specialties.

RESEARCH ACTIVITIES IN CURRENT POST

- I am currently collaborating with Dr Cinzia Vecchiato, responsible clinican for the HLA laboratory (Transfusion Service, Bolzano Hospital) on a joint research project on Autologus Reconstitution post BMT (I have previous experience of using capillary eletrophoresis ABI PRISM, see publication p1 , page 18). This project focuses on HLA and KIR relationships in autologus reconstitution. In particular we are working on a prospective study in severe aplastic anaemia (SAA) approved by the EBMT SAA-WP group. We will apply for a research grant to the South Tyrol Region. The study will be run in collaboration with the University of Innsbruck, Austria and the University of Padova, Italy (Prof Renato Zambello).

- I am leading a research study on microparticles generation and endothelial modulators in essenthial thrombocythosis, polycithemia vera and multiple myeloma in collaboration with the IBTS (Dr William Murphy, Elva Eakins, Ciaran Murphy) the Clinical Chemistry Dept, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (Dr Muriel van Schilfgaarde). This project is fully funded by a grant obtained by a Suisse Fundation on Tumors (Prof. Paolo Rebulla, Transfusion Service, Ospedale Maggiore, Milano, Italy).

- I am also working on a clinical study on a large cohort of patients with low risk Essenthial Thrombocythosis analysing full blood count fluctuations in collaboration with other North italian centers (Venice, Padova, Trento, Treviso, Mestre, Udine and the University of Innsbruck, Austria).

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TEACHING ACTIVITIES IN CURRENT POST

- I have recently started the accreditation process to become an associated Professor of Haematology in Italy (MIUR) and in Austria at the University of Innsbruck, in agreement with the medical Director of the Haematology Oncology and Internal Medicine Dept Professor Guenther Gastl. I have already given lectures at Innsbruck University.

- Supervision and teaching of medical students (from Medical Universities in Hamburg, München, and Rostock) and junior doctors (from general medical training scheme of Hamburg University) while on medical rotations.

- I participate in the hospital haematology teaching programme for staff.

- Since taking up this post I have been an invited speaker at a number of

academic haematological meetings including – a national academic meeting at Padova University, Innsbruck University (Austria) and an SPR meeting at Verona University.

- Teaching of the course of Physiopathology at the Scuola Superiore di Sanità Claudiana, Bolzano, Italy (2014)

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VERONA UNIVERSITY SPECIALIST REGISTRAR TRAINING SCHEME IN HAEMATOLOGY

(Oct 1998-Oct 2002):

In October 1998 I passed the admission exam for entry on to the Specialist Registrar Training Scheme in Haematology at Verona University, Italy under Professors G.Perona and G.Pizzolo. This is a four-year training scheme and that involves annual clinical and written exams and is recognised as equivalent to the Irish SpR training scheme in Haematology under the European Law 93/16 on the 5th April 1993 and EU Directive 2005/36/EC

Haematology Teaching Programme at Verona University: First year of Specialist training:

Course of Morphology: General Haematology and Malignancies (Dr Veneri) Course of Coagulation (Dr Manzato) Course of General Haematology (Prof. Perona) Course of Molecular Haematology (Dr Vinante) Course of Cellular Haematology (Dr Falezza) Course of Genetic Haematology and Gene Therapy (Prof Pignatti) Course of Immunology and Immunohaematology (Prof Colombatti) Course of Cellular Pathology (Prof. Cassatella) Course of Haemo-Pathology (Prof Chilosi)

Second year of Specialist training:

Course of Morphology: General Haematology and Malignancies (Dr Veneri) Course of Coagulation (Dr Manzato) Course of General Haematology (Prof. Perona) Course of Biochemical Haematology (Prof Guidi) Course of topics: Myeloma (Dr Zanotti) Course of topics: Lymphoma (Dr Zambello) Course of Haemo-Pathology (Prof. Menestrina, Dr Lanzato) Course of Genetic Haematology (Prof Pignatti, Dr Turco) Course of Immunophenotiping (Dr Krampera)

Third year of Specialist training:

Course of Morphology: general haematology and malignancies (Dr Veneri) Course of Thrombosis and Haemostatis (Prof Rodeghiero, Dr Castamann) Course of general Haematology (Prof Perona) Course of Transfusion Haematology (Dr Aprili, Dr Antonello) Course of Radiotherapy for Haematology

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Fourth year of Specialist training:

Course of morphology: general haematology and malignancies. (Dr Riccetti), this course was also integrated with a Course of morphology in malignancies by Dr MT. Danielle (University of Lyon France) Course of Transfusion Haematology (Dr Aprili, Dr Gandini) Course of Thrombosis and Haemostatis (Prof Rodeghiero, Dr Castamann) Course of Malignancies in Haematology (Prof Pizzolo) Course of HIV and Paediatric Immunodeficiencies (Dr Meneghini) Course of Transplant-Haematology (Dr Benedetti) Course of Advances in Nuclear Medicine and its application in Haematology (Dr Ferdeghini) Course of topics: Haematology and Surgery (Note: At the end of each year of training, trainees must pass an oral exam for each course attended during that year in order to be eligible to progress to the next year of training.) I successfully completed my final specialist Haematology training exams in September 2002 at Verona University Italy. In the final year of my training, I completed a research thesis (MD) based on a study (sample size=201) comparing Conventional Therapy with High Dose Therapy treatment in Multiple Myeloma. I presented this thesis at Verona University on the 21/10/2002 as part of my final specialist exams in haematology. (In order to complete specialist training in Italy, candidates must successfully present their thesis to examiners on the scheme).

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CLINICAL ROTATIONS IN HAEMATOLOGY

• From 01/10/1998 to 28/02/2001: Specialist Registrar in Haematology at the Haematology Department of Vicenza Hospital “San Bortolo”, under Prof. F.Rodeghiero. I was involved in the care of patients with acute leukaemias and other haematological malignancies. This included both diagnosis (morphological bone marrow reporting and immunophenotyping procedures), and treatment, including the prescribing of chemotherapy. I was mostly involved in the BMT Unit. I gained experience in the clinical management of patients undergoing Allogeneic and Autologus BMT, and associated complications. I also worked in the Day-Ward, where I was responsible for the medical follow-up of BMT patients, as well as the assessment and management of patients with general haematological problems. I also gained experience in coagulation through my attendance at the Coagulation Clinic. This is one of the most prominent centres in Italy for the treatment of Haemophilia patients and research on Von Willebrand’s Disease.

• From 01/03/2001 to 04/03/2002: Clinical Registrar in Haematology, at the Department of Haematology of St. James`s Hospital, Dublin, under the direction of Prof. Shaun McCann, Dr Paul Browne and Dr Eibhlin Conneally. This year of overseas training was recognised as an accredited year of training by my Italian training scheme. I worked mainly in the Day-Ward where the patient cohort consisted primarily of post-BMT patients and other chronic haematological conditions. I was also responsible for the assessment of new patients and the management of haematological emergencies. During this post I also worked in the Haematology Laboratory where my responsibilities included bone marrow and blood film reporting.

• From 05/03/2002 to 01/11/2002: Specialist Registrar in Haematology at the Haematology Department of Vicenza Hospital “San Bortolo”, under Prof. F.Rodeghiero My clinical duties were similar to those outlined above.

• From 4/11/2002 to the 31/12/2003 working in a Specialist Registrar post in Paediatric

Onco-Haematology at “Our Lady’s Hospital for Sick Children”, Dublin, under the supervision of Prof. O.Smith, Dr A O’Marcaigh and Dr C. Mc Mahon. I gained clinical experience in the treatment and management of benign and malignant paediatric-haematological conditions. My main clinical duties in the Dept of Paediatric Onco-haematology included the management of patients in the BMT-Unit, the ward, the outpatient clinic and the Day Ward. I collaborated with the accreditation/Self Assessment team in Oncology and

Haematology, created to provide and facilitate the audit and accreditation process at Our Lady’s Hospital for Sick Children under the direction of Dr Uma Rao.

• From the 01/01/04 to 31/5/04, Senior Registrar in Haematology at the Irish Blood

Transfusion Service, St James’s Hospital, Dublin, under the supervision of the National

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Medical Director, Dr. W. Murphy. My duties included giving advice on the appropriate use of blood products, platelet refractoriness, paediatric transfusion, HDN and NAITP, transfusion reactions, provision of HLA matched products; assessment and care of blood and platelet donors; the assessment, care and management of patients during therapeutic aphaeresis. I also participated on the on call rota for Specialist Registrar in Transfusion-Haematology.

• June 2004 – February 2009: PhD Research Fellowship, at the Irish Blood Transfusion

Service and the Paediatric Haematology Department Our Lady’s Children Hospital in Dublin, under the supervision of Prof O.P. Smith (University of Dublin, Trinity College, Ireland), Dr W. Murphy (National Medical Director IBTS) and Dr C. Mc Mahon (OLHSC). My PhD thesis entitled “New insights in Sickle Cell Anaemia Pathophysiology” was completed and accepted by TCD in December 2009 (full description of Ph.D provided in research experience section of CV).

ADDITIONAL EXPERIENCE

• Since September 2004 to February 2009, I am participated on the on call rota of Specialist Registrar in Paediatric Haematology at Our Lady’s Hospital for Sick Children, Dublin, under the supervision of Prof. O.Smith, Dr A O’Marcaigh, Dr C. Mc Mahon.

• Since January 2004 to February 2009, on call duty as Specialist Registrar in Transfusion-

Haematology, at the Irish Blood Transfusion Service, St James’s Hospital, Dublin, under the supervision of the National Medical Director, Dr. W.Murphy.

• November 2003 to January 2005, I participated on the haematology registrar on call rota

in the Adelaide & Meath Hospital, Tallaght, Dublin, under the direction of Dr. Helen Enright

• February 2001 to February 2005. I regularly attend and participate in the Educational

Programme for Specialist Registrar in Haematology (Director: Dr Karen Murphy, Haematology Dept., St Vincent University Hospital, Dublin).

• January 2006 to February 2009 I attended the Out Patient Haematology Clinic

(malignant and benign adult haematology OPD) at St James’s Hospital under the supervision of Dr E Conneally and Dr P Browne.

• Occasional medical consultation for the Italian Embassy in Dublin (2006-2008).

• Member of the EBMT Working Party on Severe Aplastic Anaemia for an observational

study on Autologus Reconstitution

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OTHER CLINICAL EXPERIENCE

• From 16/10/1996 until 4/04/1997: SHO on a 6-month clinical rotation which included a period of 1 month in each of the following areas: Laboratory Medicine, Internal Medicine, General Surgery, Paediatric Medicine, Gynaecology at Padua University Hospital, Italy.

• From 5/04/1997 to 18/07/1997: I completed a course in Military Medicine and Medical

Accident Emergency, at “Scuola di Sanita’ Militare” in Florence, Italy. This course included Intensive Care and Trauma Medicine, Military Health Management, Forensic Medicine, War Medicine, Bacteriological War Medicine, Nuclear War Medicine.

• From 29/07/1997 to 05/07/1998: Senior Military Medical Officer in the 48° Attack

Helicopter Squadroni Pavone of the 7° Rgt. Attack Helicopters Vega, in Belluno (Dolomites) Italy under the supervision of Dr Maggiore Medico Virdis. During this position I gained a wide range of clinical experience: medical management of soldiers admitted to the military medical unit (e.g. managing chest infections, meningitis, cardiovascular disease, etc) provision of emergency mountain rescue service with helicopters (eg managing trauma sustained from climbing accidents/skiing), vaccination of soldiers, provision of medical first aid to the military staff). In addition to clinical experience, this position allowed me to gain significant management experience ( e.g. organisational aspects of the medical care provided to military staff and resource management).

• From 29/07/1997 to 05/07/1998 during my Military Service, SHO in the General

Surgery Dept. of Belluno General Hospital (Belluno, Dolomites, Italy) under Dr. F.Favretti.

• From 15/08/1998 to 10/10/1998 SHO in Paediatric Surgery under Prof. Guglielmi in

Padua, Italy.

GENERAL PRACTICIONER LOCUM JOBS During my post-graduate training, I worked as a locum general practitioner on weekends and evenings in order to gain additional medical experience.

• December 1997, locum as GP, for Dr F. Rossi in Rovigo Italy.

• September 2000, locum as GP for Dr A. Salmaso, Vicenza Italy.

• December 2001, locum as GP for Dr M. Cocchiara, Vicenza Italy.

• August 2002, locum as GP in the Thermal Center, Hotel Eliseo, Montegrotto Terme, Italy

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MANAGEMENT EXPERIENCES

• Consultant haematologist (current position) and previous clinical posts In my current post as consultant haematologist and also in previous clinical posts, the following management skills and experience form/have formed an essential part of my routine clinical practice: clinical leadership, multidisciplinary team working, conflict resolution, time management, management of financial budgets and clinical resources.

• I have a good understanding of the structure and organisation of both the Irish and Italian Health Care System

• Diploma in Medical Management (2005) I completed a post graduate Diploma im Medical Management - Royal College of Surgeon in Ireland and Institute of Public Administration.

• PhD Thesis preparations (2004 - 2009) During the preparation of my PhD thesis I improved my management and leadership skills. For example, I gained skills in how to optimise resources (laboratories kits, delivery by couriers, travel expenses), to motivate and empower others involved in the research project (lab technicians, phlebotomists, nurses).

• Academic peer review publications During my career I have produced several publications, most of which are interdisciplinary studies with other branches of Medicine outside of Haematology. I have learnt to involve other medical colleagues and health care professionals in common tasks, creating a sense of curiosity and a common vision on projects. I have gained an appreciation of the importance of listening to different opinions and the use of constructive criticism. In order to complete my research projects, I gained important skills in time management, delegation skills, setting and meeting goals, managing and adhering to a research budget, and acting as project leader.

• Military Medical Officer experience (1997 - 1998) Senior Military Medical Officer in the 48° Attack Helicopter Squadroni Pavone of the 7° Rgt. Attack Helicopters Vega, in Belluno, Italy. In addition to clinical experience, this position allowed me to gain significant management experience (e.g. organisational aspects of the medical care provided to military staff and resource management).

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GRANTS AND SCHOLARSHIPS

• 1992/1993: Winner of a scholarship sponsored by Wűrzburg University, Germany, During this period I successfully passed the exams in Neuroradiology, Special Pathology, Internal Medicine (part I and II) and General Surgery (part I). I spent most of my time under the direction of Prof. H Müller Hermelink, in the Special Pathology Institute. I was involved in post-mortem examination, biopsy interpretation and diagnosis, immunocytochemistry, histology sample preparation (slides staining, use of microtomy).

• August 1994: Winner of a scholarship sponsored by Kiel Medicine University, North-

Germany, in the Paediatric Department for Premature Newborns (Neufrűegeborene Station).

• I was awarded a European Commission Marie Curie Actions scholarship from the

European School of Haematology , ESH-EHA, to attend the ”Diagnostic Work-up for Haematological Malignancies” (G. Zini, B.Bain, R. Foà), on the 26-28 February 2004 in Rome, Italy

• Awarded a scholarship to attend the 13th EHA Copenhagen meeting June 2008 to

present the best poster on vascular biology • I was awarded a grant of €40.000 by the “Fondazione per la ricerca sulla Trasfusione e

sui Trapianti” Lugano, Switzerland, for conducting a research project on “Microparticles in Myeloproliferative Disorders” in conjunction with the Irish Blood Transfusion Service Dublin and the Haematology Dept, Bolzano, Italy.

• Grant of €150.000 awarded by the Italian Veneto Region for a project of Translational

Research on paediatric onco-haematology with the project “Veno occlusive disease endothelial study in children withWilms Tumor’s”, under the direction of S. Cesaro, Paediatric Onco-haematology Head, Verona University, Italy (June 2011)

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PEER REVIEWER & EDITORIAL EXPERIENCE

• Since March 2006, peer reviewer for the “International Journal of Laboratory Hematology”

edited by Dr Steve Kitchen, Dept of Coagulation Royal Hallamshire Hospital, Sheffield UK. • Peer reviewer for the National Cancer Rare Diseases, Istituto Superiore Sanitá, Roma, Italy

for the project/funding “A new test for the diagnosis of the rare Disease Thrombotic Thrombocytopenic Purpura” of M Mannucci.

• Since July 2007, peer reviewer of several haematological articles for “The Journal of

Gerontology” • Peer reviewer for the “Journal of Thrombosis and Hemostasis” for articles on microparticles • Peer reviewer for the Journal of Cellular and Molecular Medicine, for articles on

microparticles • Peer reviewer for the British Journal of Haematology for articles on microparticles (2011) • Peer reviewer for the Journal of Medical Case Reports for articles on Sickle Cell Anaemia

(2011) • Peer reviewer for The British Journal of Haematology for an article on chronic myeloid

leukemia • Peer reviewer for the European Journal of Clinical Investigation, for an article on

microparticles (2009) • Peer reviewer for Bone Marrow Transplantation journal for and article on statistical

methods for analyzing engraftment in haemopoietic stem cell transplantation [BMT-2011-246].

• Peer reviewer for The British Journal of Haematology for an article on Sickle Cell Anaemia

and red cell exchange [BJH-2011-01101] • Peer reviewer for The British Journal of Haematology for an article on Chronic Myeloid

leukaemia [BJH-2012-00288] • Peer reviewer for The British Journal of Haematology for an article on Paediatric Esssential

Thrombocythemia [BJH- 2013-00797] • Peer reviewer for The "Transplant Infectious Disease" for an article on EBV-associated

central nervous system diseases after allogeneic hematopoietic stem cell transplantation [TID-12-O-109]

• Peer reviewer for The "Annals of Transplantation " for an article on PTLD [TID-12-O-109] • Peer reviewer for the “Community Dental Health” medical journal, for an article on Sickle

Cell Anaemia [CDH3126; February 2013]

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• Peer reviewer for the “Journal of Blood Disorders & Transfusion” on an article on Hemoperitoneum management [Pharma 13-2013]

• Peer reviewer for the Community Dental Health Medical Journal, for an article on Sickle Cell Anaemia [CDH3126; February 2013]

• Reviewer of grant research projects on microparticles for the National Science Centre

(NCN) an executive government agency set up to fund basic research in the Republic of

Poland (June 2012)

• Reviewer of grant research projects on “functional and molecular analysis of hypothalamus and pituitary gland hormone-dependence of clear cell renal carcinoma”for the National

Science Centre (NCN) an executive government agency set up to fund basic research in the Republic of Poland (Januar 2013-01-03)

• Peer reviewer for the "Hematology” journal of BioMed Research International Reports. For

an rticle on CML [April 2014]

• Peer reviewer for the "Journal of Clinical Pathology” for an article on multiple myeloma [Mai 2014]

• Peer reviewer for the "Journal of Clinical Pathology” for an article on acute leukaemia

[October 2014]

EDITORIAL BOARD MEMBER

• Nomination to the Editorial Board Membership and peer reviewer per il “Drug Safety

Journal. Bentham Science Publishers (doc 73)

• Editorial Board Member del giornale “Open Journal of Blood Diseases” dal mese di November 2011

• Editorial Board Member del giornale “Journal of Clinical Diagnosis and Research” dal mese di November 2013

• Editorial Board Member of the “Global Journal of Hematology and Blood Transfusion” (March 2014)

• Editorial Board Member of the “Journal of Stem Cells Research, Reviews & Reports” (June 2014)

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• Editorial Board Member of the “Journal of Blood Disorders” (July 2014)

RESEARCH EXPERIENCE

• At the present is cting as Principal Investigator (PI) in substitution of Professor Sergio Cortelazzo for the following research projectsfully sponsored by the Italian Minister of health and by the Provincia Autonoma di Bolzano (total amount > 1.000.000 euro) - PROJECT RF- 2009 -1469205: Identification and validation of biological

outcome predictors in Mantle Cell Lymphoma

- PROJECT DLCL04: Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B-cell lymphoma

• 1st MD thesis University of Padova, Italy (1993-1996) "Gene Therapy in Human Medulloblastoma, in Vivo and in Vitro" This thesis was presented and accepted by the Medical University of Padova in 1996. It was carried out under the supervision of Prof. Luigi Zanesco, director of the Dept of Paediatric Oncho-Haematology of Padua University Hospital (the largest centre for Paediatric Onco-Haemathology in Italy). This research focused on the bystander effect of gene therapy in vitro and in vivo (using a mouse model with Di George Syndrome). In particular we were able to identify the presence of connexin 43 in several cell lineages and to enhance its expression using retinoic acid. We also were able to grow medulloblastomas cell lineages in vitro and in vivo and to demonstrate the efficacy of gene therapy using the timidine kinase retroviral model. While conducting this research I gained laboratory experiences in performing Western Blot, PCR, cell culturing, working with laboratory animals, and performing intracranial stereotaxical inocula in nude mice and rats.

• 2nd MD thesis, University of Verona, Italy (1998-2000) Analysis of conventional and high Dose Therapy in a casuistic of 201 cases of Multiple Myeloma This research was completed in the Haematology Dept of Vicenza Hospital, under the supervision of Prof. Francesco Rodeghiero. It was a study on a large cohort of patients with Multiple Myeloma and the outcome results following chemotherapy, single and double autologus-BMT.

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• Genetic study on Factor V Leiden, Metyltehtrahydrofolate-reduttase and Protrombine genes mutation (2000-2001)

DNA extraction, PCR clonage, Primer for Eson 10-11 of Protrombin, Coagulation Centre for Thrombosis and Haemostasis, San Bortolo Hospital. This work was carried out under the supervision of Prof Francesco Rodeghiero

• PhD Thesis, University of Dublin, Trinity College, Ireland (2004-2009) Sickle Cell Anaemia. New insights into its pathophysiology

This thesis was presented and accepted (without needing further corrections) at University of Dublin, Trinity College, Ireland in August 2009. The degree was conferred to me in December 2009. Examiners were Prof Hann Ian (Great Hormond Street’s Hospital, London, UK) and Dr Aengus O’ Marcaigh (OLHSC, Dublin). The entire research was completed during a full time research post, shared between the Irish Blood Transfusion Service & the Dept of Paediatric Haematology, Our Lady’s Children Hospital in Dublin, under the supervision of Prof Owen Patrick Smith (University of Dublin, Trinity College) and Dr William G Murphy (National Medical Director IBTS and UCD)

The intent of this project was to provide a clinical and laboratory PhD thesis on Sickle Cell Anaemia in a paediatric population group of African origin. The research focuses on endothelium activation/apoptosis markers during all the stage of sickle cell anaemia. Ethical permission for the study was obtained and written consent signed by all the parents of the children involved in this study. A samples library was created at -80°C.

The main research focus was the study and detection of microparticles. An experimental Flow Cytometry method was designed for this purpose. This research also involved the study of endothelial marker expression (e.g. Endothelin-1, Nitric Oxide, adrenomedullin etc).

One of the main findings of this study included the presence of lower levels of protein C and free protein S in children with sickle cell crisis. In addition we found significantly lower numbers of circulating platelet-MP in steady state and crisis. However, we also demonstrated that in crisis, a significantly higher percentage of MP express markers of endothelial and red cell origin. In addition we found composite hybrid MP expressing markers of more than one cell type,

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probably brought about by severe vascular stress and close contact of various circulating cell types with vascular endothelium. We also found that vascular damage is evident in children with SCA during chest crises.

PEER REVIEWED JOURNAL PUBLICATIONS

(p1) Fluorescent polymerase chain reaction and capillary electrophoresis for IgH rearrangement

and minimal residual disease evaluation in multiple myeloma. Novella E, Giaretta I, Elice F, Madeo D, Piccin A, Castaman G, Rodeghiero F. Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy Haematologica 2002 Nov;87(11):1157-64

(p2) Outcome of bone marrow transplantation for acquired and inherited aplastic anaemia in the Republic of Ireland. A Piccin, AO’Marcaigh, OP Smith, JO’ Riordan, M Crowley, E Vanderberg, S Mc Cann St.James’s Hospital and Our Lady’s Hospital for Sick Children, Dublin, Ireland Irish Journal of Medical Science Vol 74 N3, pag 13-19, Nov 2005

(p3) Book chapter: “Malattie Emorragiche e dell’ Emostasi”

A Piccin, F Rodeghiero, G Castaman in the Special Pathology textbook “Anatomia Patologica e correlazioni anatomo-cliniche” Edited by Mariuzzi. Section 3.4, Piccin Nuova Libraria, Padova. February 2007

(p4) Prolonged overall survival with second on-demand autologous transplant in multiple myeloma. Elice F, Raimondi R, Tosetto A, D'Emilio A, Di Bona E, Piccin A, Rodeghiero F Dept. of Hematology, San Bortolo Hospital, Vicenza, Italy Am J Hematol. 2006 May 5;81(6):426-431 (p5) Adenomatoid tumor of the testis in a patient on imatinib therapy for chronic myeloid leukemia. A Piccin, E Conneally, M Lynch,ME McMenamin, Langabeer S, McCann S Dept of Haematology, St james’s Hospital, Dublin, Ireland Leuk Lymphoma. 2006 Jul;47(7):1394-6 (p6) Invasive rhino-maxillary mucormycosis diagnosed before HSCT. Andrea Piccin1, John D. Russell2, Patrick Fleming3, Karina Butler4, Michael Mc Dermott5, Owen P. Smith1, Aengus O’ Marcaigh1 1Dept of Haematology, 2Dept of ENT and Upper Airway Surgery ,3Pediatric Dentistry Unit,4Dept of Infectious Disease, 5Histopathology Dept.Our Lady Hospital for Sick Children, Dublin, Ireland Pediatr Blood Cancer. 2008 Feb;50(2):393-5 (p7) Circulating microparticles: pathophysiology and clinical implications. Andrea Piccin1, William Murphy1, Owen P Smith2

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1Irish Blood Transfusion Service, James’s street, Dublin 8, 2Our Lady’s Hospital, Dublin Blood Reviews. 2007 21, 157-171 (p8) Erythroleukaemia, diabetes insipidus and hypophyseal damage. Two case reports. A Piccin ¹, R Raimondi¹, S Laspina2, M Marchi3, F Rodeghiero¹, U Rovigatti4 ¹Department of Haematology, S. Bortolo Hospital Vicenza Italy. 2 St Lukes’s Hospital, Department of Pathology, Malta. 3Department of Neuroradiology, S. Bortolo Hospital Vicenza Italy. 4Retrovirus Centre, University of Pisa Medical School, Pisa, Italy Leuk Res. 2007 Aug;31(8):1135-9

(p9) Sickle cell disease and dental treatment A Piccin 1, 2, P Fleming3,4, E Eakins2, E Mc Govern4, OP Smith1, C Mc Mahon1. 1Dept. of Haematology, Our Lady’s Children’s Hospital, 2Irish Blood Transfusion Service, 3Dublin Dental School & Hospital, 4Dental Dept. Our Lady’s Children’s Hospital, Dublin, Republic of Ireland Journal of the Irish Dental Association 2008; 54, 75-79 (p10) Splenectomy in Sickle Cell Anaemia. A cause of further crises? A Piccin 1,2,4, OP Smith1,4, CMurphy2, A O’ Marcaigh1, M Corbally3, C Mc Mahon1

1Dept of Haematology, 3Dept of Surgery, Our Lady’s Children’s Hospital; 2Irish Blood Transfusion Service; 4Trinity College University, Dublin, Ireland Br J Haematol. 2009 Apr;145(1):144-6 (p11) Severe gastrointestinal hemorrhage, first manifestation of neonatal Haemophilia A A Piccin1,2,3, A O’Marcaigh1, C Mc Mahon1, OP Smith1,3 1National Paediatric Centre for Coagulation and Haemostasis, Our Lady’s Children Hospital; 2Irish Blood Transfusion Service; 3Trinity College University, Dublin, Ireland Haemophilia. 2009 May;15(3):817-9 (p12) Survival of patients with documented Autologous Recovery following stem cell transplantation for Severe Aplastic Anemia: a study by the WPSAA of the EBMT A Piccin1,2, S Mc Cann1, G Socié3, R Oneto4, A Bacigalupo4, A Locasciulli5, J Marsh6, H Schrezenmeier7, A Tichelli8, E Hand1, M Lawler1, J Passweg9 On behalf of the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (WPSAA, EBMT)

1St James's Hospital, Trinity College Dublin, Ireland; 2Ospedale San Maurizio Bolzano, Italy; 3Hôpital Saint Louis Paris, France ; 4Ospedale San Martino Genoa, Italy; 5Ospedale San Camillo Rome, Italy; 6St George's Hospital London, UK; 7Universitätsklinikum Ulm, Germany; 8University Hospital Basel, Switzerland; 9University Hospital, Geneva, Switzerland Bone Marrow Transplant. 2010 Jun;45(6):1008-13 (p13) Commentary: “Do we need to test blood donors for sickle cell anaemia? A Piccin1,2 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, Italy 2 University of Dublin, Trinity College, Ireland

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Blood Transfus. 2010 Jul;8(3):137-8 (p14) Immunosuppressive and anti TNF-a therapy might be associated with secondary myelodysplasia and acute leukaemia A Piccin1,2,3, S Cortelazzo1, U Rovigatti4, B Bourke5, OP Smith2,3 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy

2Haematology Dept, Our Lady’s Children’s Hospital, Dublin, Ireland

3 University of Dublin, Trinity College, Ireland

4Dept of Oncology, University of Medicine, Pisa, Italy 5Gastroenterology Dept, Our Lady’s Children’s Hospital, Dublin, Ireland Am J Hematol. 2010 Aug;85(8):634 (p15) Aggressive LGL-leukaemia presentation in old age A Piccin1,2, V Cassiba2, R Zambello3, G Negri4, M Svaldi2, V Colombetti4, S Cortelazzo2 1 Dept of Haematology, University of Dublin, Trinity College, Ireland; 2Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 3Dept of Experimental Immunology, University of Medicine, Padova, Italy; 4Pathology Dept, San Maurizio Regional Hospital, Bolzano, Italy Ann Hematol. 2011 May;90(5):603-6 (p16) Long Term Imatinib Effects (ILTE) study: a global independent assessment of imatinib in chronic myeloid leukemia patients. Carlo Gambacorti-Passerini1, Laura Antolini2*, François-Xavier Mahon3*, Francois Guilhot4, Michael Deininger5, Giuseppe Saglio6*, Arnon Nagler, MD7*, Alessandro Rambaldi8, Enrica Morra9, Elisabetta Abruzzese, MD10*, Anna D'Emilio11, Francesco Di Raimondo12*, Philipp le Coutre, MD13, Rafael Hurtado Monroy14, Valeria Santini15, Bruno Martino16, Fabrizio Pane, MD17*, Andrea Piccin 18, Pilar Giraldo 19, Sarit Assouline 20, Muheez A Durosinmi21*, Onno Leeksma, DPhil22, Il-Young Kweon23*, Josy Reiffers, MD3*, Maria Grazia Valsecchi2* and Dong-Wook Kim23 J Natl Cancer Inst. 2011 Apr 6;103(7):553-61 (p17) L’ anemia aplastica ereditaria e acquisita e l’ emoglobinuria parossistica notturna

Andrea Piccin1, Shaun Mc Cann2, Andrea Bacigalupo3

1Reparto di Ematologia, San Maurizio Regional Hospital, Bolzano, Italy; 2Dept of Haematology, University of Dublin, Trinity College, Ireland; 3Reparto di Ematologia, Ospedale San Martino Genova, Italy Book chapther, “Tecniche di laboratorio nella diagnostica delle emopatie” PARTE QUINTA Anemia aplastica e mielopatie autoimmuni, peer reviewed by Luigi Castoldi. Piccin Nuova Libraria, 2011; 391-401 (p18) La sindrome da lisi tumorale nella pratica clinica 1Andrea Piccin 1Haematology Dept, San Maurizio Regional Hospital , Bolzano, Italy Rivista Scenari, November 2010 (p19) Usefulness of p16ink4a, ProEX C and Ki-67 for the diagnosis of glandular dysplasia and adenocarcinoma of the cervix uteri.

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Giovanni Negri1, Giulia Bellisano2, Elisabetta Carico3, Gavino Faa2, Armin Kasal1, Sonia Antoniazzi1, Eduard Egarter-Vigl1, Andrea Piccin4, Paolo Dalla Palma5, Fabio Vittadello6, 1Department of Pathology, Central Hospital Bolzano, Italy; 2Deptment of Cytomorphology, Section Anatomic Pathology,University of Cagliari, Cagliari, Italy; 3U.O.D. Citopatologia, IIa Facoltà Medicina e Chirurgia La Sapienza, Rome, Italy; 4Department of Haematology, San Maurizio Regional Hospital, Bolzano, Italy; 5Pathology Unit, S. Chiara Hospital of Trento, Trento, Italy; 6Explora, Research and Statistical Analysis, Padova, Italy Int J Gynecol Pathol. 2011 Jul;30(4):407-13

(p20) Bendamustine with or without rituximab in the treatment of relapsed chronic lymphocytic leukemia: an Italian retrospective study. Iannitto E1, Morabito F2, Mancuso S1, Gentile M2, Montanini A3, Augello, A1, Bongarzoni V4, D’Arco A5, Di Renzo N6, Fazzi R7, Marasca, R3, Mulè A8, Musso M9, Musto P10, Pennese E6, Piccin A11, Rota-Scalabrini, D12, Visani G13, Rigacci L14

1 UO di Ematologia, AOUP Paolo Giaccone, Palermo; 2 UO di Ematologia, Azienda Ospedaliera, Cosenza; 3 Dipartimento di Oncologia, Ematologia e Patologie dell’Apparato Respiratorio, Università di Modena e Reggio Emilia, Modena; 4UO Ematologia, Azienda Ospedaliera "San Giovanni-Addolorata", Roma; 5UO Ematologia, Nocera Inferiore; 6 UO Ematologia e Trapianto di cellule Staminali, P.O V. Fazzi, Lecce; 7 UO Ematologia, Università di Pisa, Pisa; 8UO Ematologia, A.O. Villa Sofia-Cervello, Palermo; 9 UO Ematologia e Trapianto di Midollo, CDC "La Maddalena", Palermo; 10UO di Ematologia e Trapianto di Cellule Staminali, IRCCS-CROB, Rionero in Vulture; 11UO Ematologia e TMO, Ospedale Regionale San Maurizio, Bolzano; 12IRCC-FPO Candiolo; 13Ematologia e centro trapianto di midollo, Ospedale San Salvatore, Pesaro; 14 Ematologia Azienda Ospedaliero Universitaria Careggi Firenze. Br J Haematol. 2011 Mar 4. doi: 10.1111/j.1365-2141.2011

(p21) Secondary acute myeloid leukaemia after Peptide Receptor Radionuclide Therapy. A Piccin1, CM Grana2, G Negri3, G Paganelli2, S Cortelazzo1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy. 2Dept of Nuclear Medicine - Radiometabolic Therapy, Istituto Europeo di Oncologia, Milano, Italy.3 Pathology Dept, San Maurizio Regional Hospital, Bolzano, Italy Ann Hematol. 2012 Feb;91(2):299-300. Epub 2011 Apr 21 (p22) Composition and significance of splenic Gamna Gandy Bodies in Sickle Cell Anaemia

Andrea Piccin1, 2, 3, Hala Rizkalla4, Owen Smith2,3, Corrina Mc Mahon2, Claudio Furlan5, Ciaran Murphy3, Giovanni Negri6, Michael Mc Dermott3,4

1Dept of Haematology and BMT Unit, San Maurizio Regional Hospital, Bolzano, Italy

2Haematology Dept, Our Lady’s Children’s Hospital, Dublin, Ireland; 3 University of Dublin, Trinity College, Ireland; 4Pathology Dept, Our Lady’s Children’s Hospital, Dublin, Ireland

5Centro Universitario Grandi Apparecchiature Scientifiche, University of Padova, Italy

6Pathology Dept, San Maurizio Regional Hospital, Bolzano, Italy Hum Pathol. 2012 Jul;43(7):1028-36. Epub 2011 Nov 12 (p23) Quality of life in elderly patients with essential thrombocythaemia. An italian multicentre study Esther Natalie Oliva1, Andrea Piccin2, Maria Gabriella Mazzucconi3, Enrica Morra4, Umberto Recine5, Enrico Maria Pogliani6, Fabrizio Pane7, Marco Gobbi8, Luigi Gugliotta9, Mauro

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Krampera10, Nicola Cascavilla11, Rossella Cacciola12, Emma Cacciola12, Giuseppe Fioritoni13, Renato Fanin14, Anna Liberati15, Emanuele Angelucci16, Sante Tura17

1Hematology Unit, Azienda Ospedaliera “Bianchi-Melacrino-Morelli”, Reggio Calabria, Italy

2Dept of Haematology, San Maurizio Regional Hospital, Bolzano, Italy; 3Hematology, “Dipartimento di Biotecnologie Cellulari ed Ematologia, “Sapienza”University of Rome, Italy

4Hematology Division and UTMO, Ospedale Niguarda Ca' Granda, Milan, Italy; 5U.O.C. Medicina Interna - DH Onco-Ematologico, Ospedale Santo Spirito, Rome, Italy; 6Hematology Division, Ospedale San Gerardo, Monza, Italy; 7Dept of Medical Biochemistry and Biotechnologies, University of Naples Federico II, Naples, Italy; 8Cattedra di Ematologia, Ospedale S. Martino, Genoa, Italy; 9U.O. Ematologia Arcispedale S.Maria Nuova, Reggio Emilia, Italy; 10Sezione di Ematologia, Dipartimento di Medicina, Azienda Ospedaliera Universitaria Integrata Verona, Italy; 11Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 12Azienda Ospedaliera Universitaria V.E. Ferrarotto, Catania, Italy; 13Hematology Division, Ospedale Civile S.Spirito, Pescara, Italy; 14Cattedra di Ematologia University of Udine, Udine, Italy; 15Struttura complessa di Oncoematologia, Azienda Ospedaliera S.Maria, Terni, Italy; 16Hematology Unit, Ospedale Oncologico A. Businco, Cagliari, Italy; 17University of Medicine, Bologna, Italy Annals of Hematology. 2012,Volume 91, Number 4

(p24) Ethiology of febrile episodes in patients with acute myeloid leukemia: results from the Hema e-Chart Registry. Pagano L, Caira M, Nosari A, Rossi G, Viale P, Aversa F, Tumbarello M; Hema e-Chart Group, Italy Arch Intern Med. 2011 Sep 12;171(16):1502-3 (p25) Anti-thrombin-III reduction and Posterior Reversible Encephalopathy Syndrome (PRES) in lymphoblastic leukaemia. New insight into PRES pathophysiology. A Piccin1, R Curro Dossi2, V Cassibba1, S Stupnner3, G Bonatti3, S Cortelazzo1

1Haematology Dept and Bone Marrow Transplant Unit, San Maurizio Regional Hospital, Bolzano, Italy; 2Stroke Unit, San Maurizio Regional Hospital, Bolzano, Italy; 3Radiology Dept, San Maurizio Regional Hospital, Bolzano, Italy Ann Hematol. 2012 Oct;91(10):1669-71. Epub 2012 Mar 21

(p26) A prospective survey of febrile events in hematological malignancies

1Pagano L, 1Caira M, 2Rossi G, 3Tumbarello M, 4Fanci R, 5Garzia MG, 6Vianelli N, 7Filardi N, 8De Fabritiis P, 9Beltrame A, 10Musso M, 11Piccin A, 12Cuneo A, 2Cattaneo C 2, 13Aloisi T, 14Riva M, 15Rossi G, 16Salvadori U, 17Brugiatelli M, 18Sannicolò S, 19Morselli M, 20Bonini A, 21Viale P, 14Nosari A, and 13Aversa. For the Hema e-Chart Group*, Italy1Istituto di Ematologia, Università Cattolica S.Cuore, Roma; 2U.O. Ematologia, Spedali Civili, Brescia; 3Istituto di Malattie Infettive, Università Cattolica S.Cuore, Roma; 4Azienda Osp. Univ. Careggi – Ematologia, Firenze; 5Divisione di Ematologia Az. Osp. S.Camillo Forlanini, Roma; 6Istituto Seragnoli – Università di Bologna; 7Ematologia, Azienda Osp. Osp. S.Carlo, Potenza; 8Ematologia, Ospedale S. Eugenio, Roma; 9U.O. Ematologia Pol. Univ. Tor Vergata, Roma; 10Dipartimento di Ematoncologia ed Unità Trap. Mid. Osseo, La Maddalena, Palermo; 11Divione di Ematologia, Ospedale Generale di Bolzano; 12Istituto di Ematologia, Az. Osp.Univ. Arcispedale S.Anna, Ferrara; 13Istituto di Ematologia, Università di Perugia; 14Divisione di Ematologia e Centro Trapianti Midollo, Ospedale Niguarda Ca’ Granda, Milano; 15Unità di Ematologia; IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 16Divisione di Ematologia, Ospedale Civile "Ca Foncello"- Treviso; 17Ematologia, Ospedale Papardo, Messina; 18Divisione di Ematologia, Umberto I, Mestre; 19Divisione di Ematologia, Policlinico Universitario di Modena e Reggio; 20Divisione di

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Ematologia, Arciospedale S. Maria Nuova, Reggio Emilia; 21Clinica di Malattie Infettive, Università di Bologna.

Ann Hematol. 2012 May;91(5):767-74. Epub 2011 Nov 29

(p27) Protein C and free protein S in children with Sickle Cell Anaemia

Andrea Piccin1,2,3,4, Ciarán Murphy2, Elva Eakins2, Anthony Kinsella2, Corrina McMahon1, Owen P. Smith1,3, William G. Murphy2,4

1Department of Haematology, Our Lady’s Children Hospital, 2Irish Blood Transfusion Service, Dublin, 3School of Medicine, Trinity College Dublin, 4School of Medicine and Medical Science, University College Dublin, Ireland, 5Dept of Haematology, San Maurizio regional Hospital, Bolzano, South Tyrol, Italy Annals of Hematology accepted for publication in press 2012 (p28) Familial Hemophagocytic Lymphohistiocytosis in adults Elena Sieni1,Valentina Cetica1, Andrea Piccin2, Filippo Gherlinzoni3, Carlo Ferdinando Sasso4, Daniela Pende5, Maurizio Aricò1

1Department Pediatric Haematology Oncology, Azienda Ospedaliero Universitaria A.Meyer Children Hospital, Firenze, Italy; 2Haematology Department and BMT Unit, San Maurizio Regional Hospital, Bolzano, Italy; 3Divisione di Ematologia, Department of Medicina Specialistica, U.L.S.S. 9 - Ospedale "S. Maria di Ca' Foncello", Treviso, Italy; IRCCS A.O.U. San Martino-IST, Genoa, Italy PLoS One. 2012;7(9):e44649. Epub 2012 Sep 7 (p29) Bendamustine with or without rituximab for the treatment of heavily pretreated non-Hodgkin's lymphoma patients: A multicenter retrospective study on behalf of the Italian Lymphoma Foundation (FIL). Rigacci L, Puccini B, Cortelazzo S, Gaidano G, Piccin A, D'Arco A, Freilone R, Storti S, Orciuolo E, Zinzani PL, Zaja F, Bongarzoni V, Balzarotti M, Rota-Scalabrini D, Patti C, Gobbi M, Carpaneto A, Liberati AM, Bosi A, Iannitto E. Ann Hematol. 2012 Jul;91(7):1013-22. Epub 2012 Feb 15 (p30) La tiflite del paziente neutropenico e il suo trattamento antibiotico

1Andrea Piccin MD, PhD

1Reparto di Ematologia e Centro Trapianti di Midollo Osseo, Ospedale San Maurizio, Bolzano, Italy COLLECTIONS, Issn: 2035-3812, Wolters Kluwer Health Feb 2012 (p31) Utility of Bronchoalveolar Lavage in the Diagnosis of Pulmonary Infection in Children with Haematological Malignancies U.Rao1, A. Piccin1, A. Malone1, K. O’Hanlon1, F. Breatnach1, A. O’Meara1, M. McDermott2, K. Butler3, N. O’Sullivan4, J. Russell5, A. O’Marcaigh1,6, O. P. Smith1,6

1Departments of Haematology & Oncology, 2Histopathology, 3Infectious Disease, 4Microbiology and 5Otolaryngology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12. 6University of Dublin, Trinity College, Dublin, Ireland. Irish Journal of Medical Science March 2012

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(p32) Treatment of DIHS/DRESS syndrome with combined N-acetylcysteine, prednisone and valganciclovir – a hypothesis Oswald Moling1, Lukas Tappeiner2, Andrea Piccin3, Elisabetta Pagani4, Patrizia Rossi4, Giovanni Rimenti1, Claudio Vedovelli1, Peter Mian1

1Division of Infectious Diseases, Ospedale Generale, Bolzano, Italy

2Division of Dermatology, Ospedale Generale, Bolzano, Italy

3Division of Haematology, Ospedale Generale, Bolzano, Italy

4Laboratory of Microbiology and Virology, Ospedale Generale, Bolzano, Italy Med Sci Monit, 2012; 18(7): CS (p33) Acute generalized exanthematous pustulosis with overlap features of toxic epidermal necrolysis/Steven– Johnson syndrome 1Oswald Moling, 2Franco Perino, 3Andrea Piccin, 1Division of Infectious Diseases Bolzano General Hospital Bolzano, Italy; 2Department of Haematology, Bolzano General Hospital Bolzano, Italy; 3Department of Dermatology, Bolzano General Hospital Bolzano, Italy The International Society of Dermatology accepted for publication May 2012 (p34) Post-transplant Lymphoproliferative Disease (PTLD) of donor origin, following haematopoietic stem cell transplantation in a patient with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Andrea Piccin1, Enrico Morello2, Mirija Svaldi1,Torsten Haferlach3, Fabio Facchetti4,Giovanni Negri5, Cinzia Vecchiato6, Simona Fisogni4, Irene Pusceddu1, Sergio Cortelazzo1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Dept of Haematology, Brescia General Hospital, Brescia, Italy 3Institute of Münchner Leukämie Labor GMBH, Munich, Germany 4Pathology Dept, University of Medicine, Brescia, Italy 5Pathology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 6Dept of Transfusion Medicine, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy Haematological Oncology accepted for publication June 2012 (p35) Post Idiopathic Thrombocytopenic Purpura (ITP) resistent to Eltrombopag©, but cured with Romiplostim© Andrea Piccin1, Giovanni Amaddii1, Natolino Fabrizio2, Atto Billio1, Sergio Cortelazzo1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Pharmacology Dept, University of Padova, Padova, Italy Blood Transfusion accepted for publication Februar 2013 (p36) Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study. Pagano L, Valentini CG, Pulsoni A, Fisogni S, Carluccio P, Mannelli F, Lunghi M, Pica G, Onida F, Cattaneo C, Piccaluga PP, Di Bona E, Todisco E, Musto P, Spadea A, D'Arco A, Pileri S, Leone G, Amadori S, Facchetti F; GIMEMA-ALWP (Gruppo Italiano Malattie EMatologiche dell'Adulto, Acute Leukemia Working Party). Collaborators: Venditti A, Di Paolantonio G, Di Blasi R, Abbadessa A, Piccin A, Ballerini F, Sorasio R, Nosari AM, Invernizzi R, Aversa F, Pacilli L, Peli A, Quintini G, Forghieri F, Pavan L, Bonifacio M, Candoni A, Caramatti C, Verga L, Melillo L,

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Fraternali G, Berti E. Haematologica. 2013 Feb;98(2):239-46 (p37) Transition of idiopathic CD4 + lymphocytopenia into mycosis fungoides? Andrea Piccin1, Klaus Eisendele2,3, Ugo Rovigatti4, Daisy Corvetta5, Martina Tauber5, Guido Mazzoleni5, Mirja Svaldi1, Guenther Gastl6 & Sergio Cortelazzo1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Dermatology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 3Dermatology Dept, University of Innsbruck, Innsbruck, Austria 4Oncology Dept, University of Medicine of Pisa, Pisa, Italy 5Pathology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 6Haemato-Oncology Dept, University of Innsbruck, Innsbruck, Austria Leuk Lymphoma. 2013 Nov 1. [Epub ahead of print] (p38) Essential thrombocytemia progressing to Ph+ chronic myeloid leukemia with megakaryoblastic blasts, following anagrelide withdrawal. Piccin A1, Corvetta D2, Rovigatti U3, Mazzoleni G2, Pusceddu I1, Svaldi M1, Steurer M4, Gastl G4, Cortelazzo S1. 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Pathology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 3Oncology Dept, University of Pisa Medical School, Pisa, Italy 4University Hospital for Internal Medicine V – Hematology & Oncology, University of Innsbruck, Innsbruck, Austria Platelets. 2013 Nov 8. [Epub ahead of print (p39) Ovarian hyperstimulation syndrome in Systemic Amyloidosis Andrea Piccin1, Norberto Vezzali2, Norbert Pescosta1, Michael Steurer3, Giovanni Palladini 4, Atto Billio1 1 Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2 Radiology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 3 Haemato-Oncology Dept, University of Innsbruck, Innsbruck, Austria 4 Amyloidosis Research and Treatment Center, Foundation “Istituto di Ricovero e Cura a Carattere Scientifico” (IRCCS) Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia, Pavia, Italy Accepted by Amyloid November 2013 (p40) La Trombocitemia Essenziale e le ulcere cutanee indotte da idrossicarbamide. Prognosi e trattamento. Andrea Piccin1, Fabrizio Natolino2, Klaus Eisendle3 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Pharmacology Dept, University of Padova, Padova, Italy 3Dermatology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy MPDs in Practice 2013

(p41) Endothelial Microparticles and Endothelial Damage: “The Tip and the Iceberg” Andrea Piccin1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy Acta Haematol 2014;132:199-199 (DOI: 10.1159/000360600)

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(p42) Non-activated plasma-derived PC improves amputation rate of children undergoing sepsis 1,2,3Andrea Piccin MD, PhD, 1Aengus O’ Marcaigh, MD, FRCPI, FAAP, 1Corrina Mc Mahon, MD, MRCP, FRCPath, 3Ciaran Murphy, BMsc, 1Ikechukwu Okafor, MBBS, MSc MRCPI, 4Luigi Marcheselli, MD, 5William Casey, MB, FFARCSI, 6Liam Claffey, FFARCSI, 1,3Owen Patrick Smith, FRCPCH, FRCPath Affiliations: 1Hematology Dept, Our Lady’s Children's Hospital, Dublin, Ireland; 2Hematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 3Trinity College University, Dublin, Ireland; 4Department of Diagnostic and Clinical Medicine and Public Health University of Modena and Reggio Emilia, Modena Italy; 5Anesthesiology Dept, Our Lady’s Children's Hospital, Dublin, Ireland; 6Anesthesiology Dept, Temple Street Hospital, Dublin, Ireland Accepted by Thrombosis Research March 2014 (p43) TRANSFUSION ASSOCIATED CIRCULATORY OVERLOAD (TACO) IN IRELAND A review of cases reported to the National Haemovigilance Office (NHO)2000 -2010 Andrea Piccin1,2,3, Marina Cronin1, Roisin Brady1, Jackie Sweeney1, Luigi Marcheselli3, Emer Lawlor1,2 1Irish Blood Transfusion Service, Dublin, Ireland 2Trinity College University, Dublin, Ireland 3Haematology Dept, San Maurizio Regional Hospital, South Tyrol, Italy 4Dept of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Italy Accepted by Transfusion May 2014 (p44) Abnormal cervical cytology after allogeneic bone marrow transplantation. Negri G1, Herz M2, Deola S3, Piccin A3, Casini M3, Babich B4, Tauber M2, Messini S5, Marucci MR6, Vittadello F7 1,2 Department of Pathology, Central Hospital Bolzano, Bolzano, Italy; 3Hematology and BMT Department, Central Hospital Bolzano, Bolzano, Italy; 4Consultant Gynecologist, Bolzano, Italy; 5Department of Gynecology and Obstetrics, Central Hospital Bolzano, Bolzano, Italy; 6Department of Pathology I and II, Spedali Civili-University of Brescia, Brescia, Italy; and. 7Explora Research and Statistical Analysis, Padova, Italy. Am J Clin Pathol. 2014 Aug;142(2):222-6 (p45) La bendamustina come terapia di prima linea del linfoma follicolare in una paziente con precedente tumore mammario" in pubblicazione sulla rivista Questioni di Clinica “Esperienze cliniche in ematologia sul territorio nazionale. Volume 10” Mediprint 2014 Andrea Piccin Hematology and BMT Department, Central Hospital Bolzano, Bolzano, Italy; (p46) Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis: A Hypothesis Oswald Moling,1 Alfonsina Di Summa,2 Loredana Capone,2 Josef Stuefer,3 Andrea Piccin,4 Alessandra Porzia,5 Antonella Capozzi,5 Maurizio Sorice,5 Raffaella Binazzi,1 Lathá Gandini,1 Giovanni Rimenti,1 and Peter Mian1 1Division of Infectious Diseases, Ospedale Generale, 39100 Bolzano, Italy

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2Division of Neurology, Ospedale Generale, 39100 Bolzano, Italy 3Radiology, Ospedale Generale, 39100 Bolzano, Italy 4Division of Hematology, Ospedale Generale, 39100 Bolzano, Italy 5Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy Case Reports in Immunology. Volume 2014 (2014), Article ID 804761 (p47) Burkitt’s Lymphoma of the stomach: a case report and review of the literature. Neil Watson1,2, Vincenzo Cassibba1, Marco Casini1, Andrea Mega3, Martina Tauber4, Andrea Iori3, Raimondo Di Bella1, Andrea Piccin1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2University of Edinburgh, Scotland, United Kingdom 3Gastroenterology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 4Pathology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy Journal of Blood Disorders. October 2014 (p48) Acute coronary syndrome in essential thrombocytosis is not a contraindication per se to anagrelide therapy 1,3Andrea Piccin, 2Giovanni Tortorella, 3Michael Steurer, 3Günther Gastl 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 2Cardiology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3Haematology and Oncology Dept, Medical University of Innsbruck, Innsbruck, Austria; Journal of Blood Disorders. October 2014

(p49) Acute obstructive hydrocephalus during chemotherapy in T-Lymphoblastic Lymphoma Andrea Piccin1, Massimo Tripodi2, Vincenzo Cassibba1, Irene Cavattoni1, Raimondo Di Bella1, Andreas Schwarz2, Marco Casini1 1Haematology Dept and Bone Marrow Transplantation Unit, San Maurizio Regional Hospital, Bolzano, Italy ; 2Neurosurgery Dept, San Maurizio Regional Hospital, Bolzano, Italy Cellular and Molecular Biology. November 2014 (p50) The importance of studying red blood cells microparticles. 1,2Andrea Piccin, 2Muriel Van Schilfgaarde, 3Owen Patrick Smith 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Onze Lieve Vrouwe Gasthuis OLVG, University of Amsterdam, Amsterdam, Netherlands 3 Department of Haematology, Trinity College University, Dublin, Ireland Blood Transfus. 2014 Nov 18:1-2 (p51) Transfusion-associated circulatory overload in Ireland: a review of cases reported to the National Haemovigilance Office 2000 to 2010. Andrea Piccin1,2,3, Marina Cronin1, Roisin Brady1, Jackie Sweeney1, Luigi Marcheselli4, Emer Lawlor1,2 1Irish Blood Transfusion Service, Dublin, Ireland 2Trinity College University, Dublin, Ireland 3Haematology Dept, San Maurizio Regional Hospital, South Tyrol, Italy 4Dept of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Italy Transfusion. 2014 Dec 18

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(p52) Role of blood cells dynamism on hemostatic complications in low risk patients with Essential Thrombocythemia Andrea Piccin1,2, Michael Steurer2, Manfred Mitterer3, Elisabeth Maria Blöchl2, Luigi Marcheselli4, Irene Pusceddu1, Alessandra Marabese1, Irene Bertozzi5, Daisy Corvetta1 Maria Luigia Randi5, Elena Elli6, Enrico Maria Pogliani6, Dino Veneri7, Omar Perbellini7, Mauro Krampera7, Enrica Pacquola8, Michele Gottardi8, Mario Tiribelli9, Anna Guella10, Barbara Innella10, Paolo Vivaldi10, Ercole De Biasi11, Rosaria Sancetta12, Roberta Rocconi12, Renato Bassan12, Filippo Gherlinzoni8, Giovanni Pizzolo7, Günther Gastl2 and Sergio Cortelazzo1 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy 2Dept of Onco-Haematology, University of Medicine, Innsbruck, Austria 3Oncohaematology Unit, Meran Hospital, South Tyrol, Italy 4Dept of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Italy 5Dept of Internal Medicine, University of Medicine, Padova, Italy 6Dept of Haematology, University of Milano Bicocca, Milan, Italy 7Dept. of Medicine, Section of Hematology, University of Verona, Italy 8Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 9Dept of Haematology, Azienda Ospedaliero-Universitaria, Udine, Italy 10Dept of Haematology, Santa Chiara Hospital, Trento, Italy; 11Dept of Haematology, Camposampiero Hospital, Padova, Italy 12Dept of Haematology, Venice Hospital, Venice, Italy Internal and Emergency Medicine (IAEM). January 2015

(p53) The “Blood Apple Tree”. A simple and straight forward metaphor for teaching blood and bone marrow physiology 1,2Andrea Piccin, 1Günther Gast 1Haematology and Oncology Dept, Medical University of Innsbruck, Innsbruck, Austria 2Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy Accepted for publication by Blood Transfusion February 2015 (p54) Anagrelide treatment and cardiovascular monitoring in essential thrombocythemia. a prospective observational study 1*Giovanni Tortorella, 2*Andrea Piccin, (*co-first authors)

3Alessia Tieghi, 4Luigi Marcheselli, 5Michael Steurer, 5Günther Gastl, 3Katia Codeluppi, 3Angelo Fama, 6Umberto Santoro, 7Chiara Birtolo, 8Gabriele Gugliotta, 9Sergio Cortelazzo, 8Luigi Gugliotta for the Gimema Foundation project “Registro Italiano Trombocitemie (RIT)” 1Cardiology Unit, Azienda Ospedaliera Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy; 2Hematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 3Hematology Dept, Azienda Ospedaliera Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy; 4Clinical and Public Health Medicine Dept, University of Modena and Reggio Emilia, Modena, Italy; 5Hematology and Oncology Dept, Medical University of Innsbruck, Innsbruck, Austria; 6Statistics Dept, University of Bologna, Bologna, Italy; 7Internal Medicine Dept, S. Orsola-Malpighi University Hospital, Bologna, Italy; 8Hematology Institute “L. e A. Seragnoli”, S. Orsola-Malpighi University Hospital, Bologna, Italy; 9Hemato-Oncology Dept, Institute Humanitas Gavazzeni, Bergamo, Italy

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Leukemia Research February 2015 (p55) Complex karyotype, older age, and reduced first-line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long-term follow-up. Mosna F, Papayannidis C, Martinelli G, Di Bona E, Bonalumi A, Tecchio C, Candoni A, Capelli D, Piccin A, Forghieri F, Bigazzi C, Visani G, Zambello R, Zanatta L, Volpato F, Paolini S, Testoni N, Gherlinzoni F, Gottardi M. Am J Hematol. 2015 Jun;90(6):515-23 (p56) Acute coronary syndrome (ACS) in patients with essential thrombocytemia (ET). What is the best treatment? Tortorella G, Calzolari M, Tieghi A, Muià N, Piccin A, Gugliotta L. 1Cardiology Unit, Azienda Ospedaliera Santa Maria Nuova-IRCCS Reggio Emilia, Italy. 2Cardiology Unit, Azienda Ospedaliera Santa Maria Nuova-IRCCS Reggio Emilia, Italy. 3Hematology Unit, Azienda Ospedaliera Santa Maria Nuova-IRCCS Reggio Emilia, Italy. 4Hematology Unit, San MaurizioRregional Hospital, Bolzano, South Tyrol, Italy. 5Hematology Institute L.e A. Serignoli S.Orsola Malpighi University Hospital, Bologna, Italy. Int J Cardiol. 2015 Oct 9;203:225-227

(p57) Circulating microparticles, protein C, free protein S, and endothelial vascular markers in children withSickle Cell Anaemia A Piccin1,2,3,4, C Murphy1, E Eakins1, J Kunde5, Daiy Corvetta4,6, Di Pierro Angela4, Giovanni Negri6, Sainati L7, Corrina Mc Mahon2, OP Smith2,3 & WG Murphy1,8 1Irish Blood Transfusion Service, Dublin, Ireland 2Our Lady’s Children Hospital, Crumlin, Dublin, Ireland 3Trinity College Dublin, Dublin, Ireland; 4Haematology Dept, San Maurizio Regional Hospital, South Tyrol, Bolzano, Italy 5B.R.A.H.M.S, Biotechnology Centre, Berlin, Germany; 6Pathology Dept, San Maurizio Regional Hospital, South Tyrol, Bolzano, Italy 7Paediatric Haematology Dept, Univerity of Medicine of Padova, Padova, Italy 8University College, Dublin, Ireland; J Extracell Vesicles. 2015 Nov 23;4:28414 (58) Severe skin radiodermatitis fully healed with the use of platelet gel and a hyperbaric chamber. Piccin A, Di Pierro AM, Corvetta D, Canzian L, Gentilini I, Primerano M, Tupini C, Mercuri E, Negri G, Mazzoleni G, Fontanella F. Blood Transfus. 2015 Dec 11:1-3

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PAPERS UNDERGOING PEER REVIEW (u1) Sickle Cell Anaemia Pathophysiology Andrea Piccin1,2, Ciaran Murphy2,3, Elva Eakins3, Owen P Smith2,4 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, Italy 2Trinity College University, Dublin, Ireland 3Irish Blood Transfusion Service, Dublin, Ireland 4Dept of Haematology Our Lady’s Children‘s Hospital, Dublin, Ireland to be submitted to Blood Review (u2) Microparticles, plasminogen activator inhibitor (pai-1), and antithrombin. Key players of veno occlusive disease Andrea Piccin* 1, 2, Maria T. Sartori3, Muriel Van Schilfgaarde4, Irene Pusceddu5, Daisy Corvetta5, Luigi Marcheselli6, Alessandra Paratella7, Gianni Bisogno7, Simone Cesaro8 1Haematology, San Maurizio Regional Hospital, Bolzano, Italy, 2Department of Internal Medicine, University of Medicine, Innsbruck, Austria, 3Department of Internal Medicine, University of Medicine, Padua, Italy, 4Onze Lieve Vrouwe Gasthuis OLVG, Amsterdam, Netherlands, 5Haematology Department, San Maurizio Regional Hospital, Bolzano, 6Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, 7Paediatric Onco- Haematology Department, University of Medicine, Padua, 8Paediatric Oncology-Hematology Department, Azienda Ospedaliera Universitaria University of Medicine, Verona, Italy to be submitted to J of Thrombosis & Hemostasis; accepted as a poster presentation to ISEV 2015, Washinton, USA (u3) Blood cells derived Microparticles and vascular markers study in Essential Thrombocythaemia patients

Andrea Piccin1,2, Irene Pusceddu2, Luigi Marcheselli3, Ciaran Murphy1, Elva Eakins1, Giovanni Amaddii’2, Carlo Moesender Frajria, Dino Veneri4, Omar Perbellini4, Enrica Pacquola5, Michele Gottardi5, Filippo Gherlinzoni5, Flaviano Favaro6, Diego Faggian6, Mario Plebani6, Gianni Pizzolo4, William G Murphy1 & Sergio Cortelazzo2 1Irish Blood Transfusion Service, Dublin, Ireland 2Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy 3Dept of Onco-Haematology, Modena University Hospital, Modena, Italy 4Dept of Haematology, University of Medicine, Verona, Italy 5Dept of Haematology, Cà Foncello Hospital, Treviso, Italy 6Dept of Laboratory Medicine, University Hospital, Padova, Italy in preparation

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ABSTRACT PUBLICATIONS

(a1, poster 1) Second Autologus Stem cell Transplantation is an effective salvage therapy in relapsing or progressing Multiple Myeloma patients: a single center experience. Rosaria Sancetta, Andrea Piccin, Fabrizio Pomponi et al. Haematology Dept, S Bortolo Hospital, Vicenza, Italy Blood 2001 abstract e poster board Session 909 III

(a2) Tandem autologus stem cells transplantation or on demand second transplantation in patients with Multiple Myeloma? F Elice, A Piccin, A Tosetto et al. San Bortolo Hospital, Vicenza Italy Biology of Blood and Marrow Transplantation Vol 8, 2, 2002 (a3) Capillary electrophoresis to detect IgH heavy chain monoclonal rearrangement and to study minimal residual disease in Multiple Myeloma E Novella, I Giaretta, P Salgarelli, A Piccin, D Madeo, F Rodeghiero Dipartimento di Ematologia Ospedale san Bortolo Vicenza, Italy. 38th Congress of the Italian Society of Hematology, Florence, October 7-10, 2001 Haematologica Vol 86,10, October 2001 (a4) Complete response of pulmonary mould infection to high dose amphotericin (ambisone) following stem cell transplantation for severe aplastic anaemia. Paul Browne, Andrea Piccin, Cathrine Flynn, Shaun Mc Cann Dept of Haematology, Trinity College Dublin, St. James’s Hospital Dublin8 The Haematology Journal. Vol 3 suppl 1-June 2002 (a5) Comparison of Cyclophosphamide and ifosfamide/etoposide/epirubicin (IEV) mobilisation regimens in Multiple Myeloma. Paul Browne, Andrea Piccin, Niahm O’ Connell, Nicola Gardiner,Shaun Mc Cann Dept of Haematology, Trinity College Dublin, St. James’s Hospital Dublin8 The Haematology Journal. Vol 3 suppl 1-June 2002

(a6) P53 and P21 expression by immunocytochemistry in diffuse large B-cell Lymphoma: Strong and independent impact on patients’ survival, suggesting its integration in new prognostic models. C Visco1, F Canal1, A Ambrosetti1, M Krampera1, A Piccin1, M Lestani1, G Pizzolo1, M Chilosi1. 1Dept of Haematology, University of Verona, Italy The Hematology Journal, Vol.4, Suppl 2, June 2003, Abstr 870 (a7, poster 2) Rhinomaxillaris Mucormycosis in a neutropenic Child. U.Y.Noma, JD Russell, A Piccin, A O’ Marchaigh Poster presentation on the Irish Otorhinolaryngoiatric Society. Kilkenny 3th-4th October 2003

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(a8, oral 6)“Retrospective Statistical analysis of Aplastic Anaemia and Fanconi Anaemia patients in Ireland” A Piccin , A O’Marcaigh, OP Smith, S Mc Cann Our Lady’s Hospital for Sick Children; St.James’s Hospital, Dublin Abstract e Presentazione Orale. Irish Society of Haematology, 21 Novembre 2003

(a9) Autologus Stem Cell transplantation as first line and salvage treatment for Multiple Myeloma: a single centre experience. F Elice, A Tosetto, R Raimondi, R Sartori, S Roberti, A Piccin, F Rodeghiero Dept of Haematology, Sa Bortolo Hospital, Vicenza, Italy The Haematology Journal. Abstract# 359, June 2004

(a10, poster 3) Preliminary Characterization of a New Type of Viruses Isolated from Paediatric Neuroblastoma and Non-Hodgkin’s Lymphoma: potential Implications for aetiology. Ugo Rovigatti1, Albert Tam2, Andrea Piccin1, Renato Colognato° and Bernard Sordat3 Università degli Studi di Pisa1. Genelabs Inc., Redwood City, CA, USA2 SREC, Lausanne, Switzerland3. Oral and poster presentation. International conference of Childhood Leukaemia, Westminster London, Settembre 2004

(a11) Two case-report of refractory anemia with excess of blast, which evolved into erythroleukaemia, associated with diabetes insipidus. Andrea Piccin,Ugo Rovigatti, Maria Marchi, Francesco Rodeghiero. Dept of Haematology S. Bortolo Hospital Vicenza Italy “Blood December 2004” American Society of Haematology, San Diego, USA, Abstract #4422

(a12, oral 11) Post SCT Autologus Recovery in Severe Aplastic Anaemia patients. First EBMT data analysis. A Piccin, R.Oneto, A.Bacigalupo, S. Mc Cann Abstract and Oral Presentation, Haematology Association of Ireland, Belfast, UK, Nov 2005

(a13, oral 12) Autologus Recovery in Severe Aplastic Anaemia patients. First EBMT data analysis. A Piccin, S.Mc Cann, R.Oneto, A.Bacigalupo, A.Locasciulli, J.Marsh, H.Schrezenmeier, G.Socié, A.Tichelli, J.Passweg. Abstract and Oral Presentation (#302) EBMT meeting, Hamburg , Marzo2006 (a14; poster 5) Carcinogenesis induced by a New Type of dsRNA Viruses from Human Neuroblastoma and Lymphoma. U Rovigatti and A Piccin 2nd IFOM-IEO Meeting on Cancer, Milano, Italy May 2006

(a15, oral 15) Non activated plasma-derived Protein C (Ceprotin®) in paediatric patients with septicaemia. A Piccin 1, 2, J Blatny3, I Okafor1, M Cotter3, C Mc Mahon1, A O’ Marcaigh1,

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WG Murphy2, OP Smith1

1Haematology Dept Our Lady’s Children Hospital, 2Irish Blood Transfusion Service, 3Haematology Dept. Temple Street Hospital. Trinity College University, Dublin, Ireland Transfusion. Oct 2007; 22A, #S52-030J

(a16, oral 16) Red cell microparticles in patients with sickle cell disease

A Piccin 1, 2, E Eakins1, C Murphy1, R Larragy1, R Nieuwland3, C McMahon2, O Smith2, W Murphy1 . 1Irish Blood Transfusion Service, 2Our Lady’s Hospital for Sick Children. Trinity College University Dublin. 3Academic Medical Centre University of Amsterdam, Netherlands. Oral Presentation; Haematology Association of Ireland, Ottobre 2007

(a17) Bronchoalveolar lavage in the diagnosis of pulmonary disease/infection in children with haematological malignancies. 1U. Rao, 1A. O’Marcaigh, 1A O’Meara, 1F Breatnach,1 A Piccin 1, C McMahon1, A Gahan, 2M McDermott, 3N O’Sullivan, 4J Russell, 1O P. Smith. Departments of; 1Haematology & Oncology, 2Histopathology, 3Microbiology and 4Otolaryngology, Our Lady’s Children’s Hospital, Dublin. Oral Presentation; Haematology Association of Ireland, Ottobre 2007

(a18; poster 6) Thiopurine S-methyl transferase polymorphic status, 6 mercaptopurine and TNF-α antagonism: F (actor) or bystander in the development of myelodisplastic syndrome/monosomy 7 in a child with Crhon’s Disease. A Piccin 1, U Rovigatti4, C Mc Mahon1, J Kelly3, B Bourke2, A O’Marcaigh1 & O P Smith1 1Departments of Haematology, 2Gastroenterology and 3Cytogenetics, Our Lady’s Children’s Hospital, Dublin Ireland and 4Retrovirus Centre, University of Pisa Medical School, Pisa, Italy Haematology Association of Ireland, Ottobre 2007 (a19; poster 7) Transient myeloproliferative disorder and acute myeloid leukaemia in children with Down’s Syndrome. A single centre study A Piccin 1, A O’Marcaigh1, J Kelly2, K Lavelle3, C Mc Mahon1 & OP Smith1. 1Dept. of Haematology, 2Cytogenetics, 3Pharmacy, Our Lady’s Children’s Hospital, Dublin Haematology Association of Ireland, Ottobre 2007

(a20; poster 8) Ceprotin (Protein C zymogen) replacement therapy in children with Neisseria Meningitides induced Protein C pathway failure. A Piccin1, I Okafor1, C Murphy1, J Blatny2, A O’ Marcaigh1, C Mc Mahon1, & OP Smith1. 1Dept of Haematology, Our Lady’s Children Hospital, 2Children’s University Hospital, Temple Street, Dublin, Ireland Haematology association of Ireland, October 2007

(a21; poster 9) Micro Foci inducing virus a potential Factor/Cofactor in the Aethiology of Childhood Leukaemia U Rovigatti, R Colognato, A Piccin Childhood leukaemia Causes and Prevention. London, UK, April 2008

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(a22, poster 10) Elective splenectomy in children with sickle cell anemia: is it a cause of further crises? A Piccin, R Geoghegan, H Conroy, H Rizkalla, M McDermott, M Corbally OP Smith, C Mc Mahon #0377 EHA 13th congress, Copenhagen June 2008

(a23, poster 11) Reduction in plasma Protein C & protein S levels during vaso-occlusive crisis in children with sickle cell disease. A Piccin, C Mc Mahon, C Murphy, E Eakins, OP Smith, WG Murphy #0376 EHA 13th congress, Copenhagen June 2008

(a24, poster 12) Circulating microparticles, plasma protein C and free protein S levels in children with sickle cell anaemia. A Piccin1,2,3, E Eakins1, C Murphy1, WG Murphy1,4, C McMahon2,O Smith2,3 1Irish Blood Transfusion Service, 2Our Lady’s Children Hospital, 3Trinity College University, 4University College Dublin, Ireland #1431; ASH 50th congress, San Francisco, US, December 2008

(a25) Plasma Adrenomedullin levels are elevated in paediatric patients with severe Sickle Cell Anaemia A Piccin1,2,3, C Murphy1, E Eakins1, WG Murphy1,4, J Kunde5, C Mc Mahon2, OP Smith2,3 1Irish Blood Transfusion Service, 2Our Lady’s Children Hospital, 3Trinity College University, 4Univeristy College Dublin, Republic of Ireland, 5Brahams Research Department, Germany # 4795; ASH 50th congress, San Francisco, US, December 2008

(a26) The synergistic action of Graft versus Leukaemia, Tyrosine Kinase inhibitor and cytostatics drugs can control multi-resistent chronic myeloid leukaemia (CML) in myeloid blastic crisis 1,4Piccin A, 2Mitterer M, 1Amato B, 1Cassiba V, 13Gambacorti-Passerini C, 1Cortelazzo S

1Dept of Haematology, San Maurizio Hospital, Bolzano, Italy; 2Dept of Haematology Meran Hospital, Italy; 3University of Milano Bicocca, Monza, Italy; 4Trinity College University, Dublin, Ireland #055, Societa Italiana di Ematologia, Annual Meeting, Milano, Italy Oct 2009

(a27) Do Anti-epileptic drugs trigger Leukaemia?

1,2Piccin A, 1Cassiba V, 1De Vigili E, 1Casini M, 1Cortelazzo S

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, Italy

2Trinity College University Dublin, Ireland #044, Societa Italiana di Ematologia, Annual Meeting, Milano, Italy Oct 2009

(a28, poster 16) Late Development of Cytogenetic Abnormalities in Ph Negative Cells of Chronic Myeloid Leukemia Patients Treated with Imatinib Michael Deininger1, François-Xavier Mahon2, Francois Guilhot3, Giuseppe Saglio4, Philipp le Coutre5, Arnon Nagler6, Anna D'Emilio7, Fabio Stagno8, Enrica Morra9, Andrea Piccin10, Sarit E. Assouline11, Elisabetta Abruzzese12, Valeria Santini13, Fabrizio Panev14, Pilar Giraldo15, Laura

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Antolini16, Maria Grazia Valsecchi16, Carlo Gambacorti-Passerini17

1Knight Cancer Institute, Oregon Health & Science University, Portland, OR; 2Université Victor Ségalen Bordeaux - Institut Bergonié, Bordeaux, France; 3Oncology, Hematology, and Cell Therapy, Clinical Investigation Centre CIC P 802 INSERM, Poitiers, France; 4Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; 5Department of Hematology and Oncology, Charité - Humboldt-Universitat, Campus Virchow, Berlin, Germany; 6Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel; 7Department of Cellular Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy; 8Hematology, University of Catania, Catania, Italy; 9Department of Hematology, Niguarda Ca' Granda Hospital, Milan, Italy; 10Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 11Hematology, McGill University, Montreal, QC, Canada; 12Department of Hematology, Sant'Eugenio Hospital, Rome, Italy; 13Hematology, University of Florence, Florence, Italy; 14Haematology Unit and Dep. of Biochemistry and Medical Biotechnology, CEINGE-Advanced Biotechnology, University of Naples “Federico II”, Naples, Italy; 15Hospital Miguel Servet, Zaragoza, Spain; 16Dept. of Clinical and Preventive Medicine, Università Milano Bicocca, Monza, Italy; 17Dept. of Hematology, Università Milano Bicocca and S. Gerardo Hospital, Monza, Italy Abstract #17458, American Society of Haematology, Annual Meeting, Dec 2009

(a29) Quality of Life in Elderly Patients with Essential Thrombocythemia E Oliva1, L Gugliotta2, M Cantonetti3, A Piccin4, MG Mazzucconi5, A Candoni6, R Cacciola7, E Cacciola7, M Lunghi8, S Tura9

1Hematology Dept, Azienda Ospedaliera, Reggio Calabria, Italy; 2Hematology Dept, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3Hematology Dept, Tor Vergata University, Rome, Italy; 4Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 5Hematology Dept, Sapienza University, Rome, Italy; 6Hematology Dept, University Hospital, Udine, Italy; 7Hematology Dept, Catania, Italy; 8Hematology Dept, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy; 9University of Medicine, Bologna, Italy Abstract #20986, American Society of Haematology, Annual Meeting, Dec 2009 (a30) Transfusion Associated Circulatory Overload (TACO) Incidence and risk factors A Piccin1,2,3, M Cronin1, C Murphy1, E Eakins1, E Lawlor1

1Irish Blood Transfusion Service, 2Trinity College University, Dublin, Ireland

3Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy Abstract #17528, American Society of Haematology, Annual Meeting, Dec 2009 Poster presentation #3157, ASH 51th congress, New Orleans, Dec 2009 (a31) Composition and Significance of Splenic Gamna Gandy Bodies in Sickle Cell Anaemia Andrea Piccin1,2,3, Corrina McMahon2, Owen Smith1, Hala Rizkalla4, Claudio Furlan5, Michael Mc Dermott4

1Dept. of Haematology, San Maurizio Regional Hospital, Bolzano, Italy; 2Trinity College University, Dublin, Ireland; 3Dept. of Haematology, Our Lady's Children's Hospital, Dublin, Ireland; 4Dept. of Pathology, Our Lady's Children's Hospital, Dublin; 5Centro Universitario Grandi Apparecchiature Scientifiche, University of Medicine, Padua, Italy Abstract #17532, American Society of Haematology, Annual Meeting, Dec 2009 (a32) A recent update of three consecutive prospective trials with high-dose therapy and autograft, without or with Rituximab, as primary treatment for advanced-stage follicular lymphoma (FL) show a sizeable group of patients surviving in continuous complete remission 16 years after the end of treatment: should we still consider FL an incurable disease? Tarella C, Ladetto M, Benedetti F, Vitolo U, Pulsoni A, Patti C, Callea V, Rambaldi A, Piccin A, Magni M, Musso M, Spedini P, Liberati AM, Gini G, Gallamini A, De Crescenzo A, Rodeghiero F, Iannitto E, Di Raimondo F, Chisesi T, Specchia G, Rota Scalabrini D, Rossi G, Levis A, Carella AM, Parvis G, Majolino I, Passera R, Ruella M, Pileri A, Gianni AM, and Corradini P. On behalf of Gruppo Italiano Trapianto di Midollo Osseo (GITMO), and Intergruppo Italiano Linfomi (IIL), Italy. Accepted as oral presentation American Society of Haematology, Annual Meeting, Dec 2009

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(a33 poster) Analysis of Parameters predicting Treatment Efficacy and Outcome in Patients with Hairy Cell Leukemia (HCL) Receiving Subcutaneous Cladribine in the ICGHCL2004 Protocol by the Italian Cooperative Group on HCL. Francesco Forconi1, Emanuele Cencini1, Francesco Zaja2, Tamara Intermesoli3, Francesca Fiore4, Benedetta Puccini5, Caterina Stelitano6, Renato Cantaffa7, Alessandro Pulsoni8, Alfonso Zaccaria9, Pier Luigi Zinzani10, Andrea Piccin11, Filippo Gherlinzoni12, Alessandro Levis13, Giovanni Martinelli14, Sara Barulli15, Fortunato Morabito16, Ivana Pierri18, Miriana Ruggeri19, Alessandra Caremani20, Luciano Masini21, Giuseppe Polimeno22, Angelo Guerasio23, Elisa Sozzi1, Davide Rossi24, Francesco Bertoni25, Piero Galieni19, Marco Gobbi18, Sergio Cortellazzo11, Luigi Rigacci5, Andrea Gallamini4, Robin Foà8, and Francesco Lauria1 1Ematologia e Trapianti, Università di Siena - AOUS, Siena, Italy, 2Clinica Ematologica DIRM, Udine, Italy, 3Chair of Hematology, Bergamo, Italy, 4Hematology, Azienda Ospedaliera, Cuneo, Italy, 5Hematology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy, 6Aizenda Ospedaliera Reggio Calabria, Ematologia, Reggio Calabria, Italy, 7Ematologia, Azienda Ospedaliera Catanzaro, Catanzaro, Italy, 8Dipartimento Biotecnologie Cellulari ed Ematologia, Universita' La Sapienza, Roma, Italy, 9Ematologia-Ravenna, Italy, 10Department of Hematology/Oncology, University of Bologna, Bologna, Italy, 11Div. of Hematology and BMT, Bolzano, Italy, 12Unita Operativa Ematologia, Ospedale Ca' Foncello, Treviso, Italy, 13Ospedale Civile, Alessandria, Italy, 14Hematology, European Institute of Oncology, Milan, Italy, 15Ematologia, Azienda Ospedaliera Pesaro, Pesaro, Italy, 16O.U. Haematology, Azienda Ospedaliera, Cosenza, Italy, 18Clinical Hematology, University of Genova Italy, Genova, Italy, 19Division of Hematology, Ascoli Piceno, Italy, 20Ematologia, Azienda Ospedaliera Arezzo, Arezzo, Italy, 22Division of Hematology, Reggio Emilia, Italy. 22 UOS Oncoematologia, Divisione di Medicina, Ospedale F. Miulli, Acquaviva delle Fonti-Bari, Italy, 23 Division of Hematology and Internal Medicine, University of Turin, Orbassano, Italy, 24Division of Hematology, DIRM, University of Eastern Piedmont, Novara, Italy, 25 Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

(a34 oral presentation ASH 2010) Analysis of Toxicity and Efficacy of Subcutaneous Cladribine at Reduced or Standard Doses (Five Versus Seven Consecutive Days) in Patients with Hairy Cell Leukemia (HCL) in the ICGHCL2004 Protocol by the Italian Cooperative Group on HCL Francesco Forconi1, Emanuele Cencini1, Francesco Zaja2, Tamara Intermesoli3, Francesca Fiore4, Benedetta Puccini5, Caterina Stelitano6, Renato Cantaffa7, Alessandro Pulsoni8, Alfonso Zaccaria9, Pier Luigi Zinzani10, Andrea Piccin11, Filippo Gherlinzoni12, Alessandro Levis13, Giovanni Martinelli14, Sara Barulli15, Fortunato Morabito16, Ivana Pierri18, Miriana Ruggeri19, Alessandra Caremani20, Luciano Masini21, Giuseppe Polimeno22, Angelo Guerasio23, Elisa Sozzi1, Davide Rossi24, Piero Galieni19, Marco Gobbi18, Sergio Cortellazzo11, Luigi Rigacci5, Andrea Gallamini4, Robin Foà8, and Francesco Lauria1. 1Ematologia e Trapianti, Università di Siena - AOUS, Siena, Italy, 2Clinica Ematologica DIRM, Udine, Italy, 3Chair of Hematology, Bergamo, Italy, 4Hematology, Azienda Ospedaliera, Cuneo, Italy, 5Hematology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy, 6Aizenda Ospedaliera Reggio Calabria, Ematologia, Reggio Calabria, Italy, 7Ematologia, Azienda Ospedaliera Catanzaro, Catanzaro, Italy, 8Dipartimento Biotecnologie Cellulari ed Ematologia, Universita' La Sapienza, Roma, Italy, 9Ematologia-Ravenna, Italy, 10Department of Hematology/Oncology, University of Bologna, Bologna, Italy, 11Div. of Hematology and BMT, Bolzano, Italy, 12Unita Operativa Ematologia, Ospedale Ca' Foncello, Treviso, Italy, 13Ospedale Civile, Alessandria, Italy, 14Hematology, European Institute of Oncology, Milan, Italy,

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15Ematologia, Azienda Ospedaliera Pesaro, Pesaro, Italy, 16O.U. Haematology, Azienda Ospedaliera, Cosenza, Italy, 18Clinical Hematology, University of Genova Italy, Genova, Italy, 19Division of Hematology, Ascoli Piceno, Italy, 20Ematologia, Azienda Ospedaliera Arezzo, Arezzo, Italy, 22Division of Hematology, Reggio Emilia, Italy. 22UOS Oncoematologia, Divisione di Medicina, Ospedale F. Miulli, Acquaviva delle Fonti-Bari, Italy, 23 Division of Hematology and Internal Medicine, University of Turin, Orbassano, Italy, 24Division of Hematology, DIRM, University of Eastern Piedmont, Novara, Italy 53th ASH, December 2011, oral presentation, abstract #701

(a35, poster 22) Hydroxyurea Treatment In 1075 Patients with Essential Thrombocythemia and Occurrence of Extra-Hematological Adverse Events: A Preliminary Report of the Registro Italiano Trombocitemia Luigi Gugliotta, MD1, Cristina Papayannidis2*, Andrea Piccin, MD3*, Alessia Tieghi4*, Nicola Vianelli5*, Potito Rosario Scalzulli6*, Anna Candoni7*, Alfredo Dragani8*, Andrea Patriarca8*, Monia Lunghi, MD9*, Rosanna Ciancia10*, Vincenzo Martinelli11*, Anna Marina Liberati12*, Giorgina Specchia13*, Annalisa Imovilli14*, Alessandro M. Vannucchi, MD15, Rosa Di Gaetano16*, Maria Luigia Randi17*, Francesco Passamonti, MD18*, Fausto Palmieri19*, Maria Gabriella Mazzucconi20*, Lucia Mastrullo21*, Giuseppe Cimino, MD22, Ivana Pierri23*, Emma Cacciola24, Alessandro Lucchesi25*, Annalisa Luraschi26*, Giovanni Martinelli2 and Michele Baccarani, MD2* 1S. Orsola-Malpighi Hematology-Oncology, University of Bologna, Bologna, Italy. 2Department of Hematology-Oncology, University of Bologna, Bologna, Italy. 3Hematology Unit, Ospedale Civile, Bolzano, Italy. 4Hematology, Reggio Emilia, Reggio Emilia, Italy. 5Istituto di Ematologia L. A. Seràgnoli, Policlinico Sant'Orsola Malpighi, Bologna, Italy. 6Hematology Unit, Casa sollievo della Sofferenza, S. Giovanni Rotondo (FG), Italy. 7Chair and Division of Haematology, University Hospital of Udine., Chair and Division of Haematology, University Hospital of Udine., Udine. 8Hematology Unit, Ospedale S. Spirito, Pescara, Italy. 9Division of Hematology, BRMA - Amedeo Avogadro University of Eastern Piedmont, Novara, Italy. 10Hematology, Federico II University, Napoli, Italy. 11Hematology Division, Department of Biochemistry and Medical Biotechnology, University Federico II, Naples, Italy. 12Hematology Unit, Università, Terni, Italy. 13University of Bari, Bari, Italy. 14Ematologia, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. 15Hematology, Dept of Medical and Surgical Care, Florence, Italy. 16Hematology Unit, Ospedale Castelfranco Veneto, Castelfranco Veneto. 17University of Padua, Italy. 18Department of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. 19Hematology Unit, AORN S. Giuseppe Moscsti, Avellino. 20Department of Cellular Biotechnologies and Hematology, University of Rome, Rome, Italy. 21Hematology Unit, Ospedale S. Gennaro, Napoli. 22Univ.Polo Pontino, Latina, Italy. 23Chair of Hematology, University of Genova, Genova. 24Biomedical Science, Section of Hematology, University of Catania, Catania, Italy. 25Hematology Unit, Ospedale, L'Aquila, Italy. 26Hematology Unit, Ospedale di Verbania, Verbania, Italy 52° ASH Conference meeting. Poster I-953; Abstract#1973 (a36, poster) Cytoreductive combination therapy in essential thrombocythemia: preliminary report of the registro italiano trombocitemia (RIT) Gugliotta, Luigi, S. Orsola University Hospital, Bologna, Italy (Presenting author) Scalzulli , P , Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy Tieghi, A , Arcispedale S.Maria Nuova, Reggio Emilia, Italy Codeluppi, K , Arcispedale S.Maria Nuova, Reggio Emilia, Italy

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Valvano, R , Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy Candoni, A , Clinica Ematologica Policlinico Universitario, Udine, Italy Chiozzotto, E , Clinica Ematologica Policlinico Universitario, Udine, Italy Liberati, M , Oncoematologia Ospedale S.Maria, Terni, Italy Apolloni, V , Oncoematologia Ospedale S.Maria, Terni, Italy Specchia, G , Cattedra di Ematologia Policlinico Ospedale GiovanniXXIII, Bari, Italy Cacciola, E , Dipartimento Scienze Biomediche Sez. Ematologia, Catania, Italy Cacciola, R , Dipartimento Scienze Biomediche Sez. Ematologia, Catania, Italy Mastrullo, L , Ospedale S. Giovanni Bosco Divisione di Ematologia, Napoli, Italy Villa, M , Ospedale S. Giovanni Bosco Divisione di Ematologia, Napoli, Italy Crugnola, M , Ospedale Maggiore Dipartimento Oncoematologico, Parma, Italy Martinelli, V , Università Federico II Dipartimento Ematologia, Napoli, Italy Ciancia, R , Università Federico II Dipartimento Ematologia, Napoli, Italy Mazzucconi, MG , Dipartimento Biopatologia Umana Sezione di Ematologia, Roma, Italy Santoro, C , Dipartimento Biopatologia Umana Sezione di Ematologia, Roma, Italy Campana, P , Ospedale Umberto I Medicina Interna e Oncoematologia , Nocera Inferiore, Italy Randi, ML , Università di Padova Dip Scienze Mediche Medicina Interna, Padova, Italy De Biasi, E , Centro Malattie del Sangue e degli Organi Emopoietici, Castelfranco Veneto, Italy Maschio, N , Centro Malattie del Sangue e degli Organi Emopoietici, Castelfranco Veneto, Italy Lanza, F , Istituti Ospitalieri Ematologia e CTMO, Cremona, Italy Antonioli, E , Azienda Ospedaliera Universitaria Careggi, Firenze, Italy Pierri, I , DIMI Clinica Ematologica, Genova, Italy Di Ianni, M , Ospedale S. Salvatore Ematologia Universitaria, L'Aquila, Italy Iurlo, A , Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Milano, Italy Piccin, A , Azienda Sanitaria di Bolzano Divisione di Ematologia, Bolzano, Italy Cascavilla, N , Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy Poster 12th Congress of the European Hematology Association Vienna, Austria, June 2007

(a37, poster 28) Blood cells dynamic and thrombo-haemorragic events in low risk Essential Thrombocytosis patients. A North Italian and Austrian study Andrea Piccin1, Michael Steurer2, Manfred Mitterer3, Elisabeth Maria Blöchl2, Luigi Marcheselli4, Irene Pusceddu1, Alessandra Marabese1, Irene Bertozzi5, Maria Luigia Randi5, Elena Elli6, Enrico Maria Pogliani6, Dino Veneri7, Omar Perbellini7, Enrica Pacquola8, Michele Gottardi8, Mario Tiribelli9, Anna Guella10, Barbara Innella10, Paolo Vivaldi10, Ercole De Biasi11, Rosaria Sancetta12, Renato Bassan12, Filippo Gherlinzoni8, Gianni Pizzolo7, Günther Gastl2, Sergio Cortelazzo1 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy 2Dept of Onco-Haematology, University of Medicine, Innsbruck, Austria 3Oncohaematology Unit, Meran Hospital, South Tyrol, Italy 4Dept of Oncohaemathology, University of Medicine, Modena, Italy 5Dept of Internal Medicine, University of Medicine, Padova, Italy 6Dept of Haematology, University of Milano Bicocca, Milan, Italy 7Dept of Haematology, University of Medicine, Verona, Italy 8Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 9Dept of Haematology, University of Medicine, Udine, Italy 10Dept of Haematology, Santa Chiara Hospital, Trento, Italy; 11Dept of Haematology, Camposampiero Hospital, Padova, Italy 12Dept of Haematology, Venice Hospital, Venice, Italy Poster presentation, ASH Meeting, Atlanta, USA, December 2012 (a38, poster 29) Blood cells derived Microparticles (MP) and vascular markers study in Essential

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Thrombocythaemia (ET) patients Andrea Piccin1,2, Irene Pusceddu2, Luigi Marcheselli3, Ciaran Murphy1, Elva Eakins1, Giovanni Amaddii’2, Carlo Moesender Frajria, Dino Veneri4, Omar Perbellini4, Enrica Pacquola5, Michele Gottardi5, Filippo Gherlinzoni5, Flaviano Favaro6, Diego Faggian6, Mario Plebani6, Gianni Pizzolo4, William G Murphy1 & Sergio Cortelazzo2 1Irish Blood Transfusion Service, Dublin, Ireland; 2Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy; 3Dept of Onco-Haematology, Modena University Hospital, Modena, Italy; 4Dept of Haematology, University of Medicine, Verona, Italy; 5Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 6Dept of Laboratory Medicine, University Hospital, Padova, Italy. Poster presentation, Haematology Association of Ireland Oct 2012 (a 39; poster 31) Thrombosis History and Relationship With Low Thrombocytosis, Leukocytosis, and Other Characteristics At Diagnosis In 977 Essential Thrombocythemia Patients A Multivariate Analysis Of The Registro Italiano Trombocitemie (RIT) Luigi Gugliotta, MD1, Alessandra Iurlo, MD*,2, Alessia Tieghi, MD*,3, Gabriele Gugliotta, MD*,4, Anna Candoni, MD*,5, Elisa Rumi, MD*,6, Elisabetta Antonioli, MD*,7, Alessandra Ricco*,8, Monica Lunghi, MD*,9, Rosario Potito Scalzulli, MD*,10, Anna Rita Scortechini, MD*,11, Katia Codeluppi*,3, Bruno Martino, MD*,12, Alfredo Dragani, MD*,13, Andrea Patriarca, MD*,13, Vincenzo Martinelli, MD*,14, Giorgia Battipaglia, MD*,15, Maria Luigia Randi, MD*,16, Elisabetta Cosi, MD*,16, Anna Marina Liberati, MD17, Viviana Appolloni, MD*,18, Nilla Maschio, MD*,19, Lucia Mastrullo, MD*,20, Maria Rosaria Villa, MD*,21, Maria Rosaria Esposito, MD*,22, Nicola Cantore, MD*,23, Fausto Palmieri, MD*,24, Maria Langella, MD*,25, Flavia Rivellini, MD*,26, Maria Gabriella Mazzucconi, MD*,27, Cristina Santoro, MD*,28, Ercole De Biasi, MD*,29, Angela Rago, MD*,30, Nicola Polverelli, MD*,31, Pierangelo Spedini, MD*,32, Emma Cacciola, MD33, Rossella R Cacciola, MD34, Ivana Pierri, MD*,35, Laura Mitsheunig, MD*,36, Marzia Salvucci*,37, Ferdinando Porretto, MD*,38, Andrea Piccin, MD, PhD*,39, Umberto Santoro*,40, Gianluca Gaidano41, Giuseppe Cimino, MD42, Francesco Lanza, MD*,32, Agostino Cortelezzi, MD43, Giuseppe Tagariello, MD44, Serena Rupoli, MD*,45, Giorgina Specchia46, Francesco Passamonti, MD*,47, Alessandro M. Vannucchi, MD48, Fabrizio Pane49, Nicola Vianelli, MD*,50, Rossella Miglio*,40, and Paola Monari*,40 ASH annual meeting, #poster 2829; Blood: 122 (21) 2013

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POSTERS PUBLICATIONS

(poster1) Second Autologus Stem cell Transplantation is an effective salvage therapy in relapsing or progressing Multiple Myeloma patients: a single center experience. 1Rosaria Sancetta, 1Andrea Piccin, 1Fabrizio Pomponi et al. 1Haematology Dept, S Bortolo Hospital Vicenza, Italy. Blood 2001 board Session 909 III

(poster 2) Rhinomaxillaris Mucormycosis pre allogeneic HSCT

A Piccin, U.Y.Noma, JD Russell, A O’ Marchaigh Poster presentation on the haematology association of Ireland Oct 2003

(poster 3) Preliminary Characterization of a New Type of Viruses Isolated from Paediatric Neuroblastoma and Non-Hodgkin’s Lymphoma: potential Implications for aetiology. Ugo Rovigatti1, Albert Tam2, Andrea Piccin1, Renato Colognato° and Bernard Sordat3 Università degli Studi di Pisa, Italy1. Genelabs Inc., Redwood City, CA, USA2; SREC, Lausanne, Switzerland3 International conference of Childhood Leukaemia, Westminster London, September 2004

(poster 4) Surgical treatment of Rhinomaxillaris Mucormycosis. U.Y.Noma, JD Russell, A Piccin, A O’ Marchaigh Poster presentation on the Irish Otorhinolaryngoiatric Society.Kilkenny, Ireland,Dec 2003

(poster 5) Carcinogenesis induced by a New Type of dsRNA Viruses from Human Neuroblastoma and Lymphoma. Ugo Rovigatti1, Andrea Piccin2. 1Università degli Studi di Pisa, Italy; Haematology Dept, Our Lady’s Children’s Hospital, Dublin, Ireland 2nd IFOM-IEO Meeting on Cancer; IFOM-IEO Campus, Milan, IT 05-08 May 2006

(poster 6) Thiopurine S-methyl transferase polymorphic status, 6 mercaptopurine and TNF- antagonism: F (actor) or bystander in the development of myelodisplastic syndrome/monosomy 7 in a child with Crhon’s Disease. A Piccin1, U Rovigatti4, C Mc Mahon1, J Kelly3, B Bourke2, A O’Marcaigh1 & O P Smith1 1Departments of Haematology, 2Gastroenterology and 3Cytogenetics, Our Lady’s Children’s Hospital, Dublin Ireland and 4Retrovirus Centre, University of Pisa Medical School, Pisa, Italy Haematology association of Ireland, October 2007

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(poster 7) Transient myeloproliferative disorder and acute myeloid leukaemia in children with Down’s Syndrome. A single centre study A Piccin1, A O’Marcaigh1, J Kelly2, K Lavelle3, C Mc Mahon1 & OP Smith1. 1Dept. of Haematology, 2Cytogenetics, 3Pharmacy, Our Lady’s Children’s Hospital, Dublin, Ireland Haematology association of Ireland, October 2007 (poster 8) Ceprotin (Protein C zymogen) replacement therapy in children with Neisseria Meningitides induced Protein C pathway failure. A Piccin1, I Okafor1, C Murphy1, J Blatny2, A O’ Marcaigh1, C Mc Mahon1, & OP Smith1. 1Departments of Haematology, 1Our Lady’s Children Hospital, Crumlin & 2Children’s University Hospital, Temple Street, Dublin Haematology association of Ireland, October 2007 (poster 9) Micro Foci inducing virus a potential Factor/Cofactor in the Aethiology of Childhood Leukaemia U Rovigatti, R Colognato, A Piccin Childhood leukaemia Causes and Prevention. West Minster, London UK, April 2008

(poster 10; a22) Elective splenectomy in children with Sickle Cell Anaemia: is it a cause of further crises? A Piccin, R Geoghegan, H Conroy, H Rizkalla, M McDermott, M Corbally, OP Smith, C McMahon Poster # 0377 EHA 13th congress, Copenhagen, June 2008

(poster 11; a23) Reduction in plasma Protein C & protein S levels during vaso-occlusive crisis in children with sickle cell disease. A Piccin, C Mc Mahon, C Murphy, E Eakins, OP Smith, WG Murphy. Poster #0376; EHA 13th congress, Copenhagen June 2008 (poster 12; a24) Circulating microparticles, plasma protein C and free protein S levels in children with sickle cell anaemia. A Piccin1,2,3,E Eakins1,C Murphy1,WG Murphy1,4, C McMahon2,O Smith2,3 1Irish Blood Transfusion Service, 2Our Lady’s Children Hospital, 3Trinity College University, 4University College Dublin, Ireland Poster #1431; ASH 50th congress, San Francisco, US, December 2008 (poster 13) Splenic Gamna Gandy bodies in Sickle Cell Anaemia. A Piccin1,2,4, M Mc Dermott3,4, H Rizkalla3, C Furlan5, C Mc Mahon1, O Smith 1,4 1Haematology Dept, 3Pathology Dept, Our Lady’s Children’s Hospital; 2Irish Blood Transfusion Service; 4Trinity College University; Dublin, Ireland; 5Centro Universitario Grandi Apparecchiature Scientifiche (CUGAS); University of Padua, Italy. Poster presentation at the Haematology Association of Ireland, Kilkenny, Ireland, Oct 2009

(poster 14) Transfusion Associated Circulatory Overload in Ireland. A Piccin1,2, M Cronin1, C Murphy1, E Eakins1, E Lawlor1

1Irish Blood Transfusion Service, 2Trinity College University, Dublin, Ireland Poster presentation at the Haematology Association of Ireland, Kilkenny, Ireland, Oct 2009

(poster 15) Transfusion Associated Circulatory Overload (TACO) Incidence and Risk Factors. A Piccin1,2,3, M Cronin1, C Murphy1, E Eakins1, E Lawlor1

1Dept of Haematology, Bolzano Regional Hospital, Italy

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2Irish Blood Transfusion Service, 3Trinity College University, Dublin, Ireland Poster presentation #3157, ASH 51th congress, New Orleans, Dec 2009

(poster 16) Late Development of Cytogenetic Abnormalities in Ph Negative Cells of Chronic Myeloid Leukemia Patients Treated with Imatinib Michael Deininger1, François-Xavier Mahon2, Francois Guilhot3, Giuseppe Saglio4, Philipp le Coutre5, Arnon Nagler6, Anna D'Emilio7, Fabio Stagno8, Enrica Morra9, Andrea Piccin10, Sarit E. Assouline11, Elisabetta Abruzzese12, Valeria Santini13, Fabrizio Panev14, Pilar Giraldo15, Laura Antolini16, Maria Grazia Valsecchi16, Carlo Gambacorti-Passerini17

1Knight Cancer Institute, Oregon Health & Science University, Portland, OR; 2Université Victor Ségalen Bordeaux - Institut Bergonié, Bordeaux, France; 3Oncology, Hematology, and Cell Therapy, Clinical Investigation Centre CIC P 802 INSERM, Poitiers, France; 4Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; 5Department of Hematology and Oncology, Charité - Humboldt-Universitat, Campus Virchow, Berlin, Germany; 6Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel; 7Department of Cellular Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy; 8Hematology, University of Catania, Catania, Italy; 9Department of Hematology, Niguarda Ca' Granda Hospital, Milan, Italy; 10Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 11Hematology, McGill University, Montreal, QC, Canada; 12Department of Hematology, Sant'Eugenio Hospital, Rome, Italy; 13Hematology, University of Florence, Florence, Italy; 14Haematology Unit and Dep. of Biochemistry and Medical Biotechnology, CEINGE-Advanced Biotechnology, University of Naples “Federico II”, Naples, Italy; 15Hospital Miguel Servet, Zaragoza, Spain; 16Dept. of Clinical and Preventive Medicine, Università Milano Bicocca, Monza, Italy; 17Dept. of Hematology, Università Milano Bicocca and S. Gerardo Hospital, Monza, Italy #17458, American Society of Haematology, Annual Meeting, Dec 2009

(poster 17) Composition and Significance of Splenic Gamna Gandy Bodies in Sickle Cell Anaemia Andrea Piccin1,2,3, Corrina McMahon2, Owen Smith1, Hala Rizkalla4, Claudio Furlan5, Michael Mc Dermott4

1Dept. of Haematology, San Maurizio Regional Hospital, Bolzano, Italy; 2Trinity College University, Dublin, Ireland; 3Dept. of Haematology, Our Lady's Children's Hospital, Dublin, Ireland; 4Dept. of Pathology, Our Lady's Children's Hospital, Dublin; 5Centro Universitario Grandi Apparecchiature Scientifiche, University of Medicine, Padua, Italy

Poster #0697, European Haematology association, Annual Meeting, Jun 2010

(poster 18) Bendamustine (B) alone or in combination with rituximab (R-B) for patients with relapsed/resistant chronic lymphocytic leukemia (CLL): a multicentre retrospective analysis of GISL-NHLSG. Andrea Piccin1,2,3, Poster # 0774 , European Haematology association, Annual Meeting, Jun 2010

(poster 19) Extra-haematological adverse events in 1075 essential thrombocythaemia patients treated with hydroxyurea:a preliminary report of the registro italiano trombocitemia (RIT)

1Gugliotta L, 2Tieghi A, 3Piccin A, 1Papayannidis C, 4Candoni A, 5Specchia G, 6Passamonti F, 7Scalzulli PR, 8Lunghi M, 9Radaelli F, 9Iurlo A, 10Vannucchi AM, 11Ciancia R, 12Randi ML , 13Palmieri F, 14Liberati M, 15Mazzucconi MG, 16Cacciola R, 16Cacciola E, 17Dragani A, 18Cimino G, 19Mastrullo L, 20Federici AB, 21Porretto F, 22Lucchesi A, 1Vianelli N, 1Martinelli G

1Istituto di Ematologia Seragnoli, Bologna; 2Reggio Emilia, 3Bolzano, 4Udine, 5Bari, 6Pavia, 7San Giovanni Rotondo, 8Novara, 9Milano P, 10Firenze, 11Universita’ Federico II, Napoli; 12Padova, 13Avellino; 14Terni; 15Roma; 16Catania; 17Pescara; 18Latina; 19Napoli SG; 20Milano; 21Palermo; 22L’Aquila. Poster 0988, European Haematology Association, Annual Meeting, Barcelona, June 2010

(poster 20) Extra-haematological adverse events in 1075 essential thrombocythaemia patients

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treated with hydroxyurea:a preliminary report of the registro italiano trombocitemia (RIT)

1Gugliotta L, 2Tieghi A, 3Piccin A, 1Papayannidis C, 4Candoni A, 5Specchia G, 6Passamonti F, 7Scalzulli PR, 8Lunghi M, 9Radaelli F, 9Iurlo A, 10Vannucchi AM, 11Ciancia R, 12Randi ML , 13Palmieri F, 14Liberati M, 15Mazzucconi MG, 16Cacciola R, 16Cacciola E, 17Dragani A, 18Cimino G, 19Mastrullo L, 20Federici AB, 21Porretto F, 22Lucchesi A, 1Vianelli N, 1Martinelli G

1Istituto di Ematologia Seragnoli, Bologna; 2Reggio Emilia, 3Bolzano, 4Udine, 5Bari, 6Pavia, 7San Giovanni Rotondo, 8Novara, 9Milano P, 10Firenze, 11Universita’ Federico II, Napoli; 12Padova, 13Avellino; 14Terni; 15Roma; 16Catania; 17Pescara; 18Latina; 19Napoli SG; 20Milano; 21Palermo; 22L’Aquila. Poster, (abstract 1973) Blood ASH Annual Meeting 2010

(poster 21) Analysis of Parameters predicting Treatment Efficacy and Outcome in Patients with Hairy Cell Leukemia (HCL) Receiving Subcutaneous Cladribine in the ICGHCL2004 Protocol by the Italian Cooperative Group on HCL Francesco Forconi1, Emanuele Cencini1, Francesco Zaja2, Tamara Intermesoli3, Francesca Fiore4, Benedetta Puccini5, Caterina Stelitano6, Renato Cantaffa7, Alessandro Pulsoni8, Alfonso Zaccaria9, Pier Luigi Zinzani10, Andrea Piccin11, Filippo Gherlinzoni12, Alessandro Levis13, Giovanni Martinelli14, Sara Barulli15, Fortunato Morabito16, Ivana Pierri18, Miriana Ruggeri19, Alessandra Caremani20, Luciano Masini21, Giuseppe Polimeno22, Angelo Guerasio23, Elisa Sozzi1, Davide Rossi24, Francesco Bertoni25, Piero Galieni19, Marco Gobbi18, Sergio Cortellazzo11, Luigi Rigacci5, Andrea Gallamini4, Robin Foà8, and Francesco Lauria1 1Ematologia e Trapianti, Università di Siena - AOUS, Siena, Italy, 2Clinica Ematologica DIRM, Udine, Italy, 3Chair of Hematology, Bergamo, Italy, 4Hematology, Azienda Ospedaliera, Cuneo, Italy, 5Hematology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy, 6Aizenda Ospedaliera Reggio Calabria, Ematologia, Reggio Calabria, Italy, 7Ematologia, Azienda Ospedaliera Catanzaro, Catanzaro, Italy, 8Dipartimento Biotecnologie Cellulari ed Ematologia, Universita' La Sapienza, Roma, Italy, 9Ematologia-Ravenna, Italy, 10Department of Hematology/Oncology, University of Bologna, Bologna, Italy, 11Div. of Hematology and BMT, Bolzano, Italy, 12Unita Operativa Ematologia, Ospedale Ca' Foncello, Treviso, Italy, 13Ospedale Civile, Alessandria, Italy, 14Hematology, European Institute of Oncology, Milan, Italy, 15Ematologia, Azienda Ospedaliera Pesaro, Pesaro, Italy, 16O.U. Haematology, Azienda Ospedaliera, Cosenza, Italy, 18Clinical Hematology, University of Genova Italy, Genova, Italy, 19Division of Hematology, Ascoli Piceno, Italy, 20Ematologia, Azienda Ospedaliera Arezzo, Arezzo, Italy, 22Division of Hematology, Reggio Emilia, Italy. 22 UOS Oncoematologia, Divisione di Medicina, Ospedale F. Miulli, Acquaviva delle Fonti-Bari, Italy, 23 Division of Hematology and Internal Medicine, University of Turin, Orbassano, Italy, 24Division of Hematology, DIRM, University of Eastern Piedmont, Novara, Italy, 25 Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. Poster ASH 2010 (Abstract 1369)

(poster 22) Hydroxyurea Treatment In 1075 Patients with Essential Thrombocythemia and Occurrence of Extra-Hematological Adverse Events: A Preliminary Report of the Registro Italiano Trombocitemia Luigi Gugliotta, MD1, Cristina Papayannidis2*, Andrea Piccin, MD3*, Alessia Tieghi4*, Nicola Vianelli5*, Potito Rosario Scalzulli6*, Anna Candoni7*, Alfredo Dragani8*, Andrea Patriarca8*, Monia Lunghi, MD9*, Rosanna Ciancia10*, Vincenzo Martinelli11*, Anna Marina Liberati12*, Giorgina Specchia13*, Annalisa Imovilli14*, Alessandro M. Vannucchi, MD15, Rosa Di Gaetano16*, Maria Luigia Randi17*, Francesco Passamonti, MD18*, Fausto Palmieri19*, Maria Gabriella Mazzucconi20*, Lucia Mastrullo21*, Giuseppe Cimino, MD22, Ivana Pierri23*, Emma Cacciola24, Alessandro Lucchesi25*, Annalisa Luraschi26*, Giovanni Martinelli2 and Michele

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Baccarani, MD2* 1S. Orsola-Malpighi Hematology-Oncology, University of Bologna, Bologna, Italy. 2Department of Hematology-Oncology, University of Bologna, Bologna, Italy. 3Hematology Unit, Ospedale Civile, Bolzano, Italy. 4Hematology, Reggio Emilia, Reggio Emilia, Italy. 5Istituto di Ematologia L. A. Seràgnoli, Policlinico Sant'Orsola Malpighi, Bologna, Italy. 6Hematology Unit, Casa sollievo della Sofferenza, S. Giovanni Rotondo (FG), Italy. 7Chair and Division of Haematology, University Hospital of Udine., Chair and Division of Haematology, University Hospital of Udine., Udine. 8Hematology Unit, Ospedale S. Spirito, Pescara, Italy. 9Division of Hematology, BRMA - Amedeo Avogadro University of Eastern Piedmont, Novara, Italy. 10Hematology, Federico II University, Napoli, Italy. 11Hematology Division, Department of Biochemistry and Medical Biotechnology, University Federico II, Naples, Italy. 12Hematology Unit, Università, Terni, Italy. 13University of Bari, Bari, Italy. 14Ematologia, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. 15Hematology, Dept of Medical and Surgical Care, Florence, Italy. 16Hematology Unit, Ospedale Castelfranco Veneto, Castelfranco Veneto. 17University of Padua, Italy. 18Department of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. 19Hematology Unit, AORN S. Giuseppe Moscsti, Avellino. 20Department of Cellular Biotechnologies and Hematology, University of Rome, Rome, Italy 21Hematology Unit, Ospedale S. Gennaro, Napoli. 22Univ.Polo Pontino, Latina, Italy. 23Chair of Hematology, University of Genova, Genova. 24Biomedical Science, Section of Hematology, University of Catania, Catania, Italy. 25Hematology Unit, Ospedale, L'Aquila, Italy. 26Hematology Unit, Ospedale di Verbania, Verbania, Italy 52° ASH Conference meeting. Poster I-953; Abstract#1973 (poster 23) Blastic plasmacytoid dendritic cell leukemia: preliminary results of a retrospective italian multicentric study L Pagano, C Valentini, G Di Paolantonio, L Melillo, G Gaidano, A Venditti, G Specchia, C Cattaneo, G Pica, A Spadea, A D'Arco, A Candoni, F Rodeghiero, A Piccin, A Abbadessa F Ballerini, R Sorasio, A Nosari, C Caramatti, R Invernizzi, F Aversa, L Pacilli, P Musto, A Peli, G Quintini, F Forghieri, F Facchetti, L Pavan, G Leone, A Pulsoni Catholic University, Insitute of Hematology, Rome, Italy On behalf of GIMEMA and AML working Part, Poster #054, EHA annual meeting 2011

(poster 24) Blastic Plasmacytoid Dendritic Cell neoplasm (BPDC) and Post-transplant Lymphoproliferative Disease (PTLD) Andrea Piccin 1, Enrico Morello2, Mirija Svaldi1, Torsten Haferlach3, Giovanni Negri4, Fabio Facchetti5, Simona Fisogni5, Irene Pusceddu1, Sergio Cortelazzo1 1Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 2Dept of Haematology, University Hospital, Brescia, Italy 3Institute of Münchner Leukämie Labor GMBH, Munich, Germany 4Pathology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy 5Pathology Dept, University of Medicine, Brescia, Italy Poster presentation, Haematology Association of Ireland Oct 2011 (poster 25) Anti-thrombin-III reduction and Posterior Reversible Encephalopathy Syndrome (PRES) in lymphoblastic leukaemia

Andrea Piccin1, Roberto Curro Dossi2, Vincenzo Cassibba1, Sigmund Stupnner3, Giampietro Bonatti3, Sergio Cortelazzo1 1 Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy 2 Stroke Unit, San Maurizio Regional Hospital, Bolzano, Italy 1Radiology Dept, San Maurizio Regional Hospital, Bolzano, Italy

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Poster presentation, Haematology Association of Ireland Oct 2011

(poster 26) Blood cells dynamic and thrombo-haemorragic events in low risk Essential Thrombocytosis patients. A North Italian and Austrian study Andrea Piccin1, Michael Steurer2, Manfred Mitterer3, Elisabeth Maria Blöchl2, Luigi Marcheselli4, Irene Pusceddu1, Alessandra Marabese1, Irene Bertozzi5, Maria Luigia Randi5, Elena Elli6, Enrico Maria Pogliani6, Dino Veneri7, Omar Perbellini7, Enrica Pacquola8, Michele Gottardi8, Mario Tiribelli9, Anna Guella10, Barbara Innella10, Paolo Vivaldi10, Ercole De Biasi11, Rosaria Sancetta12, Renato Bassan12, Filippo Gherlinzoni8, Gianni Pizzolo7, Günther Gastl2, Sergio Cortelazzo1

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy

2Dept of Onco-Haematology, University of Medicine, Innsbruck, Austria

3Oncohaematology Unit, Meran Hospital, South Tyrol, Italy

4Dept of Oncohaemathology, University of Medicine, Modena, Italy

5Dept of Internal Medicine, University of Medicine, Padova, Italy

6Dept of Haematology, University of Milano Bicocca, Milan, Italy

7Dept of Haematology, University of Medicine, Verona, Italy

8Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 9Dept of Haematology, University of Medicine, Udine, Italy

10Dept of Haematology, Santa Chiara Hospital, Trento, Italy; 11Dept of Haematology, Camposampiero Hospital, Padova, Italy

12Dept of Haematology, Venice Hospital, Venice, Italy Poster presentation, ESH on MPN, Vienna, Austria, Oct 2012

(poster 27) Blood cells dynamic and thrombo-haemorragic events in low risk Essential Thrombocytosis patients. A North Italian and Austrian study Andrea Piccin1, Michael Steurer2, Manfred Mitterer3, Elisabeth Maria Blöchl2, Luigi Marcheselli4, Irene Pusceddu1, Alessandra Marabese1, Irene Bertozzi5, Maria Luigia Randi5, Elena Elli6, Enrico Maria Pogliani6, Dino Veneri7, Omar Perbellini7, Enrica Pacquola8, Michele Gottardi8, Mario Tiribelli9, Anna Guella10, Barbara Innella10, Paolo Vivaldi10, Ercole De Biasi11, Rosaria Sancetta12, Renato Bassan12, Filippo Gherlinzoni8, Gianni Pizzolo7, Günther Gastl2, Sergio Cortelazzo1

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy

2Dept of Onco-Haematology, University of Medicine, Innsbruck, Austria

3Oncohaematology Unit, Meran Hospital, South Tyrol, Italy

4Dept of Oncohaemathology, University of Medicine, Modena, Italy

5Dept of Internal Medicine, University of Medicine, Padova, Italy

6Dept of Haematology, University of Milano Bicocca, Milan, Italy

7Dept of Haematology, University of Medicine, Verona, Italy

8Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 9Dept of Haematology, University of Medicine, Udine, Italy

10Dept of Haematology, Santa Chiara Hospital, Trento, Italy; 11Dept of Haematology, Camposampiero Hospital, Padova, Italy

12Dept of Haematology, Venice Hospital, Venice, Italy Poster presentation, Haematology Association of Ireland, Cork, Ireland, Oct 2012

(poster 28) Blood cells dynamic and thrombo-haemorragic events in low risk Essential Thrombocytosis patients. A North Italian and Austrian study

Andrea Piccin1, Michael Steurer2, Manfred Mitterer3, Elisabeth Maria Blöchl2, Luigi Marcheselli4, Irene Pusceddu1, Alessandra Marabese1, Irene Bertozzi5, Maria Luigia Randi5, Elena Elli6, Enrico Maria Pogliani6, Dino Veneri7, Omar Perbellini7, Enrica Pacquola8, Michele Gottardi8, Mario

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Tiribelli9, Anna Guella10, Barbara Innella10, Paolo Vivaldi10, Ercole De Biasi11, Rosaria Sancetta12, Renato Bassan12, Filippo Gherlinzoni8, Gianni Pizzolo7, Günther Gastl2, Sergio Cortelazzo1

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy

2Dept of Onco-Haematology, University of Medicine, Innsbruck, Austria

3Oncohaematology Unit, Meran Hospital, South Tyrol, Italy

4Dept of Oncohaemathology, University of Medicine, Modena, Italy

5Dept of Internal Medicine, University of Medicine, Padova, Italy

6Dept of Haematology, University of Milano Bicocca, Milan, Italy

7Dept of Haematology, University of Medicine, Verona, Italy

8Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 9Dept of Haematology, University of Medicine, Udine, Italy

10Dept of Haematology, Santa Chiara Hospital, Trento, Italy; 11Dept of Haematology, Camposampiero Hospital, Padova, Italy

12Dept of Haematology, Venice Hospital, Venice, Italy Poster presentation, ASH Meeting, Atlanta, USA, December 2012 (poster 29) Blood cells derived Microparticles (MP) and vascular markers study in Essential Thrombocythaemia (ET) patients Andrea Piccin1,2, Irene Pusceddu2, Luigi Marcheselli3, Ciaran Murphy1, Elva Eakins1, Giovanni Amaddii’2, Carlo Moesender Frajria, Dino Veneri4, Omar Perbellini4, Enrica Pacquola5, Michele Gottardi5, Filippo Gherlinzoni5, Flaviano Favaro6, Diego Faggian6, Mario Plebani6, Gianni Pizzolo4, William G Murphy1 & Sergio Cortelazzo2 1Irish Blood Transfusion Service, Dublin, Ireland; 2Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy; 3Dept of Onco-Haematology, Modena University Hospital, Modena, Italy; 4Dept of Haematology, University of Medicine, Verona, Italy; 5Dept of Haematology, Cà Foncello Hospital, Treviso, Italy; 6Dept of Laboratory Medicine, University Hospital, Padova, Italy Poster presentation, Haematology Association of Ireland Oct 2012 (poster 30) BLOOD CELLS DERIVED MICROPARTICLES AND VASCULAR MARKERS STUDY IN ESSENTIAL THROMBOCYTHAEMIA PATIENTS A. Piccin(1), I. Pusceddu(1), L. Marcheselli(2), C. Murphy(3), E. Eakins(3), G. Amadii(1), C. Moesender Frajria(1), D. Veneri(4), O. Perbellini(4), E. Pacquola(5), M. Gottardi(5), F. Gherlinzoni(5), F. Favaro(6), D. Faggian(6), M. Plebani(6), G. Pizzolo(4), W. Murphy(3), S. Cortelazzo(1) 1Haematology, San Maurizio Regional. Hospital,Bolzano/Bozen, South Tyrol, Italy 2Onco-Haematology, Modena University Hospital, Italy 3Irish Blood Transfusion Service, Dublin, Ireland 4Haematology, University of Medicine, Verona, Italy 5Haematology, Cà Foncello Hospital, Treviso, Italy 6Laboratory Medicine, University Hospital, Padova, Italy Poster presentation, Euromed Lab Milano, May, 2013 (poster 31) Thrombosis History and Relationship With Low Thrombocytosis, Leukocytosis, and Other Characteristics At Diagnosis In 977 Essential Thrombocythemia Patients A Multivariate Analysis Of The Registro Italiano Trombocitemie (RIT) Luigi Gugliotta, MD1, Alessandra Iurlo, MD*,2, Alessia Tieghi, MD*,3, Gabriele Gugliotta, MD*,4, Anna Candoni, MD*,5, Elisa Rumi, MD*,6, Elisabetta Antonioli, MD*,7, Alessandra

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Ricco*,8, Monica Lunghi, MD*,9, Rosario Potito Scalzulli, MD*,10, Anna Rita Scortechini, MD*,11, Katia Codeluppi*,3, Bruno Martino, MD*,12, Alfredo Dragani, MD*,13, Andrea Patriarca, MD*,13, Vincenzo Martinelli, MD*,14, Giorgia Battipaglia, MD*,15, Maria Luigia Randi, MD*,16, Elisabetta Cosi, MD*,16, Anna Marina Liberati, MD17, Viviana Appolloni, MD*,18, Nilla Maschio, MD*,19, Lucia Mastrullo, MD*,20, Maria Rosaria Villa, MD*,21, Maria Rosaria Esposito, MD*,22, Nicola Cantore, MD*,23, Fausto Palmieri, MD*,24, Maria Langella, MD*,25, Flavia Rivellini, MD*,26, Maria Gabriella Mazzucconi, MD*,27, Cristina Santoro, MD*,28, Ercole De Biasi, MD*,29, Angela Rago, MD*,30, Nicola Polverelli, MD*,31, Pierangelo Spedini, MD*,32, Emma Cacciola, MD33, Rossella R Cacciola, MD34, Ivana Pierri, MD*,35, Laura Mitsheunig, MD*,36, Marzia Salvucci*,37, Ferdinando Porretto, MD*,38, Andrea Piccin, MD, PhD*,39, Umberto Santoro*,40, Gianluca Gaidano41, Giuseppe Cimino, MD42, Francesco Lanza, MD*,32, Agostino Cortelezzi, MD43, Giuseppe Tagariello, MD44, Serena Rupoli, MD*,45, Giorgina Specchia46, Francesco Passamonti, MD*,47, Alessandro M. Vannucchi, MD48, Fabrizio Pane49, Nicola Vianelli, MD*,50, Rossella Miglio*,40, and Paola Monari*,40 ASH annual meeting, #poster 2829; Blood: 122 (21) 2013

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PUBLISHED TEXTBOOK TRANSLATIONS

1) Translation from German to Italian of the German Atlas “Anatomie des Menschen” of Rohen, Yokochi et al, Vol I “Kopf und Hals”, Schattauer Verlag, Stuttgart, Germany. Piccin Nuova Libraria Publishing House.Padova, Italy, April 2000 2) Translation from English to Italian of the book “A dictionary of pharmacology and allied topics”by Desmond Lau rence. Italian Editio1n: Dizionario di Farmacologia e materie affini. M.Ferrari, R.Padrini, A.Piccin Piccin Nuova Libraria Publishing House.Padova, Italy, March 2001

3) Translation from English to Italian of Chapter 57, “Hematological Cardiac diseases“ in the Cardiology. Textbook by Eugene Braunwald, Saunders Publishing House. Piccin Nuova Libraria Publishing House.Padova, Italy, May 2002 4) Translation from English to Italian of the BCSC, Hematologic Disorders, of the American Academy of Ophtalmology, Section1 – Update General Medicine, 2002-2003, Piccin Nuova Libraria Publishing House.Padova, Italy, May 2002; Chapter VII 147-158 5) Translation from English to Italian of Current Medical Diagnosis and Treatment, by Lawrence Tierney, Appleton and Lange publisher. Chapter 13th: Blood. Piccin Nuova Libraria Publishing House. Padova, Italy, May 2008 6) Translation from English to Italian of CURRENT EMERGENCY: Diagnosis & Treatment" 5/ed. C. Keith Stone e Roger Humphries, Chapter 39. The McGraw-Hill Companies, Inc. Piccin Nuova Libraria Publishing House.Padova, Italy, June 2004 7) Translation from English to Italian of the Chapter 40, Cancer, of the book of LM Tierney Internal Medicine, Lippincott, UK, 2005 Piccin Nuova Libraria Publishing House. Padova, Italy, May 2008

8) Translation from English to Italian of the Chapter 13, Blood Diseases, of the book of LM Tierney Internal Medicine, Lippincott, UK 2005 9) Translation from English to Italian of the book “Case based Haematology,” S Mc Cann, R Foá, O Smith, E Conneally, Blackwell 2005

10) Translation from Spanish to Italian of the chapter “Sangre”, from the “Atlas del Cuerpo Humano”, Gorg Blanc Editore 2005

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ORAL PRESENTATIONS

O1) 1stMD Graduation thesis: "Gene Therapy in Human Medulloblastoma, in Vivo and in Vitro" A. Piccin Paediatric Onco-Haematology Department, Padua Padua University, Italy, Nov 1996 O2) Updating in Thrombotic thrombocytopenic purpura and Hamolytic uremic syndrome A. Piccin Teaching Session in Haematology, St. James’s Hospital, Dublin,Ireland March 2002 O3) 2ndMD: Specialization thesis Analysis of conventional and high Dose Therapy in a casuistic of 201 cases of Multiple Myeloma Andrea Piccin, Alberto Tosetto , Francesa Elice, Francesco Rodeghiero Dept of Haematology S. Bortolo Hospital Vicenza Italy. Verona University, Italy, Oct 2002

O4) “Mediastinic Lymphoma”. Cases and review of the literature A Piccin Teaching Session for SHO and Registrar in Paediatric Haematology and Ocology, Our Lady’s Hospital for Sick Children, Dublin, Sept 2003

O5) “Aplastic Anaemia and Fanconi Anaemia” A Piccin Teaching Session for SHO and Registrar in Paediatric Haematology and Ocology, Our Lady’s Hospital for Sick Children, Dublin, November 2003 O6) Retrospective Statistical analysis of Aplastic Anaemia and Fanconi Anaemia patients in Ireland. Andrea Piccin , Angus O’Marcaigh, Owen Smith, Shaun Mc Cann Our Lady’s Hospital for Sick Children; St.James’s Hospital, Dublin. Irish Society of Haematology, Tullamore, Ireland, November 2003

O7) “Iron Deficiency Anaemia”. Tutorial session for Medical graduates A Piccin St James’s Hospital. Dublin, Ireland, Jan 2004 O8) “Appropiate Transfusion” A Piccin, E Lawlor

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Teaching Session in Haematology at St. James’s Hospital, Dublin, Ireland, April 2004 O9) Preliminary Characterization of a new type of viruses isolated from Paediatric Neuroblastoma and Non-Hodgkin’s Lymphoma: potential Implications for aetiology. Ugo Rovigatti1, Albert Tam2, Andrea Piccin1, Renato Colognato3 and Bernard Sordat3 University of Pisa Medical School & Retrovirus Center, Pisa, Italy1 Genelabs Inc., Redwood City, CA, USA2 SREC, Lausanne, Switzerland3. Oral Presentation International conference of Childhood Leukaemia, London, UK, September 2004

O10) “Invasive Mucormycosis pre-SCT” Andrea Piccin, Aengus O’ Marcaigh, Owen Smith Department of Haematology, Our Lady’s Children Hospital, Dublin Oral Presentation, EBMT annual meeting of Infection Disease WP, Padua, Italy, October 2005 O11) Autologus Recovery in Severe Aplastic Anaemia. First EBMT data analysis Andrea Piccin, Andrea Bacigalupo, Jacob Passweg, Shaun Mc Cann. Haematology Dept, St James’s Hospital, Dublin Oral Presentation Haematology Association of Ireland , Belfast,UK, November 2005

O12) Post SCT Autologus Recovery in Severe Aplastic Anaemia patients. First EBMT data analysis. A.Piccin, S.Mc Cann, R.Oneto, A.Bacigalupo, A.Locasciulli, J.Marsh, H.Schrezenmeier, G.Socié, A.Tichelli, J.Passweg Oral Presentation (#302) EBMT meeting, Hamburg, March 2006 O13) Circulating Microparticles Pathophysiology and Clinical implications

A.Piccin1, 2, E Eakins1, C Murphy1, R Larragy1, R Nieuwland3, C McMahon2, O Smith2, W Murphy1

1Irish Blood Transfusion Service, 2Our Lady’s Hospital for Sick Children. Trinity College University Dublin. 3Academic Medical Centre University of Amsterdam, Netherlands Oral Presentation National Blood Centre, Product Development Meetings, Dublin November 2006 O14) “Iron Deficiency Anaemia”. Tutorial session for Medical graduates, A.Piccin Oral Presentation, St James’s Hospital, Dublin, Ireland, January 2007 O15) Non activated plasma-derived Protein C (Ceprotin®) in paediatric patients with septicaemia. A Piccin1, 2, J Blatny3, I Okafor1, M Cotter3, O’Marcaigh A1, C Mc Mahon1, Murphy C2, OP Smith1

1Haematology Dept Our Lady’s Children Hospital, 2Irish Blood Transfusion Service, 3Haematology Dept. Temple Street Hospital. Trinity College University, Dublin, Ireland Oral Presentation; America Associated Blood Banking, Anaheim, California, October 2007 (a14) O16) Red cell microparticles in patients with sickle cell disease

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A Piccin1, 2, E Eakins1, C Murphy1, R Larragy1, R Nieuwland3, C McMahon2, O Smith2, W Murphy1

1Irish Blood Transfusion Service, 2Our Lady’s Hospital for Sick Children. Trinity College University Dublin. 3Academic Medical Centre University of Amsterdam, Netherlands Oral Presentation; Haematology Association of Ireland, October 2007

O17) Bronchoalveolar lavage in the diagnosis of pulmonary disease/infection in children with haematological malignancies. 1U Rao, 1A O’Marcaigh, 1A O’Meara, 1F Breatnach, 1A Piccin, C McMahon1, A Gahan, 2MMcDermott, 3N O’Sullivan, 4J Russell, 1O P Smith. Departments of 1Haematology & Oncology, 2Histopathology, 3Microbiology, 4ENT, Our Lady’s Children’s Hospital, Dublin. Oral Presentation; Haematology Association of Ireland, October 2007

O18) Circulating microparticles, Protein C, protein S and vascular markers in Sickle cell anaemia. A Piccin1, 2, E Eakins1, C Murphy1, WGMurphy, O Smith, C McMahon2

1Irish Blood Transfusion Service, 2Our Lady’s Hospital for Sick Children, Trinity College University Oral Presentation; Haematology Association of Ireland, October 2008

O19) The relationships between natural occurring anticoagulant, endothelial modulators and circulating microparticles in sickle cell anaemia. A Piccin1, 2,3, E Eakins1, C Murphy1, WG Murphy1, O Smith2,3, C McMahon2, WG Murphy1

1Irish Blood Transfusion Service, 2Our Lady’s Hospital for Sick Children,. Trinity College University Oral Presentation; Product Development Seminar IBTS November 2008, Dublin,Ireland

O20) Composition and significance of splenic Gamna Gandy bodies in Sickle Cell Anaemia. A Piccin1,2,4, M Mc Dermott3,4, H Rizkalla3, C Furlan5, A Fassina6, C Mc Mahon1, O Smith 1,4 1Haematology Dept, 3Pathology Dept, Our Lady’s Children’s Hospital; 2Irish Blood Transfusion Service; 4Trinity College University; Dublin, Ireland; 5Centro Universitario Grandi Apparecchiature Scientifiche (CUGAS); 6Istituto di Anatomia Patologica; University of Padua, Italy Oral Presentation Royal Academy of Medicine in Ireland, Dublin, Ireland, January 2009 O21) Primitive and secondary anaemias. A Piccin1 1Haematology Dept, Bolzano Regional Hospital, South Tyrol Italy

Italian Radio and Television ,RAI radiofonic programme, Bolzano, Italy, June 2009

O22) Plasmacell Leukaemia, 1A Piccin, 1N Pescosta, 1S Cortelazzo

1Haematology Dept, S Maurizio Hospital, Bolzano Italy

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Myeloma workshop. University of Padua, Italy June 2009

O23) Endothelial damage and microparticles in Sickle Cell Anaemia patients. A Piccin1, 2,3, E Eakins1, C Murphy1, WG Murphy1, O Smith2,3, C McMahon2, WG Murphy

1Irish Blood Transfusion Service, 2Our Lady’s Hospital for Sick Children,. 3Trinity College

University, Dublin, Ireland University of Medicine, Innsbruck, Austria, Oct 2009

O24) Quality of Life in Elderly Patients with Essential Thrombocythemia E Oliva1, L Gugliotta2, M Cantonetti3, A Piccin4, MG Mazzucconi5, A Candoni6, R Cacciola7, E Cacciola7, M Lunghi8, S Tura9

1Hematology Dept, Azienda Ospedaliera, Reggio Calabria, Italy; 2Hematology Dept, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3Hematology Dept, Tor Vergata University, Rome, Italy; 4Haematology Dept, San Maurizio Regional Hospital, Bolzano, Italy; 5Hematology Dept, Sapienza University, Rome, Italy; 6Hematology Dept, University Hospital, Udine, Italy; 7Hematology Dept, Catania, Italy; 8Hematology Dept, A Avogadro University of Eastern Piedmont, Novara, Italy; 9University of Medicine, Bologna, Italy O25) Prospective chimerism study on Autologus Reconstitution in Aplastic Anaemia patients Post HSCT A Piccin1

1 Bolzano Regional Hospital, South Tyrol, Italy;

EBMT SAA-Working Party, Engelberg, Switzerland, Oct 2009

O26) Microparticles and endothelial damage. A Piccin1 (invited speaker)

1Bolzano Regional Hospital, South Tyrol, Italy; Castelfranco Hospital, Treviso, Italy, Dic 2009

O27) A recent update of three consecutive prospective trials with high-dose therapy and autograft, without or with Rituximab, as primary treatment for advanced-stage follicular lymphoma (FL) show a sizeable group of patients surviving in continuous complete remission 16 years after the end of treatment: should we still consider FL an incurable disease ? Tarella C, Ladetto M, Benedetti F, Vitolo U, Pulsoni A, Patti C, Callea V, Rambaldi A, Piccin A, Magni M, Musso M, Spedini P, Liberati AM, Gini G, Gallamini A, De Crescenzo A, Rodeghiero F, Iannitto E, Di Raimondo F, Chisesi T, Specchia G, Rota Scalabrini D, Rossi G, Levis A, Carella AM, Parvis G, Majolino I, Passera R, Ruella M, Pileri A, Gianni AM, and Corradini P. On behalf of Gruppo Italiano Trapianto di Midollo Osseo (GITMO), and Intergruppo Italiano Linfomi (IIL), Italy. Accepted as oral presentation American Society of Haematology, Annual Meeting, Dec 2009 O28) A recent update of 3 consecutive prospective trials with high-dose therapy and autograft, without or with rituximab, as primary treatment for advanced-stage follicular lymphoma shows

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a sizeable group of patients surviving in continuous complete remission C. Tarella, M. Ladetto, F. Benedetti, U. Vitolo, C. Patti, V. Callea, A. Rambaldi, A. Piccin, L. Devizzi, M. Musso, E. Iannitto, P. Spedini, A.M. Liberati, F. Ciceri, A. Gallamini, F. Rodeghiero, G. Gini, A. De Crescenzo, F. Di Raimondo, A. Levis, T. Chisesi, T. Perrone, D. Rota Scalabrini, G. Rossi, A.M. Carella, G. Parvis, I. Majolino, R. Passera, M. Ruella, A. Pileri, A.M. Gianni, P. Corradini On behalf of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO), and Intergruppo Italiano Linfomi (IIL), Italy. 36th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) Vienna, Austria, march 2010. # O241 O29) “La gestione dell’Emoglobinuria Parossistica Notturna: Ultimi sviluppi nella diagnosi e nel trattamento”

Andrea Piccin (invited speaker) SIE – Società Italiana di Ematologia; SIES – Società Italiana di Ematologia Sperimentale Hotel Boscolo Maggior Consiglio, Treviso, Italy, June 2010 O30) “Ruolo di Mab Campath nelle sindromi linfoproliferative” Andrea Piccin (invited speaker) Convegno Triveneto,Venezia Mestre, Italy, September 2010 O31) Analysis of Toxicity and Efficacy of Subcutaneous Cladribine at Reduced or Standard Doses (Five Versus Seven Consecutive Days) in Patients with Hairy Cell Leukemia (HCL) in the ICGHCL2004 Protocol by the Italian Cooperative Group on HCL Francesco Forconi1, Emanuele Cencini1, Francesco Zaja2, Tamara Intermesoli3, Francesca Fiore4, Benedetta Puccini5, Caterina Stelitano6, Renato Cantaffa7, Alessandro Pulsoni8, Alfonso Zaccaria9, Pier Luigi Zinzani10, Andrea Piccin11, Filippo Gherlinzoni12, Alessandro Levis13, Giovanni Martinelli14, Sara Barulli15, Fortunato Morabito16, Ivana Pierri18, Miriana Ruggeri19, Alessandra Caremani20, Luciano Masini21, Giuseppe Polimeno22, Angelo Guerasio23, Elisa Sozzi1, Davide Rossi24, Piero Galieni19, Marco Gobbi18, Sergio Cortellazzo11, Luigi Rigacci5, Andrea Gallamini4, Robin Foà8, and Francesco Lauria1 1Ematologia e Trapianti, Università di Siena - AOUS, Siena, Italy, 2Clinica Ematologica DIRM, Udine, Italy, 3Chair of Hematology, Bergamo, Italy, 4Hematology, Azienda Ospedaliera, Cuneo, Italy, 5Hematology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy, 6Aizenda Ospedaliera Reggio Calabria, Ematologia, Reggio Calabria, Italy, 7Ematologia, Azienda Ospedaliera Catanzaro, Catanzaro, Italy, 8Dipartimento Biotecnologie Cellulari ed Ematologia, Universita' La Sapienza, Roma, Italy, 9Ematologia-Ravenna, Italy, 10Department of Hematology/Oncology, University of Bologna, Bologna, Italy, 11Div. of Hematology and BMT, Bolzano, Italy, 12Unita Operativa Ematologia, Ospedale Ca' Foncello, Treviso, Italy, 13Ospedale Civile, Alessandria, Italy, 14Hematology, European Institute of Oncology, Milan, Italy, 15Ematologia, Azienda Ospedaliera Pesaro, Pesaro, Italy, 16O.U. Haematology, Azienda Ospedaliera, Cosenza, Italy, 18Clinical Hematology, University of Genova Italy, Genova, Italy, 19Division of Hematology, Ascoli Piceno, Italy, 20Ematologia, Azienda Ospedaliera Arezzo, Arezzo, Italy, 22Division of Hematology, Reggio Emilia, Italy. 22UOS Oncoematologia, Divisione di Medicina, Ospedale F. Miulli, Acquaviva delle Fonti-Bari, Italy, 23 Division of Hematology and Internal Medicine, University of Turin, Orbassano, Italy, 24Division of Hematology, DIRM, University of Eastern Piedmont, Novara, Italy. Oral presentation ASH 2010116: Abstract 701 O32) Autologus Reconstitution in SAA, a prospective study On behalf of the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (WPSAA, EBMT) A Piccin1, S Mc Cann2, G Socié3, R Oneto4, A Bacigalupo4, A Locasciulli5, J Marsh6, H Schrezenmeier7, A Tichelli8, E Hand1, M Lawler1, J Passweg9

1Ospedale San Maurizio Bolzano, Italy; 2St James's Hospital, Trinity College Dublin, Ireland

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3Hôpital Saint Louis Paris, France; 4Ospedale San Martino Genoa, Italy; 5Ospedale San Camillo Rome, Italy; 6St George's Hospital London, UK; 7Universitätsklinikum Ulm, Germany; 8University Hospital Basel, Switzerland; 9University Hospital, Geneva, Switzerland Oral presentation, Leiden, Holland, Oct 2010

O33) Extra-haematological adverse events in 1075 essential thrombocythaemia patients treated with hydroxyurea:a preliminary report of the registro italiano trombocitemia (RIT)

1Piccin A, 2Gulgiotta L. 1Dept of Haematology, San Maurizio regional Hospital, Bolzano, South Tyrol, Italy. 2Istituto Seragnoli, Bologna University, Bologna, Italy Oral presentation HAI meeting Galway, Ireland, Oct 2010 O34) Thrombocytosis and Myeloproliferative neoplasms in children

1Piccin A (invited speaker). 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy. Oral presentation, University of Verona, November 2010 O35) Diagnosi e terapia della Trombocitemia Essenziale

1Piccin A (invited speaker)

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy University of Padova, Italy, October 2011 O36) LA LEUCEMIA A CELLULE DENDRITICHE PLASMACITOIDI: RISULTATI PRELIMINARI DI UNO STUDIO RETROSPETTIVO MULTICENTRICO ITALIANO Pagano L., Valentini C.G., Di Paolantonio G., Melillo L., Gaidano G., Venditti A., Specchia G., Cattaneo C., Pica G., Spadea A., D’Arco A., Candoni A., Rodeghiero F., Abbadessa A., Piccin A., Ballerini F., Sorasio R., Nosari A., Caramatti C., Invernizzi R., Aversa F., Pacilli L., Musto P., Peli A., Quintini G., Forghieri F., Facchetti F., Pavan L., Mannelli F., Bonifacio M., Leone G., Pulsoni A. (Roma, San Giovanni Rotondo, Novara, Bari, Brescia, Genova, Nocera Inferiore, Udine, Vicenza, Caserta, Bolzano, Cuneo, Milano, Parma, Pavia, Perugia, Rionero in Vulture, Palermo, Modena, Padova, Firenze, Verona) 43° Congresso Nazionale SIE 2011, Società Italiana di Ematologia, oral presentation#C112 O37) “Nuove terapie per il paziente anziano o unfit”

1Piccin A (invited speaker)

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy Approfondimenti sulle sindromi mielodisplastiche e mieloproliferative Convegno interregionale Societa' Italiana di Ematologia (SIE), Udine University, Italy, May 2012 O38) “La safety di anagrelide nel lungo termine”

1Piccin A (invited speaker)

1Dept of Haematology, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy Anagrelide nella trombocitemia essenziale: line guida e pratica clinica anche alla luce dei dati RIT e EXELS Firenze, Italy, December 2012

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O39) “Microparticles and vascular markers relationship in patients with Essential Thrombocythaemia Andrea Piccin1,2, Irene Pusceddu2, Luigi Marcheselli3, Ciaran Murphy1, Elva Eakins1, Giovanni Amaddii’2, Carlo Moesender Frajria, Dino Veneri4, Omar Perbellini4, Enrica Pacquola5, Michele Gottardi5, Filippo Gherlinzoni5, Flaviano Favaro6, Diego Faggian6, Mario Plebani6, Gianni Pizzolo4, William G Murphy1 & Sergio Cortelazzo2 1Irish Blood Transfusion Service, Dublin, Ireland 2Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy 3Dept of Onco-Haematology, Modena University Hospital, Modena, Italy 4Dept of Haematology, University of Medicine, Verona, Italy 5Dept of Haematology, Cà Foncello Hospital, Treviso, Italy 6Dept of Laboratory Medicine, University Hospital, Padova, Italy, ISEV - International Society for Extracellular Vesicles, Boston, USA, April 2013

O40) “Platelets disease” Andrea Piccin 1 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy University of Medicine, Innsbruck, Austria, July 2013

O41) HÄMOGLOBINOPATHIEN. Schwangerschaft und perioperatives Management Andrea Piccin 1 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy Oesterreichische Gesellschaft fuer Hematologie und Onkologie Innsbruck, Austria, April 2014 (Invited Speaker) O42) “Ancora Trombocitemie Essenziale?” Andrea Piccin 1 1Dept of Haematology, San Maurizio Regional Hospital, Bolzano/Bozen, South Tyrol, Italy Capotaormina, Catania, Italy, May 2014 (Invited Speaker)

ATTENDANCE AT MEETINGS

I regularly attend relevant meetings for continuing medical education (CME). I recently attended the following: “Il Trapianto di cellule Staminali Autologhe in Ematologia” Milano, November 2000 “Haematological Problems in Pregnancy and Neonates”, Dublin, March 2001 “ Molecular Haematology” (Prof Madrigal) Dublin, March 2001 “A Postgraduate Teaching Session in Paediatric Haematology”, Dublin, May 2001 “Haematology Irish Association, annual meeting ”, Kilkenny, October 2001 “Use of Coagulation Factor Concentrates in Blood Transfusion” Dublin, November 2001 “Advances in Haematology : CML and new drug” Dublin, February 2002 “Uso dell` Interferon nel Mieloma Multiplo” Roma, March 2002

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“I recettori che regolano l’ attivita’ citotossica delle cellule NK umane” Padova, Aprile 2002 “EHA annual meeting” Florence, June 2002 “New advances in Vaccinotherapy in Cancer” Vicenza, September 2002 “Annual SPR spring-meeting in Haematology” Galway, February 2003 “Advances in the study of GVHD” (Prof. A.Bacigalupo), Dublin, March 2003 “Advances in Haematology “ Dublin, April 2003 “Statistical Analysis in Clinical Trials” Dublin, May 2003 “Haematological aspects of pregnancy” Dublin, September 2003 “6th Annual meeting of the Institute of Molecular medicine” Dublin, November 2003 “Haematology Irish Association, annual meeting” Tullamore, November 2003 “vCJD- An update”, (Dr W. Murphy) IBTS, Dublin, February 2004 “Advances in Haematology 2004”, Dublin, February 2004 “Therapeutic Aphaeresis principles and practice” J Armstrong, Dublin, May 2004 “International Society for Cellular Therapy” Annual meeting, Dublin, May 2004 “52°meeting of Thrombosis and Haemostasis” Venice, June 2004 “HLA in Unrelated Donor Stem Cell Transplantation: Applying the Data for Optimal Donor Selection”, IBTS, Dublin, July 2004 “National Haemovigilance Conference”, Naas Co. Kildare, October 2004 “7th Annual meeting of the Institute of Molecular medicine” Dublin, November 2004 “The American Society of Haematology 46th Meeting” San Diego, USA, December 2004 “Removal of Infectious Prions from Red Cell Preparations”, IBTS, Dublin, January 2005 “Hematology annual meeting of Ireland” Belfast, UK, November 2005 “Recent developments in Acute Lymphoblastic Leukaemia” Prof O.P. Smith, Royal Academy of Medicine in Ireland Dublin, January 2006 “EBMT annual meeting” Hamburg, 19-22 March 2006 International Visions on Blood Substitutes, 17-10 September 2006, Parma, Italy “Haematology Association of Ireland”, Cork, November 2006 “9th Annual meeting of the Institute of Molecular medicine” Dublin, November 2006 “Advances in Haematology”, Dublin, February 2007 “Dasatinib: a new treatment opportunity in CML”, Dublin February 2007. “Microparticles in health and disease”, R Nieuwland, May 2007 6th International Symposium on Translational Research in Oncology. Dublin. October 2007 Haematology Association of Ireland, Sligo, October 2007 America associated Blood Banking, Anaheim, California, October 2007 Hot Topics in Paediatrics, Dublin, October 2007-11-07 Thrombosis and Hemostasis issue in Cancer, Bergamo (Italy), October 2007 “10th Annual meeting of the Institute of Molecular medicine” Dublin, November 2007 Irish Thrombosis and Vascular Biology Meeting, Dublin, November 2007 “Hot Topics in Paediatric/adolescent leukaemia and other blood diseases” November 2007 EBMT SAA-Working Party,Engelberg, Switzerland, Oct 2009 “Riunione GIMEMA sulle malattie mieloproliferative” Florence, February 2010 (doc 60) “Medicina Trsfusionale nei Trapianti” Bolzano, April 2010 European Haematology Association, Barcelona, Spain, June 2010 Post ASH austrian national meeting, Innsbruck, January 2011 Diagnosi e terapia della Trombocitemia Essenziale – Padova, Italy, October 2011 Refractory Hematological Malignancies, Bolzano, Italy, November 2011 ESH myeloproliferative neoplasms, Vienna October 2012 Haematology Association of Ireland, Cork, October 2012 “The American Society of Haematology Meeting” Atlanta, USA, December 2012 ISEV - International Society for Extracellular Vesicles, Boston, USA, April 2013 European Haematology Association, Stockolm, Sweden, June 2013 Oesterreichische Gesellschaft fuer Hematologie und Onkologie, Austria, April 2014

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COURSES ATTENDED I regularly attend courses as part of my continuing further medical education. In recent years I have attended the following: “ Corso Nazionale di Aggiornamento in Ematologia Clinica” Roma, November 2000 “Advances in Haematology at Hammersmith Hospital” London, April 2001 “ Corso avanzato di aggiornamento sul Mieloma Multiplo” Vicenza, March 2002 “ Course in Haematology Morphology “ St Mary Hospital (B.Bain), London April 2002 “Course of Statistical Methods in Medicine” Dublin, Trinity College, April-June 2003 “Manchester Blood Coagulation Course” Manchester, September/October 2003 “ESH-EHA Diagnostic work-up for hematological malignancies” (G. Zini, B.Bain, R. Foà), Roma, February 2004. “ Intensive Transfusion Course for MRCPath” in Brentwood, London, April 2004 “Haemoglobinopathy Course” St Thomas Hospital, London, October 2004 “Diploma Course in Medical Management”, Royal College of Surgeons, Dublin. May 2005. “Flow cytometry, FACS calibur Training Course”, Oxford 22-24 Agosto 2005 “MTLS course in Manipulating Nucleic acids”, Caledonian University, Glasgow, 29 Aug-2 Sept 2005 “Training course in PCR theory and practice”, Caledonian University, Glasgow, 5-9 Sept 2005 8th Training Course of EBMT-IDWP, “ Diagnosis and Strategies for management of infectious complications after stem cell transplantation” Universitá di Padova, October 2005 9th Training Course of EBMT-IDWP, “ Diagnosis and Strategies for management of infectious complications after stem cell transplantation” Trinity College University, Dublin , October 2006 Excel intermediate, Dublin, April 2008 “Corso Nazionale di Aggiornamento in Ematologia Clinica”, Bolzano 18-19 June 2009 Myloproliferative disorders, Cagliari October 2009 “Sickle cell anaemia and haemoglobinopathy course”, Verona, Italy, January 2011 ESH myeloproliferative neoplasms, Lisbona October 2014

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FOREIGN LANGUAGES

ENGLISH: fluent speaker

1999 English course at the Language Centre of Ireland, Dublin 2004 English course at the Dublin School of English

TOEFL diploma (July 2004 )

GERMAN: fluent speaker

I) Diploma “Zertifikat Deutsch als Fremdsprache”,Goethe-Institut München, Germany I) Diploma “Kleines Deutsches Sprachdiplom”, Goethe-Institut München, Germany

II) Diploma Universitary Diploma of bilinguism italian/german (Zweisprachigkeitsprüfung Stufe A). Bolzano/Bozen, Italy (October 2009)

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REFEREES Prof. Owen P Smith Consultant Haematologist University of Dublin, Trinity College, Ireland Phone: +353- 87-2484111 Fax: +353-1-4558873 E-mail: owen.smith@olhsc.ie Prof Shaun Mc Cann Consultant Haematologist University of Dublin, Trinity College, Ireland Phone: +353- 86-2525121 E-mail: shaunmccann@eircom.net Dr William Murphy University College Dublin, UCD IBTS - Irish Blood Transfusion Service, Ireland Phone: +353-1-4322861 E-mail: nmd@indigo.ie

_____________________________ Dr Andrea Piccin

Dated: 09.02.2016