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ISFR 2016
15th BIennIal ConFeRenCe07–10 JUne, 2016 I MUnICh, GeRMany
www.isfr2016.com
Scientific Program
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Smith & Nephew GmbH, Friesenweg 4, Haus 21, 22763 HamburgTel. +49 (0)40 87 97 44 0, Fax +49 (0)40 87 97 44 375, www.smith-nephew.de
1 | Journal of Orthopedic Trauma (JOT); January of 2009, The Treatment of Intertrochanteric Fractures: Results Using an Intramedullary Nail With IntegratedCephalocervical Screws and Linear Compression, Authors: Andreas H. Ruecker, MD, M. Rupprecht, MD, M. Gruber, MD, M. Gebauer, MD, F. Barvencik,MD, D. Briem, MD, PhD, and J. M. Rueger, MD
2 | Evaluation of Cyclic Cut-Out Failure in Intramedullary Nails: A Comparison Between Single Lag Screws and Integrated Interlocking Screws, Russell, TA;+ Summy, SA; Whitten, SA, Campbell Clinic, Germantown, TN, Smith & Nephew, Inc., Memphis
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Organization and Imprint .............................................................................................. 4
Welcome Note ............................................................................................................. 5
International Society for Fracture Repair (ISFR) ............................................................ 6
Spotlight Speakers and Scientific Committee ............................................................... 7
General Information ..................................................................................................... 8
Plan of Conference Area and Travel Information ........................................................... 9
Sponsors and Scientific Sponsors ............................................................................... 10
Industrial Exhibition ..................................................................................................... 11
Social Program ............................................................................................................ 12
Program Overview ........................................................................................................ 13
Pre-Course • Tuesday, 7 June 2016 ............................................................................ 14
Scientific Program Wednesday, 8 June 2016 .............................................................................. 15 Thursday, 9 June 2016 ................................................................................. 20 Friday, 10 June 2016 .................................................................................... 24
Poster Presentations .................................................................................................... 26 Index of Invited Speakers, Chairs and Presenting Abstract Authors .............................. 31
Table of Contents
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Organization and Imprint
Venue DateTechnische Universität München TUM 7–10 June 2016Klinikum Rechts der Isar MRILecture Hall PavillonEinsteinstrasse 22 • 81675 Munich (DE)
Hosting SocietyInternational Society for Fracture Repair (ISFR) www.fractures.com
Conference Homepage www.isfr2016.com
Conference ChairsPeter AugatTrauma Center • BGU Murnau • Murnau (DE)
Peter BiberthalerDepartment of Trauma Surgery • TU Munich • Munich (DE)
Program Chairs Peter AugatTrauma Center • BGU Murnau • Murnau (DE)
Gerhard SchmidmaierHeidelberg University Hospital • Heidelberg (DE)
Professional Congress Organizer (PCO) and Industrial ExhibitionConventus Congressmanagement & Marketing GmbHMarlen SchillerCarl-Pulfrich-Strasse 1 • 07745 Jena (DE)Phone +49 3641 31 [email protected] • www.conventus.de
Design/LayoutLayout www.krea.tif–art UG (haftungsbeschränkt)Print SIBLOG | Schneller ist besser! Logistik GmbHCirculation 250Editorial Deadline 20 May 2016
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Dear colleagues,
The International Society for Fracture Repair is an organization of individuals from around the world who are dedicated to the advancement and interchange of science of fracture repair and its application to improvement of patient care.
The biennial conference of the ISFR in 2016 will be held in Munich, Germany. Being an in-ternational society the home of our biennial conference travels between continents. The last two were held in Kyoto, Japan 2012 and New York, USA 2014. In 2016 the conference travels back to Europe and will be held in the south of Germany in the wonderful setting of Munich.
The conference program will highlight the most up to date research in fracture repair including basic and clinical research. Spotlight sessions will focus on burning issues such as fragility fractures, bone infections and bone biomechanics. The presidential speaker will emphasise the consensus on outcome measurement for fracture research and further presentations will add to clinical trial knowledge.
Using modern osteosynthesis technology most bone fractures heal uneventful. However, some fractures remain a challenge for the orthopaedic surgeon and can seriously compromise patient’s health. Research in fracture repair aims at those fracture situations which potentially endanger the patient with a fracture. The ISFR conferences provide a unique opportunity for basic researchers and orthopaedic surgeons to discuss advances in fracture treatment and improve patient care. It should encourage new collaborations and interactions.
Join the ISFR 2016 conference in Munich to participate in this exciting endeavor. Interact with basic researchers in bone biology, engineers in bone biomechanics, trauma surgeons and orthopedic specialists. ISFR 2016 offers a stimulating atmosphere for young scientists, experienced reseachers, surgeons early in their clinical career as well as dedicated trauma experts.
Peter Augat Peter Biberthaler Jörg GoldhahnConference Chair Conference Chair ISFR President
Welcome Note
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International Society for Fracture Repair (ISFR)
Board of Directors of the International Society for Fracture Repair
President Jörg Goldhahn (Zurich/CH)
President Elect David Hak (Denver, CO/US)
Past President Takashi Matsushita (Tokyo/JP)
Secretary General Ralph Marcucio (San Francisco, CA/US)
Treasurer Amy Hoang-Kim (Toronto/CA)
Meeting Chair & Membership Secretary Peter Augat (Murnau/DE)
Members at Large Mathias Bostrom (New York, NY/US) Alan Johnstone (Aberdeen/GB) Gerhard Schmidmaier (Heidelberg/DE) Emil Schemitsch (Toronto/CA) Allen E. Goodship (Stanmore/GB) Cyril Mauffrey (Denver, CO/US) Chantal Chenu (London/GB) Yoshinobu Watanabe (Tokyo/JP)
For more information and for membership application, please visit the societies website www.fractures.com.
Meetings of the International Society for Fracture Repair
ISFR Board of Directors Meeting Tuesday, 7 June 2016 • 16:00–18:00 Friday, 10 June 2016 • 13:00–15:00
ISFR General Assembly Wednesday, 8 June 2016 • 17:00–18:00
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Spotlight Speakers and Scientific Committee
Spotlight Speakers
Volker Alt UKGM University of Giessen Giessen (DE)
Dorcas Beaton St. Michaels Hospital Toronto Toronto (CA)
Michael Bottlang Legacy Health
Portland (OR/US)
Volker Bühren BGU Trauma Center
Murnau (DE)
Peter Giannoudis University of Leeds
Leeds (GB)
Allen Goodship University College London
London (GB)
Philip Procter Medical Device Consultant
Rhone-Alpes (FR)
Scientific CommitteeVolker Alt (Giessen/DE)Per Aspenberg (Linköping/SE)Peter Biberthaler (Munich/DE)Taco Blokhuis (Utrecht/NL)Mathias Bostrom (New York, NY/US)Chantal Chenu (London/GB)Kwok-Sui Leung (Hong Kong/CN)W. H. Louis Cheung (Hong Kong/CN)Georg Duda (Berlin/DE)Allen Goodship (Stanmore/GB) Jörg Goldhahn (Zurich/CH)David Hak (Denver, CO/US)Amy Hoang-Kim (Toronto/CA)Jörg Holstein (Homburg/DE)
Anita Ignatius (Ulm/DE)Alan Johnstone (Aberdeen/GB)Christian Kammerlander (Munich/DE)Joseph Lane (New York, NY/US)Sune Larsson (Uppsala/SE)Ralph Marcucio (San Francisco, CA/US)Takashi Matsushita (Tokyo/JP)Cyril Mauffrey (Denver, CO/US)Emil Schemitsch (Toronto/CA)Werner Schmölz (Innsbruck/AT)Hamish Simpson (Edinburgh/GB)Martijn van Griensven (Munich/DE)Yoshinobu Watanabe (Kyoto/JP)Dirk Wähnert (Münster/DE)
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General Information
Registration Fees ISFR Member 430 EUR Non Member 530 EUR Student* 250 EUR ISFR 2016 Pre-Course 100 EUR Conference Dinner 50 EUR * Confirmation of status is required.
General Terms and Conditions Please find all details at our website at www.isfr2016.com.
Opening Hours
Tuesday Wednesday Thursday Friday
Conference Program 13:00–18:00 08:30–18:00 08:30–16:00 09:00–12:30
Industrial Exhibition 10:00–17:00 08:30–16:00 09:00–11:00
Poster Exhibition 08:30–17:00 08:30–16:00 09:00–11:00
Registration Desk/ 12:00–19:00 07:30–17:00 07:30–16:15 08:00–13:00
Speakers Ready Room
Education Credits and Certification The conference is requested by the “Medical Chamber of Bavaria” in Category B as follows:
7 June 2016 6 Points 9 June 2016 3 Points 8 June 2016 6 Points 10 June 2016 3 Points
For certification all attendants are required to sign the certification list near the registra-tion daily. Certificates of attendance may be picked up upon leaving the conference at the registration desk.
Catering and LunchTea, coffee, refreshments and snacks will be available free of charge during all pro-gram breaks within the industrial exhibition area.
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Plan of Conference Area and Travel Information
.
Travel InformationNavigation AddressIsmaninger Strasse 22 • 81675 Munich (Germany)In general we recommend to use the public transportation system, since the parking situation around the venue is not well.
Public Transportationfinal destination “Max-Weber-Platz” • Underground trains: U4/U5 • Tram: 15/16/19/25 • Bus: 91/191/192
By CarIn case you decide to arrive by car we recommend the following parking options: • parking bays on Einsteinstrasse • 81675 Munich • underground parking “Daseinstein Stahlgruber” – Einsteinstrasse 130 • 81675 Munich • car park “Parkhaus am Hofbräukeller” – Innere Wiener Strasse 15 • 81667 MunichPlease use your navigation system (see address above) for the optimal route.
For further information regarding your travel from the airport Franz-Josef-Strauß please note the details at our conference website.
© Klinikum rechts der Isar • Technische Universität München
Plenary Hall
Main Entrance
Metro: No. No.
No.
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Sponsors and Scientific Sponsors
We would like to give our sincere thanks to the following sponsors:
Gold SponsorSmith & Nephew GmbH (Hamburg/DE)
Silver SponsorsAQ Implants GmbH (Ahrensburg/DE)
BONESUPPORT GmbH (Frankfurt a. M./DE)
Cerapedics, Inc. (Westminster, CO/US)
GOM – Gesellschaft für optische Messtechnik mbH (Braunschweig/DE)
Johnson & Johnson Medical GmbH (Norderstedt/DE) – DePuy Synthes
Königsee Implantate GmbH (Allendorf/DE)
Medartis AG (Basel/CH) Orthofix GmbH (Ottobrunn/DE)
RISystem AG (Davos/CH)
Stryker GmbH & Co. KG (Duisburg/DE)
We would like to thank the following scientific sponsors for their great support:
Berufsgenossenschaftliche Unfallklinik Murnau
Paracelsus – Medizinische Privatuniversität
Osteosynthesis and Trauma Care Foundation (OTCF)
TraumaTec
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Industrial Exhibition
The following exhibitors are looking forward to welcoming you at their booth:
Company Booth No.AQ Implants GmbH (Ahrensburg/DE) 7BONESUPPORT GmbH (Frankfurt a. M./DE) 6Cerapedics, Inc. (Westminster, CO/US) 5GOM – Gesellschaft für optische Messtechnik mbH (Braunschweig/DE) 10Johnson & Johnson Medical GmbH (Norderstedt/DE) 8
– DePuy SynthesKönigsee Implantate GmbH (Allendorf/DE) 3Medartis AG (Basel/CH) 4Orthofix GmbH (Ottobrunn/DE) 2RISystem AG (Davos/CH) 9Smith & Nephew GmbH (Hamburg/DE) 1Stryker GmbH & Co. KG (Duisburg/DE) 11
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Social Program
Welcome Reception • Tuesday, 7 June 2016 We are looking forward to welcoming you to the Welcome Reception on Tuesday at 18:00 in the cafeteria downstairs of the conference building. Enjoy a first meet and greet with your colleagues and other delegates in a relaxed atmosphere. This Get Together is included in the registration fee.
Conference Dinner • Thursday, 9 June 2016 Don’t miss the ISFR conference dinner and awards presentation aboard a cruise boat on spectacular lake Starnberg. During the evening you are invited to exchange and discuss current work and research findings with your colleagues and friends while enjoying the boat trip.
Landing stage StarnbergBoat MS SeeshauptDeparture 18:45 Landing 21:45
There will be a bus shuttle provided for the ride from the venue to the landing stage and back at the following times:
Departure Venue 16:15 (including “Bavarian Reception”)Arrival Boat 18:30
Departure Boat 22:00Arrival Venue 23:00Registration Fee 50 EUR
Please note: Registration is required.
© CandyBox Images - Fotolia.com
© Grischa Georgiew - Fotolia.com
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Program Overview
* 7 June 2016, 15:00–18:00 10 June 2016, 13:30–15:00 ISFR Board of Directors Meeting ISFR Board of Directors Meeting
7 June 8 June 9 June 10 June
08:30–10:00 08:30–10:00
Bone Defect Tissue Engineering
Fracture Healing Complications 09:00–10:30
p. 15 p. 20 Basic Research
p. 24
10:30–11:50 10:30–12:00
Infection, Inflammation, Stimulation
Fragility Fractures 11:00–12:30
p. 16 p. 21Clinical Trials and Outcome Research
11:55–12:20Poster Teaser p. 24
12:15–13:45 12:30Adjourn
13:00–17:50 Lunchworkshop
13:30–15:00 p. 22Fracture Fixation 14:00–14:30
Presidential Guest Lecture
p. 18 14:30–16:00
Best Paper Session (Lennart Stroemberg
15:30–17:00 p. 22Basic Research in Fracture
Healing
p. 19
17:00–18:00
p. 14ISFR General Assembly
from 18:00Welcome Reception
from 18:30
Conference Dinner on Lake Starnberg & Awards
p. 12
Pre-Course Experimental Research Methods in
Fracture Repair
Smith & Nephew GmbH,Intertan Gold
Award)*
*
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Pre-Course • Tuesday, 7 June 2016
13:00–17:50 Experimental Research Methods in Fracture RepairRoom PavillonChairs Volker Alt (Giessen/DE), Hamish Simpson (Edinburgh/GB)
13:00 Welcome and Introduction Peter Augat (Murnau/DE)
13:10 Basic principles of fracture repairIS 01 Georg Duda (Berlin/DE)
13:40 Mechanobiology of fracture healingIS 02 Allen Goodship (London/GB)
14:30 In-vivo models of fracture repairIS 03 Hamish Simpson (Edinburgh/GB)
15:00 In-vivo models of bone infectionIS 04 Volker Alt (Giessen/DE)
15:30 Biomechanics of fracture fixationIS 05 Michael Bottlang (Portland, OR/US)
16:20 Computational biomechanics for fracture fixationIS 06 Ulrich Simon (Ulm/DE)
16:50 Molecular biological techniquesIS 07 Esther van Lieshout (Rotterdam/NL)
17:20 Tissue engineering in bone repairIS 08 Matthias Schieker (Munich/DE)
16:00–18:00 ISFR Board of Directors MeetingRoom Meetingroom 2
18:00–19:30 Welcome ReceptionRoom Cafeteria
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Scientific Program • Wednesday, 8 June 2016
08:30–10:00 Bone Defect Tissue EngineeringRoom PavillonChairs Gerhard Schmidmaier (Heidelberg/DE), Peter Giannoudis (Leeds/GB)
08:30 Scaffold dependent differences of osteogenic activity in bone marrow OP 01 mononuclear cell-supported therapy of large femoral bone defects in rats Maren Janko (Frankfurt/DE)
08:40 DBM as an alternative carrier for BMP2 – burst release combined with OP 02 long term binding Britt Wildemann (Berlin/DE)
08:50 In-vivo tracking of injected endothelial progenitor cells in a rat bone OP 03 defect model Brent Bates (Toronto/CA)
09:00 Quantifying cervical fusion using porosity and directionality structural OP 04 quantification of bone remodelling Donal McNally (Nottingham/GB)
09:10 Bone tissue engineering – biotechnological aspects and clinical results in OP 05 treatment of combat-related trauma Dmytro Zubov (Kiev/UA)
09:20 Fabrication, characterization and osteogenic properties of 3D printed PCL OP 06 and PCL-Bioactive glass composites Sònia Font Tellado (Munich/DE)
09:30 An expedited approach for extended delivery of BMP-7 to bone defects OP 07 using gene activated fragments of subcutaneous fat Volker Betz (Dresden/DE)
09:40 Longitudinal in vivo micro-CT discriminates physiological and impaired OP 08 healing patterns in mouse femoral defect models Esther Wehrle (Zurich/CH)
10:00–10:30 Coffee Break within the Industrial ExhibitionRoom Foyer
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Scientific Program • Wednesday, 8 June 2016
10:30–11:50 Infection, Inflammation, Stimulation Room PavillonChairs Volker Bühren (Murnau/DE), Mathias Bostrom (New York, NY/US) 10:30 Spotlight – Bone infection and fracture healingIS 09 Volker Alt (Giessen/DE)
10:50 Treatment of open fractures of the tibia with a locked intramedullary nail with OP 09 a core release of antibiotics (SAFE DualCore Universal) – comparative study with standard locked intramedullary nail Nuno Craveiro-Lopes (Lisbon/PT)
11:00 Fracture blister fluid – Is it sterile or infected?OP 10 David Hak (Denver, CO/US)
11:10 Killing of MSSA and MRSA using the IlluminOss photodynamic implant for OP 11 fracture repair – blue light and sterilization of orthopaedically relevant pathogenic bacteria Robert Rabiner (East Providence, RI/US)
11:20 Antibiotic release from an embroidered scaffold applied for the tissue OP 12 engineering of long bone Annette Breier (Dresden/DE)
11:30 Different effect of alendronate in metaphyseal versus diaphyseal bone healingOP 13 Olof Sandberg (Linköping/SE)
11:40 Spatiotemporal signaling associated with fracture-induced inflammationOP 14 Jonathan Boyd (Morgantown, WV/US)
11:55–12:20 Poster TeaserRoom PavillonChair Gerhard Schmidmaier (Heidelberg/DE)
11:55 Subtrochanteric fracture in an adult female with osteogenesis imperfecta on P 01 long-term intravenous pamidronate therapy – A case of atypical femoral fracture? Jose Monteiro (Torres Vedras/PT)
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Scientific Program • Wednesday, 8 June 2016
11:58 Blockade of NGF/TrkA signaling for treatment of fracture-related pain does P 02 not influence the healing outcome in mice Anna Elise Rapp (Ulm/DE)
12:01 The lack of the collagen binding Integrin α2β1 leads to faster fracture healing P 03 due to increased matrix generation, faster differentiation and increased remodeling Daniel Kronenberg (Münster/DE)
12:04 Optimised device configuration can reduce screw loosening risk in P 04 osteoporotic bone while maintaining fracture site stimulation Hamish Simpson (Edinburgh/GB) 12:07 The lack of Syndecan-4 influences bone quality and healing dependent on P 05 inflammatory signals Melanie Timmen (Münster/DE) 12:10 Impaired inflammatory responses after estrogen-deficient osteoporotic P 06 fracture injury Simon Kwoon-ho Chow (Hong Kong/CN) 12:13 Responsiveness of the Japanese versions of the Knee Injury and P 07 Osteoarthritis Outcome Score (KOOS) and the Oxford Knee Score (OKS) in patients with high tibial osteotomy Sabine Goldhahn (Duebendorf/CH) 12:16 Outcome of posterior plating without anterior stabilization for vertically P 08 unstable sacral fractures using a new anatomical plate Toru Matsugaki (Fukuoka/JP)
12:30–13:30 Lunch Break within the Industrial Exhibition & PostersRoom Foyer
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Scientific Program • Wednesday, 8 June 2016
13:30–15:00 Fracture FixationRoom PavillonChairs Michael Bottlang (Portland, OR/US), Kwok-Sui Leung (Hong Kong/CN) 13:30 Spotlight – Perspectives in IM NailingIS 10 Volker Bühren (Murnau/DE) 13:50 Is locking screw fixation in carbon fiber composite plates mechanically OP 15 equivalent to stainless steel plates? David Hak (Denver, CO/US) 14:00 Minimally invasive stabilization of upper limb pathological fractures with an OP 16 intramedullary polymer Steffen Heck (Cologne/DE) 14:10 Comparison of mechanical behaviours of less invasive locking plate (LISS) OP 17 between different screw configurations at different healing stages Qing Kino Ye (Edinburgh/GB) 14:20 Vancouver B1 periprosthetic fractures of the femur – biomechanical OP 18 investigations with two angular stable plate constructs and the potential of double plating Dirk Wähnert (Münster/DE) 14:30 The mechanical effects of angular stability and other locking option on the OP 19 stability of intramedullary nails Martin Winkler (Murnau/DE) 14:40 Screw plugs increase the fatigue strength of locking plates in stainless steel OP 20 but not in titanium Jinn Lin (Taipei/CN) 14:50 Biomechanical comparison of the use of bone substitute versus K-wireOP 21 augmentation in the treatment of unstable distal radius fractures with external fixation Leonieke van Heeswijk (Rotterdam/NL) 15:00–15:30 Coffee Break within the Industrial ExhibitionRoom Foyer
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Scientific Program • Wednesday, 8 June 2016
15:30–17:00 Basic Research in Fracture HealingRoom PavillonChairs Jörg Goldhahn (Zurich/CH), Hamish Simpson (Edinburgh/GB) 15:30 Spotlight – Treatment of bone defects – the past, present and futureIS 11 Peter Giannoudis (Leeds/GB) 15:50 Patient-specific stress risk assessment osteosynthesized femoral neck OP 22 fracture using dynamic 3D finite element model Yukiko Nakamura (Kobe/JP) 16:00 miR-21, miR-93, miR-100 and miR-125b are up-regulated in serum, tissue, OP 23 osteoblast and osteoclast cells during osteoporosis and correlate to bone mineral density values Elizabeth Rosado Balmayor (Munich/DE)
16:10 A comparison of bone regeneration with human Mesenchymal Stem Cells OP 24 (MSCs) and human Mesenchymal Stem Cell-derived chondrocytes (MSC-DCs) in SCID mouse Yoshinobu Watanabe (Tokyo/JP)
16:20 Double plating using a helical plate – a biomechanical studyOP 25 Mark Lenz (Jena/DE) 16:30 CD31 leukocytes support a pro-regenerative milieu in disturbed bone OP 26 healing situations – an approach to avoid the manifestation of non-unions by an early intervening strategy Anke Dienelt (Berlin/DE) 16:40 Osteoblasts are target cells for complement component C5a in fracture healingOP 27 Yvonne Hägele (Ulm/DE) 16:50 Hypochlorhydria-induced calcium malabsorption does not affect fracture OP 28 healing but increases post-traumatic bone loss in the intact skeleton Melanie Haffner-Luntzer (Ulm/DE)
17:00–18:00 ISFR General AssemblyRoom Meetingroom 1
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Scientific Program • Thursday, 9 June 2016
08:30–10:00 Fracture Healing ComplicationsRoom PavillonChairs Peter Biberthaler (Munich/DE), Takashi Matsushita (Tokyo/JP) 08:30 Arginine availability in reamed intramedullary aspirate – influences on fracture OP 29 healing and nonunion development Dennis Meesters (Maastricht/NL) 08:40 Femoral non-union with mal-alignment – reconstruction and biological OP 30 stimulation with the chipping technique Yoshinobu Watanabe (Tokyo/JP) 08:50 Exchange nailing for lower limb diaphyseal fracture non-unions. Absence of OP 31 periosteal reaction is predictive of failure Shao-Ting Jerry Tsang (Edinburgh/GB) 09:00 Treatment of bone defect for osteomyelitis using the Masquelet techniqueOP 32 Kana Ebisuzaki (Kurume City, Fukuoka/JP) 09:10 Chronic calcium- and vitamin-D-deficiency impairs fracture healing and OP 33 induces posttraumatic bone resorption in mice Verena Heidler (Ulm/DE)
09:20 Intermittent parathyroid hormone treatment improves bone formation in OP 34 devitalized allografts in a murine model of femoral segmental defect Tito Rocha (Rio de Janeiro/BR) 09:30 Missing influence of rhBMP-2 and rhBMP-7 in surgical revision of aseptic OP 35 clavicular nonunion Christian von Rüden (Murnau/DE) 09:40 Gene expression changes of the Wnt signalling pathway in bone of type 2 OP 36 diabetes mellitus – A biomolecular basis for diabetic bone disease? Alexander T. Haug (Munich/DE)
09:50 Delayed fracture healing is partly caused by a severe hemorrhagic shock in a OP37 murine model Katrin Bundkirchen (Hanover/DE)
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Scientific Program • Thursday, 9 June 2016
10:00–10:30 Coffee Break within the Industrial ExhibitionRoom Foyer
10:30–12:00 Fragility FracturesRoom PavillonChairs Alan Johnstone (Aberdeen/GB), Amy Hoang-Kim (Toronto/CA) 10:30 Spotlight – Bone augmentation – closing the gap between unmet clinicalIS 12 needs and biomaterials Philip Procter (Rhone-Alpes/FR) 10:50 Surgial treatment of 4-part fractures of the proximal humerus in the elderly: OP 38 Plate fixation or reversed shoulder arthroplasty? Chlodwig Kirchhoff (Munich/DE) 11:00 Cement augmentation of locking plates in the treatment of osteoporotic distal OP 39 femur fractures – biomechanical investigations Dirk Wähnert (Münster/DE) 11:10 Risk factors related to one-year mortality in displaced intracapsular hip OP 40 fracture patients Jianghui Qin (Hong Kong/CN) 11:20 Fractures of the distal radius fractures on the elderly patient; IlluminOss OP 41 offers a new method of treatment Robert Rabiner (East Providence, RI/US) 11:30 Augmentation of instable pertrochanteric fractures in the osteoporotic elderly OP 42 patient – operative technique for 1 or 2 head screw systems Giacomo Trivellin (Verona/IT) 11:40 Does the timing of cement application and reposition affect pedicle screw OP 43 anchorage? Christian Heinrichs (Innsbruck/AT) 11:50 What will happen next? Perceptions of prognosis following a hip fractureOP 44 Amy Hoang-Kim (Toronto/CA) 12:00–14:00 Lunch Break within the Industrial Exhibition & PostersRoom Foyer
22
Scientific Program • Thursday, 9 June 2016
12:15-13:45 Lunchworkshop • Smith & Nephew GmbH Room Pavillon
Intertan Gold Introduction and presentation of the system Peter Biberthaler (Munich/DE)
Hands on workshop Peter Biberthaler, Chlodwig Kirchhoff (Munich/DE)
14:00–14:30 Presidental Guest LectureRoom PavillonChairs Jörg Goldhahn (Basel/CH), David Hak (Denver, CO/US)
It is time to agree: moving towards consensus on outcome measurement for fracture research Dorcas Beaton (Toronto/CA) 14:30–16:00 Best Paper Session (Lennart Stroemberg Award)Room PavillonChairs Jörg Goldhahn (Basel/CH), David Hak (Denver, CO/US) 14:30 Spotlight – Lennart Stroemberg memorial lectureIS 13 Allen Goodship (London/GB) 14:45 Mast cells regulate inflammation and bone regeneration in fracture healingOP 45 Jochen Kroner (Ulm/DE) 14:55 The potential of plate fixation in the greater trochanter fixing periprosthetic OP 46 fractures Vancouver typ B1 – a biomechanical study Marc Lenz (Jena/DE) 15:05 Improved bone regeneration in diabetic rats by sulfated hyaluronan via OP 47 scavenging sclerostin and enhancing osteoblast function Ann-Kristin Picke (Dresden/DE) 15:15 Using new objective tests to compare the Supra-patellar and Infra-patellar OP 48 techniques for inserting tibial nails – the Supra-patellar technique significantly reduces anterior knee symptoms and tenderness Carol A. Carnegie (Aberdeen/GB)
23
Scientific Program • Thursday, 9 June 2016
15:25 Development of a single-surgery approach for bone repair using BMP-2 gene OP 49 activated subcutaneous fat tissue – evaluation in a sheep model Volker Betz (Dresden/DE) 15:35 Exchange nailing for tibial diaphyseal fracture non-unions. Risk factors for failureOP 50 Shao-Ting Jerry Tsang (Edinburgh/GB) 15:45 Photodynamic Therapy (PDT) to enhance healing of femur fractures with a OP 51 critically sized defect Margarete Akens (Toronto/CA) 15:55 Role of interleukin-6 in the inflammatory and repair phase of fracture healingOP 52 Katja Prystaz (Ulm/DE)
16:15 Bus Transfer to the Conference Dinner 18:30–22:00 Conference Dinner and Awards (please refer to page 12)
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Scientific Program • Friday, 10 June 2016
09:00–10:30 Basic ResearchRoom PavillonChairs Chantal Chenu (London/GB), Anita Ignatius (Ulm/DE) 09:00 Spotlight – The past and future of dynamic platingIS 14 Michael Bottlang (Portland, OR/US) 09:20 Finite element analysis comparing the new fracture fixation concept, DBS, OP 53 with a conventional locked fixation system Mauricio Toro (Medellin/CO) 09:40 Time varying bone stress distribution visualization technique for proximal OP 55 femur via biomechanical analysis under physiological gait loading scenario Yukiko Nakamura (Kobe/JP) 09:50 Intermittent parathyroid hormone enhances fixation of a physiologically OP 56 loaded tibial implant in ovariectomized mice Mathias Bostrom (New York, NY/US) 10:00 Global absence of complement receptor C5aR impairs fracture healing in mice OP 57 Anna Kovtun (Ulm/DE) 10:10 Intertrabecular bone healing – Immediate mesenchymal cell activity?OP 58 Magnus Bernhardsson (Linköping/SE)
10:20 Endothelial progenitor cell therapy and bone defect repair – a doseresponse OP 59 study David Ramnaraign (Toronto/CA)
10:30–11:00 Coffee Break within the Industrial ExhibitionRoom Foyer 11:00–12:30 Clinical Trials & Outcome ResearchRoom PavillonChairs Cyril Mauffrey (Denver, CO/US), Dorcas Beaton (Toronto/CA)
11:00 Topical cutaneous application of carbon dioxide using a hydrogel increases OP 60 blood flow of the fractured limb in bone fracture patients Takahiro Niikura (Kobe/JP)
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Scientific Program • Friday, 10 June 2016
11:10 Consideration of osteosynthesis for coronal shearing fracture of the proximalOP 61 femur Kazuo Sato (Sapporo/JP) 11:20 The use of an oblique screw with distal femoral locking plates in the presenceOP 62 of metaphyseal comminution – a review of radiographic and healing outcomes Sonya Khurana (Valhalla, NY/US) 11:30 Functional analyses after tibial shaft fractureOP 63 Janina Lackner (Murnau/DE) 11:40 Filipov’s method of biplane double-supported screw fixation extremely OP 64 reduces the risk of fixation failure in femoral neck fractures – clinical outcomes in 207 patients Orlin Filipov (Sofia/BG) 11:50 The added value of real-world monitoring in hip fracture trials – a pilot studyOP 65 Jörg Goldhahn (Zurich/CH) 12:00 Adapting the type of treatment to the patient (non-randomized) gives better OP 66 functional results than randomized treatment allocation (randomized control trial) in patients with midshaft clavicle fracture – a review of 1098 patients with clavicle fracture Frederic Vauclair (Lausanne/CH)
12:10 Injuries of the trochanteric region – Can analysis of radiographic indices help OP 67 in prediction of recurrent osteoporotic fractures? Andrea Pellegrini (Parma/IT) 12:20 Relationships of power and trust – implications for delivering prognoses to OP 68 patients following hip fracture Amy Hoang-Kim (Toronto/CA)
13:00–15:00 ISFR Board of Directors MeetingRoom Meetingroom 2
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Poster Presentations
Posters will be displayed during the whole duration of the conference.The posters P 01–P 08 are pre-selected for the poster award. They will be presented in the Poster Teaser session on Wednesday, 8 June 2016, 11:55.
P 01 Subtrochanteric fracture in an adult female with osteogenesis imperfecta on long- term intravenous pamidronate therapy – a case of atypical femoral fracture?
Jose Monteiro (Torres Vedras/PT)
P 02 Blockade of NGF/TrkA signaling for treatment of fracture-related pain does not influence the healing outcome in mice
Anna Elise Rapp (Ulm/DE)
P 03 The lack of the collagen binding Integrin α2β1 leads to faster fracture healing due to increased matrix generation, faster differentiation and increased remodeling
Daniel Kronenberg (Münster/DE)
P 04 Optimised device configuration can reduce screw loosening risk in osteoporotic bone while maintaining fracture site stimulation
Hamish Simpson (Edinburgh/GB)
P 05 The lack of Syndecan-4 influences bone quality and healing dependent on inflamma- tory signals
Melanie Timmen (Münster/DE)
P 06 Impaired inflammatory responses after estrogen-deficient osteoporotic fracture injury Simon Kwoon-ho Chow (Hong Kong/CN)
P 07 Responsiveness of the Japanese versions of the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Oxford Knee Score (OKS) in patients with high tibial
osteotomy Sabine Goldhahn (Duebendorf/DH)
P 08 Outcome of posterior plating without anterior stabilization for vertically unstable sacral fractures using a new anatomical plate
Toru Matsugaki (Fukuoka/JP)
P 09 Function of the C5a complement receptor C5L2 in bone healing Stephanie Bergdolt (Ulm/DE)
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Poster Presentations
P 10 Notch sensitivity jeopardizes titanium locking plate fatigue strength Jinn Lin (Taipei/CN) P 11 Estrogen receptor expression in primary osteoblasts is not enhanced in vitro by low-magnitude high-frequency vibrational stimulation without estrogen supplement Simon Kwoon-ho Chow (Hong Kong/CN) P 12 Improving socket design of locking screw head to prevent stripping Jinn Lin (Taipei/CN) P 13 Osteoporotic distal forearm fractures – stabilization with an angle stable minimal invasive intramedullary Polymer Steffen Heck (Cologne/DE) P 14 Concomitant intra-articular glenohumeral injuries in displaced fractures of the lateral clavicle Marc Beirer (Munich/DE) P 15 Interfragmentary motion associated with common rat femur fixation devices under physiological loads Nicholaus Meyers (Ulm/DE) P 16 Assessment of bone mineral density from digital radiography of the distal radius Greg Robertson (Edinburgh/GB) P 17 Intramedullar polymer for rapid stabilization of pathological pelvic fractures Steffen Heck (Cologne/DE) P 18 A new animal model to investigate the influence of sarcopenia on osteoporotic fracture healing Ning Zhang (Hong Kong/CN)
P 19 Altered expression of SDF-1 and CXCR4 during fracture healing in diabetes mellitus Sang Yang Lee (Kobe/JP) P 20 Assessment of bone mineral density from digital radiography of the proximal femur Greg Robertson (Edinburgh/GB)
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Poster Presentations
P 21 Comparison between different methods for biomechanical assessment of ex vivo fracture callus stiffness in small animal bone healing studies1 Nicholaus Meyers (Ulm/DE)
P 22 Local delivery of cefazolin using calcium phosphate cement – an in vitro study Yu Kuroiwa (Kobe/JP) P 23 The treatment of intertrochanteric fractures using a new device Shirahama Masahiro (Kurume/JP) P 24 Locking plate as a definitive external fixator for treating open tibial shaft fractures Xu-Sheng Qiu (Nanjing/CN) P 25 Tension band wiring of the patella – Is it gold standard? Katie Baillie (Stockport/GB) P 26 Case Report – management of 5.5 cm bone defect following infected malunion of the distal tibia using Masquelet technique and bioglass void filling Marc Hanschen (Munich/DE) P 27 Local delivery of cefazolin and gentamycin using calcium phosphate cement: an in vitro study Takahiro Niikura (Kobe/JP) P 28 The radiographic union scale in tibial (RUST) fractures – reliability of the outcome measure from an independent centre Jun Min Leow (Edinburgh/GB) P 29 Mesenchymal Stem Cell-Derived Chondrocytes (MSCDCs) presented bone regeneration even in established atrophic nonunion in rat femur Yoshinobu Watanabe (Tokyo/JP) P 30 The quest for accurate patient-specific guides for distal radius osteotomy surgery Mauricio Toro (Medellin/CO) P 31 Enhancing the regeneration of bone defects by alkalizing the peri-implant zone: an in vitro approach Anne-Marie Galow (Rostock/DE)
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Poster Presentations
P 32 Role of Toll Like Receptor 3 and Toll Like Receptor 9 in cartilage homoeostasis during posttraumatic and degenerative osteoarthritis Josef Stolberg-Stolberg (Münster/DE)
P 33 Fracture of the femoral neck in a patient with osteogenesis imperfecta – a case report Benoit Maeder (Lausanne/CH) P 34 The role of dynamic contrast-enhanced MRI in a child with sport-induced avascular necrosis of the scaphoid – a case report and literature review Baris Koc (Sittard-Geleen/NL) P 35 Evaluation of a new imaging tool to accelerate identification of life threatening conditions in major trauma Chlodwig Kirchhoff (Munich/DE) P 36 Human adipose-derived stem cells in combination with a novel bioceramic scaffold for bone tissue engineering Oliver B. Betz (Munich/DE) P 37 Characterization of the time-dependent viscoelastic properties of distraction callus Nicholaus Meyers (Ulm/DE) P 38 Vitamin D insufficiency and deficiency in elderly patients with hip fracture Takahiro Niikura (Kobe/JP) P 39 Styloid first fixation then arthroscopic reduction technique for intra-articular distal radius fractures Shiro Yoshida (Kurume City, Fukuoka/JP) P 40 Pseudoaneurysm of the anterior tibial artery after interlocking tibial nailing: An unexpected complication Frederik Greve (Munich/DE) P 41 Inflammatory cell signature in healing cancellous and cortical bone Per Aspenberg (Linköping/SE) P 42 Biomechanical comparison of the use of bone substitute to prevent fractures after 10x10mm defect creation of distal radius volar cortex Leonieke van Heeswijk (Rotterdam/NL)
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Poster Presentations
P 43 Mid-term outcome following revision surgery of clavicular non- and malunion using anatomic locking compression plate and iliac crest bone graft Marc Beirer (Munich/DE)
P 44 Ostheosinthesys in paediatric Osteogenesis Imperfecta patients Alin Gabriel Sterian (Bucharest/RO) P 45 Targeting method based on ultrasonographic examination can improve bone union rate of delayed unions treated by low-intensity pulsed ultrasound Shota Harada (Fukushima/JP) P 46 BonAlive/Bioglas vs. Herafill/Gentamycine beads clinical outcome in treatment of osteomyelitis, antiseptic vs. antibiotic approach a battle between Lister and Flemming Frithjof Wagner (Murnau/DE) P 47 Structural peculiarities of m. quadriceps of femur in experimental rats in the conditions of femur deformity forming Kostiantyn Romanenko (Kharkiv/UA) P 48 Long gamma nails for unstable pertrochanteric fractures and subtrochanteric fractures Yoshinori Yasuhara (Suita/JP) P 49 Impact of the cholinergic system in implant assisted fracture healing Katrin Susanne Lips (Giessen/DE)
P 50 Case Report – bone reconstruction following bone loss of 18 cm following open fracture of the tibia using antibiotic eluting ceramic bone void filler Stefan Huber-Wagner (Munich/DE) P 51 Analysis of lateral malleolar length of the ankle joint Yukinobu Nishii (Kochi/JP)
P 52 Lithium enhances comminuted fracture healing in osteoporotic bone Vachhain Kathak (Toronto/CA)
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Index of Invited Speakers, Chairs and Presenting Abstract Authors
AAkens, Margarete 23Alt, Volker 7, 14, 16Aspenberg, Per 7, 29Augat, Peter 5, 6, 14
BBaillie, Katie 28Bates, Brent 15Beaton, Dorcas 7, 22, 24Beirer, Marc 27, 30Bergdolt, Stephanie 26Bernhardsson, Magnus 24Betz, Oliver B. 29Betz, Volker 15, 23Biberthaler, Peter 5, 7, 20, 22Bostrom, Mathias 6, 7, 16, 24Bottlang, Michael 7, 14, 18, 24Boyd, Jonathan 16Breier, Annette 16Bühren, Volker 7, 16, 18Bundkirchen, Katrin 20
CCarnegie, Carol A. 22Chenu, Chantal 6, 7, 24Chow, Simon Kwoon-ho 17, 26, 27Craveiro-Lopes, Nuno 16
DDienelt, Anke 19Duda, Georg 7, 14
EEbisuzaki, Kana 20
FFilipov, Orlin 25Font Tellado, Sònia 15
GGalow, Anne-Marie 28Giannoudis, Peter 7, 15, 19Goldhahn, Jörg 5, 6, 7, 19, 22, 25Goldhahn, Sabine 17, 26Goodship, Allen 7, 14, 22Greve, Frederik 29HHaffner-Luntzer, Melanie 19Hägele, Yvonne 19Hak, David 6, 7, 16, 18, 22Hanschen, Marc 28Harada, Shota 30 Haug, Alexander T. 20Heck, Steffen 18, 27Heidler, Verena 20Heinrichs, Christian 21Hoang-Kim, Amy 6, 7, 21, 25Huber-Wagner, Stefan 30
IIgnatius, Anita 7, 24
JJanko, Maren 15Johnstone, Alan 6, 7, 21
KKathak, Vachhain 30Khurana, Sonya 25Kirchhoff, Chlodwig 21, 22, 29Koc, Baris 29Kovtun, Anna 24Kronenberg, Daniel 17, 26Kroner, Jochen 22Kuroiwa, Yu 28LLackner, Janina 25Lee, Sang Yang 27Lenz, Mark 19
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Index of Invited Speakers, Chairs and Presenting Abstract Authors
Leow, Jun Min 28Leung, Kwok-Sui 7, 18Lin, Jinn 18, 27Lips, Katrin Susanne 30
MMaeder, Benoit 29Masahiro, Shirahama 28Matsugaki, Toru 17, 26Matsushita, Takashi 6, 7, 20Mauffrey, Cyril 6, 7, 24McNally, Donal 15Meesters, Dennis 20Meyers, Nicholaus 27, 28, 29Monteiro, Jose 16, 26
NNakamura, Yukiko 19, 24Niikura, Takahiro 25, 28, 29Nishii, Yukinobu 30
PPellegrini, Andrea 25Picke, Ann-Kristin 22Procter, Philip 7, 21Prystaz, Katja 23
QQin, Jianghui 21Qiu, Xu-sheng 28
RRabiner, Robert 16, 21Ramnaraign, David 24Rapp, Anna Elise 17, 26
Robertson, Greg 27Rocha, Tito 20Romanenko, Kostiantyn 30Rosado Balmayor, Elizabeth 19
SSandberg, Olof 16Sato, Kazuo 25Schieker, Matthias 14Schmidmaier, Gerhard 6, 15, 16Simon, Ulrich 14Simpson, Hamish 7, 14, 17, 19, 26Sterian, Alin Gabriel 30Stolberg-Stolberg, Josef 29
TTimmen, Melanie 17, 26Toro, Mauricio 24, 28Trivellin, Giacomo 21Tsang, Shao-Ting Jerry 20, 23
Vvan Heeswijk, Leonieke 18, 29van Lieshout, Esther 14Vauclair, Frederic 25von Rüden, Christian 20
WWagner, Frithjof 30Wähnert, Dirk 7, 18, 21Watanabe, Yoshinobu 6, 7, 19, 20, 28Wehrle, Esther 15Wildemann, Britt 15Winkler, Martin 18
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Index of Invited Speakers, Chairs and Presenting Abstract Authors
YYasuhara, Yoshinori 30Ye, Qing Kino 18Yoshida, Shiro 29
ZZhang, Ning 27Zubov, Dmytro 15
Did youKnow?
Conventus is the ProfessionalCongress Organiser for the15th Biennial Conference ISFR 2016
Erfahren Sie mehr über berührungslose Messtechnik für Ermüdungs versuche und Belastungstests sowie Verformungs- und Bewegungs analysen mit der kostenfreien GOM Testing Workshop CD sowie dem Anwendungs-Webinar.
Biomechanical Testingfür erhöhte Sicherheit, mehr Patientenkomfort und zuverlässigen Simulationsabgleich
Besuchen Sie die Webinar-Aufzeichnung zum Biomechanical Testing. Bestellen Sie zusätzlich die kostenlose CD zum GOM Testing Workshop via www.gom.com/de/events oder senden Sie eine E-Mail an [email protected].
Erfahren Sie mehr über berührungslose Messtechnik für Ermüdungs versuche und Belastungstests sowie Verformungs- und Bewegungs analysen mit der kostenfreien GOM Testing Workshop CD sowie dem Anwendungs-Webinar.
Biomechanical Testingfür erhöhte Sicherheit, mehr Patientenkomfort und zuverlässigen Simulationsabgleich
Besuchen Sie die Webinar-Aufzeichnung zum Biomechanical Testing. Bestellen Sie zusätzlich die kostenlose CD zum GOM Testing Workshop via www.gom.com/de/events oder senden Sie eine E-Mail an [email protected].
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