Lola
Kel
ly S
mal
ls, P
hD, M
BA, L
aurie
Els
tun,
MS,
Am
y C
apre
tta,
BS,
Pau
la H
artw
ig, B
S, M
icha
el T
hom
as, M
BA, D
avid
Sw
aile
, PhD
, P&
G B
eaut
y, C
inci
nnat
i, O
hio
USA
INTR
OD
UC
TIO
NPr
escr
iptio
n (R
x) a
ntip
ersp
irant
(AP)
pro
duct
s are
wid
ely k
now
n to
indu
ce ir
ritat
ion
(ery
them
a, st
ingi
ng, b
urni
ng)
due
to t
he h
ighl
y ac
idic
natu
re o
fth
e A
P ac
tive
in
vehi
cles
that
are
not
opt
imiz
ed t
o bu
ffer
the
skin
rea
ctio
ns.
This
axill
ary
skin
irr
itatio
n lim
its p
atien
t com
plian
ce, t
hus
impe
ding
pro
duct
effi
cacy
. Pre
viou
sly, w
e sh
ared
da
ta
from
tw
o w
ell-c
ontro
lled
clini
cal
stud
ies
that
es
tabl
ished
th
e pr
escr
iptio
n st
reng
th A
P ef
ficac
y fo
r an
OTC
AP
com
pare
d to
a R
xA
P1 . Th
is pr
escr
iptio
n st
reng
th w
etne
ss p
rote
ctio
n O
TC A
P w
as f
orm
ulat
ed t
o be
gen
tle t
o th
e sk
in b
y de
liver
ing
skin
-soo
thin
g be
nefit
s vi
a pe
trolat
um a
nd d
imet
hico
ne. I
n th
ese
clini
cal
stud
ies
we
dem
onst
rate
th
e ut
ility
of
no
n-co
ntac
t SI
ASc
opy
(Spe
ctro
phot
omet
ricIn
tracu
tane
ous
Ana
lysis,
NCS
), an
imag
e an
alysis
met
hod
that
m
aps s
kin
chro
mop
hore
s(he
mog
lobi
n, e
umela
nin,
der
mal
colla
gen)
2, 3
, 4, t
o ex
amin
e th
e re
gion
al di
strib
utio
n an
d co
ncen
tratio
n of
hem
oglo
bin
in a
xilla
ry s
kin
treat
ed
with
a m
ild O
TC A
P an
d an
irrit
atin
g pr
escr
iptio
n A
P.
Ove
rall,
th
ese
data
de
mon
stra
te
that
no
n-co
ntac
t ch
rom
opho
rem
appi
ng v
ia SI
Asc
opy
is an
effe
ctiv
e to
ol
for
the
asse
ssm
ent
of
axill
ary
irrita
tion
and
is co
nsist
ent
with
exp
ert
clini
cal
irrita
tion
asse
ssm
ents
, an
d su
bjec
t self
-per
ceiv
ed d
ata.
Add
ition
ally,
the
mild
er “
Soft
Solid
”O
TC A
P m
ay in
crea
se su
bjec
t co
mpl
iance
, lea
ding
to a
mor
e co
nsist
ent t
reat
men
t reg
imen
as
com
pare
d to
the
mor
e irr
itatin
g Rx
A
lum
inum
Chl
orid
e A
P.
Curr
ently
, th
e im
age
analy
sis
met
hod
wor
ks
well
in
sh
aved
un
dera
rm s
kin.
Th
e m
etho
d ha
s no
t be
en o
ptim
ized
for
uns
have
d sk
in.
In
clini
cal
trials
, ex
pert
irrita
tion
asse
ssm
ent
is alw
ays
reco
mm
ende
d in
co
njun
ctio
n w
ith
imag
e an
alysis
m
etho
ds.
Ackn
owle
dgem
ents
:Im
age
Ana
lysis
by
Mic
hael
Mar
mor
& K
ukiz
oM
iyam
oto.
Eva
luat
e th
e ut
ility
of n
on-c
onta
ct S
IAsc
opy
for t
he a
sses
smen
t of a
xilla
ry ir
ritat
ion
via
chro
mop
hore
map
ping
of
hem
oglo
bin
with
com
paris
on t
o ex
pert
clini
cal a
nd
subj
ect p
erce
ived
irrit
atio
n in
axi
llary
ski
n tre
ated
with
a m
ild p
resc
riptio
n st
reng
th
wet
ness
pro
tect
ion
OTC
AP
and
an ir
ritat
ing
pres
crip
tion
AP.
OBJ
ECTI
VE
MET
HO
DS
Two
well
-con
trolle
d, r
ando
miz
ed a
nd b
linde
d pa
ired
com
paris
on c
linica
l st
udies
w
ere
cond
ucte
d to
eva
luat
e ax
illar
y irr
itatio
n an
d A
P ef
ficac
y of
a R
x A
P co
ntain
ing
6.25
% A
lum
inum
Chl
orid
e ve
rsus
an
OTC
anh
ydro
us, A
lum
inum
Tric
hlor
ohyd
rex
GLY
AP.
The
stu
dy w
as c
ondu
cted
for
7-d
ays
in h
ealth
y fe
male
s (n
=19
), w
ith
treat
men
ts a
pplie
d 1X
/day
in
the
even
ing.
Th
e pa
nelis
ts w
ere
evalu
ated
for
irr
itatio
n at
eac
h vi
sit.
If a
pan
elist
had
an
irrita
tion
scor
eof
2 o
r ab
ove
(Sca
le:
0=N
one
to 3
=E
xtre
me)
, pro
duct
app
licat
ion
was
disc
ontin
ued
for
subj
ect
safe
ty
and
the
high
est i
rrita
tion
and
imag
e sc
ores
for t
hat p
aneli
st w
ere
carr
ied fo
rwar
d fo
r th
e an
alysis
. St
udy
mea
sure
men
ts:
Dail
y hi
gh
reso
lutio
n im
age
capt
ure
for
subs
eque
nt n
on-c
onta
ct S
IAsc
opy
evalu
atio
n, A
P ef
ficac
y (P
ost-t
rt 6)
, dail
y ex
pert
irrita
tion
scor
ing,
and
dail
y su
bjec
t sel
f-rep
orte
d sy
mpt
oms.
The
data
wer
e as
sess
ed
usin
g m
ixed
mod
els o
r the
mar
gina
l hom
ogen
eity
test
.
RESU
LTS
CO
NC
LUSI
ON
S
Ref
eren
ces
1.Th
omas
M, K
elly
Sm
alls L
R, L
eaze
r TM
, Fin
n E
, Elst
un L
T,
Har
twig
P, S
wail
e D
, Cap
retta
A. A
ltern
ativ
e To
pica
l Tre
atm
ent t
o an
Alu
min
um C
hlor
ide
Ant
iper
spira
nt th
at P
rovi
des P
resc
riptio
n St
reng
th E
ffica
cy w
ith S
igni
fican
tly L
ess I
rrita
tion.
Am
eric
an
Aca
dem
y of
Der
mat
olog
y 65
thA
nnua
l Mee
ting,
200
7.
2.M
atts
, PJ,
Fink
, B, ,
Gra
mm
er, K
, Bur
ques
t, M
. Col
or h
omog
eneit
y an
d vi
sual
perc
eptio
n of
age
, hea
lth, a
nd a
ttrac
tiven
ess o
f fem
ale
faci
al sk
in. J
Am
Aca
dD
erm
atol
2007
; 57:
977
-84.
3.
Mat
ts P
J, Ca
rey
J, Co
tton
SD. C
hrom
opho
rem
appi
ng: a
new
te
chni
que
to c
hara
cter
ized
age
ing
hum
an sk
in, i
nviv
o, A
mer
ican
A
cade
my
of D
erm
atol
ogy
63rd
Ann
ual C
onfe
renc
e, 20
05.
4.K
imba
ll A
, Mat
ts, P
J. Ch
arac
teriz
ing
Hyp
er-p
igm
ente
d Fa
cial
Lesio
ns U
sing
Clin
ical
Eva
luat
ion
and
a N
ew C
hrom
opho
re-
Map
ping
Tec
hniq
ue.
Am
eric
an A
cade
my
of D
erm
atol
ogy
64th
Ann
ual M
eetin
g, 2
006.
Ch
rom
op
ho
reM
app
ing
of
Hem
og
lob
in f
or
the
Ass
essm
ent
of
Axi
llary
Irri
tati
on
: C
om
par
iso
n o
f O
TC a
nd
Pre
scri
pti
on
An
tip
ersp
iran
ts
This
wor
k w
as f
unde
d by
P&
G B
eaut
y.CO
NC
LUSI
ON
S
01234567
Visi
t 1Vi
sit 2
Visi
t 3Vi
sit 4
Visi
t 5Vi
sit 6
Visi
t 7
Mean Change from Baseline Hemoglobin Value (higher= more irritation)
A (F
emal
e O
TC A
nhyd
rous
"S
oft S
olid
")C
(Rx
AlC
l3 A
P)
p=0.
0337
p=0.
0001
p=0.
0011
p=0.
0003
p<0.
0001
Rx
Alu
min
um
Ch
lori
de
AP
An
hyd
rou
s “S
oft
So
lid”
OTC
AP
Ori
gin
al Im
age
NC
S H
emo
glo
bin
Map
Ori
gin
al Im
age
NC
S H
emo
glo
bin
Map
Female Underarms
0
0.51
1.52
2.53
3.54
Vis
it 1
Vis
it 2
Vis
it 3
Vis
it 4
Vis
it 5
Vis
it 6
Vis
it 7
Mean Subject Perceived Irritation Score (higher= more irritation, Scale- 0-10)
A (F
emal
e O
TC A
nhyd
rous
"So
ft S
olid
")C
(Rx
AlC
l3 A
P)
p=0.
0148
p=0.
0138
p=0.
0114
p=0.
0104
p=0.
0146
Non
-con
tact
chr
omop
hore
map
ping
of h
emog
lobi
n in
dica
ted
that
ther
e w
as si
gnifi
cant
ly (p
<0.
05) m
ore
irrita
tion
for t
he
Rx A
P as
com
pare
d to
the
OTC
AP
(Visi
ts 3
-7).
Add
ition
ally,
the
hem
oglo
bin
data
wer
e co
nsist
ent
with
sig
nific
ant
findi
ngs
(p<
0.05
) for
exp
ert c
linica
l visu
al irr
itatio
n sc
ores
(Visi
ts 3
-7) a
nd s
ubjec
t self
-ass
essm
ents
(p<
0.05
, Visi
ts 3
-7).
Subj
ect p
erce
ptio
n da
ta in
dica
ted
that
the
irrita
tion
from
the
Rx A
P m
ost o
ften
felt
like
stin
ging
and
bur
ning
. Fo
r sub
ject
sa
fety
, tre
atm
ent w
as d
iscon
tinue
d at
leve
l 2 ir
ritat
ion
(Sca
le:0-
3): n
=7
on R
x A
P an
d n=
0 on
Anh
ydro
us O
TC A
P.
Subj
ect S
elf P
erce
ived
Irrit
atio
n Sc
ore
by V
isit
Imag
e An
alys
is-C
hang
e fro
m B
asel
ine
Hem
oglo
bin
Valu
es
01020304050607080
Visi
t 1Vi
sit 2
Visi
t 3Vi
sit 4
Visi
t 5Vi
sit 6
Visi
t 7
% of Subjects Unfavorable Irritation Comments(higher= more unfavorable)
A (F
emal
e O
TC A
nhyd
rous
"So
ft So
lid")
C (R
x Al
Cl3
AP)
p=0.
0007
p=0.
0038
p=0.
0024
p=0.
0038
p=0.
0079
Subj
ect S
elf-P
erce
ived
Irrit
atio
n U
nfav
orab
le C
omm
ents
Exp
ert V
isua
l Irr
itatio
n As
sess
men
t by
Visi
t
0
0.2
0.4
0.6
0.81
1.2
1.4
Visi
t 1Vi
sit 2
Visi
t 3Vi
sit 4
Visi
t 5Vi
sit 6
Visi
t 7
Mean Expert Visual Irritation Score(higher= more irritation, Scale- 0-3)
A (F
emal
e O
TC A
nhyd
rous
"So
ft So
lid")
C (R
x Al
Cl3
AP)
p=0.
0124
p=0.
0018
p=0.
0003
p=0.
0007
p=0.
0004
P100
0
Recommended
