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HLSHemolymphatic Systems

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Figure 8.12: Non-enzymatic addition of glucose to haemoglobin ;,

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174 Pilrt II

I>ROTEINS

Homoglobin A

Homoqlobin M

Figuro7·53S\lb~tjlulj()n of tyro~ine ror thepmxilllal histidinc (FH) rc:;ult,.; in theI"ormation nf i\ heillog-iobin M. Thenq.;;llivcly diaq.;ed oXYgcl\ ;uQm-oftyro.,inc is ,,,urdinaled to Ihe ironalOlll. which is in thc krric .~tiHc,

Wal<.:r rather thall O~ is bound al Ihe~ixlh coordination po~itiol1 .

. Figure7-S4Location oCpilel1},IOllaninc CDl. innorl)\.11 11l!lllogl'lbin, '!'lIe ;lf11ll10l1icring 01"thi~ r<.:~idlJcis in (onl;ICl withIII{: heine. In hemog-Iobin

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Figure 3.19Amino acid substitutions in HbS and HbC.

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Figure 3.20

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Glutathione peroxidaseH,O, -=7=-=O"':"'::..:c..,,\;,-:..:..cc--+, 2H,O

2GSH 2-G-S-S-GReduced glutathione Oxidised glutathione A

Glutathionereductase,

~NADPH + H+, c~~~~:;XNAD

'Qxidants (certain dr~gS)·. Methaerrioglobin reduCtase€J p'h'~.G<t,"" /_. _ cytochrome b5 B_sulfh.". "";aU-?

ck~.c..a.lJ:<J -f -t€.. HbFe" NADH + H'l.l)'\,ti'o1...t..} ~JC.,: .5"~+" yt Methaemoglobin

0.10- .)<'~S '- Jj. •Figures 8.17A and B: Erythrocyte mechanisms for detoxification of melhaemoglobin

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