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Dr Kylie Dyson International variation in survival after out-of-hospital cardiac arrest: a validation study of the Utstein template Dyson K, Brown SP, May S, Koster RW, Beesems SG, Kuisma M, Salo A, Finn J, Sterz F, Nürnberger A, Smith K, Morrison LJ, Olasveengen TM, Callaway CW, Shin SD, Gräsner JT, Daya M, Ma MH, Herlitz J, Strömsöe A, Aufderheide TP, Masterson S, Wang H, Christenson J, Stiell I, Vilke G, Idris A, Nishiyama C, Iwami T, Nichol G @kyliedyson_au

International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

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Page 1: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Dr Kylie Dyson

International variation in survival after out-of-hospital cardiac arrest: a validation study of the Utstein templateDyson K, Brown SP, May S, Koster RW, Beesems SG, Kuisma M, Salo A, Finn J, Sterz F, Nürnberger A, Smith K, Morrison LJ, Olasveengen TM, Callaway CW, Shin SD, Gräsner JT, Daya M, Ma MH, Herlitz J, Strömsöe A, Aufderheide TP, Masterson S, Wang H, Christenson J, Stiell I, Vilke G, Idris A, Nishiyama C, Iwami T, Nichol G

@kyliedyson_au

Page 2: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Utstein template

@kyliedyson_au

Page 3: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

@kyliedyson_au

46% 13%29%

12%

German Resuscitation RegistryHelsinki Cardiac Arrest RegistryIrish OHCAR CAVAS Project

ARRESTVACARVICARROC

Swedish Register of CPRTaipei OHCA RegistryOslo and Akershus RegistrySJA-WA Cardiac Arrest Registry

@kyliedyson_au

Page 4: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

@kyliedyson_au

Page 5: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Methods• 12 cardiac arrest registries• 2006-2011 (6 years)• Generalized linear mixed models• 2004 Utstein template• 21 core data elements • 6 core time events

@kyliedyson_au

Page 6: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

@kyliedyson_au

34% FEMALE

66%MALE

n=86,759 65

YEARS 25%SHOCKABLE

Results

Page 7: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Overall survival to hospital discharge

@kyliedyson_au

Range 2% to 22%

10%

Page 8: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Overall survival cerebral performance category 1 or 2

@kyliedyson_au

Range 2% to 20% (available for 9/12 registries)

8%

Page 9: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Adjusted association between age and survival

@kyliedyson_au

Page 10: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Adjusted association between EMS response time and survival

@kyliedyson_au

Page 11: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Adjusted association between witness and survival

@kyliedyson_au

Page 12: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Adjusted association between bystander actions and survival

@kyliedyson_au

Page 13: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Adjusted association between initial rhythm and survival

@kyliedyson_au

Page 14: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Subgroup analysis

@kyliedyson_au

Aetiology

Non-traumatic

Cardiac

Non-cardiac

Initial rhythm

Shockable

Non-shockable

Witness

EMS witnessed

Not EMS witnessed

Age group

Adults (≥18 years)

Child (1 to <18 years)

Bystander witnessed Shockable

Page 15: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

@kyliedyson_au

Survival

↑ Patient age

EMS response time

Page 16: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

@kyliedyson_au

Survival

Public location

Witnessed event

Bystander defibrillation

Page 17: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Extent of survival predicted by the Utstein data elements

@kyliedyson_au

Area-under-the-curve for the Utstein model 0.85 (Wald CI: 0.85-0.85)

Page 18: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

How much of the variation in survival is explained by

the Utstein factors?

@kyliedyson_au

Page 19: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Variation in OHCA survival explained by Utsteinfactors

@kyliedyson_au

51%

Page 20: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

The 49%... • Factors in the 2015 Utstein template• Supplementary (non-core) Utstein data elements • Other non-Utstein factors• Community and population factors• EMS performance and initiatives

@kyliedyson_au

Page 21: International variation in survival after out-of-hospital ... · Methods • 12 cardiac arrest registries • 2006-2011 (6 years) • Generalized linear mixed models • 2004 Utstein

Utstein factors explain 51% of the variation in OHCA survival

@kyliedyson_au 21

51%