Controlled Release Society

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22000088

July 12-16, 2008

New York, New York, USA

Volume 1 of 3

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Copyright© (2008) by the Controlled Release Society. All rights reserved. For permission requests, please contact the Controlled Release Society at the address below. Controlled Release Society 3340 Pilot Knob Road St. Paul, Minnesota 55121

TABLE OF CONTENTS

Volume 1

Distinct Pharmacokinetic Performance of Biodegradable Microspheres of Hydrophilic Cefazolin with Different Release Characteristics ....................................................... 1

T. Zhu, J. Hong, J. Shah, D. Chow

Investigation of Rivastigmine Transport Through Human Colon Carsinoma Cells, Caco-2 .................................................................................................................................................. 3

B. Mutlu, Z. Degim, S. Yilmaz, D. Essiz, L. Altintas, G. Gunkaya

Design of the Semi-permeable Membrane for an Osmotic Drug Delivery System ...................... 5J. Yuan, N. Clipse, D. Dunn, R. Newton

Effects of Nano-hydroxyappatite on Poly (Lactide-co-Glycolide) Degradation as an In-situ Forming Implant ................................................................................................................. 7

M. Enayati, H. Mobedi, H. Mirzadeh, S. Hojjati-Emami

Formulation Optimization of a Controlled-Release Matrix System Utilizing Design of Experiment ...................................................................................................................................... 9

F-Y. Lin, F-H. Hsiao, Y-C. Changchien

Synergistic and Antagonistic Effects of Drugs and Ionic Salts on the Morphology and Functionality of the Gel Layer in HPMC Hydrophilic Matrices ............................................. 11

S. Pygall, P. Timmins, C. Melia

Translating Technology to Improve Global Health........................................................................ 13N. Bailey

Physicochemical Characterisation of a Solid Dispersion Containing a Poorly Water-soluble API ............................................................................................................................. 15

Y. Turner, C. Roberts, M. Davies, I. Weuts, S. Stokbroekx, F. Van Dycke, R. Leemans

Is Particle Size a Decisive Parameter for Nanoparticle Clearance from the Airways? ............................................................................................................................................ 17

A. Henning, M. Schneider, M. Bur, C-M. Lehr

Comparative Study of MPC and PEG for Protein Conjugation .................................................... 19A. Lewis, Y. Tang, S. Brocchini, J. Choi, A. Godwin

Drug Eluting Beads in the Treatment of Peritoneal Carcinomatosis .......................................... 21A. Lewis, C. Heaysman, Y. Tang, M. Keese, J. Lohr

Drug Eluting Beads in the Treatment of Glioma ............................................................................ 23A. Lewis, S. Baltes, T. Brinker

Preservation of the Active Lactone Form of Irinotecan Using Drug Eluting Beads .................. 25Y. Tang, P. Czuczman, S. Chung, A. Lewis

Anti-obesity Agents Based on Galegine......................................................................................... 27G. Coxon, S. Fogarty, B. Furman, D. Hardie, A. Harvey, S. Hawley, M. Mooney, R. Waigh

Develop a Methodology for an in Vitro-in Vivo Correlation (IVIVC) Model of Propranolol Extended-release Matrix Formulations ..................................................................... 29

H-L. Lee, Y-J. Lee, Y.H. Tsai, P-C Wu

PEG Microparticles Loaded with Diazepam Obtained by Particles from Gas Saturation Solution Technique: Production, Characterization and in Vitro Dissolution......................................................................................................................................... 31

I. Pasquali, L. Pezzini, R. Menabeni, R. Bettini

Biocompatibility and Biodegradation of PEG-based Fumarate Hydrogels for Gene delivery: in Vivo Studies ........................................................................................................ 33

M. Dadsetan, S. Ameenuddin, B. Currier, A. Windebank, M. Yaszemski

Bcl-2 Expression As a Proxy Redox Stimulus to Modulate Activity of Redox-sensitive Polyplexes ......................................................................................................................... 35

D. Manickam, D. Putt, S. Banerjee, F. Sarkar, L. Lash, D. Oupicky

Peg Based Micelles As Triggered System for Selective Targeting of Drugs.............................. 37S. Salmaso, F. Mastrotto, P. Caliceti

Polymeric Micelles for Amphotericin-B Delivery: A Comparative Study .................................... 39S. Salmaso, A. Brossa, S. Bersani, P. Caliceti

Thermosensitive Polymer Decorated Gold Nanoparticles As Switchable Delivery Systems ............................................................................................................................................. 41

S. Salmaso, P. Caliceti, V. Amendola, M. Meneghetti, G. Pasparakis, C. Alexander

Encapsulation and Release of an Insect Repellent (DEET) from a Starch-oil Microemulsion................................................................................................................................... 43

J. Wille, R. Toronyi

In Vitro Wound Healing Model for Drug Delivery Studies Into Sutured Surgical Incision............................................................................................................................................... 45

P. Kasha, C. Anderson, D. Ostrow, H-W. Hui, A. Banga

Nanoparticle with a Therapeutic Antisense Inhibit Restenosis in Rabbit Carotid Model .................................................................................................................................................. 47

J. Yang, Y. Zeng, Y. Li, C. Song

A Veterinary Delivery Odyssey - turned into a Story of Success by means of IVIVC ................................................................................................................................................... 49

C. Schmidt

Preliminary Evaluation of Glibenclamide Suppositories Based on Solidified Reverse Micellar Solution (SRMS) .................................................................................................. 51

A. Attama, O. Uchechi

Use of Carbohydrates in the Development of Synthetic Vaccines .............................................. 53P. Simerska, A-B. Abdel-Aal, Y. Fujita, W. Zhong, M. Batzloff, M. Good, I. Toth

Embryonic Stem Cells and Other Pluripotent Stem Cells as Versatile Tools for Biology, Cell Therapy and Drug Discovery .................................................................................... 55

N. Nakatsuji

PEGylated Oligonucleotide Duplexes and Their Self-assemblies with Polyamidoamine Dendrimers .......................................................................................................... 56

M. Elsabahy, M. Zhang, S-M. Gan, K. Waldron, J.C. Leroux

Leukotriene B4-loaded Microspheres: a New Therapeutic Strategy to Regulate Cell Activation ................................................................................................................................... 58

R. Nicolete, C. Rius, L. Piqueras, P-J. Jose, M-J. Sanz, L-H. Faccioli

Synthesis of Galactose-Poly(-caprolactone) and in Vivo Pharmacokinetic Study .................... 60W-J. Lin, K-L. Chang

Self-Assembling Hydrogels Formed by Beta-Cyclodextrin/Cholesterol Interactions ........................................................................................................................................ 62

F. van de. Manakker, M. van der. Pot, T. Vermonden, C. Van Nostrum, W. Hennink

Ligand-Targeted Delivery of Therapeutic and Imaging Agents to Pathologic Cells and Tissues ....................................................................................................................................... 64

S. Kularatne, W. Xia, W. Ayala-Lopez, B. Varghese, C-P. Leamon, I. Vlahov, C. Paulos

Evaluation of Recombinant Lysine-Histidine-FGF2 Analogues for Targeted Gene Transfer .............................................................................................................................................. 66

B. Canine, Y. Wang, A. Hatefi

Peritoneal Macrophage Depletion by Liposomal Alendronate Inhibits Implant Growth, Adhesions and Macrophage Infiltration in a Rat Model of Endometriosis .................. 68

E. Haber, N. Koroukhov, M. Schaghter, G. Golomb

Targeting Breast Cancer Cells via HER-2-mediated Endocytosis ............................................... 70S-C. Wuang, K-G. Neoh, E-T. Kang, D. Pack, D-E. Leckband

Tunable Delayed Release of Proteins with Polymer-Inorganic Composite Microspheres ..................................................................................................................................... 72

P. Pitukmanorom, J-Y. Ying

Cow Milk as Nutraceutical and Functional Food: Effect of Homogenization and Skimming on Lipid Globules Size Distribution .............................................................................. 74

M. Faustini, M. Bucco, A. Riccardi, C. Colombani, T. Chlapanidas, U. Conte, M. Torre, D. Vigo

Enhancing Dissolution of Poorly Water Soluble Drugs: Co-milling of Indomethacin and Ranitidine HCl Binary Mixtures ....................................................................... 76

N. Chieng, J. Aaltonen, D. Saville, T. Rades

Biorecognition of Lectin-immobilized Fluorescent Nanospheres with Surface Poly(N-vinylacetamide) Chains, against Various Human Colorectal Cancer Cells ................... 78

S. Sakuma, K. Hiwatari, T. Yano, Y. Masaoka, M. Kataoka, H. Tachikawa, Y. Shoji, R. Kimura, S. Yamashita

Exploring Changes in Early Gel Layer Formation and Drug Release from HPMC Matrices in the Presence of Dietary Sugars ................................................................................... 80

H.D. Williams, I.J. Hardy, R. Ward, C. Melia

Intestinal Absorption of Nanoparticulate Delivery System for Insulin........................................ 82B. Sarmento, D. Ferreira

The Interplay of Drug, Polymer, and Solvent Properties in the Release Characteristics of Phase Inversion ................................................................................................. 84

A-J. Mchugh, D. Ma

Permeation Enhancing and Mucoadhesive Properties of Chitosan-thioglycolic Acid Conjugates................................................................................................................................ 86

G. Perera, M. Greindl, A. Bernkop-Schnurch

Monodisperse Hydrogel Microparticles based on Crosslinked Hyperbranched Polyglycerol ....................................................................................................................................... 88

M. Oudshoorn, R. Penterman, R. Rissmann, J. Bouwstra, D-J. Broer, W. Hennink

Polymer-Drug Conjugates as Inhibitors of Cellular Apoptosis.................................................... 90M.J. Vincent, L. Mondragon, M. Orzaez, L. Dieudonne, A. Moure, A. Arminan, P. Sepulveda, L. Pen, I. Goicoechea, A. Alcaraz, A. Messeguer, E. Perez-Paya

Three Dimensional Co-culture of Nucleus Pulposus Cells and Adipose Stromal Vascular Fraction .............................................................................................................................. 92

T. Chlapanidas, P. Gaetani, F. Crovato, F. Caviggioli, M. Bucco, M. Faustini, P. Pisano, D. Levi, D. Vigo, M. Klinger, M. Marazzi, M. Torre

Adipose-derived Stem Cells for Regenerative Medicine: Yield of Stromal Vascular Fraction from Liposuction or Lumbar Resection .......................................................................... 94

M. Bucco, F. Caviggioli, P. Gaetani, F. Crovato, M. Faustini, T. Chlapanidas, V. Sansone, P. Pisano, D. Vigo, M. Marazzi, M. Klinger, M. Torre

Essential Fatty Acid Required for Healthy Skin............................................................................. 96P. Wertz

Development of a Biomimetic Vector for Targeted Gene Transfer.............................................. 98Y. Wang, B. Canine, A. Hatefi

Inventive Academics Can Make New Pharmaceuticals for Global Use..................................... 100S. Shaunak

Monitoring Sustained-release Film Coating Quality and Dissolution Using ............................ 101L. Ho, R. Muller, K. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P. Taday, J. Zeitler

Development of Novel Amphotericin B loaded Environment Sensitive Micelles for Treatment of Systemic.................................................................................................................... 103

T. Diezi, Y. Bae, G. Kwon

Pharmacokinetics of p(NIPAM-co-MAA-co-Acrylamide) as Excipients in Drug Delivery ............................................................................................................................................ 105

N. Bertrand, J.C. Leroux

Nanocarrier based on Polyelectrolyte Multilayers for Photodynamic Therapy........................ 107M. Schneider, N. Reum, K. Low, A. Wiehe, H. Briesen, C. Lehr

Liposomal Vasoactive Intestinal Peptide for Lung Application: Protection from Proteolytic Degradation.................................................................................................................. 109

B. Stark, F. Andreae, R. Prassl

Preparation and Evaluation of Paclitaxel/OK432-Eluting Silicone/Polyurethane Membrane for Bile Duct Stent........................................................................................................ 111

S.S. Hong, M. Kim, S. Jeong, J.H. Maeng, D. Lee

Investigating the Precorneal Residence Time of Ophthalmic In-situ Gelling Systems Using Gamma Scintigraphy ........................................................................................... 113

I.D. Rupenthal, C.R. Green, I.M. Hassan, M. Rutland, R. Alany

Antisense Oligonucleotide Loaded In-situ Gelling Systems for Improvement of the Corneal Wound Healing After Refractive Surgery ................................................................ 115

I.D. Rupenthal, C.R. Green, R. Alany

Thiolated Polycarbophil as an Adjuvant for Permeation Enhancement ................................... 117A. Vetter, R. Martien, A. Bernkop-Schnurch

Assessment of Suitability of Solid Lipid Nanoparticles (SLN) for Incorporation of Miconazole ....................................................................................................................................... 119

A. Silva, D. Santos, D. Ferreira, E. Souto

Bridging Polymer Chemistry, Polymer Physics, Biology and Medicine to Design Injectable.......................................................................................................................................... 121

P. Zawaneh, S. Singh, J. Spector, D. Putnam

Yeast-based Delivery System and Its Release Triggers ............................................................. 123G. Dardelle, V. Normand

Targeted Photothermal Ablation Effect of Hollow Gold Nanoshells in Tumor-bearing Mice .................................................................................................................................... 125

W. Lu, C. Xiong, G. Zhang, Q. Huang, R. Zhang, Z. Cheng, C. Li

Brain Cancer Therapy in Rats Using Tumor-suppressor Peptide, p53p-Ant............................ 127D. Kaneko, T. Ozeki , H. Okada

A Polymer Blend System for Lower Intestine-targeted Drug Delivery ...................................... 129T. Omura, M. Tauchi, Y. Inoue, M. Haratake

Adipose Stromal Vascular Fraction from Knee Hoffa's Body as Feed-Layer........................... 131F. Crovato, F. Mingotto, M. Bucco, T. Chlapanidas, F. Caviggioli, P. Gaetani, M. Faustini, D. Vigo, M. Klinger, M. Marazzi, M. Torre, V. Sansone

Analysis of Human Growth Hormone Structure Following Encapsulation Using Supercritical CO2............................................................................................................................. 133

C. Kelly, A. Lewis, A. Naylor, T. Gamble, L. Romero, P. Van Hooff, C. Upton, M. Whitaker, S. Howdle

Poly (ethyleneimine) Nanoprobes for Magnetic Resonance and Multiple Molecular Imaging ............................................................................................................................................ 135

M.A. Do, H. Lee, E. Oh, J.H. Yeum, H. Ghim, K. Jeon, H. Chung, Y. Jang, J. Choi

A Fast/slow Biphasic Delivery System for Ibuprofen Release ................................................... 137C. Lopes, P. Costa, J. Pinto, J.M. Lobo

Intranasal Delivery of Insulin Using a Microemulsion System .................................................. 139S. Botner, H. Levy, A. Sintov

pH-responsive Hydrogel for Delivery of VEGF ............................................................................ 141J. Garbern, P. Stayton, A. Hoffman

Microemulsion-based Nanoparticles Loaded with Insulin ......................................................... 143A. Graf, K. Jack, A. Whittaker, S. Hook, T. Rades

Human Fat as a Scaffold Material for Tissue Engineering ......................................................... 145J. Choi, H. Yang, Y. Park, Y. Yun, Y. Cho, H. Lee

The Influence of Degree of Esterification on In Situ Gelling Pectin Formulations .................. 147S. Miyazaki, K. Itoh, A. Takahashi, D. Attwood

Oligonuleotide Delivery into Liver using Dendritic Poly (L-lysine) ........................................... 149T. Niidome, Y. Sugao, K. Watanabe, T. Mori, Y. Katayama

Electrospun Core-sheath Ultrafine Fibers as Carriers for Protein Delivery System ............... 151Y. Yang, X. Li

Star-like Antibody-Targeted Polymer-Drug Conjugates ............................................................. 152T. Etrych, L. Kovar, M. Sirova, B. Rihova, K. Ulbrich

Improving Oral Bioavailability of Somatostatin Cylic Peptide Analogs by Multiple N-Methylation .................................................................................................................................. 154

O. Ovadia, E. Biron, J. Chatterjee, C. Gilon, H. Kessler, A. Hoffman

Structural Modifications Related to Temperature and Medium Influence in Vivo Efficiency of Amphiphilic ............................................................................................................... 156

C. Roques, K. Bouchemal, G. Ponchel, Y. Fromes, E. Fattal

In Vitro-In Vivo Correlation of Controlled Release HPMC Matrix Tablets: A Gamma Scintigraphic Study ........................................................................................................................ 158

M. Ghimire, S.M. Connolly, L.A. Hodges, J. Band, B. O'Mahony, A. Stanley, F. Mcinnes, A. Mullen, H. Stevens

Phospholipid – Decorated Microcapsules Used As Ultrasound Contrast Agent..................... 160R. Diaz-Lopez, N. Tsapis, V. Nicolas, D. Libong, P. Chaminade, E. Fattal

Solubilization and Release Patterns of Sodium Diclofenac into Monoolein/Ethanol/Water Delivery Systems ................................................................................ 162

R. Efrat, A. Aserin, N. Garti

Optimized Lipid Transfer Method for the Preparation of asymmetrical Membrane Vesicles ............................................................................................................................................ 164

M. Holzer, J. Momm, R. Schubert

Influence of Pharmaceutical Surfactants as Modulators of the Efflux Transporter P-glycoprotein ................................................................................................................................. 166

M. Leonhardt, U. Adam, S. Nagel, W. Weitschies

Cyclosporine Solid Lipid Nanoparticles: Evaluation of In-vivo Drug Release in Rabbit Eyes...................................................................................................................................... 168

E. Gokce, G. Sandri, S. Egrilmez, M. Bonferoni, T. Guneri, C. Caramella

Preparation and Characterization of Ibuprofen Self-Emulsified Drug Delivery System (IBSEDDS) to Enhance Solubility and Dissolution ........................................................ 170

A. Zaghloul, A. Nada, I. Khattab, S. Al-Saidan

Preparation, Characterization, and Aerosolisation Studies Of Optimized Poly (D, L- Lactide) Microspheres for Pulmonary Delivery ........................................................ 172

X. Song, P. Seville, Y. Perrie

Active Targeting of Liposomes with the B-chain of Mistletoe Lectin I...................................... 174V. Bunjes, K. Winkler, R. Peschka-Suess, R. Schubert

COHOGM – A novel Membrane Anchor Molecule for the Preparation of Membrane Skeleton Liposomes ....................................................................................................................... 176

C. Zimmer, E. Breitling, M. Muller, A. Neub, R. Schubert

Dodecaborate Cluster Lipids in Liposome Preparations for Use in Boron Neutron Capture Therapy.............................................................................................................................. 178

A. Burghardt, T. Schaffran, D. Gabel, R. Peschka-Suess, R. Schubert

Development and Scale-Up Considerations for Novel Solvent Free Injection Molding Delivery Systems ............................................................................................................. 180

S.P. Li, D. Lee, D. Wynn, H. Sowden, F. Bunick, G. Mcnally

Formulation Development of Nano-Liposomes for Sustained and Targeted Dermal Delivery ............................................................................................................................... 182

M. Madan, A. Bajaj, N. Amrutiya

Synthesis of a Novel Fluorescent Transglutaminase Inhibitor for Controlled Release from Catheters and Other Implant Devices ................................................................... 184

N. Daneshpour, R. Colligan, Y. Perrie, A. Mongeot, D. Rathbone, P. Lambert, M. Griffin

Introducing a Novel Thiolated Chitosan ....................................................................................... 186G. Millotti, H. Hoyer, A. Bernkop-Schnurch

Transferrin Coupled Liposomes for Brain Targeting of 5-Florouracil....................................... 188A. Jain, V. soni, S. Jain

Increased Intestinal Permeability Induced by the Antimicrobial ............................................... 190S. Maher, X. Wang, V. Bzik, S. Mclean, D. Brayden

Comparison of Three in Vitro Intestinal Mucosa Diffusion Systems ........................................ 192V. Bzik, D. Brayden

Influence of the Hydration Kinetics and the Viscosity Balance on the Drug Release Performance of Push-pull Osmotic Systems ................................................................ 194

V. Malaterre, H. Metz, J. Ogorka, K. Mader, R. Gurny, N. Loggia

A Pharmacoscintigraphic Study to Assess the Performance of Novel Gastroretentive................................................................................................................................ 196

V.E. Cowles, S.Y.E. Hou, R. Fell, T. Gordi, R. Gu, P. Evans, A. Church, A. Connor, I. Wilding, B. Berner

Delivery of Foreign Antigen Vaccines by Recombinant Outer Membrane Vesicles ................ 198D. Chen, S. Metzger, N. Osterrieder, D. Putnam

Bio-inspired Symmetrical Lipids for Controlled Drug Delivery.................................................. 200S. Yazdi, D. Putnam

In Vivo Delivery of anti-kITENIN siRNA Complexed with Biodegradable PEI-alt-PEG Suppressed Colon Carcinorma Established Subcutaneously in Mice ............................. 202

K. Kim, D. Jere, C.S. Cho, I. Chung

Investigation of the Effect of Microsphere Size and PLGA Molecular Weight on the Internal pH of Degrading PLGA Microspheres ...................................................................... 204

K. Stovall, D. Pack

Synthesis and Characterization of Hyperbranched Poly (amido amine)s for Gene Delivery ............................................................................................................................................ 206

Y.Z. You, J. Chen, D. Manickam, Q.H. Zhou, L. Wan, G. Mao, D. Oupicky

In Vivo Whole Body Imaging with a New Lipid Core Micelle-based Near Infrared Imaging Agent ................................................................................................................................. 208

A. Papaqiannaros, A. Kale, D. Chovatia, T. Levchenko, W. Hartner, D. Mongayt, V. Torchilin

JNK1 as a Molecular Target to Limit Cellular Damage Under Hypoxia ..................................... 210S. Betigeri, O. Garbuzenko, T. Minko

Hyaluronic Acid-Paclitaxel Conjugate Micelles: Synthesis, Characterization, and Anti-tumor Activity.......................................................................................................................... 212

H. Lee, T. Park

Development of an Anti-thrombogenic Drug Eluting Stent: Combinational Drug Approach ......................................................................................................................................... 214

K. Vedantham, I.K. Kwon, S. Kim, K. Park

Molecular Weight Effect and Potential as a Gene Carrier of Chitosan Oligosaccharides and Low Molecular Weight Water Soluble Chitosan.................................... 216

M.K. Jang, D. Kim, J.W. Nah

Reducible r9 Polyplex Enhances Gene Expression .................................................................... 218Y.W. Won, S.J. Lee, M.H. Lee, Y. Kim

All-Trans Retinoic Acid Release from Ion Complex Polymeric Micelles of Methoxy Poly (Ethylene Glycol)-Grafted-Chitosan ..................................................................................... 220

M.K. Jang, D. Kim, C.N. Jeong, Y. Park, J.W. Nah

Design of Magnetic Resonance Imaging Contrast Agent for Angiogenic Therapy ................. 222J.I. Jo, L. Xue, I. Aoki, Y. Tabata

A Novel Functional Scaffold Combined with Controlled Release of Bone Morphogenetic Protein Enhances Stem Cell-based Regeneration After Radiation Therapy: an Experimental Study in Rabbits................................................................................. 224

M. Yamamoto, A.Hokugo, Y. Takahashi, Y. Tabata

Preparation of Sustained Release Granules containing Highly Water Soluble Drug and Evaluation of Tolerance to Mechanical Stress in Gastrointestinal Tract .......................... 226

Y. Yaqinuma, N. Yoshida

Rapid Screening of Drug Release and Penetration into Stratum Corneum Membrane ........................................................................................................................................ 228

E. Stelmach, J. Lenn, V. Wirth, R. Buchta, H. Hofland

Receptor Targeted Polymers, Dendrimers, Liposomes: Which Nanocarrier is the Most Effective For Tumor Specific Treatment and Imaging?..................................................... 230

M. Saad, O. Garbuzenko, E. Ber, P. Chandna, J. Khandare, V. Pozharov, T. Minko

Evaluation of Phototoxicity Induced by Hydroxycinnamic Acid Upon UVA Exposure .......................................................................................................................................... 232

P. Batheja, R. Sivalenka, P. Wu, N. Dayan, B. Michniak

In Vivo Delivery of Bio-nanocapsules Displaying L4-PHA Isolectin to Malignant Tumors Overexpressing N-Acetylglucosaminyltransferase V ................................................... 234

T. Kasuya, J. Jung, H. Kadoya, T. Matsuzaki, K. Tatematsu, T. Okajima, E. Miyoshi, K. Tanizawa, S. Kuroda

Influence of Size, Charge, Shape, and Route of Liposomes Administration on Their Cellular Uptake, Tumor and Organ Distribution in Mice ................................................... 236

O. Garbuzenko, M. Zhang, M. Saad, S. Betigeri, E. Ber, T. Minko

Formulation Development Intended for Increasing Compliance and Improving the Hardness and the Friability of Tablets Containing Valacyclovir................................................ 238

H.G. Shin, H.C. Chang, M.S. Lee, S. Choi

Delivery of Interleukin 18-encoding Plasmid DNA to Lung Cancer Cells using Cationic Emulsion........................................................................................................................... 240

H. Kang, S.J. Jin, J.K. Kim, S. Hwang, J.S. Park

Development and in Vitro Evaluation of Novel Gastroretentive Sustained Release Tablet Formulation of Norfloxacin ................................................................................................ 242

P.D. Mair, N.S. Kulkami, N.S. Ranpise, M.V. Gaikwad

Improved Dermal Delivery of Lipophilic Agents from Nanoparticle Encapsulated Emulsions ........................................................................................................................................ 244

N. Eskandar, S. Simovic, C. Prestidge

pH-Responsive Anionic Hydrogel Microparticles for Intelligent Drug Delivery System ............................................................................................................................................. 246

Y. Shin, S. Lee, K. Kim, W. Ryoo, B. Kim

Pharmacokinetic and Pharmacodynamic Study of Biadhesive Transdermal Formulation ..................................................................................................................................... 248

S. Amin, S. Mir, K. Kohli, R. Khar, K. Pillai

Preparation and Properties of Inhalable Nanocomposite Particles for Treatment of Lung Cancer................................................................................................................................ 250

K. Tomoda, K. Hirota, H. Terada, T. Nakajima, G. Sonavane, K. Makino

Gene Transcription is Regulated by the Motility of DNA Strand, but not by Extent of DNA Compaction ........................................................................................................................ 252

Y. Katayama, Y. Sato, K. Terada, T. Niidome, T. Mori

Microspheres for Controlled Release of Biopharmaceuticals Prepared via S/O/W Emulsion .......................................................................................................................................... 254

Y. Kakizawa, J. Michizoe, R. Nishio, M. Koiwa, M. Nukiwa, N. Ida

Comparison of In-vitro, In-vivo Data by Different Granulation Method in a Matrix Controlled-Release System ........................................................................................................... 256

Y.L. Wang, W.T. Huang, Y.C. Changchien

Development of a Transdermal Patch of Pentazocine: In Vitro Evaluation Across Hairless Mouse Skin ....................................................................................................................... 258

T. Furuishi, T. Io, T. Fukami, T. Suzuki, K. Tomono

Sustained Release with Ibuprofen Eluting Microspheres: in Vivo Quantification with Infrared Microspectroscopy .................................................................................................. 260

J.Namur, M. Wassef, J.P. Pelage, A. Lewis, M. Manfait, A. Laurent

Nerve Conduits Releasing Two Different Neurotrophic Factors ............................................... 262S. Madduri, M. Papaloizos, B. Gander

Improved Absorption of Salmon Calcitonin from Rat Small Intestine in Vivo with Sodium Caprate and a Mucolytic (n-acetyl-cysteine).................................................................. 264

X. Wang, M. Tambuwala, D. Brayden

Immobilized Trypsin for in Vivo Detection of Gastric A1-antitrypsin ........................................ 266E. Khazanov, N. Emmanuel, A. Azab, E. Yavin, Y. Barenholz, A. Rubinstein

Doxorubicin Eluting Beads for Liver Embolisation: Pathological Findings and Correlation with Drug Distribution in Tissue ............................................................................... 268

J. Namur, M. Wassef, J.M. Millot, A. Lewis, M. Manfait, A. Laurent

Controlled Release Formulation of Tamsulosin HCl using EUDRAMODETM Technology ...................................................................................................................................... 270

S. Mohite, A. Samel, S. Bodinge, H. Ravishankar, B. Broegmann, U. Loeffler, K. Glaenzer

Effects of Unfocused Shock Wave Stimulation on Human Microvascular Endothelial Cell Line HMEC-1 ........................................................................................................ 272

M.C. D'Agostino, C. Bonora, E. Ungaro, M. Faustini, T. Chlapanidas, F. Crovato, M. Bucco, D. Vigo, P. Gaetani, M. Marazzi, M. Klinger, V. Sansone, M. Torre

Influence of the Components of Polymer Film on Mechanical Properties Influence of the Components of Polymer Film on Mechanical Properties ................................................ 274

R. Tunio, W. Sawicki

The Effect of Simulated Intestinal Fluid on the Stability and Efficacy of a Novel Cyclodextrin Gene Delivery Vector ............................................................................................... 276

M. O'Neil, M. Walsh, C. Byrne, R. Darcy, C. O'Driscoll

Enhanced Drug Skin Penetration and Intracellular Delivery for Topical Basal Cell Carcinoma Therapy......................................................................................................................... 278

D. Ainbinder, E. Touitou

Investigation of the Absorption Enhancing Effect of Ethanol in Rats ...................................... 280X. Wang, M. Tambuwala, D. Brayden

Buspirone Transdermal Delivery in Rats from Ethosomes ........................................................ 282M. Shumilov, E. Touitou

Transferrin Appended Long Circulating Nanoparticles for Brain Targeting ............................ 284A. Jain, S. Jain

Synergistic UV Protection Efficacy of NLC Loaded with Ternary Sunscreen Mixture ............................................................................................................................................. 286

M. Joshi, S. Nikolic, R.H. Muller

Physicochemical Characteristic of Lyophilized Coenzyme Q10 Nanocrystals........................ 288R. Mauludin, A. Hommoss, J. Knauer, R.H. Muller

Dissolution Velocity of Coenzyme Q10 Nanocrystal-Loaded Capsules ................................... 290R. Mauludin, S. Kobierski, J. Knauer, R.H. Muller

Ultrasound: An Effective Tool for Controlling the Release of Drugs from PEGylated Liposomes .................................................................................................................... 292

A. Schroeder, R. Honen, M. Brandl, A. Gabizon, Y. Barenholz, J. Kost

Microsphere-Adjuvant Combinations to Improve Tuberculosis Vaccine Efficacy .................. 294D. Kirby, V. Bramwell, Y. Perrie

Enhanced Delivery of Doxorubicin to Cancer Cells Via Folate Coupled Liposomes .............. 296Y. Gupta, A. Jain, S. Jain

Tween 80 Affects the Released Rate of Lipid-based Microemulsion with Entrapped Curcumin....................................................................................................................... 298

H.Y. Lin, J. Thomas, C.C. Lin, H.C. Chen, M.H. Lee

Human Plasma Levels of Quercetin Following Oral Administration ......................................... 300D. Kaushik, K. O'Fallon, P. Clarkson, B. Michniak-Kohn

Automated Controlled Release Multiple Layer Coating.............................................................. 302D. Chinta, R. Graves, S. Pamujula, T. Mandal

Pegylated PLGA Nanoparticles for Cellular Drug Delivery......................................................... 304S. Pamujula, S. Hazari, G. Bolden, R. Graves, D. Chinta, S. Dash, V. Kishore, T. Mandal

Engineered Nanoparticles Using High Pressure Homogenization ............................................ 306R. Graves, S. Pamujula, D. Chinta, L. Bostanian, T. Mandal

Enteric HPMC Capsules: Formulation and in Vitro Performance .............................................. 308A. Smith, Y. Perrie

Stability of BCG Loaded Alginate Beads...................................................................................... 310A. Smith, H. Batchelor, Y. Perrie

Sodium Alginate Drug Delivery Films........................................................................................... 312S. Skulason, T. Kristmundsdottir, J. Thrainsson

Role of a Novel Excipient Poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in Delivery of Lysozyme from PLGA Microspheres .................................... 314

A. Taluja, Y. Bae

Formulation and Stability Aspects of Gas-Filled Liposomes: An Effective Aid To Extract Earth’s Oil?......................................................................................................................... 316

A. Vangala, R. Morris, M. Bencsik, Y. Perrie

Controlled Release Formulation of Liposomal Tea Tree Oil ...................................................... 318U. Bhujbal, M. Kenward, C. Martin

Development of Glucose Oxidase Encapsulated Microspheres against Multidrug Resistant Breast Cancer Cells ....................................................................................................... 320

J. Cheng, Q. Liu, A. Rauth, X. Wu

P.L.E.A.S.E.®: a Promising Tool for Intraepidermal Drug Delivery ........................................... 322Y.G. Bachhav, S. Summer, A. Heinrich, T. Bragagna, C. Bohler, Y.N. Kalia

Effect of Epidermal and Dermal Tissue on Triptorelin Stability in Solution and the Impact of P.L.E.A.S.E.® Treatment on Its Permeation Kinetics Across Porcine Skin in Vitro ..................................................................................................................................... 324

Y.G. Bachhav, S. Summer, A. Heinrich, T. Bragagna, C. Bohler, Y.N. Kalia

Trans-ungual Iontophoretic Delivery of Terbinafine Hydrochloride.......................................... 326A.B. Nair, H. Kim, P. Friden, J. Singh, M. Zaman, A. Gupta, S.N. Murthy

Taste Masking of Sodium Chloride in Beverages Using Nanolipidic Particle Technology ...................................................................................................................................... 328

M. Fountain, K.M. Miller, S.F. Staggs, G.M. Santalucia, G. Delaportas

Influence of Voltage Application on Electrophoretic Transdermal Delivery of Fentanyl ........................................................................................................................................... 330

B. Schroder, E. Meyer, U. Nickel, G. Lee

Effect of Particle Size of Mannitol on Polymethacrylate Matrices Prepared by Direct Compression ........................................................................................................................ 332

L. Chatteriee, A.K. Baier, T. Rades, I. Tucker

Characterisation, Swelling and Release from Liquid Crystalline Systems of Phytantriol and Glycerylmonooleate As Platforms for Controlled Release of Bioactives ........................................................................................................................................ 334

S.B. Rizwan, B.J. Boyd, T. Rades, S. Hook

In-vitro Activity of Phytantriol Cubosomes Containing the Adjuvants Imiquimod or Monophosphoryl Lipid A in Bone Marrow Derived Dendritic Cells ...................................... 336

S.B. Rizwan, W. McBurney, B.J. Boyd, T. Rades, S. Hook

In Vivo Investigation of a Thermosensitive Chitosan Hydrogel as a Sustained Release Vaccine Delivery System ................................................................................................. 338

S. Gordon, A. Saupe, W. McBurney, T. Hennessy, T. Rades, S. Hook

In Vitro Transdermal Delivery of Penbutolol Sulfate ................................................................... 340K. Ita, A. Banga

Thermo-sensitive Radiopaque Copolymers for Embolization ................................................... 342B. Lee, C. Leon, M. Preul, B. Vernon

Direct Detection of Absolute Protein Content and Drug Release of Plga-nanoparticles by Spectrophotometry and Fluorimetry............................................................... 344

M. Holzer, T. Pisternick, V. Vogel, K. Langer

Novel Combination of Monocaprin and Doxycycline in Treatment of Cold Sores................... 346S. Skulason, T. Kristmundsdottir, W.P. Holbrook, H. Thormar

Enhanced Targeted Tumorotoxicity and Reduced Cardiotoxicity with Bispecific Antibody-Polymer-Prodrug Complexes: In Vitro Studies with BT-20 Human Breast Carcinoma and Embryonic Cardiocytes....................................................................................... 348

K. Gada, V. Patil, B.A. Khaw

Evaluation of Therapeutic Efficacy and Adriamycin Distribution Encapsulated in Polymeric Micelles by Convection-enhanced Delivery............................................................... 350

M. Nishihara, T. Inoue, Y. Yamashita, S. Sugiyama, Y. Sonoda, T. Kumabe, T. Tominaga, M. Yokoyama

Development of a Recombinant Non-viral Vector for Targeted Breast Cancer Gene Therapy .................................................................................................................................. 352

S.S. Mangipudi, A. Hatefi

Research and Development Focuses on Drug-eluting Stents in Post-LST Era ....................... 354J.Z. Zhao

siRNA Delivery to the Metastatic Tumor....................................................................................... 355S. Li, S. Chono, L. Huang

In Vitro Determination of Gastrointestinal Mucoadhesion Formulations ................................. 357S. Jang, J.T. McConville

Effect of Tapping Massage using Micro-Fibers on Transdermal Delivery................................ 359E. An, J. Shim, J. Lee, Y. Kim, B. Kim, J. Kim

Use of Capmul MCM as a Skin Penetration Enhancer: Influence of Capmul Concentration and Vehicle............................................................................................................. 361

L. Lopes, A. Nornoo

Development of a Canine Gastric Emptying Model for Evaluation of Prokinetic Agents .............................................................................................................................................. 363

L.A. Hodges, F. McInnes, V. Lewis, E. Engmann, W. Speed, N.J. Clear, C.G. Wilson, H. Stevens

Responsiveness of Glial Cells to Metallic Nanoparticles ........................................................... 365D. Maysinger

Ultrasonic Disruption of Pluronic F127 Coated Liposomes ....................................................... 367M.H. Lee, S.Y. Yang, J. Thomas, H.Y. Lin

Organoleptically Appealing Immediate Release EUDRAGIT® Coatings................................... 369A. Samel, P. Haksar, J. Iyer-Chavan, H. Ravishankar, T. Morita

Preparation and Characterization of Liposomes Coated with Thiolated Poly (acrylic Acid) for Oral Drug Delivery ............................................................................................. 371

M. Werle, H. Takeuchi

Preparation and Characterization of Drug-in-Adhesive Type Patches Containing Meloxicam ........................................................................................................................................ 373

Y. Ah, Y. Choi, J. Choi, H. Kim, J. Bae

Characterization of Acyclovir Skin Depot Following Iontophoretic Delivery in Vivo .............. 375S. Siddoju, P. Friden, A. Banga

Poly (epsilon-caprolactone)-Polyglycidol Hyperbranched Conjugates .................................... 377L. Wang, X. Li, C. Song

Formulation and Evaluation of Liposomal Drug Delivery System for L-Asparaginase................................................................................................................................... 379

M. Senthil, D. Venkatesh, K. Gowthmarajan, M.K. Samanta, B. Suresh

Comparison of Molecular Weight, Intrinsic Viscosity, Zeta Potential and Antibacterial Activities of Five Alkylated Chitosan Derivatives................................................. 381

A.M.M. Sadeghi, M.X. Weinhold, M.R. Avadi, M. Rafiee-Tehrani, H. Junginger

Generation of CTLs Capable of Targeting and Injuring Tumor Vessels for Adoptive Immunotherapy............................................................................................................... 383

N. Kanagawa, T. Yanagawa, Y. Mukai, Y. Yoshioka, N. Okada, S. Nakagawa

Anti-CD20 – Hpma Copolymer Conjugate Radiopharmaceuticals ............................................ 385V. Subr, M. Hruby, K. Kynclova, L. Kronrad, K. Ulbrich

Design and Evaluation of Drug-in-Adhesive Fentanyl Transdermal Bioequivalent Therapeutic System ........................................................................................................................ 387

G. Goyal, P. Vavia

A Novel Spermine-based Reductable Carrier for Gene Expression and Silencing Studies in Lung Cancer .................................................................................................................. 389

D. Jere, J.E. Kim, M.H. Cho, C.S. Cho

Surface Plasma Resonance Analysis for Binding Affinity Assessment of Anti-VEGF 2’-OMe-RNA Aptamer before and after PEGylation .......................................................... 391

K. Kim, H. Kang, E. Oh, J.K. Park, S. Hahn

Polypeptide-based Polymersomes as Biomimetic Nano-carriers ............................................. 393W. Agut, C. Sanson, D. Taton, A. Soum, C. Schatz, J.F. Le Meins, S. Lecommandoux

HIV-Tat Analog-modified Mpeg-PCL Diblock Copolymeric Nanoparticles As a Non-viral Gene Vector .................................................................................................................... 395

T. Kanazawa, Y. Shibata, K. Sakurai, Y. Takashima, H. Okada

Target Specific Intracellular Delivery of siRNA Complexed with PEI-HA Conjugate............... 397S. Hahn, G. Jiang, K. Park, J. Kim, K. Kim

Supramolecular Control of pDNA Delivery to Cell Nuclei and Translation: Efficacy of Amine Groups on Biocleavable Polyrotaxanes....................................................................... 399

A. Yamashita, D. Kanada, R. Katoono, N. Yui, T. Ooya, A. Maruyama, H. Akita, H. Harashima

Carrier-based Radiochemotherapy ............................................................................................... 401T. Lammers, V. Subr, K. Ulbrich, P. Peschke, F. Kiessling, P. Huber, W. Hennink, G. Storm

Camptothecin-loaded Solid Lipid Nanoparticles for Brain Delivery.......................................... 403S. Martins, D. Ferreira, E. Souto, M. Brandl

Biodistribution Study of Nanoparticle-bound Rifabutin ............................................................. 405S. Gelperina, A. Bud'ko, O. Maksimenko, L. Vanchugova, E. Shipulo, A. Ivanov, J. Kreuter

Transcutaneous Immunization with Diphtheria Toxoid-loaded Elastic Vesicle Formulations following................................................................................................................... 407

Z. Ding, S. Romejin, H. Hirschberg, G. Kersten, M. Bivas-Benita, W. Jiskoot, J. Bouwstra

Accurate GI targeting with EUDRAGIT® FS 30 D / L 30 D - 55 mixtures ................................... 409M. Assmus, T. Dassinger, G. Galayo, B. Skalsky

Some HPMA Conjugates do not Need Calreticulin to Evoke Anti-tumor Resistance ....................................................................................................................................... 411

L. Kovar, T. Etrych, J. Strohalm, D. Plocova, K. Ulbrich, B. Rihova

Controlled Iontophoretic Delivery of 5-OH-DPAT for the Treatment of Parkinson’s Disease............................................................................................................................................. 413

O. Ackaert, J. Van Smeden, J. De Graan, D. Dijkstra, M. Danhof, J. Bouwstra

Co-iontophoresis of Dexamethasone Sodium Phosphate, Granisetron and Metoclopramide for Treating Chemotherapy Induced Nausea and Vomiting .......................... 415

J. Cazares-Delgadillo, A. Ganem-Rondero, D. Quintanar-Guerrero, Y.N. Kalia

The Effect of HPMA Drug Based Therapy on the Local Tumor Microenvironment ................. 417O. Hovorka, D. Vetvicka, R. Joskova, E. Baumgartnerova, K. Ulbrich, B. Rihova

Depot Formulation of Vasoactive Intestinal Peptide by Protamine-Oligonucleotide Nanoparticles .................................................................................................................................. 419

K. Wernig, M. Griesbacher, F. Andreae, W. Mosgoeller, J. Wagner, A. Zimmer

Iontophoretic Delivery of Dexamethasone Sodium Phosphate Across Porcine Skin in Vitro ..................................................................................................................................... 421

J. Cazares-Delgadillo, A. Ganem-Rondero, D. Quintanar-Guerrero, Y.N. Kalia

Gamma Sterilisation of Non-Viral Transfection Agents.............................................................. 423S. McNeil, A. Mohammed, Y. Perrie

In Vivo Comparison of the Inhibitory Effect of Thiolated Poly (acrylic Acid) of Various Molecular Masses and Various Concentrations on Intestinal MRP2 Efflux Pumps .............................................................................................................................................. 425

J. Hombach, M. Greindl, A. Bernkop-Schnurch

Synthesis and In Vitro Characterization of a Novel Poly (acrylic acid)-4-Aminothiophenol Conjugate .......................................................................................................... 427

D. Sakloetsakun, H. Hoyer, A. Bernkop-Schnurch

Studies on Insitu Hydrogel – A Smart Way for Safe and Sustained Ocular Drug Delivery ............................................................................................................................................ 429

D. Shastri, L.D. Patel

Self-assembly of Recombinant Oligopeptide Into Vesicles ....................................................... 431A. Van Hell, W. Jiskoot, D. Crommelin, W. Hennink, E. Mastrobattista

Co-encapsulation of Proteins and Magnetic Particles in Biocompatible Polymer Nanoparticles .................................................................................................................................. 433

J.D. Garza, C. Schatz, S. Lecommandoux

Nanosizing Indomethacin by Wet Ball-Milling Technique – An Efficient Method to Improve the Solubility Properties of the Poorly Soluble NSAID ................................................ 435

R. Kettunen, L. Peltonen, M. Karjalainen, J. Hirvonen

Effect of Water Soluble Carriers on the Dissolution and Physical Stability of Meloxicam Solid dispersions......................................................................................................... 437

L. Emara, R. Badr

Preparation and Evaluation of Nanosuspensions from Thiolated Polymers via High Pressure Homogenization..................................................................................................... 439

W. Schlocker, H. Hoyer, A. Bernkop-Schnurch

Modification of the Tumor Microenvironment by a Plasmid Encoding an Antiangiogenic Factor .................................................................................................................... 441

N. Crokart, N. Goncalves, L. Daugimont, F. Danhier, B. Ucacar, B. Jordan, V. Gregoire, O. Feron, B. Gallez, V. Preat

Simple and Reproducible Ion-pair HPLC Assay for Determination of SN-38 in Nanoparticles .................................................................................................................................. 443

P. Ebrahimnejad, F. Atyabi, A. Sajadi, M.R. Jaafari, R. Dinarvand

Preparation and Characterization of a Poly Lactide-co-glycolydes .......................................... 445P. Ebrahimnejad, S. Sajadi, M.R. Jafari, F. Atyabi, F. Ramezani, R. Dinarvand

Analysis of Drug Pharmacokinetics and Pharmacodynamics by PET Imaging: Novel Method for the Development of Nanocarrier-related Drugs ............................................ 446

Y. Katayama, T. Urakami, S. Akira, A. Kawaguchi, N. Harada, H. Ysukada, N. Oku

Development of Nano-sized PICsomes and Evaluation of Their Properties ............................ 448Y. Anraku, A. Kishimura, Y. Yamasaki, K. Kataoka

Engineering Electrospun Silk Scaffolds with Dual Drug Gradients .......................................... 450A. Wandrey, V. Vogel, H. Merkle, L. Meinel

Flow Cytometry for Counting, Sizing and Sorting of Nanoparticles in Biological Fluids................................................................................................................................................ 452

E. Van Gaal, R. Hulikunta, W. Hennink, D. Crommelin

Enhanced Intestinal Delivery and Stability Both in Vivo and in Vitro of Site Specific PEGylation of Salmon Calcitonin to Different Molecular Sizes of Polypeg®.......................................................................................................................................... 454

S. Ryan, X. Wang, G. Mantovani, D. Haddleton, D. Brayden

Anti-tumor Immunity in Mice Following the Treatment with HPMA-based Copolymer Conjugate of Doxorubicin .......................................................................................... 456

M. Sirova, J. Strohalm, V. Subr, D. Plocova, K. Ulbrich, B. Rihova

Polymer-Coiled-Coil Therapeutics as Molecular Switches: Towards New Treatments for the Zaire Ebola Virus ............................................................................................ 458

S. Deacon, B. Apostolovic, H.A. Klok, R. Duncan

Intracellular Delivery of Doxorubicin to Tumor Cells Through the M6P/IGFII Receptor: a Novel Strategy to Target Cancer Cells..................................................................... 460

J. Prakash, A. Harapanahalli, M. Zeinstra-Smith, L. Beljaars, K. Poelstra

Determination of Drug Release and Distribution from Drug-eluting Stents Employing a Novel Dissolution Test Method ............................................................................... 462

A. Neubert, S. Nagel, K. Stemberg, W. Weitschies

Polymer Microsphere Particle Standards Containing High Explosives .................................... 464M. Staymates, R. Fletcher, J. Verkouteren, J. Coleman, C. Berkland, G. Gillen

Alginate Based Beads for Controlled Release of Levobupivacaine Base ................................ 466C. Blackshields, E. Conway, A. Crean

Ex vivo Evaluation of Natural and Methylated Cyclodextrins as Buccal Permeation Enhancers for Omeprazole Delivery ........................................................................ 468

A. Figueiras, J. Hombach, F. Veiga, A. Bernkop-Schnurch

Effect of Nanoparticle Characteristics on Interaction with Endothelial Model Cell Membrane ........................................................................................................................................ 470

C. Peetla, V. Labhasetwar

Enhancing the Intracellular Release of siRNA with Biodegradable Poly (Ethylene Imine) as Carrier System ................................................................................................................ 472

M. Breunig, C. Hozsa, U. Lungwitz, A. Goepferich

Smart Hybrid Magnetic Self-Assembled Polymer Vesicles ........................................................ 474S. Lecommandoux, O. Sandre, R. Perzynski

pH-Responsive Micelles and Vesicles Based on Polypeptide Diblock Copolymers ............... 476S. Lecommandoux, F. Checot, J. Babin

Development of a Novel Caco-2 based 3D model of the Inflamed Intestinal Mucosa: Initiation of Inflammation................................................................................................ 478

F. Leonard, E.M. Collnot, C. Lehr

Biopharmaceutical Characterisation of Melt-Extrudates Using the Caco-2-Cell-Model: Cytotoxicity and Permeability Screening ........................................................................ 480

J. Kanzer, I. Tho, M. Degenhardt, M. Magelein, G. Fricker, M. Brandl

Long Circulating Biodegradable Polymeric Micelles: Towards Targeted Drug Delivery ............................................................................................................................................ 482

C. Rijcken, R. Schiffelers, C. Van Nostrum, W. Hennink

Amino Acid-based Organogelators for the Preparation of Injectable Implants ....................... 484G. Bastiat, A. Vintiloiu, J.C. Leroux

Effect of Ethanol as a Co-Solvent on the Characteristics of PLGA Microspheres .................. 486A. Rawat, U. Bhardwaj, D. Burgess

Permeation of Benzocaine Across Pig Ear Skin from Bioadhesive Films................................ 488D.R. De Aranjo, C. Padula, P. Santi

Mixed Immunomicelles for Delivery of Poorly Soluble Anticancer Drugs: Improved Solubilization and In Vitro Cytotoxicity....................................................................... 490

R. Sawant, V. Torchilin

Next Generation Targeting: Multifunctionalized Nanoparticles for Enhanced Cancer Chemotherapy.................................................................................................................... 492

Y. Patil, J. Panyam

Experimental and Theoretical Investigation of Corneocyte-drug Interactions: Effect of Hydration on Stratum Corneum Partitioning of Caffeine ............................................ 494

S. Hansen, A. Nagel, M. Heisig, G. Wittum, D. Neumann, C. Lehr, U. Schafer

Polyelectrolyte Complexed Nanoparticles Deliver Insulin for Oral Dosage Form ................... 496C. Woitski, R. Neufeld, A. Ribeiro, F. Veiga

The Architecture of Ligand Attachment to Nanocarriers Controls Their Interaction with Target Cells ............................................................................................................................. 498

R. Sawant, R. Sawant, A. Kale, V. Torchilin

Cytotoxic Effect of Methotrexate-Loaded Microemulsion on Human Breast, Ovarian and Prostate Carcinoma Cell Lines ................................................................................ 500

H.Y. Karasulu, G. Kantarci, B. Karaca, T. Guneri

Paclitaxel pH-sensitive Liposomes and Its Action on B16F10 Melanoma Cells ...................... 502H. Karanth, R. Gude, R.S.R. Murthy

Enhancement of the Intestinal Absorption of Orlistat, a Lipophilic Drug with Anticancerous Properties, by Using Lipid-based Systems........................................................ 504

P. Houer, M. Guhmann, J. Correia, T. Vandamme

A Novel PEG-chelating Agent Conjugate for Protein Delivery................................................... 506G. Pasut, A. Mero, T. Ishino, I. Chaiken, M. Sergi, F. Veronese

Targeted Nanomedicines Delivering siRNA Potentiation of Silencing Activity by Photochemical Internalization ....................................................................................................... 508

R. Schiffelers, S. Oliveira, M. Woddle, A. Hogset, G. Storm

Epirubicine-PEG-folate Conjugates: the Effects of Folic Acid and Folic Acid / Polymer Ratio on Conjugates Cytotoxicity and Cellular Uptake ............................................... 510

F. Canal, G. Pasut, M.J. Vincent, F. Veronese, O. Schiavon

Efficient siRNA Delivery Using Water Soluble Lipopolymer for Anti-angiogenic Gene Therapy .................................................................................................................................. 512

W. Kim, C.W. Chang, M. Lee, S. Kim

Investigating the Impact of Humidity on Drug - Propellant Interactions for Metered Dose Inhaler Systems..................................................................................................................... 514

P. Jannick, F. Thielmann, M. Naden, D. Burnett

Chitosan Systems for Acyclovir Controlled Release .................................................................. 516R. Ruiz, T. Marras, M. Saiz, M. Veiga

Mucoadhesive Hydrogel Films Based on Blends of Poly (Acrylic Acid) and Methylcellulose for Buccal Drug Delivery .................................................................................... 518

O. Khutoryanskaya, V. Khutoryanskiy, M. Naderi, D. Burnett

High-Throughput Study on the Impact of Freeze-Drying Conditions on the Stability of Co-Lyophilized Protein-Saccharide Formulations ................................................... 520

K. Ward, I. Cook, F. Thielmann, D. Burnett

A Novel Micelle-like Nanoparticle (MNP) for In Vivo Gene Delivery .......................................... 521Y. Ko, A. Kale, L. Bhave, V. Torchilin

Fusion Studies of Charged Heterogeneous Membranes: Effect of pH and Cholesterol ...................................................................................................................................... 523

M. Bhagat, S. Sofou

TATp-bearing Immunoliposome for In Vivo Gene Delivery to Ischemic Myocardium ..................................................................................................................................... 525

Y. Ko, W. Hartner, L. Bhave, V. Torchilin

Volume 2

Preparation and Characterization of Insulin Loaded Polyanhydride Microspheres ................ 527

C. Manoharan, J. Singh

Intramuscular Gene Delivery Using Cationic Nanoparticles for Prevention of Type 1 Diabetes ........................................................................................................................................ 529

A. Basarkar, J. Singh

Development and Characterization of HER2-Specific Affibody-Conjugated Thermosensitive Liposomes for Improved Delivery of Therapeutic Agents to HER2-Positive Tumors ................................................................................................................... 531

A. Yavlovich, R. Campbell-Massa, S.B. Lee, G. Kramer-Marek, S. Tele, J. Capala, R. Blumenthal, A. Puri

β-Lapachone Micellar Nanotherapeutics for Lung Cancer Treatment ...................................... 533E. Blanco, E. Bey, D. Boothman, J. Gao

Influence of the Molecular Weight of Polyethylene Glycol on the Enteric Properties of Hard Shell Capsules ................................................................................................ 535

H. Bruce, V. Wolf, L. Felton

Effect of Particle Size on the Deposition of Magnetic Aerosol Particles .................................. 537Y. Xie, Y. Xu, J. Wang, B. Hammer, T. Wiedmann

PEG-PE Micelles with Novel Poorly-soluble Pro-apoptotic Agent: Activity in vivo................. 539I. Skidan, P. Dholakia, A. Degterev, V. Torchilin

Thermosensitive Injectable Implants: a Good Candidate for Long Term Controlled Delivery of Protein .......................................................................................................................... 541

Y. Tang, J. Singh

Evaluation of Sodium-deoxycholate Gels Containing Betamethasone-17-Valerate................ 543T. Senyigit, O. Ozer

Combination of Novel Pro-Apoptotic Agent DM-PIT-1 and TRAIL in the Same Micellar Preparation Provides Increased Cytotoxicity in both TRAIL-resistant and TRAIL-sensitive Cells ..................................................................................................................... 545

I. Skidan, A. Degterev, V. Torchilin

Pharmacokinetic Profile Modulation of a Poorly-Water Soluble Compound Using Poloxamers ...................................................................................................................................... 547

C. Popescu, O. Magnusson, J. Bjornsson, M. Thorsteinsdottir, J. Singh, M. Gurney

Photodynamic Therapy of B-16 Melanoma in Mice with Tumor-targeted meso-Tetraphenylporphin-loaded PEG-PE Micelles.............................................................................. 549

I. Skidan, P. Dholakia, V. Torchilin

Stability of Anti-Inflammatory Agents in Stealth Nanoparticles ................................................ 551X. Lu, M. Howard, J. Rinehart, M. Leggas, M. Jay

Synthesis and Characterization of Novel Starch-Xanthan Gum Hydrogels for Controlled Drug Delivery................................................................................................................ 553

A. Shalvin, Q. Liu, M. Abdekhoadie, X. Wu

Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell PLGEOF Nanoparticles .................................................................................................................................. 555

X. He, J. Ma, A. Mercado, W. Xu, E. Jabbari

Carbon Nanotubes as Drug Delivery Systems ............................................................................ 557I. Degim, X. Xu, A. Rawat, D. Burgess

In Vitro Permeation Studies of Novel Buprenorphine Prodrugs in Human Skin...................... 559S. Banks, D. Hammell, M. Golinski, J. Howard, A. Stinchcomb

Carbon Nanotubes (CNTs) for Enhancing Drug Transport Through Skin ................................ 561I. Deqim, S. Verma, F. Papadimitrakopoulos, D. Burgess

Low Residual Solvent Microparticle Formulations ..................................................................... 563D. Biggs, H. Nettles, G. Winchester, P. Markland

The Cleavage of HIV-I TATp in Human Plasma by Protease Activity ........................................ 565J. Grunwald, T. Rejtar, V. Torchilin

Respirable PLGA-Microspheres for Pulmonary Delivery of Hepatitis B Vaccine .................... 567C. Thomas, A. Rawat, F. Ahsan

Acrylic-Rubber Hybrid Polymer for Transdermal Drug Delivery ............................................... 569J. Ouyang, P. Foreman

Inhaled Cationic Liposomes of Low Molecular Weight Heparin in the Treatment of Venous Thromboembolism............................................................................................................ 571

S. Bai, F. Ahsan

Efficient Modulation of T Cell Response by Single Microparticle-mediated, Combinatorial Delivery of IL-10 Silencing siRNA and Plasmid DNA Vaccine .......................... 573

A. Singh, H. Nie, K. Roy

Degradation and Sustained Release from Injectable, Bioresorbable, Thermosensitive Copolymer, Poly (NIPAAm-co-dimethyl-γ-butyrolactone acrylate-co-acrylic Acid) ................................................................................................................ 575

Z. Cui, B. Lee, B. Lunt, B. Vernon

Polyethylene Glycol-phosphatidylethanolamine (PEG-PE) Micelles Loaded with Paclitaxel and Surface-modified with a Pro-apoptotic PBR-ligand for a Synergistic Anticancer Effect by Receptor-mediated Intracellular Drug Delivery ....................................... 577

T. Musacchio, A. Latrofa, G. Trapani, V.P. Torchilin

Poly (etherhydroxylamine) PEHAM Dendrimer Nanoparticles for Combination Therapy and Diagnostic ................................................................................................................. 579

S. Svenson, A. Chauhan, M. Zhuravel

New Formulation of Dual Agent Solid Polymer-Lipid Hybrid Nanoparticles: Exploitation of the Anti-Cancer Synergy of Doxorubicin and Mitomycin C against Multidrug Resistant Human Breast Cancer Cells ........................................................................ 581

A. Shuhendler, A. Connor, A. Rauth, X. Wu

Water-soluble Vitamins Loaded in Biodegradable Nanoparticles ............................................. 583M. Stevanovic, M. Jevtic, D. Uskokovic

Investigation of Different Lipid-Based Systems Designed To Enhance the Oral Bioavailability of Lipophilic Drugs ................................................................................................ 585

M. Guhmann, J. Correia, P. Houer, T. Vandamme

Chitosan/PEG Diblock Copolymer as a Thermosensitive Hydrogel.......................................... 587F. Ganji, M. Abdekhoadie

PGE1 Microparticles for the Treatment of Pulmonary Arterial Hypertension ........................... 589V. Gupta, A. Rawat, F. Ahsan

Hydrophilic Surface Characteristics of PEO-modified Silicone Gels ........................................ 591S. Sivas, N. Hoy, K. Reichel

Phage Coat Protein pVIII as a Novel Targeting Ligand for the Formulation of Tumor Targeted Pharmaceutical Nanocarriers............................................................................ 593

G.G.M. D'Souza, T. Wang, P.K. Jayanna, V.A. Petrenko, B.P. Stenberg, V.P. Torchilin

Surface Modification of Pharmaceutical Nanocarriers with Ascorbate Residues as a Novel Approach for Tumor Cell Targeting and Killing............................................................. 595

G.G.M. D'Souza, T. Wang, M. Toniutti, K. Rockwell, V.P. Torchilin

Screening of Particle Size Distribution Affecting Variables in a Rotating Pan Granulation Process Using a 27-3 Fractional Factorial Design ................................................... 597

J. Chan, S. Vogel, J. Wen, R. Alany

Study of the Release Mechanisms of the Diphacinone Granules for Controlled Release Delivery Using a Fractional Factorial Design ................................................................ 599

J. Chan, S. Vogel, R. Alany, J. Wen

Development of Organic Hydrogel Matrix Based Wound Dressing Containing Antibiotics........................................................................................................................................ 601

S. Jin, H.J. Park, J.K. Park, J. Kim, B. Cha, M. Yoo, H.G. Choi

Development of a Citric Acid - PEG Polyester Gel with Biodegradability and pH Responsive Drug Release .............................................................................................................. 603

K. Uchida, S. Sakata, H. Ooba, K. Sutani, M. Fujishima, K. Fuji

Preparation of Nano Complex of DA 6034, a New Drug Candidate for Gastritis and Evaluation of its Gastroprotective Effect ..................................................................................... 605

S. Jang, S. Han, J. Kim, B. Cha, M. Yoo, K. Lee

A Novel Targeted Proapoptotic Drug Delivery System for Efficient Anticancer Therapy ............................................................................................................................................ 607

P. Chanda, M. Saad, Y. Wang, E. Ber, J. Khandare, A. Vetcher, V. Soldatenkov, T. Minko

Internally Quaternized PAMAM-OH Dendrimers as Efficient siRNA Delivery Systems: the Effect of Targeting Moiety and Degree of Quaternization ................................... 609

M. Khang, M. Patil, O. Taratula, H. He, T. Minko

Toward in vivo Targeting Delivery of siRNA for Efficient Cancer Therapy............................... 611O. Taratula, P. Kirkpatrick, R. Savla, I. Pandya, T. Minko, H. He

Multifunctional siRNA Delivery System for Cancer Therapy...................................................... 613R. Savla, O. Taratula, I. Pandya, A. Wang, T. Minko, H. He

Novel Chinese Traditional Medicine Pellets Prepared by Extrusion-Spheronization Method .................................................................................................................. 615

W.H. Chuo, T.H. Wu, T.R. Tsai, Y.T. Huang, T.M. Cham

A Novel Nanostructured Oral Delivery System for Lipophilic Drugs ........................................ 617A. Tan, S. Simovic, A. Davey, T. Rades, C. Prestidge

Application of Melt Granulation Technology to Enhance Tabletting Properties of Poorly Compactible Drug Substance at High Dose .................................................................... 619

J. Lakshman, J. Kowalski, M. Vasanthavada, W.Q. Tong, A. Serajuddin, Y. Joshi

Can PECA Nanoparticles be used to Achieve a Biological Response to Sterility Agents for the Brushtail Possum?................................................................................................ 621

A. McDowell, A. Kafka, J. Crawford, D. Eckery, B. McLeod, T. Rades

Effect of pH and Glutathione on the Dissociation Kinetics of Redox Sensitive Polyplexes ....................................................................................................................................... 623

L. Jayanthi, A. Wani, D. Oupicky

New Shapes for Drug Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage ....................................................................... 625

S. Cai, T. Harada, T. Minko, D. Discher

Separable Dissolving Microneedles for Rapid Vaccine Delivery to Skin.................................. 627L. Chu, M. Prausnitz

Study on the Blend of Kollidon SR and Ibuprofen ...................................................................... 629G. Dorairaju, B. LaBrec, A. Listro, L. Acquarulo

Influence of Particle Size and Preparation Methods on the Physical and Chemical Stability of Amorphous Simvastatin ............................................................................................. 631

F. Zhang, J. Aaltonen, F. Tian, D. Saville, T. Rades

The Use of MALDI TOF Mass Spectrometry to Identify Co-polymerization in PACA Nanoparticles .................................................................................................................................. 633

A. Kafka, T. Kleffmann, T. Rades, A. McDowell

Liposomal Tissue Plasminogen Activator with Biological Half-life Enhancement .................. 635J.Y. Kim, E. Ban, Y. Choi, C.K. Kim

Novel Cationic Solid Lipid Nanoparticles Enhanced P53 Gene Transfer to Lung Cancer Cells .................................................................................................................................... 637

S. Choi, S. Jin, E. Ban, S. Kim, Y. Choi, C.K. Kim

Anticancer Activity and DDS Application of Green Tea Polyphenol Derivatives..................... 639K. Matsumura, K. Kaihatsu, S. Mori, S.H. Hvon

Formulation Development of Derris Emulsifiable Concentrate for Crop Pest Control.............................................................................................................................................. 641

A. Yoon, R. Wiwattanapatapee, J. Petcharat, C. Ovatlamporn, A. Itharat

Preparation and Functional Analyses of Water-dispersed Carbon Nanohorns for Cancer Chemotherapy.................................................................................................................... 643

T. Murakami, H. Sawada, M. Yudasaka, S. Lijima, K. Tsuchida

Targeted Delivery of SU5416 and Antiangiogenic Cancer Therapy Using Tumor Vasculature-targeted Liposomes .................................................................................................. 645

T. Ida, Y. Katanasaka, K. Shimizu, T. Asai, N. Maeda, K. Baba, N. Oku

Antineovascular Therapy by Using Dual-targeting Liposomes ................................................. 647Y. Murase, Y. Katanasaka, T. Asai, N. Maeda, T. Tanaka, N. Oku

Permeability Study of NNZ-2566 (an analogue of glycine-proline-glutamate, N-terminal tripeptide of insulin-like growth factor-I) Across a Human Intestinal Epithelium Cell Line (Caco-2) ........................................................................................................ 649

J. Wen, G. Thomas, D. Bachelor, P. Gluckman

Direct and Quantitative Measurement of Liquid Flow on a Microfluidic Chip .......................... 651C. Haber, U. Kanne

Simple Method for Preparation of Solid Lipid Nanoparticles With High Entrapment Efficiency of Hydrophilic Drugs ............................................................................... 653

R. Patil, P.V. Devarajan

Polymeric Micelles for MRI Contrast Agent, Tumor Targeting and Imaging by Magnetic Resonance Imaging ....................................................................................................... 655

K. Shiraishi, K. Kawano, T. Minowa, Y. Maitani, M. Yokoyama

Immunosuppressive Vaccine Via Transcutaneous Immunization............................................. 657N. Ohmori, T. Nakano, S. Goto, K.C. Chiang, Y. Shimada, K. Mori, T. Miyagi, S. Kawamoto, K. Ono, T. Goto, S. Sato

Preparation, Characterization, and Antidiabetic Potentials of Bile Acids Modified Exendin-4 ......................................................................................................................................... 659

S. Son, C.H. Jin, S. Chae, K. Lee

Surface Charge-modified PEG-liposomes for Enhancement of Cellular Uptake and Anti-tumor Activity .................................................................................................................. 661

H. Seong, S. Jung, S. Kim, S. Jung, D. Lim, E. Kim, S. Cho, B. Shin

Thermosensitive and Chemically Crosslinkable Poly (organophosphazene) Gels ................. 663T. Potta, S.C. Song

Transdermal Delivery Test of Maltose Microneedle into Human Skin ...................................... 665Y. Tobinaga, T. Kitagawa

Functionalized PLGA Foams for Controlled Gene Delivery: Influence of Surface Modification on Matrix-DNA Interaction ....................................................................................... 667

H. Nie, S. Khew, L. Lee, K. Poh, Y. Tong, C. Wang

Bi-phase Alginate Carriers for Controlled Release of BMP-2 .................................................... 669H. Lim, E. Oh, K. Jeon, H. Chung, J. Choi, H. Ghim

Development of Novel Vehicles for Topical Glucocorticoid Formulation: an in Vitro and in Vivo Evaluation .......................................................................................................... 671

J. Bae, K. Hong, S. Jeong, B.D. Park, S. Lee

Preparation of N-Isopropylacrylamide Hydrogel-Coated Gold Nanorods ................................ 673A. Shiotani, T. Kawano, T. Mori, Y. Niidome, Y. Katayama, T. Niidome

Functional Assessment of Polyplex Micelles with Cyclic RGD Peptide Ligands and Disulfide Crosslinked Core..................................................................................................... 675

M. Oba, K. Aoyagi, K. Miyata, N. Nishiyama, H. Koyama, K. Kataoka

Application of TNF-related Apoptosis-Inducing Ligand (TRAIL) for Rheumatoid Arthritis Therapy ............................................................................................................................. 677

C.H. Jin, S. Chae, E. Lee, H. Yoo, Y. Hong, K. Lee

PLGA/Chitosan Composites from a Combination of Spay Drying and Supercritical Fluid Foaming Techniques: New Carriers for Gene Delivery ..................................................... 679

H. Nie, L. Lee, H. Tong, C. Wang

Triblock Copolymer Micelles with Biocompatible, Endosomal Escaping, DNA-Condensing Functions for Systemic Gene Delivery ................................................................... 681

K. Miyata, M. Oba, M. Kano, S. Fukushima, N. Nishiyama, K. Miyazono, K. Kataoka

Methods for Producing Oral Aqueous Solution Containing Ubidecarenone ........................... 683S.M. Seo, J.B. Lee, S.B. La, H.k. Tan, S. Kim

Environmental Sensitivities of the Polyion Complex Vesicles (PICsomes) ............................. 685A. Kishimura, S. Liamsuwan, H. Oana, Y. Yamasaki, K. Kataoka

Measurement of Compaction Force and Displacement Parameters for Quantification of Compactability of Pharmaceuticals ................................................................ 687

S. Patel, A. Kaushal, A. Bansal

An Innovative Transcutaneous Vaccination System Using a Hydrogel Patch Formulation ..................................................................................................................................... 689

Y. Ishii, N. Okada, Y.S. Quan, F. Kamiyama, Y. Mukai, Y. Yoshioka, S. Nakagawa

Micro Mechanical Investigation of Fracture Properties of Roller Compacted Acetaminophen ............................................................................................................................... 691

S. Patel, A. Kaushal, A. Bansal

A Novel Sulfated Polysaccharide from Red Microalgae: Applications of Polysaccharide Gels ....................................................................................................................... 693

S. Arad

Amphiphilic Poly-N-vinylpyrrolidones as Alternative Coatings for Long-circulating Liposomes .................................................................................................................... 695

M. Shtilman, A. Kuskov, V. Torchilin, A. Tsatsakis

A Novel Gene Carrier Responding to Virus Protease ................................................................. 697M. Kuramoto, D. Asai, T. Mori, T. Niidome, H. Nakashima, Y. Katayama

Novel Transdermal Delivery System Using the Water Vapor Controllable Fabrics ................. 699K. Hong, H.J. Park, S. Jeong, B.D. Park

The Use of Reconstructed Human Epidermis for the Evaluation of the Skin Irritation Potential of PX-13 and PX-18 Nanosuspension ........................................................... 701

J. Pardeike, R. Muller

Fabrication of Micro-Patterned Surfaces by Polymer Inkjet Printing........................................ 703J. Kim, Y. Yun, B. Lee, Y. Cho

The Effects of Manufacturing Process on the Wet Granules for ODTs..................................... 705J. Wang, H. Lim, K. Kim, S. Park, G. Seomoon, S. Hwang, H. Chung, C. Pai, K. Park

Tolerability Evaluation of PX-13 and PX-18 in Primary Human Fibroblasts and Keratinocytes Monolayer Cell Cultures ........................................................................................ 707

J. Pardeike, R. Muller

Effects and Mechanisms of Luteolin on Modulation of Multidrug Resistance and Induction of Apoptosis in Caco-2 Cells ........................................................................................ 709

Y.L. Lo, R.L. Ran, C.T. Ho

Primary Porcine Alveolar Epithelial Cells (pAEpC) as a Model for Drug Permeability Assays ....................................................................................................................... 711

H. Eixarch, A. Steimer, E. Haltner-Ukomadu, U. Bock

Efficiency and Skin Irritation Potential of Solid Lipid Nanoparticles (SLN) and Dendritic Core-Multishell Nanocarriers ........................................................................................ 713

S. Kuchler, M. Radowski, R. Haag, M. Schafer-Korting

Improvement of Dissolution from Tablets Made by Compression of Solid Dispersions...................................................................................................................................... 715

T. Hoshino, F. Tanno

Effect of Immunization to Ovalbumin Administrated by Biocompatible Microneedle Sheets ........................................................................................................................ 716

H.H. Park, M. Han, S. Lee, S. Kim, C.W. Cho, D. Hyun, C. Kim, C.G. Kim

Freeze-dried Chitosan-hyaluronic Nanoparticles as Vehicles for DNA Delivery ..................... 718A. Vila, M. De La Fuente, M. Alonso

Development of Angiogenic Vessel-targeted Polycation Liposomes for Delivering Small Interfering RNA ..................................................................................................................... 720

S. Matsushita, T. Asai, Y. Suzuki, T. Ishida, N. Maeda, T. Dewa, H. Kiwada, M. Nango, N. Oku

Effect of Polymer and its Molecular Weight on the in vitro Cytotoxicity of Ribonuclease Conjugates .............................................................................................................. 722

B. Treethammathurot, E. Ferguson, L. Diuedonne, D. Schmaljohann, R. Wiwattanapatapee, R. Duncan

Dissolution Media Dependent Susceptibility of Dosage Forms to Biorelevant Mechanical Stress........................................................................................................................... 724

G. Garbacz, W. Weitschies

Oligomer Chitosan Nanocapsules for Targeted Delivery of Docetaxel in Cancer Cells.................................................................................................................................................. 726

M.V. Lozano, D. Torrecilla, D. Torres, A. Vidal, M.J. Alonso, F. Dominguez

A Liposomal Drug Delivery System for Targeting the Brain ...................................................... 728H.F. Liang, Y.C. Chen, L.W. Chang, Y.C. Lo, M. Lo

Nanocarriers for Gene Silencing in Vitro, in Situ and in Vivo .................................................... 730B. Pitard, C. Gourden, E. Letrou-Bonneval, R. Chevre, R. Labas

Particle Tailoring for User-Friendly Inhalation Devices .............................................................. 732K. Kawakami, C. Sumitani, Y. Uchida, Y. Yoshihashi, E. Yonemochi, K. Terada

Effect of Methods for Applying of the Polymer Microneedle-Roller on the Permeation of L-Ascorbic Acid in Rats ........................................................................................ 734

C.W. Cho, S.K. Yu, H.H. Park, M. Han, S. Lee, D. Hyun, C.H. Kim

Inorganic Apatite-liposome Complex: Novel Hybrid Carrier for mRNA Based Gene Delivery ............................................................................................................................................ 736

F. Zohra, E. Chowdhury, T. Akaike

The Role of a Lipophilic Adjuvant to Produce High Respirable Tobramycin Powders for Inhalation ................................................................................................................... 738

C. Parlati, R. Bettini, F. Sonvico, P. Colombo, F. Buttini