Seattle Englisch 2

8/3/2019 Seattle Englisch 2

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H. U. MAY:

Facts and hypotheses concerning the causal orsymptomatic therapeutic use of currents in

oncology - direct and indirect effects upon cells,

tissues and the whole organism.

The possibilities to optimize the efficacy of currents

by variation or fixation of their parameters in

dependence on the intended therapeutic purpose.


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Introduction

concerning the history

of therapeutic use of currentsfor the treatment of tumor patients


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Already in the middle of the 18th century the twoGerman physicists HAUSEN & WINKLER tried with

their electrical machine, based on friction, to treattumors.

After the spreading of the inventions of GALVANI

(1737 - 1798) andVOLTA

(1745 - 1827) since the19th century electricity has been used morefrequently to treat tumor patients.

Not only symptomatic treatments for pain relief but

even mainly causal treatments consisting in trials todestroy the tumors were usual.


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In standard dictionaries and encyclopedias fromthe second part of the 19th century and the firstdecades of the 20th century you can find verymuch more general information and specialdescription of the

electrolytic destruction of tumorsby direct currents

under the catchword electrotherapy than in the

second part of the 20th century and today.


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Until today the galvanic current as the primarily preferred currentin the causal treatment of tumor patients is used in various

clinics and hospita

ls, for instance in

Austria according therecommendations of PEKAR given in his 3 books about the

percutaneous galvanotherapy in cases of tumors, publishedsince 1988, basing on experiences since 1977.

Also in Sweden NORDENSTRM used direct currents (DC) forthe treatment of tumors, basing on his theory of biologicallyclosed electric circuits (1983). The DC method requires needlesto be placed inside the tumor. It is an invasive method. I know,that in Germany, Denmark, Italy and China in special hospitalsthis invasive DC method is in use, however in Germany withoutpublic advertising.


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Just before the 1st world warVERAGUTH & SEYDERHELM(1913 and 1914, Zrich and Straburg) found the tendency ofvarious direct and alternating currents, applied as whole bodytreatments in a 4 cell bath, to reduce the number of white bloodcells in leukemia patients.

The histories ofRIFEs work in the United States and

independently from him ofLAKHOVSKYs work in Franceconcerning cancer treatment using alternating electrical fields ofvarious frequencies are well described in the

RIFEReport, written by Barry LYNES and published 1987,

andin LAKHOVSKYs Secret oflife, published the first time 1929.


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Tone frequency currents,a not very precise term introduced by KOEPPEN 1935 in hispaper Tone frequency currents in medicine, has been changed

1944 by the German physiologist GILDEMEISTER in Leipziginto the term middle frequency currents (MF), definedby the frequency range between 1 kHz and ca. 100 kHz.

GILDEMEISTER and his pupilSCHWARZ, furthermore WYSS in

Zrich, investigated the very interesting and specialadvantageous physiological properties of these MF currents,howevermore from the standpoint of physiology as a theoretical field ofmedicine than with a practical therapeutic view.

Consequently, they did not take into account any thoughtsconcerning the effects ofMF upon tumors.


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Without any knowledge about the publicationsconcerning MF currents

published mainly in journals of physiology

the electronic engineerDoctorNEMECfromAustria in the late 40s up to 1952 usedMF currents between 4000 and 4100 Hz

for his invention ofinterferential current,

realized by the company NEMECTRON as the

Nemectrodyn machine.


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Dr. Hanna FRESENIUS, a female generalpractitioner in Steinau in Hessen (Germany) was

one of the first medical doctors, who experiencedthe wide range of indications of the newequipment including pain relief in cancer patients.

Additionally she observed in the majority of thepatients not only pain relief but additionally ageneral increase of their condition, of their quality

oflife, in some of the patients even an inhibitionof tumor growth or a shrinking of the tumor.


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After several years of successful treatments ofcancer patients with these interferential currents

other medical doctors, competitors which werenot familiar with the new treatment, suggested adamning of the new electrotherapeutic method

in cancer patients by the regionally responsibleprofessional instance.

Dr. Hanna FRESENIUS was not agree. She

moved with her practice to Bavaria and pursuedsuccessfully to treat cancer patients but moresecretly.


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Convinced by the beneficial effects of interferential currents in

cancer patients Dr.Hanna FRESENIUS initiated animal

experiments together with theU

niversity of Freiburg.S

he fedtwo groups of rats with the carcinogeneous butter yellow(dimethylaminoazobenzol). One group was treated nearlyeveryday with interferential current.

Only the animals of the other group developed liver tumors.

In this time I was

as a neurologist, physiologist and pharmacologist with long experiences inbiomedical engineering and biocybernetics in the University of Karlsruhe

a member of the medical-scientific research and deve

lopmentdepartment ofNemectron in Karlsruhe, responsible for all

theoretical and practical medical questions.


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With monetary, technical and scientific support byNemectron and with prepared rats from

Prof. Ferdinand SCHMIDT(Institute for Preventive Oncology of the University Heidelberg-Mannheim)

Hanna FRESENIUS started new series in rats sufferingfrom chemically induced subcutaneous tumors.

When the tumors were detected early enough and thediameter of the tumor was not larger than 8 to 10 mm,the treatments with interferential current (carrierfrequencies around 4000 Hz) leaded to a shrinking and

finally to a disappearance of the tumors:


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Larger tumors did not disappear. They sustained togrow, partially up to the size of apples, and the

tumors seemed to cause intensive itch sensations.The rats injured the skin in the region of thesubcutaneous tumor and finally the tumor itself.

The initially solid tumor had changed to a cyst filledwith a fluid. The cyst opened by the teeth of the ratcollapsed, was infected, and the rat died within hoursor few days.

These kinds of animal experiments could not be continued because of anew law concerning the use of animals for scientific research.


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Therefore, with financial support by the German MinistryforResearch and Technology in the laboratories of

Nemectron and 4 institutes of the medical faculties ofvarious universities and scientific centers (Freiburg,Aachen,German CancerResearch Center Heidelberg, German NuclearResearch Center

Karlsruhe) investigations concerning the influences of middlefrequency currents were carried out with normal andvarious tumor cells.

In 2 doctor dissertations (M. NOSZVAI-NAGY, Karlsruhe,1993/94, W. PETROW,Aachen, 1988), in lectures and

papers on a symposium in Karlsruhe, 1990, and aGerman CancerCongress in Hamburg 1994 the resultswere presented.


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The most important results were:

1. Some kinds of tumor cells in vitro can be killed

during the application of middle frequency currents(with frequencies in the lowerMF range, mainly4000 Hz); they suddenly disappear by destructionof their cell membrane.Abnormallarge cells appeato be more sensitive. However, not all types of thetumor cells had the same sensitivity.

2. MF currents can facilitate the growth of normal

fibroblasts in dependence on the strength of theelectric field.


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3. MF currents can influence the adenylcyclaseresulting in changes of the intracellular cAMP

formation, that means MF currents can havehormone-like effects. This corresponds with theresults of other authors.

4. MF currents can cause an increase of the number

and the size of mitochondria.5. Alternating electric fields within the MF range

facilitate and consequently accelerate the diffusionalong the lines of the electric fields in the twoopposite directions. This result was predictable dueto physical, electrochemical and statisticalconsiderations.


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The cell culture research program supported by theGerman government unfortunately could not becontinued because of monetary restrictions.

Additional psychological problems between thesupervisory board and the leading management of

Nemectron caused repetitive changes within the topmanagement team.

Finally the owner ofNemectron, the margrave ofBaden, had to sale his company.

After few years the ownership changed again.


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My own experiences with interferential current (MF between 4000and 4100 Hz) as a neurologist not an oncologist in tumorpatients were different. Some examples:

Tumor Result

Astrocytoma No success

Glioblastoma No success

Chordoma Stop of the growth of the tumor formany years, but not destructionPatient was found dead in his bed inthe morning after a long evening of a

festival during his vacation in Spain.


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Tumor Result

Melanoma with metastasesin the central nervous system,

earlier and larger in the spinalcord resulting in paraplegia, Slowing of growthlater and smaller in the medullaoblongata causing dizziness

and circulatory disturbances Not treatable

In general: Significant pain relief,reduction of the analgesic drugs,enhancement of the quality oflife,6 months prolongation of the

survival time, life at home with hisfamily instead of an immediate deathunder high dosages of narcotics at theintensive care station of theDermatological department of the

University ofKln


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Tumor Result

The same patient suffered since All the lipomas disappeared within

his early childhood from multiple few weeks after the begin of thebenignant tumors of the fatty daily electrical treatments.tissue, lipomas, disseminated tothe whole body, rump and limbs.


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1981 THIESS & DIETRICH in Heilbronn and1994 KUKLINSKI in Rostockalso reported conspicuous beneficial however finally not healing

effects in tumor patients treated with interferential currents.

In KUKLINSKIs study a group of37 patients received interferential current(IFC) treatment twice per day. Modulation frequency was scanned between 0.5 and 150 Hz.Results:Partial remissions were observed in patients with superficial cutaneousmetastases or ulcerative mammary carcinomas (n=3).Tumor progression was lowered in 2 patients with pancreatic carcinomas.Responses of tumors of the pulmonary and bowel tracts were generally poor.In many cases, a considerable reduction of inconveniencies associated withthe disease was noted (e.g. reduction of pain, rapid improvement of physical

condition, etc.)Conclusion: In order to improve the response of malignant tumors,particularly of deep-lying tumors, hitherto existing parametersand strategies of IFC-treatment seem to require revision.


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Taking into account the fact thatin cell culture experiments and in patients

the desired effects ofMF currentsseemed to be dependenton the type of the tumor,

the question arose:

Is the sensitivityof the special type of tumor cells

dependent on the frequency of the MF current?


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This was the origin of my idea to usethe modulation of the frequency

in a mathematically continual wayover a wide range

in accordance with the technical and legitimate possibilities,avoiding arbitrary irregular and to large steps

andto minimize the differences

betweenthe theoretically optimum frequency

andthe really generated frequency.


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Additionally,the electrical, neurophysiologic and

psychophysical possibilitiesconcerning the intensities of the appliedfrequency-dependent currents should be

optimized.

Thedistance to local and systemic tolerance limits

should be as large as possible tomaximize the therapeutic width.


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The manufacturer is the company gbo, GertebauOdenwald, in Rimbach, manufacturing and

distributing too still traditionallow-frequency andinterferential electrotherapy units ofSiemens.

The frequency is modulated in quarter tone stepsbetween 4096 and 32768 Hz.

With 73 frequencies (tones in the high tone andlow ultrasound ranges) 3 octaves are covered.

The maximum distance to a theoretically optimum

frequency or to a frequency in an harmonic relationto this optimum frequency is 1/8 tone step.


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Facts and hypotheses

concerningthe causal or symptomatic therapeutic

use of currents in oncology direct and indirect effects upon

cells, tissues and the whole organism


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Causal therapeutic use

Facts:

Some facts as results of experimental studiesare already itemized in the

introduction under number 1 5.


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Hypotheses

regarding inhibitory effects of un-modulated, amplitude-

modulated and simultaneously frequency- and amplitude-

modulated middle frequency currents upon tumor growth

Direct effects of currents upon transformed cells

Changes and renormalizations of pathological processes intumor cells, caused by stimulatory and multi-facilitatory

(electro-biochemical, non-stimulatory) effects

induced by electrically triggered molecular conformationchanges within the cell membrane, that means a kind of

simulation of hormone effects, resulting in the (normalizationof) formation of intracellular second messengers, forexample cyclic AMP


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induced by capacitively coupled effects

through the cell membrane into the intracellular space

(cytosol),through the outer mitochondrial membrane into theintermembrane space and

through the inner mitochondrial membrane into the

mitochondrial matrix,for instancemulti-facilitatory effects upon the metabolism:

facilitation of diffusion processes

facilitation of enzymatically mediated processes ofthe intracellular metabolism


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facilitation of enzymatically mediated processes of the

intracellular metabolism, basing on

the increase of the kinetic energy of molecules involved inmetabolic processes, lowering the differences to the requiredactivation energy,

the increase of the probability of the events of the importantaccidentalmeetings between enzyme and substrate,

the increase of the probability of the events of the importantaccidental meetings between enzyme and substrate in the

correct position(according to DAFFORN & KOSHLAND:A. DAFFORN & D. E. KOSHLAND jr., Biochem. Biophys. Res. Commun. 52, 780, (1973) )


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direct influences upon the transport mechanisms ofprotons and electrons within the inner membrane of

the mitochondria

preference of the aerobic metabolic pathwaysinstead of the anaerobic glycolysis


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induced by direct influence upon theintercellular communication ("cleaning effect" concerning ionchannels including gap junctions), resulting in

partial or total recovery of the disturbedelectrical and chemical communication between tumor cellsmutually and between tumor cells and the cells in the adjacenttissue

(one step to a redifferentiation)partial or total recovery of the disturbedmetabolic cooperation between tumor cells mutually andbetween tumor cells and the cells in the adjacent tissue

(a second step to a redifferentiation)partial or total recovery of the disturbedfunctional coordination between tumor cells mutually andbetween tumor cells and the cells in the adjacent tissue(a third step to a redifferentiation)


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partial or total recovery of the disturbed probablyelectrically mediatedcontrol of the target of the normal

topographic-anatomical and histological

structure of the referred body region

(last step and desired main goal of redifferentiation)


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Over-stress of the pathologically changedmetabolism of the tumor cell,

caused by frequently generated depolarizationand the required repolarisation

(stimulatory effect, possible with supra-threshold intensities only)


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Indirect effects

Primary effects:

Activation of cells of the immune system

by means ofsustained depolarization (non-stimulatory effect)of the involved cells of the immune system, causing an increaseof cell division rates of normal cells which are able to increase

their mitotic activity if such increase is required,

by means ofcyclic AMP formation(non-stimulatory multi-facilitatory and stimulatory effect)within the involved cells of the immune system,

by facilitation of intercellular communication (non-stimulatorymulti-facilitatory effect)


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by an increaseof generation of natural killer cells (NKC),observed by KUKLINSKI as a result ofstimulatory effects, probably possible withnon-stimulating currents too.


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Enhancement of the efficacy of the activity of the

cells of the immune system

in the neighborhood of the tumor by means of theequilibration effect upon concentration differencesnormalizing the pH values.

Due to the preference of the anaerobic metabolism intumor cells with an increase oflactic acid productionthe pH is lowered in the extracellular space within thetumor and in its neighborhood; the lowered pH isimpairing the function of the cells of the immunesystem.


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Partial or total recovery of the disturbed communicationbetween the asocial cells of the tumor takes place by means

of the electrochemica

lshaking effect.

Stimulation of the sympathetic nervous system (by stimulatory effects)

release of transmitters (mainly nor-epinephrine)

from the varicosities of the sympathetic nerve endings

reduction of inflammatory tissue changesin the neighborhood of the tumor

activation of receptors within the cell membranes involved in

the tumor growth inhibiting processes


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Secondary effects:

The activation of cells of the immune

system could result in the following

secondary effects:

Increase of phagocytosis

Increase of the release of mediatorsacting as inhibitors of tumor growthor even as tumor cell destroying agents

(for instance tumor necrosis factor)


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Symptomatic therapeutic use

The symptomatic therapeutic use concerns mainly1. pain relief

2. edema reduction

3. prevention of venous thromboses4. reduction of the required dosage of pain relieving

and other drugs with reduction of their side effects

5. inhibition of cachexia by F-mimetic effects

6. general enhancement of the quality oflife


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The possibilities to optimize the efficacy of currents

by variation or fixation of their parameters in dependence

on the intended therapeutic purpose

Pain relief

Five pain relieving effects are available:

1. Distribution and thinning of mediators of pain and inflammation

2. Real nerve block by reversible sustained partial depolarization,plateau effect

3. Pseudo block associated with tea, transient excitatory activity

4. Counter-irritation (GAMMON & STARR, 1941)

and F -endorphin release

5. In cases of painful swellings indirect causal pain reliefby edema reduction


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The following parameters should be preferred:

1. High intensities during blocks with higher fixed frequencies

(max. 32768 Hz)orSimulFAM along the threshold curve, SimulFAMi

2. Maximum tolerable intensity with higher fixed frequencies(max. 32768 Hz)

3. High intensity with higher fixed frequencies (max. 32768 Hz)

4. SimulFAMXwith crossing of the threshold curve, frequencyof modulation: 100 Hz

5. SimulFAMXwith crossing of the threshold curve, frequencyof modulation: 10 Hz


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2. Edema reduction (in general) andprevention of venous thromboses

a. caused by stimulation of sympathetic fibers

b. (in lowerlegs an feet) caused byactivation of the muscle pump

c. caused by reversible sustained partial depolarization of thesmooth muscles of the lymphatic vessels and the blood

vessels, plateau effectThe following parameters should be preferred:

a. SimulFAMX with crossing of the threshold curve,frequency of modulation 10 Hz

b. SimulFAMX with crossing of the threshold curve,frequency of modulation 0.3 Hz

c. High intensity with higher fixed frequencies (max. 32768Hz)


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3. - 5.

The therapeutically desired effectsmentioned above concerning

reduction of drugs and their side effects,

inhibition of cachexia andgeneral enhancement of the quality oflife

are present in all cases of parameter selection.

They do not require special parameters.


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Selected Literature:

dARSONVAL,A.:Action physiologique des courants alternatifs.C. R. Soc. Biol. Paris 43, 453 (1891)

dARSONVAL,A.:Recherches d lectrothrapie. La voltaisation sinusoidale.Arch. Physiol. norm. pathol. 24, 69 (1892)

dARSONVAL,A.:Effects physiologiques de la voltaisation sinusoidale.Arch. Physiol. norm. pathol. 25, 387 391 (1893)

dARSONVAL,A.:

Action physiologique des courants alternatitifs grande frquence.Arch. Physiol. norm. pathol. 25, 401 408 (1893)


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dARSONVAL,A.:Production des courants de haute frquence et de grandeintensit: leurs effects physiologiques.

Comptes Rendus de sances et memoires de la. Socit deBiologie et de ses filiales. Paris 45, 122 - 124 (1893)

dARSONVAL,A.:Influence de la frquence surles effect physiologiques des

courants alternatifs.Lindustrie lectrique 2, 168 - 169 (1893)

dARSONVAL,A.:Action physiologique et thrapeutique des courants haute

frquence.Ann. Electrobiol. 1, 1 (1898)


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BOWMAN, B. R.:Electrical block of peripheral motor activity.A dissertation submitted to the Faculty ofElectricalEngineering

Edvard Kardelj University ofLjubljana, YugoslaviaIn partial fulfilment of the requirements for the degreeDoctor ofScience (ElectricalEngineering)May 1981Conducted at Rancho LosAmigos Rehabilitation EngineeringCenter,Rancho LosAmigos Hospital, Downey, California

BRIGHTON, C. T., & P. F. TOWNSEND:Increased cAMP production after short term capacitively coupled

stimulation of bovine growth plate chondrocytes.Transactions of the 6th annual meeting of the BioelectricalRepair and Growth Society (BRAGS), vol.VI, p. 43, Oct. 19th 22nd 1986


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BROMM, B., & H. LULLIES:ber den Mechanismus derReizwirkung mittelfrequenter

Wechselstrme auf die Nervenmembran.PflgersArch. 289, 215 226 (1966)

CLARK, H. R.:The cure of all cancers

San Diego, CA, USA: New Century Press 1993

CLARK, H. R.:The cure for all diseasesS

anD

iego,CA

,USA

:N

ewC

entury Press 1995


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CONE, C. D, Jr.:Control of cell division by the electrical voltage of the surfacemembrane

Molecular Biophysics Laboratory, Langley Research Center, NationalAeronautics and SpaceAdministration, Hampton, Virginia 23365

Presentation toThe 12th AnnualScience Writers Seminar, SanAntonio,Texas, March 20-25 1970 ,

American CancerSociety

CONE, C. D, Jr.:Unified theory on the basic mechanism of normal mitotic

controland oncogenesis.J. theor. Biol. 30, 151 181 (1971)

CONE C D Jr :


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CONE, C. D., Jr.:The role of the surface electrical transmembrane potential innormal and malignant mitogenesis.Annals of the New York Academy ofSciences 238, 420 435(1974)

CONE, C. D. Jr., & C. M. CONE:Induction of mitosis in mature neurons in central nervous systemby sustained depolarization.

Science 192, 155 - 157 (1976)

CONE, C. D. Jr. & M. TONGIER:Contact inhibition of division: Involvement of the electricaltransmembrane potential.

Cell Pysiology 82, 373 386 (1973)DAFFORN,A. & D. E. KOSHLAND jr.:Biochem. Biophys. Res. Commun. 52, 780, (1973)


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DALZIEL, C. F.:Electric shock.Advances in Biomed. Engineering 3, 223 248 (1973)

DALZIEL, C. F.:Dangerous electric currentsAIEETransactions 65, 579 584 (1946)

DALZIEL, C. F.:The threshold of perception currents.AIEETransactions 73, 990 995 (1954)

DALZIEL, C. F., J. B. LAGEN & J. L. THURSTON:Electric shockAIEETransactions 60, 1073 1078 (1941)


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DALZIEL, C. F., E. OGDEN & C. E.ABBOTT:Effect of frequency on let-go currents.

AIEETransactions 62, 745 749 (1943)

DUDEK, J.:Terapia energotonowa.Oglnopolski Przeglad Medyczny (OPM) 11/2002, 22

Katowice: Elamed Wydawnictwo 2002

EHMEN,G.:Diffusionsbeeinflussung im Knochengewebe durch

Interferenzstromverfahren.Diplomarbeit, Fachhochschule Wilhelmshaven, 1990


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FRESENIUS, Hanna:Krebsfrsorge (Letter to th editors)Selecta 22, 329 331 (1980)(Heft 4, 28. Jan. 1980)

FRESENIUS, Hanna:Niederfrequenter Interferenzstrom gegen maligne Entartung

rztliche Praxis 37, 2529 (1985)

FRESENIUS, Hanna:Was das Leben lebendig macht.Erzhlungen aus Steinau an derStrae

pp. 266 269: Experiences with interferential therapy in cancerpatients.Marquartstein, Bavaria, Germany: Th. Breit 1986


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GAMMON, G. D., & I. STARR:Studies on the relief of pain by counter-irritation.J. clin. Invest. 20, 13 21 (1941)

GEDDES, L. A., L. E. BAKER,A. G. MOORE & T. W.COULTER:Hazards in the use oflow frequencies for the measurement ofphysiological events by impedance.Med. & biol. Engineering 7, 289 296 (1969)

GILDEMEISTER, M.:Untersuchungen ber die Wirkung von Mittelfrequenzstrmen aufden Menschen.PflgersArch. 247, 366 404 (1944)

GREEN, R. T.:The absolute threshold of electric shock.Brit. J. Psychol. 53, 107 115 (1962)


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HANSJRGENS,A., & H. U. MAY:ElektrischeDifferentialtherapie - EDiTKarlsruhe: Nemectron 1990

HAUSER-TILLMANN, HildegardDr. med., M. D., Frauenrztin, Gynecologist, in D -88677 Markdorf,Gutenbergstr. 1a):Personal communication:Arzt-Bericht vom 21. Oktober 1997 ber eine von Mrz bis September 1997

durchgefhrte erfolgreiche Hochton-Behandlung einer Patientin mitGallensteinen und hufigen Koliken.Clinical report, dated from October 21st 1997 concerning a successful high tonetherapy treatment of a female patient with gall-stones and frequent bilious colicsover a period of seven months (March September 1997)

HNES, R. D.:DerEinflu von Interferenzstrom auf das Wachstumsverhalten von Zellkulturen.Inauguraldissertation. Freiburg i. Br. 1983


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HUMPERT, P. M., G. RUDOFSKY, M. MORCOS,A. BIERHAUS& P. P. NAWROTH:Hochtontherapie zu Behandlung schmerzhafterNeuropathie bei

Typ 2 Diabetikern verbessert die mikrovaskulreEndothelzellfunktionHigh tone therapy for the treatment of painful neuropathy in type2 diabetic patients improves the microvascular endothelialfunction. Poster andAbstract.

41. Jahrestagung derDeutschen Diabetes-Gesellschaft,Leipzig, 24. 27. Mai 2006, Diabetologie und Stoffwechsel2006, DOI: 10.1055/s-2006-94

JAMAKOSMANOVIC,A., & W. LOEWENSTEIN:.

Intercellular communication and tissue growth III. Thyreoidcancer.J. Cell Biology 38, 556 - 561 (1968)


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JOOS, U., H. U. MAY & C. MITTERMAYER:Stimulation of fibroblast proliferation by means of electrical current.8th Int. Conf. OralSurg., Berlin, June 25 30, 1983

KEILHOLZ, L., U. RANDOLL, R. SAUER & E. STEINHUSER:Supportive interferential current therapy in the treatment of advanced headand neck tumors.21. DeutscherKrebskongre, Hamburg, 7.-11. Mrz 199421th NationalCancerCongress of the German CancerSociety

Supplement to Journal ofCancerResearch and ClinicalOncology Vol. 120,05.09.03 (1994)

KNEDLITSCHEK, G., K. F. WEIBEZAHN & H. DERTINGER:Zellulre Wirkungen des Interferenzstromes21. DeutscherKrebskongre, Hamburg, 7.-11. Mrz 199421th NationalCancerCongress of the German CancerSocietySupplement to Journal ofCancerResearch and ClinicalOncology Vol. 120,05.09.02 (1994)


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KOEPPEN, S.:ber dieAnwendung von Tonfrequenzstrmen in derMedizin.Verhandlungen derDeutschen Gesellschaft fr innere Medizin, Mnchen, 47,

458 460 (1935)KOMITOWSKI,D., & V. EHEMANN:DerEinflu von elektrischen Mittelfequenz-Wechselfeldern auf normaleFibroblasten, normale und transformierte Hepatocyten sowie normaleNierenepithelzellen des Rattenknguruhs.

The influence of alternating middle-frequency electric fields upon fibroblasts,normal and transformed hepatocytes and normal epithelial kidney cells of therat kangarooVortrge, gehalten ber am Deutschen Krebsforschungszentrum inHeidelberg durchgefhrte Untersuchungen auf einem Symposion zum ThemaTumoren und Strme am 16. Mai 1990 in KarlsruheLectures about the results of a study carried out in the German CancerResearch Center Heidelberg, presented during a Symposion Tumors andCurrents in Karlsruhe, Germany, May 16th 1990


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KORENSTEIN, R., D. SOMJEN, H. FISCHLER & I. BINDERMAN:Capacitively pulsed electric stimulation of bone cells. Induction of cyclic-AMP changes and DNA synthesis.

Biochimica et BiophysicaActa 803, 302 307 (1984), ElsevierSciencePublishers

LAABS, W.A., E. MAY,K. D. RICHTER, H. J. HHLING, J.ALTHOFF, P. QUINT &A.HANSJRGENS:

Knochenheilung und dynamischer Interferenzstrom (DIC) Erste vergleichende tierexperimentelle Studie an Schafen.Teil I: Experimentelles Vorgehen und histologische Ergebnisse.Teil II: Physikalische und chemische Ergebnisse.LangenbecksArch. Chir. 356, 219 229 u. 231 241 (1982)

LANGMAN

,L., & H.

S. BURR

:A technique to aid in the detection of malignancy of the female genitale tract.Am. J. Obst. & Gynec 57, 274 281 (1949)


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LOEWENSTEIN, W.:Permeability of membrane junctionsIn: Conferenc on biological membranes: recent Progress.

Annales New YorkAcademy ofSciences 137, 441 472 (1966)

LOEWENSTEIN, W., & Y. KANNO:Intercellular communication and the control of tissue growth:Lack of communication between cancer cellsNature 209, 1248 1249 (1966)

LOEWENSTEIN, W., & Y. KANNO:Intercellular communication and tissue growth I. Cancerous growth.J. Cell Biology 33, 225 234 (1967)

LOEWENSTEIN, W., & R. D. PENN:

Intercellular communication and tissue growth

II.T

issue regeneration.J. Cell Biology 33, 235 - 242 (1967)


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JAMAKOSMANOVIC,A., & W. LOEWENSTEIN:.Intercellular communication and tissue growth III. Thyreoid cancer.J. Cell Biology 38, 556 - 561 (1968)

JOOS, U., H. U. MAY & Ch. MITTERMAYER:Stimulation of Fibroblast proliferation by mean of electrical currentPresentation (Poster) to the 8th InternationalConference on OralSurgery,Berlin, 25-30 June 1983

KUKLINSKI, B.:

Interferential current therapy of tumors: Preliminary results21. DeutscherKrebskongre, Hamburg, 7.-11. Mrz 199421th NationalCancerCongress of the German CancerSocietySupplement to Journal ofCancerResearch and ClinicalOncology Vol. 120,05.09.05 (1994)

LAKHOVSKY, Georges:The secret oflife.London, 152, Landor road, Stockwell, S.W.9.: 1951


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LYNES, B.:The cancer cure that worked! Fifty years of suppression. The RIFE report.

Queensville,O

ntario,C

anada,M

arcus Books, 1st printingM

arch 1987, 6thpr. October 1997

MAY, H. U.:Simultaneous modulation of frequency and amplitude of middle frequencycurrents between high tone and low ultrasound range applied physiology

for differentiated electrotherapy concerning the distinction and specificproportional mixture of stimulatory and non-stimulatory (metabolic and/orblocking) effects.In:Abstracts of the Joint Meeting ofThe PhysiologicalSociety, Scandinavian PhysiologicalSociety andD

eutsche Physiologische Gese

llschaft (81st

Annua

lM

eeting)15-19 March 2002, Tbingen, GermanyEurop. J. Physiol. 443, Suppl., (P 53-9) 363 (2002)


65/75

MAY, H. U.:Extremely comfortable trancutaneous electrical stimulation of nerves including motor and sympathetic fibres by simultaneous modulation of

frequency and amplitude of midd

le frequency currents.In:Abstracts of the 83rdAnnualMeeting

Deutsche Physiologische Gesellschaft14-17 March 2004, Leipzig, GermanyEurop. J. Physiol. 447, Suppl.1, (P 35-11) S156 (2004)

MAY, H. U.:High Tone Frequency PowerTherapy with HiToP in general and particularlyin cases of painful conditions of the musculo-skeletal system in specialconsideration oflow back pain,including a part of the results of a clinical study carried out and evaluated byE

.R

HADES

& B.SC

HNE

IDER

Paper presented at the4thAnnual InternationalCongress ofEgyptian Society of Back Pain, Cairo,Egypt, 16 - 17April 2004


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MAY, H. U.:High Tone PowerTherapyScientific development to optimise the physical, physiological and therapeutic

effects of middle frequency currentsPaper presented at the6thAnnual InternationalCongress ofEgyptian Society of Back Pain, Cairo,Egypt, 19 20April 2006

MAY, H. U., &A. HANSJRGENS:ElektrischeDifferentialtherapie1Electric DifferentialTherapy13 Posters (56 cm x 43 cm - in fourlanguages), prepared for theMedical center of the Olympic Village during the Olympic Games in Seoul 1988:1) Electric DifferentialTherapy (in general),

2) Pain Management with EDiT3) Treatment of edema usin EDiTKarlsruhe, Nemectron 1988


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MAY, H. U., F. NIPPEL & G. KONIECZNY:Schmerzbehandlung als Voraussetzung fr die Rehabilitation und dietherapeutischenMglichkeiten der Interferenzstromtherapie. ErfolgsratenundAnwendungsquoten bei verschiedenen mit Schmerzen verbundenenKrankheitsbildern - eine statistischeAnalyse. Zeitschrift fr PhysikalischeMedizin 11, 63 - 67, 1982

MAY, H. U., F. J. NIPPEL,A. HANSJRGENS & K. MEYER-WAARDEN:Acceleration of ossification by means of interferential current.In: DIXON,A. D., & B. G. SARNAT (editors):Normal and abnormal bone growth: Basic and clinical research, pages 469

478 (1985).Progress in Clinical and BiologicalResearch, Vol. 187, New York:Alan R.Liss, Inc. 1985

MEYER, J.:Les courants croiss de moyenne frquence composante interfrenciellede basse frquence (courant de Nemec) en dermatologie.Synthse de Smiologie et Thrapeutique 23, 3 (1952)

MONJ M :


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MONJ, M.:ber die Wirkung von Wechselstrmen verschiedener Frequenz auf dieHautsensibilitt.Zeitschrift frSinnesphysiologie 67, 2 18 (1936)

NEMEC, H.:Reizstromtherapie mit Interferenzstrmen.DerDeutsche Badebetrieb 51, 320 323 (1960)

NIKOLOVA-TROEVA, L.: Physiotherapie der chirurgischen Erkrankungen.Mnchen, Berlin, Wien: Urban & Schwarzenberg 1970

NIKOLOVA-TROEVA, L.: Lecenije s interferenten tok. (Behandlung mitInterferenzstrom)Sofia: Medizina i Fiskultura 1971

NIKOLOVA-TROEVA, L.: Treatment with interferential current. Edingurgh,London, Melbourne, New York: ChurchillLivingstone 1987

NIKOLOVA, L., & M. DAVIDOV: Fermentaktivitten in traumatisierten Nervenund ihre Beeinflussung durch Interferenzstrme (ExperimentelleUntersuchungen).Voprosy Kurortol., Fisiotherap. i lecebn. Fisic. Kultury 43,54 57 (1978)


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NORDENSTRM, B. W. E. :Biologically closed electrical circuits:Clinical experimental and theoretical evidence for an additional circulatory

system.Stockholm, Sweden: Nordic Medical Publications 1983

NOSZVAI-NAGY,M.:Wirkung mittelfrequenterStrme auf Zellen in Suspension.Diplomarbeit,Universitt Karlsruhe, Fakultt fr Bio- und Geowissenschaften,Mrz 1988

NOSZVAI-NAGY,M.:Wirkung des Mittelfrequenzstromes auf nicht-erregbare Zellen.Dissertation.Universitt und KernforschungszentrumKarlsruhe, 1993/94

PATTERSON,M.:Hooked? NET: The new approach to drug cure.London: Faber & Faber 1986


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PEKAR, R.:Die perkutane Galvano-Therapie bei Tumoren.Schwachstrombehandlung von zugnglichen Neoplasmen und ihre vitale

Hybridisation inT

heorie und PraxisWien,Mnchen, Bern: WilhelmMaudrich 1988

PEKAR, R.:Die perkutane Bio-Elektrotherapie bei Tumoren.Eine Dokumentation zu Grundlage und Praxis der perkutanen

GalvanotherapieWien,Mnchen, Bern: WilhelmMaudrich 1996

PETROW, W.:Untersuchungen ber die Wirkung mittelfrequenter Interferenzstrme auf

humaneT

umorzellenInauguraldissertation.

Institut frAnatomie und Zellbiologie derUniversitt Marburg 1988

PETROW, W., & H. W. KREYSEL:


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Adjuvant therapy of malignant melanoma by interferen tial currents21. DeutscherKrebskongre, Hamburg, 7.-11. Mrz 199421th NationalCancerCongress of the German CancerSocietyS

upplement to

Journa

lofC

ancerR

esearch andCl

inicalO

ncology

Vol.120

,05.09.04 (1994)

RACHMILEVIC, L. S., & I.A. JURASOVAPrimenenije peremennovo toka castotoi 6 kHz dlja elektrostimulazii myschz weksperimentje i klinikje.Voprosy Kurortol., Fisiotherap. i lecebn. Fisic. Kultury 34, 515 520 (1969)

REICHSTEIN, L., S. LABRENZ, D. ZIEGLER & S. MARTIN:Effective treatment of symptomatic diabetic polyneuropathy by high-tone-frequency external muscle stimulation.Diabetologia 48, 824 828 (2005)

RIFE, R. R.:History of the development of a successful treatment for cancer and othervirus, bacteria and fungi.Rife Virus Microscope Institute, San Diego, Ca., 1953

SAVERY, F.,A.A. ORTIZ & H. U. MAY:


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Clinical application and effects ofEDiT and Endosan treatment ondiabetic neuropathy and gangrene of toeAdvances in Therapy 7, 283 288 (1990)

SAVERY, F.,A.A. ORTIZ, O. HAIKAL, K. FATHIE, G. S. CHOUDHURY, H. U.MAY & R. SORGNARD:Electric differential treatment (EDiT) and Endosan treatment for ischemicdiseases.Advances in Therapy 8, 11 21 (1991)

SAVERY, F., F. SILVER, R. EDWARD,A. FANN, R. MANN, C. ROGERS, H.U. MAY & R. SORGNARD:Assessment of electric differential treatment (EDiT) and Endosantreatment for ovarian cysts and concomitant symptomsAdvances in Therapy 8, 243 249 (1991)

SCHWARZ, F.: (Physiolog. Inst.Universitt Leipzig)ber die Reizung sensiblerNerven des Menschen durch mittelfrequenteWechselstrme.PflgersArch. 247, 405 440 (1944)

THIES, H.A., & W. DIETRICH:


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S, , CEine neue therapeutische Mglichkeit bei inoperablenAdenocarcinomen (des Magen-Darm-Traktes)A new therapeutic possibility in cases of inoperable adenocarcinoma of the bowel tractLecture No. 6.VIII. HeilbronnerKolloquium ber klinische ChirurgieI. Stdt. Chirurg. Klinik Heilbronn, 3. Oktober 1981 Heilbronn

VERAGUTH, O., & R. SEYDERHELM:ber raschwirkende Beeinflussung abnormerLeukozytenbilder durch ein neuesVerfahren.

I. und II. Mitteilung.Mnch. Med. Wochenschr., 2211 2214 (1913) und 301 304 (1914)

WILK, M., W. W. FIBIGER & B. FRANZUK:Zastowanie terapii energotonowej w rehabilitacji pacjentw po uszkodzeniach tkanekmiekkich stawu kolanowego.

The application of high-tone power therapy in rehabilitation of patients with soft-tissuedamage to the knee joint.Fizjoterapia Polska (Polish Journal of Physiotherapy) 2, 118 121 (2002)


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