Farmacologia CTO 7

Embed Size (px)

Citation preview

1|lI00uCC0 8 8 8Im8C0C6lC8>J4 1.1.DS0IC0h5J4 1.2.SIlD0C0h5J5 1.J.b0II8S0Im8C0h5J5 1.4.LXCI6C05J5 1.5.Lml60 06 8Im8C0S 6 8C80S, 6mD8I8Z0 y h0S5J6 1.6.|8lm8C0ChIC8 ChC85J6 1.7.h68CC0h6S 80v6lS8S 8 m60C8m6I0S5J8 1.8.|hl6l8CC0h6S m60C8m6I0S8S5J9 1.9.|8lm8C0S g6hlC0S54O |8Im8C00g8 C8I00v85Cu8I y 06 88I8l0 I65I8l0I0>41 2.1.|8lm8C0l0g8 06 SSl6m8 6lv0S0 80l0h0m0541 2.2.|0II0C0S544 2.J.0IlC0S546 2.4.hI8g0hSI8S06 C8C0 |v6I88ml0, 60h0, 0I8C6m, 6000, 8m00h0, l8C0h0)546 2.5.NII8I0S547 2.6 |D00l6S 06 l8 LL |C8I0ll, 6h8l8ll, 0S0I, |8mI)547 2.7.I8g0hSI8S06 l0S l6C6I0I6S 06 l8 8hg0I6hS8 |l0S8II8, v8S8II8) |h||)547 2.8.g0hSl8S Z 80l6hIgC0S547 2.9.bl0m0l0 06 |l8Il00. 10II00547 2.1O.160h8547 2.11.Ll0m0glC8I0 S00C0 y h600Cl0m. M0I6l0K8Sl548 2.12.L0lIC006S548 Jl00lC05>49 J.1.6h6I80806S549 J.2.b6I8l8CI8mC0S549 J.J.l0C0I00S |v8C0mC8 y I6C08h8)552 J.4.m0g0C0S00S |g6hI8mCh8, 8mk8Ch8, 6SII6I0mCh8, h60mC8, I0DI8mCh8)552 J.5.M8CI000S |6lll0mCh8, C8III0mCh8, 8Zll0mC8, I0XII0mC8, ]0S8mC8)55J J.6.|hC0S8m8S |Cl08mC8)55J J.7.L0l8h6C0l y l8h6hC0l55J J.8.16Il8CClh8S |I6ll8CCh8, 00XCCh8 y m0CCl8)55J J.9.b0l8m08S |S0lS0X8Z0l, S0808C8, S08m6l0X8Z0) y lIm6I0Im554 J.1O.Q0h0l08S |8C00 h80XC0, 8C00 6m0C0, h0l0X8C0, CI00X8Ch0, 00X8C0, m0Xh0X8Ch0, 6v00X8C0)554 J.11.h8mCh8S554 J.12.M6II008Z0555 J.1J.hID0lC0S l0C8l6S|D8CII8Ch8,8C000S0C0,m0I0Ch8)555 J.14.LSIl6Il0gl8m8S. L6Z00. 16lll0mC8555 J.15.hImC0D8CI6l8h0S |I0D6IC00SS y 0II8S myC0D8CI6l8S)555 J.16.lhgC0S555 J.17.Ivl8l6S556 J.18.l8l8SI8I0S557 U+Qum0t0r ntn00Ic+.1.lhII00uCCl0h33O +.Z.Fg6hI6S 8qu8hI6S33O +.o.L0Uu6SI0S 06 l8lh0 |CS8Ilh0 y C8ID08Ih0|33O +.+.FhIU6I8D0lI0S33V +.3.FC80l06S 06 0Ilg6h v6g6I833V +.U.lhhDl00I6S 06l8 I00lS0U6I8S833V +.1.FhIlD0IlC0S 8hIlIuU0I8l6S33V +.O.II0S 8g6hI6S33V +.V.1I8l8Ul6hI0 6h00CIh03UU +.1U.1I8I8U0hI0 Dl00gC03UU U3nt0I0tc03.1.|dIU8C0S 8hI60IC0S 06 uS0 h8DlIu83U1 3.Z.|dIU8C0S 8hI6l0IlC0S 06 66CCl0h3U1 3.o.M6C8hSU0 06 8CCl0h3U1 Ubng0c0, ntr0tc0 ntnhmt0r0 n0 0t0r0d00U.1.Fh8lg0SlC0S U6h0I6S3Uo U.Z.Fh8lg0SlC0S U8y0I6S |0ldC60S|3U+ U.o.1I8I8Ul6hI0 06l 000I3U3 U1|nt0xcc0n01.1.lhI0XC8C0h 0I SC0II00S3UU 1.Z.|hI0XC8C0h 0I 8h8lg0SlC0S3U1 1.o.|hI0XlC8Cl0h 0I 0I0g8S 06 8DuS03U1 1.+.II0S dIU8C0S qu6 C8uS8h |hI0XlC8Cl0h C0h I6Cu6hC83U1 1.3.FhIl00I0S 6S6ClC0S3UO BIl0uu00I0B ulBu000IB0II0u 0 NhM UebespmuybIenIOsCOnCeptOs devIdmedI,m|spOnIbIIIddyVIumendedIsttIbuCIn(MIR06-07,222).mbIn es muy |mpOttnte que COnOzCs IOs ptInC|pes MtmCOs InduCtOtes e InhI-b|dOs deI metbOIIsmO heptICO. LI testO deICp|tuOesbstntemenOstentbIe. Lpttede|ntetCCIOnesmedICmentO-ss se sOIp COn Is mdICs, IhbIt deI t|tm|entO de Cd enIetmedd. m|| [|} LIt|nspOtteCtIvOseCtCtetIzpOt ptOduC|tgstOde enetg|,dIIetenCIde OttOs meCn|smOs. L v| OtI es I ms utIII2d, petO tIene eI InCOnvenIente deI ptImet psO heptICO. M L vI subI|nguI evIt eI ptImet psO hept|CO y I bsOtCIn es muy mpId. L bsOtC|n pOtvI |eCt es ItteguIt y evI-t ptCImente eI ptImet psO heptICO. M >On|nduCtOtes deI metbOIIsmOheptICO. |enItOIn, tb|tI, t|Iamp|C|n, CrDmCep|n, tbCO y ICOhOI. M >On InhIb|dOtes deI mIIsmO heptICO. L|met|d|n,,et|ttOmIC|n,CIdO vIptOICO. L b|Od|spOnIb|IIddteptesenl I ItCCIn de I|mCO que ICnz lnte|d I C|tCu- |CIn sIstmIC. vId medI es eI tIempO que I COnCenttC|n deItmCOttdenteduCItseI mItd. L /srmscoc||csCl l |\C UC| IUcU|UQUC Cl\UUl l CVU|UclCI,Cl UCc|I, |l cUIcCI\Ic|UICl UC| UCUlcUCI!UCIC| UIQI|lUU,CIIuIc|CIUCl\lCUU yUC| UUl|l.I\,UClUCUIUI\UUCVIl\U|IUlcUycUI\|!\lVU, |UlICICUCIUlUCUC\C|U|II|U| lUl|clCI UCUI IIUcUCI lU |UQI UCcclCI |\l|UCl IU|UUCUUllIcclCI CjU l cul lCUUlIll!| ClU|c|CI, Ull\|lCUclCI, UC\CU|llUU U ClU!IIlIU|Uc|CI, y CcICclCIU C|lUlclCI UC lUlUCU|cUCI!Ul. |l\Ul Ic\U|Cl (lIc|U|U | IU|U UCUUl|Icc|CI), UC\C|U|II l cUIcCI\Ic|CI UC UI IIUcU CI lU |UQI UCcclCI, UC l cUlUCCIUCICI QIII\ClUlCICc\Ul!CICU\|cUl.L /srmscom|cs Cl\UU| lUl CICc\Ul C|UulU|cUl yIl|UlCQcUlUC|UlIIUcUlylulUCcIllUUlUCcclCI,cUIUU|I!C|cc|UIIcUIlUU|I,CII uIc|CIUC|cUIcCI!|clCI UC| IIUcU CI lU lUQIUCcc|CI.L V|lClllUU I|UcUc|IC!lc y I|UcUU|IUlc C| |c UO I!C UC |l UIICICIcll CI ll |ClUCl\l \CICU!|cl y!C|cl UC |UlU| l\|I\Ul lIUlV|UuUl |UlUCU|cUCI!Ul. |I| QUIlIUI|lllC|IUClCIVUU CICc\UlUCU|cUCI!UlUl UcU |C|!U|Cl, lU cUl UlU luQI lIc|UlCI!U UC l Formocogenco.bC lCC UC CI ClQCIUU |UUIU C|l!CI U||UUIllUUl UC| LN I|CcUCI\CluCUUIICllcI IClUCl!lUlICICI\Cl |OIIUcUl. || cUIUc|U|CI\U UCCl\Ul U| |UUIIlUUl UCUC || CVI ICUCc|I | |ClUCl! CI cU lIUVlUUU |UlIIUcDl, C lIUlVlUU| |2I UUl| ly!lCUUl I UC]U||| |ClCl! y CVl\I |CcclUICl UVC|ll. |l\CcUU lUCl\uUl l Formocogenmco.1.1. 080|000 bC UCIUUlI ClU|c|CI | lU UC uI IIUcU UClUCCl C\C|U|| UCUlU |I\C|IU. || l\CIcU\|UIc\U|ClUCUC\C|UlII | ClU|c|CI UC UI I|UcU.cUIcCI\|clCI,lU|UClllUU,|C UC l lUC|BclC ClUICCI!C C l||| QclCIUClUl!C]lUUlUUIUClCCl!CUU|I|l\IIUU | U|UQLUlIIUcUl\IV|ClI |lUCUCIIlUI |Ull|QUICI\ClUCcI|lUUl\.IIusInpsIv (|llul!Ic|l | | UlUluClCllC UllUClVCICICl cUUUICI!C llU|UCUUCllUCUC|IlcClulICl,yll|| U|UlU| uC|Cl,UCCjUClUUU|CcUlI,lI\IVClUCU|UlUcI|Cl).2.tnspOtteespeC|I|2dO(\IIlUI\C c!|VU CI cUI\IUCUI QIU|CI\C C|Cc\IUUUIcU U UCcUIcCI\Ic|CI,cUIcUIlUUUUCCIC|Q(M| R 9A-95, \73) U| Iul|CIIcl | |!UIVU|UCUIQIUlCI\CUCcUIcCI\|clCI).| 0F0IT|dCI0|!t5mIH C.m|s.Js. wes0j I3 Cm II!I!I | I!I(1! I}Ll Vl UC UU|I| l!IclCI UC UI IIUcU UCUCI lC|U|ICc\lU |IUl|Cc\l |I C| |lUC| lC \|VlClI llC||C|l I!u|lCl (|Cl,UUcUl, C!) IUUuc|CIUU UICI|cclCI UC ll U|lUl. |l uI Vl |IUl|Cc\ cUIUU ClUCU|cUCI!U \lCICUC \|VClI | CIICI I\UI| UIllUl lUU.V|ll0l|Ol. V|OtI(bsOtCIn gsttOIntestInI).|lIc| | y lCQUI,CIUl\lCIUUlu!UUUlI| l\|c|CI UC lUlIIUcUl|l|UlIl|U|CQ|cy l Ul U\ll l2U. |I clU UC lUCICUUllIcclCI, lC UCUCIC!l |I Icl |UCI\C lI IU | \IIlcUII| UU UCUllUU \lCUU. bl ICUC|QU, IClCI\ lIcUIVCIlCI\Cl, CI\|C lUl UC UCl\c lCI UCUllUU |CI\ |CUlC|lC CI lI!uclCI UC CUC|QCIc|, l |ClCIc| UCl lUCI!UlyU\|UlUCUlcUCI!UlCI C| I\U UlQCl\lVUUUU|hc l IlUC7 C II\CIl|UU UC | ClUIc|CI, cUUUU|CjCU|U Cl |lC|IU, ll !C\|clcl |Il, | U|clllIU C|clc|U. L clUC7 UCl ]uQUQl!|lcU U l IClCIc| UC CI2lUl |U!CU|!lcl uCUCI IIc\lVI Q|I IUCIU UCIIUcUl (Cl\C lIcUIVCI|CI!C uCUC UCVlIlC |CcU||lCIUUl CUlCU UCclullCI!CIIcl). LUlUCU|cUCI\Ul\lCICIuC !IVCl|CllIl!CU U|\ uUlCIUUlCI |Ic\lVUUl!U!lU IcllUCI!C (CICc!U I|UCI lU |C\|cU). NU lC uCUCU!lll2ICl!VlcUIUUC|c|CI\CCl\C|IcUIlc|CI\Cb.V|buCysubIInguI.C|C|\U IuUC|U UC I|UcUlcU|UcUUl lUC|C | UUcUl CUcl, IUIUlUCI\C UCC]UUC l lCIQU, lC ClU|CCI cUI QII I|UC7, UCCIUU l ClclU ClClU|UCl C|\CllUy luIIcVlcu|I |2c|CI. || l| l\CU VCIUlU UC | UUcUl CUcl U|CI U|ICc\UCI\CCI |VCIcVyIUCIl UI!,CluUICIUUCl|lUC|lU|C\lcU. L Il\|UQl lcC|lI lC UCUCUU|I|l\II U|Cl\Vl CI |lc|l l| lIQ|IUll,C| c\U|ll CI llc|ll| l |lC|!CIllVly |UlUlcCUl| lI|QCl|.C. VlteCtI. LUlI|UcUl UUlIll\IUUlUICl\ V lCClU|CCI UCIU|U |IICQUlI, uCUCI lI|l\I l UucUl y8CU80A L5V0D5lUI IcCUUUUl UC UUlI|l\||.h0mOffOl05 0MfOf05bII CUC|QU, uCUC |Ccu||l|lC M0UDUtf50l5M0- Cll CI CIICIUUl |IcUIlclCI!Cl.mCV,55UfOf05,0 O.|luUCIc|lUCI\CC| lUUI C||QUU y IU lUI UCl\IU|UUl UI|lCI2|Ul U|QCl\|VUl. |jCUUl: UlcCU CI |UlIlnUlCuCnUl,UCl|ZlI y cUI\|cUlUCl CI | CIICIUCUUlIIlU\U|l |I!Cl!IIl.BB..............0 .....................I||5||UIJ0 |1L |ID|05tM6lv0l|IR|1 1 ~~.~~~'.~.~.~.~" TqH~~~~~~~.~..~~......~.~

4 .~~~~..~~~ .~~.~~~~~......KN08u |0Pu080|8|S0uy0 |8 u udVCu!n8. L l6| 6$ u v| U6 C$DIClC UUyU6C|6n!6, y U6 CDn$! U6 u 6l!6||D Dll6$!I!lBCUDU6 Cclu|$ CD||BCU$ CDn luClCID!6C!DI,6|D nDC$DIC6!6, u6 D U6 $| Qu l $u$!C|$ |l U|D$D|UCl6$. bln 6UCIQD, |Os|C|6$ !I$Uc|UlCD$ U6 l!|l!D$ (nQDI), D6$!ICQ6D$ (U6Du$l/ D$!6DDID$|$)yl6n!n||D (DlC6D, | lQ6$l LIClC) $6 U!lll2CDnlI6CU6C|.V'l0||tIlV uCCu!n8. cI l|UCD 6n $DluClCD $U$6$|C$6lny6C!U6CDU6l|6|,UlIUnU6!|vc$U6 l$u$!C|IunUU6!lU6|!6jlUDCD6C!lvD y6n6!|66l !DI|6!6Cl|Cul!D||D!Ivc$U6 lD$C|l|6$L62|U |||UIDn|U$lvD|6C6 lU|lu$|Cn6lC|6U6n!lv6lDClUUU6C$D|C|C,$|CDUDI| | CClCU6ClD|y6IU$j6.lDI6l CDn!I|lD, |UUl l$!|ClCU6v$DCD$!|lC!DI6$ D| ||CC|C U6 II|D I6!|$n y |6UuC6 I C$D|C|Cn. b6UU| n|$!In DI 6$! v| CD I|6CU6C|. |6|l$ U6CjD 6$D UDI6CU|I,UDIln6 |$U| | n.C.Vt|nl|muCu||.LC$D|ClC6$ U$ |lUU6C|UDl UyDI |IIlQClCU6! U$CulD6$!I|UD.L6C66v|!|$6| UU| n|$!|ClC U6 $$!C|$ l||l!!6$ U6 |DvDCnn6CID$|$ UU$CU|I. L$ n6C6$I|D 6vl!| l uClC U6 Un!|DICDn6Iv|D$DDU6 uv$D.ND$6U6C6 u!lll2|6C$DU6 n!|CDQU|C|CnD$| 6l$!6 u |NDQD|.C.V |nl|vCu||. L U$ 6Ul6U6$ | |O!|0v6OOS0, |IU|CUI| nC|lU6!66C$D$ U66U6|Q6Cly|UUln|$!II U6U|CU6D!D$ |I|l!n!6$ D| D!I$ v|$, 6|Ul!6 | UU| n|$!IC|Cn U6 I|UCD$ D U6 $DluClD6$6n6|lU$|C CDn!|nU. Lv| |O!/00|!6||0| $6u!l l |2 6 C$DU6 U| U|D!6|| I6QlDn| U6 l QuD$ !uUD|6$ (|6!DCIClDU | nD6|C|6), UUl l$!|ClC U6 CD!|$!6$IUlDDCD$,D||UU| n|$!IC|CnU6v$DU| l!UD|6$6I6l !|!U| 6!DU66UCDl l$|!6I|l6$.1.. 8I00000 L| IIUCD,Un v62C$D|C|UD,$6 U|$|CUy66!I6 l$nQI6 y| D$!6j|UD$,$UD ! |vc$ U6v|l$ U6UCI$C|D|CQlC$yun|cUD$6 U|v6I$D$ ClDDIIU6|D$L IIUCDClnc!|C CD$lU6I 6l DIQ|$UD UlvlUUD 6nCDU|!lU6!D$ vl|!u!6$ 6 | D$u6 6l U6U|CU6!D6$! U|$!|lCulUD ulID|6U6!6. Ll nU6|D U6 CDU|!|U6!D$ U66U6I U6 l !u|I62 d6 I|UCD. blc$!6 nD |6$6n! BlUU D| n| nQn I6U6!DD|QlCDy$6 U| $!|| CUy6 DI!DU6| QU CD|D||,$6 ! |! U6|S0l0uy0l Pu0l80l u UDU6ID U6 U| $!I| CuClCn UDDCDUI!| U6!| . lD|6I CD!II|D, $| 6l IIUCD nD $6 |$!I|CUy6 l$!!n6U6n!6 D |D |C6 U6 lDIU |6!6IDQc6, $6 |CII U6Un UDU6lD U6 Ul!I|CuClCn UU|!lCDUI!|U6!|. Ln I$Q|6, lD$ I|UCD$$6 6nCu6!In 66$!UD l | C|6, BUD$ l$ID!6I$l$U!lC$D ulUD$ lD$6|l!|DCl!D$.L IICClCn C!lv 6$ | | | C|6. u6llD$ lI UCD$ u6 $6U|$!||CUy6n C$l6CIU$lvU6!6DI 6I l$U y U6 $6Un6 UUC|D ID!6|n$l$U!|C$$UlI6Q|U6$ vIlClD6$ 6n $U CDnC6n!|C|C | |CI6 CDn CulUl6I lC!DIU6 UDU|hu6$U Un| Cn UlC|$|D!6|n$|$U!|C$.Un66UlD U|U!lCD U6 6$!D $Dn lD$ n!|CDQU|n!6$DII6$(w|I|l).L Il6QU y lCCn U6l l|UCD |Os !6|UD$ UDU666|C6$u CC|C U66nU6 U6. l U|l6I6C| U6 CDnC6n!IC|CU6lIUCD6n!I6l$IQI6y6l !6|UD,6| !UID,l l|D$D| uCl | |UU, 6l Q|UD U6 | DnlC| Cn y | un|C ID!6|$ | $U!|C$, 6| llUD $nQU|6D u6 I6C|C 6| !6|UD,6| U|U6!ID C| |I,| $C|C!6I |$! | C$U6 | C|I6IU6 |U6!|v6$| (| CI|6I |6U!D6C6I| lCy lIC6!|lUl hCu| !6l $D U6$U$!nCl$ ||UIDl||I$),$I CDUD |$Dl uCl | |UU U6l l|UCD 6n CU !|D U6!6j| UD(N H98-99, 2AA) 1.J. 0|8080|M8000 b66n!| 6nU6DI C| D!|n$IDIUC|C|D$CUC|D$ ClDuIU| CD$v6||BCUD$ 6n6| D|Ql$UD U6U|n!6 | D$CUl6$I$$u$!C|$6!II$$6 CDv6|!66 D!|$ U$ lDl2U$,U$Dl|6$,U$ |lUID$DIUCl6$,U6D$UllU$|Cl6$yU$ICl l U6!66| l Ul nCl6$ u6 l$u$!nClDIl Q| | . cl U6!CDI|$UD U6 l D$I|UCD$ !|66 |UQ|6nUD$6!$, |C|!U|U6n!6 U6 ID|U $6Cu6Cll. L$I6CC|D6$U6 C|D!|$lDIUC|C U6 !|66 |UQ|6n | |0S6 (|nC!|vD U6$!IUy66l I|UCD) $Dn.DlUC|C,I6UuCClC,|lU|CI|$l$ y U6C|CD|IClCn L$ I6CClD6$ U6 |0S6 || (|D|C6 U$ Dl|) $Dn. $I!6$l$ D CDnjuQC|C. L|C|$I6CC|D6$$DI6I|2U$DI 6| $l$!6U UlCID$DUl, |$Ul!DCDnU|l$, 6n2U$ $D|UCl6$ 6 Cl!D$Dl, ||$D$DU$ yllDI l!6$!l n| . L UyD|I U6 |D$ l|UCD$ $6 U6!CDll2n6n6l ||QUD U6ClUD | Q|!UIDU6|CIQnD,$u6|6vUD ||6QD $QuI6Dy l 6|$!6ClU6QIn Cn!|UUU662|U$ U6!CD| |2UD|$.Ll Il U6|$D U6I U6!CDl | $UD U6 UUC|D$ I|UCD$6$ C!|l2UD D| un Q|uD U6 D|U$$ U6 IUCl CnUl!, U6DUl U$$l $!6UU6l Cl!DLIDUD4o0,U6$6 6nCU6!I 6n 6l I6!Cu| D 6UDl $UlCD U6l |6!DC|!D L|$!6n U| v6|$$ |$DlD|U$ U6 C|!DLIDUD 4o0(Cl) CD U| $!| !$ 6$6C|llC|UU6$ U6 $U$!I!D, $, y$ClD UDUD U6 66UID,6I ClzL U6!CD| |2 n!l|I|!UlCD$, n!l U6|6$lvD$ y | QunD$ C6!C|DU6I!6$,6| ClzC! U6!CDll2 6| DU6I2D| y 6I U|C6U,6n!|6 D!ID$.Hy lI UCD$ CC6$ U6 lUUCl|6l uU6!D6 l |DUUCClC U6 6$!$ 6I2lU$ (l nUuC!DI6$ 62lU!lCD$),6n!I66l l D$$66OCu6!|l l6n|!DI, l6nDCIC|!lDIlIU| C| n(NlH00-0l |,223), $I CDUD6| |C|!D U6luUI D6IlCD|D|lD|6l CD!||lD,6|$!6nlIUCD$u6 |n||C6I6l U6!CD| | $UD D|U!lvD U6 D!ID$ CDUu6$!D$ lICD|CQ|CD$ (l | ClUDI6$ 6n2| U!|CD$), CDUD DI 6j6U|D.C|U6!|U|n 6!DCDn2Dl, 6|l!|DUlC|n D vl|D!D. UU6 l$ $D6n2lU$ U6| Cl!DLIDUD U6 UyDI nU6|D U6lI UCD$ U6!CD| |2 6$ | Cl, CDUD DI 66UlD,u| l Ul , l6Ul|nD, U6!|||6U|$D|Dn, C|CUC6l8CU80 L MDtOD,I, C6n2DU|C6|n$ y ClClD$COmOC$ClO5QfD,tm- DI|n $! |$D6nlU 6$ lnDqDNUC0D0f5|lClUD|6I k6!DCDn2Dly|D$gDgV0D0OfCO55.UC|CllUD$, UUl6nUD IDUUC|I CuUulCC,DI 66UlD, U6 ClC|D$D|ln CDn uI|UD|!n!6 UU6!D U6 $u$ 6I6C!$6CuU||D$,CDUDl6|!6$lC, Ul ID$|lC , ||6I!I|CD$|$ 6 ||6Il$lQ|IQlv (NIH 00-0\ |.223) L I6$6Cl U6 lUuC!D|6$ D C|DU6I!6 6n2lU!lCD$,U6| $|$!6U C!DCIDUD 4o0U6U6 U6!6|U|I||I6lCClD!DlClUU!6|cU!lC (NIH 02-03, \A0) 1.0. tI0I0000 L6| | Ul ClCU6 lD$I|UCD$!l66 luQ|I|C||U6n!6 6 6l IlICD y 6 6l |IQUD. b6 6| | UlI U6jD|U U6U|CU6!D C0!D U$ D|I 6$ (U$ ||UID$DlUC|6). LD$U6UlCU6n!D$I|D$DIuC|6$!|66I, 6n Q6I6Il, uI vlUU6U| U$ |IQ. cl vDl uU6 U6 U|$!I|CUC|Cn 6U6DIvD|6C6 | 6| | UlC|C y u v|U U6U| U$ CD!. L|n!6$lUUCD U6ulIUCD$6 u6I$ID!6In$ U6|l$U!UCl c| nllUy6 6n Il|CC|CI u6 u6U6 $6|6!IIU DI 6l |QD u CIQnD$U66l l U|C|Cn,y u6 ll|CC|C u6 $6U6U6 U6UII6$ | llCI6.L |n!6|CClCnl|UCDID!6I U| $Ul uy6 l UlIu$|Cn,I6!IUI6lU|ClC,y$6!u|I (|lICI)DU6U|!6 U|||$|$(NH00-0\ F,22), yDlDQ6l 6l6C!D.Ln6l IlICn, |6| | Ul ClC6$!d6!6|U| nUDIIll!IC|Cn, l $6LI6ClCyl I6C$D|C|C L 6l !CU|D|6nl$Dn$6C|6!UD$ U| v6I$D$ l|UCD$ DI $|$!6U$ U6 !I$DI!6 U6 C|UD$ D|Q|CD$. L | n|| C|ClCn U6 6$!D$ $|$!6U$u6U6|DUUC|I l UUuIC|Cn 6C6$|v U6UI l|UCD.L I6n| | Cu!2D, 6l |DC66ClU yID$ $IlC| |!D$ | n||C6nCDU6!|!|vU6n!6 6$!6$l$!6UU6!In$DI!6.AptIE0tI|[|||E|cOncepIOde acaram|enIO hacerelerenc|aa|vO|umen||DredelrmacOpOrun|daddeI|empO.Las reacc|Ones adversas ms lrecuenIessOn|asdOs|s-depend|enIes, y |as msgra-ves,|as|d|Os| ncrs|cas.MEn |Os anc|anOs, hay muchas masreaccOnes adversas a med|camenIOs que en |aenIeOven.Causaspr|nc|pa|es:T. D|sm|nuc|nde||IradOrena|,2.PO||med|cac|npOrp|ur|paIO|Oga.5Onreacc|OnesadversdOs|sdend|enIes.MEne|emDarazO, |Os camD|Oslarmac|nI|cOspr|nc|pa|essOn:aumenIOde|adepu-rac|nye||m|nac|nrena|,ye|aumenIOde|vO|umended|sIr|Duc|n.POre||O,d|sm|nu-yen|ascOncenIrac|Onesp|asmI|casde|OslrmacOs.c >ecrecn Lubulr renl cOnLrbuye >u>LncilmenLel elimincin Oe l pencilin, prOce>O que ueOe>er|nh|biOOpO|elprObeneciO.Ln c>O Oe in>uhcienci |en|, >e prOOuce un menOrOepurcin Oe| larmcO y, pOr LntO, un reLr>O en >uelimincin. ce e>Le mOOO, un OeLe|minO puL OeOO>ihcc|n p|OOucira myO| cumulcin Oel meOicmenLOen elO|gn|>mOyma>pO>ibiliOOe>Oe que p|ezcnelecLO>txicO>.CunOO>eLrtOeunlamcOOev|OmeOilrgeinO|ceLerpeuLicOe>L|echO(O|gOxin,liL|O,minOgluc>iOO> ...) (M|R 02-0J, 14) e> impOrLnLeque lpuLOeOO>ihccin>emOOihquee>Lrechmente(Ml R02-0J,22).cl elecLO Oe l> heptOpt> >Obre l biOLrn>|Ormcin Oe lO> larmcO> e> impO>|ble Oe prever. 5e mnie>LLnLOpOr elevciOne>cOmOpOrOe>cen>O>enlOepu|c|n Oe lO> mi>mO>. c> LeOlin>, e|iLrOm|cinO benzOOicepin> >On ejemplO> lrecuenLe> Oe meOicmenLO> que >e cumuln en c>O Oe in>u|ciencihepLOb|lir.cn c>O Oe |n>u||ciencic|OicOchOquecirculLOriO,el larmcO >e reprLe en un vOlumen Oe Oi>LribucinmenOr, en elp|>m hycOncenl|ciOne>ma> elevO>OellarmcOylO>Lej|OO>mejOrpe|lunOiOO>rec|benma>cnLiOO Oel mi>mO. AOema>, l menO| perlu>in Oe|||nn y Oe| higOO pueOe Oi>m|nuir l Oepurcin Oe|larmcO pOr e>LO> rgnO>, y pO| lO LntO, lvOrecer >ucumulc|n. .b.LN|00 00 l|N008 00 00|008, 0N0|I0 ] 0|008 0O|B00S (Ml R00-01|,224)ll/5%Oe|O>meOicmenLO>>epre>cr|benncinO>.LncOnjunLO, l>per>On>myOre>Oe 5O>Lienen h>L5 vece> ma> prObbiliOO Oe recciOne> Over>>, que,Oema>, >On ma> grve>. Ll80% Oe lO>ncinO>LOmnenLre4 ylarmcO>,yprOx|mOmenLeel z5%OeellO>>u|re |gn LipO Oe reccin Over>. cO> lctOre> quemOO|cnl re>pue>LLerpeuL|cOelO>ncinO>lO>meOicmenLO> y lmyO| inc|OenciOe |ecciOne>Over>>>epueOenOiviOiren..|c!OlC|n!||DCCO(OerivOO> OelprOce>OOe envejecim|enLO) que OeLerm|nn mOO||cciOne> l|mcOcineLic>ylrmcOOinamic>(1bl ! ).D. |!Orese!|nsecs (Oe|ivOO>Oe|prOce>O Oe pre>c||pcin),enLre|O>cule>Oe>LcnlpluripLOlOgieinLercciOne>meOicmenLO>>,pre>cripcininOecuOyml|n|O|mcin,exce>ivOcOn>umOymlcumplimienLO,y|uLOmeO|ccinLn|e>umen,>e lLernLOOO>lO>p>O>l|mcOc|neLicO>en Oi>Lint meOiO. Ll que menO> lecLOO >e ve e> lb>Orc|n,y que |myOrprLe Oe lO>meOicmenLO>>e b>Orben pOr Oilu>in p>iv. Ll p|Oce>O que >e vema>lecLOOe>lelim|nc|n Oexcrecin|enl,yquellunc|n|enl>e reOuceen|eun J: y un :0% en lO>ncinO>, un>in pOecer nel|OpLi.AOema>, hy unreOcc|nOelm>OehepLOc|LO>yOelriegO>nguineOlhigOO,cOnOi>minuc|nOe|>recc|One>Oe l>eOeb|Ot|n>lOrmc|n.Ln cunLO l> lLerciOne>lrmcOO|namic>, Oe>Lcun myOr >en>ibiliOO lO>|armcO> crO|Ov>cu|re>,Oel>i>Lemne|v|O>OcenLr|ynLicOgulnLe>Orle>.L00B|M0 Ll embrzO >upOne l p|icin Oe mOOi|cciOne>.lrmcOc|neLic>que pueOen |Lerrl re>pue>t |O> larmcO>.AOema>,>einrOOuceunnevO, e>eci Oel leLO, que pueOe ver>e lecOOOi O:iO:queLOm|mOre.c> mOO|cc|One> l|mcOcineLic> en el embrzO >ere>umenenlLbl z.LleCtOssODree| letO. 5egn ll>e Oelge>Lc|nenque>eLOmenlO>meO|cmenLO>Le|LgenO>,lO>eecLO> >eran O|lerenLe>. A|, en l l>e Oe gmeLOgene>i>,>e prOOuc|ra e>Le|i|iOO, en l l>e Oe >egmenLcin,bOrLO O |e>t|tucin cOmplet, en l OrgnOgene>i>KLCULKOALo$ atIbt-(emb|in), mllOrmciOne>, yco$ de ecI e a emba-en|l>eOeleLO,lLerciOne>fada $olo$ mtala Qm(- lunciOnle> tr> e| nc|mienco$,Comoaalg$c0elIgetO, cOmO pOr ejemp|O, hipOe|pa cetamo g|ucem| cOn nLiOibeLicO>Orle>,hpOLOn|yOep|e>|nre>p||LOricOnbenzOOicep|n>,O cOmpl|cc|One> hemO|ragic> cOn >pirinyAlNL>(Ml R02-0J, 259)Ll||e>gOOeLOx|c|OO|et|Oe|O>|a|mcO>>ecl>i|cenl>>iguienLe>cLegOri>.L!er|.|armcO>>egu|O>.U.`OcO|ie>gO,>epueOenuL|||z|cOnre|Liv>eguriOOL.MyOr||e>gO,unque>|OehyOemO>LrOOterLOgeniciOOniml,pe|OnO hun.U. Hie>gOlet|cOn|mOO, >lOOebenuLilir>e >i el bene|ciO>upercOnmuchOl||e>gO.L. COntr|nO|cOO>, yque >u benehciO nunc >uperelrie>gOLntre lO>la|mcO>Oeu>O l|ecuenLe,cOnL||nOcOO>ene|embrO,pOOemO>Oe>Lcr.nLicOgu|nLe>Or|e>,L|iOOmiO, reLinO|Oe>, teL|ciclin>, eLOcOnzOl,qu|nOlOn>,OieLile>tilbe>L|Ol.c myOri Oe |O> la|mcO> >e el|minn en lgun prOpOrcin cOn | |eche, |unOmenLlmenLe pOr O|lu>inp>iv. |>n, >Ob|e tOOO, |O> larmcO> lipOli|cO> (pO|ejemplO,benzOO|cep|n>Oc|O|n|enicOl).d|H0S clcOnL|nuOOe>|rOllO l|>icOOu|nLe l inlnc|>ecOmp Oe un lrmcOc|nelic cmbinle :egn l eOO,>ObreLOOOen elp||mer nOOeviO,quehcenece>riOun ju>Leen|>put>OeOO|cc|n.|O>cmbiO>ma>impO|Lnte>>ere>umenen|LblJ .0. ||N000|00l|0 0||0|0 cO>p|Oce>O>Oeb>O|c|n,O|>Lribuc|n, meLbOli>mOyelimincinOete|minn|evOluc|nen e|L|empOOel>cOncenL|c|One>Oeun |a|mcO en elOrgni>mO,ye>L>,| re>pue>L ||mcO|g|c. |r pOOe| prever e| cur>OLempOr| Oe |> cOncenLrc|One> pl>maLc> y Oi>enr>iunputlg|cOeOm|n>Lrcin,>erequ|erecOnOcer el vlO| Oe lO>p||nc|p|e>prametrO>Oe ||mcOcineLicclinic,ue>e Oenend cOnLinuc|n.Tr> | Om|ni>trcin |nL|venO> Oe un la|mcO, >e lcnzuncOncent|c|n max|men>ngre, (Cmx) c>iinmeOitmente. `O>te||Ormente, | cOncentrcin Oi>minuyeenz l>e>O|>t|nt>.`rime|O hy un Oe>cen>O rapiOO, c Jc J||,en lcu|, meO|OqueOe>cienOen |O>nive|e> >ericO>,umenLn en lO> tej|OO> h>Lque >e lcnz| l>e Oeequilib||O O |>e Oe e||m|ncin. Ln e>L, |> cOncenLrciOn0> pl:maLic: y L|:u|re> Oe>c|enOen Oe lO|m prlel. c> cOncent|iOne> pl>matic> Oe| larmcO, ene>Ll>e,cOn>Lituyenun inOice vliO>OOe l>cOncenLrc|One>L|>ulre>,yunbuengu|Le|peuLic.1P0|d0I0005dIRd000I00IOd500 0d00Id00F0LU0LImL0 W|c0s00000m00|a00a0 } 8S||000| |0u00|00 0l8S0|0l008S||08 |00|||0808S|0l0S|08|y ||8S00l V80|8008S|l00 |uj050u|00|0S|08 8|8 0 80S0|0|00 0 |8 0u00S8y 0| |80S0| 80|V0 ||uj0580ul00|0|80uS0ul8| |08S8 y8u8 00|0|8l 08| } |8S800|0|8| |0|08S y8|0u0|08S |8S08|08S |80|00 0 |8 |uS|00 Su|8| |08S8 y0u0|0006ul8S 8l08S ||uj0S80u|00 0800 |0880|0800X|08|V8 ||uj0 50u|00|08| LIImI0ac|00|l|80|00|00|u|8|,|0u|80|0000|8|0|08} |S0|0|00u0u|8| 6am0I0s|V|00l080080S0|0|00 08|u00S 8|0800S |000lS000|||080 |0l00|S000|||080 0| Vl8 |0|80uS0u|8| |V0|u00 0 0S||0u0l00 0 8|0800S 0|0|0N00S } V0|u00 0 0|S0|0u0|00 0 8|800S|00||O0S } |800|00||0|080|V80 |0S8|08DS 0800||S0008lu00S 8|0800S[X|800l0008|0808j8| 000| ||0| 8S0 y 0l 0800||S00 0 8|0800S0008|8 X|800|00 08|08 } 0|00|S00|0||080 0 8|0800S 000 |00|8000 0 ||0| 8S0 ||l0|080l00 |08l0 8|0800S T 2 M00II0d0!0I\05 dI!Hd000I!l0I0d5 00 0 0R0d|dZ0F0LmM mIc0s 00|a00a0 +V80|80085||00 |00|080 8S|0|0S|08| } uj0 S80u|00 0 |,0u00S8S y 0uS0u|0 } 8u8 00|0|8l 08| ||858Su00u808 |00000080|00 0 |0|08S +0 } 0880|080 0Z08|08 0|58S|S h|8S0 080S0|0|00 + }0olS000|||080 0|08|0|80u50u|8| } V0|u0000|S||0u0000!8|0800S l|0|||00S V0|u00 0 0|S||0u000y 0 l8|800|00 0 8|0800 00 u0|00 8 |0|08S 008 8080|000|0S 80|00|00|800S |||0|080|00 0 ||80l0|08 } ||80|00 |00|u|8| ylu|0S80ul00"u00|00 u0u|8|0u|80l00|08ly |V0800|80||0|080|00 J|M00II0d0I0005dI |1d000I00I0d5 00 0 0l00Ia00a0 6m00000a0 |8S||000||0u00l000 |8S0|0|008S|l08|8 08S8l0S 800S 00|||0808S|0|0S|08l 800 } 0|0|S00|0|||080 0 08SS ||0S0| 0 |8 || 800 } 0|00|S00|0||080 |05||0||0Fu50u|8|O|l gl Dal C>.!a|mcO:de:cub|e|LO:,inve:igdO:, |egi:L|dO: ycOme|c|lizdO:pO| unlbO|tO|iO,quCtiCnClpLenLe.b. Ll CCDCl a>. medi cmCnLO: O| gi n| e: l b|i cdO:pO| OL|O: | bO|LO|i O: cOn licenci dC| qC pO:CCl pLenLe. C.COp|a>.mCdicmentO:O|iginle:lb|icdO:pO|OL|O:|bO|LO|iO:cundOe:La cducd OnOCx|:tC |penLe.pueden :e|cOnm|c O l|:O gene|icO.O. L>pCClallOaOC> la|maCuIlCas gCDC|lCa>. C:pCci||dd cOn | mi:m lO|m l|mceuLic e |gu| cOmpO:ic|n culitL|v y cunLitLiv en :u:tnci: mCdicinle:1 0l CC00| |110000|10 quC C:pCciidd O|ig|nlde|ele|enc|,cuyOpe||ldeChcc| y :egu||dd e:te :uhc|entemente e:LbecidOpO|:ucOntinudOu:Oc|n|cO.LDS KqUlSllDS 0 OS EFGSDD(Ml K000T , 220).! .Oebehbe|dCmO:L|dO|Cqu| vlenciLe|peuL|ccOnl e:pec|lidd de|ele|encimCdintC C:LudiO:dCbiOequiv|enci.OO::u:Lnci::OnbiOequivlCnLe:cundOp|OpO|c|Onn| m|:mbiOdi:pOn|bilidden mgnitudy ve|Oc|dd.5C cCpLnv|iciOne: del'0% |C:pCcLOlO||g|n|.z. NOtene|unm|genLC|peuLicOC:L|CchOnic|cte||:tic:dCb|Od| :pOn|bi|idd e:pec|le:.J. L:t| cO||CctmCnLC |dent|cd (debe pOne| elnOmb|egene|icOde|cOmpue:LO).4. 'igu||ene|et|queLdO| ::|g|:L|CvDlO]OS 0 DS EFG! . chcc|y:Cgu|idddemO:L|d:.z. Ll u:O de un :OlO nOmb|e |educe l cOnlu:|n(p|e:c||pcin, dm|n|:L|cin, di:pCn:cin y uL|||zc|npO|C|pc|ente).J.NOex|:Lendile|enc|:ent|epi:e:4.HC|cincO:teecc|lvO|b|e.5.COnL||buyelmnLCnim|CntOdCl5|:LCmdC5|ud.6060C|d S|C0I008, l6000d,d0|6|6|C08, d0|C0006|g|C08 Md/0I C00lu8|00|duC00d 0|C0||06|g|C08 C|C||C08, 06u|0|6|C08.] |duC00ddgu00H|6||0l|d|08d|Cd 0|C0|06|g|C08 h660C|00 060II0d08ul|C|60C|dCd|0|dC8 b6d0|0qu6d068, 6|8d0||0, AlNL O068 68C00608dC|00H1 lNL L|6dC|00I6||0d|d 6||l6||C8 b6d0|0qu6d068 du0|CdC|00LP0C b680l0qu6d068,0|dC608 b ,06|68|00|68||d0|Idl08ul|C|60C|dh60d| |NL, d0|0Q|uC08|008, 0|uI6|C08 |60d dgu00|d0668 ANL lLA |%|60d| dgu00|u|6|C08,C0R|C0|068H|6|g|uC60|d6|68|00 b6d0l0qu6d068,d0|P|6|608|0806dCC|00C60|db6000|dC6|0d8, 686|0|068LXdIC60dC|00HI0d860|d |g0X|0dU|Cu86IC0 AlNLd0|C08gu|d068 H600I|dg|d0|g8. .dIMd000I8 00 8|80M800N0$0 80000M0 L| S|SIE0d DE|V|CSC dUIDC0C ES UD S|SIE0d OE dOdIdC|D d|0EO|C EXIE|0C y |EQU|dCl0 OE| 0EO|C |0IE|DCUEUDC|C0dd UD 0|VE|SUDCC0SC|E0IE.|DE|Vd |d 0USCU| dIu|d | | Sd VdSCU|d|yV|SCE|d|, |dS Q| d0OU| dS EDOCC||DdS yEXCC||0dS, y |dS CC| U| dS d|E0QU|0dICSdS OE O| VE|SCS |Qd0CS yS|SIE0dS. |U0C|C0d OE C|0d |DVC|UDId||d.L0I|E|dSOlSI|DIdSU0C|CDESQUE|ESE0Id,SEEDCUEDI|d0.|d O|SI||DUC|D OE| ||EQC SdDQU|DEC y E|0dDIE0l0|EDICOE | d E|US|0 OE |CSIE||OCS, |d |EQU|dC|DOE|d |ES|Dd|IE||d|, | d |EQU|dC|0 OE| VC|U0E0 y CC0CS|C|D OE|0EO|C EXI|dCE|U| d|, E|CC0SU0C OE EDE|Q|d,E| dC|IEOESUSI|dICS d|d E|0EIdDC||S0C,y E|CC0I|C| OE| d 0USCU| dIU|d||SdV|SCE|d| yQ| d0OU| d|.Ld ucc!|/co/|nu (PCD) ESE| DEU|CI|d0S0| SC||EQdDQ| | C0d|OE |dSOCSO|V|S|C0ESOE|blP, yId0D| C0OE| dSDEU|C0dSCSIQd0Q| | C0d|ES OE| d|dS| 0dI|CC y d|QUDdS DEU|C0dS S| 0dI|CdS CSIQd0Q| | C0d|ES (Q|dDOU|dS SUOC||d|dSEC||0dS,y QU|Zd d d|QUDCS VdSCS Sd0QU|DECS QUE ||EQdD|d 0USCU|dIU|d ESQUE|CI|Cd). LCS DE|V|CS ED CUydS IE|0||dC|CDES SE | | DE|d PCD SCD OE I|C co/|nc/gico. Ld nomd/cnu/|nu (lP) ES E| DEU|CI|dDS0|SC| OE |dS DEU|CDdSS|0dI|CdS CSIQdDQ| |CDd|ES, ESICS DE|V|CS SCD OE I|Cud/cnc/g|co.! . b|S\00R0fVOSOS0\|COy 0OU SUfff0R.LCS| 0U| SCSS| 0dI|CCS DdCEDEDE| I|CDCCOE| EDCCd|C,ED |d C|0dC|0 |EI|CU| d|OE |d |CIUDE|dDC|d y, SCD|EICOC,OE|DU| DC,OC0OECO||d0CSOEC| |QUEESIdE| ccn|/o|mpo||codc/|/oncodc/cncc/u/o,Q|UCOE DEU|CDdSOE EXC| IdC|0 S| 0dI|Cd QUE OESCd|QdD I0|Cd0E0IE(0d0I|EDE0 E|IC0C S| RdI|CC). LSIdS 0EU|CDdS |EC|DE08E|E0C|dS SUE||C|ES (D| CId|d0C) y ESIdD|ECED CC|EX|C0ESCC0 | dCC| U00d| 0IE|0EO| C| dIE|d| OE| d 0COU|8 OE T d L_ OC0OE ESId0 | dS DEU|CDdS |EQd0Q| |C0d|ESOE| S|SIE0d DE|VlCSC S| 0dI|CC, QUE |DE|VdD | d CdOE0dOEQdDQ| | CS S| 0dI|CCS, |EVE|IED|d| ESC d|dVE|IED|d|ES (VE|IdD|d ! 0). LX|SIE0 O|VC|SdS SUSId0C|dS QU| 0| CdS QUE 0CO||Cd0 C0COU| d0 (dC| | | Id| C | 0||DE0) | d | | DE|dC|0 OE 0C|dO|E0d| | Dd E0 |dSIE|0|0dC|C0ES 0E|V|CSdS S| 0dI|CdS, ED |ESUESIdd U0| 0U| SCDE|V|CSC`.NOOUOOf0S f0S|R\COS | RD| D|OOf0S. CdIECC| d0| 0dS SCD|E |ECEIC|ESPCD SCD|E |ECEIC|ES0USCd||0|CCS, OCd0| Dd SCD|E |ECEIC|ES c || SId0| 0d SCD|E |ECEIC| H SE|CIC0| 0d, |CSIdQ| d0O| 0dS,E0CEd| | DdS,dOEDCS|Dd.D. NOOUOOf0S f0SR\|COS C|\OOf0S! CdIECC| d0l 0dS SCD|E |ECEIC|ES PC| SCD|E |ECEIC|ES0|CCI|0|CCSyd0Q| CIE0S|Dd | | . 2.bS\00OO0 Rfg|CO0f|f|CO.Ld OCd0| Dd |E|dd E|ES|DIE| ESCdQ|CC |DE||C|, |EI|dSdE| VdC|d0lE0ICQdSI||CC, |COUCE VdSCO||dIdC|D E0 |d C||CU|dC|0 d|IE||d| |E0d|y 0ESEDIC||Cd, |DD|DE |d SEC|EC|0OEd| OCSIE|C0d,ESI|0U|d | dEXC|EC|0 |EDd|OE SCO|CE | 0|| DE |d ||DE|dC|0 OE lP E0 |dS IE|0|DdC|C0ES DE|V|CSdSS|DdI|CdS.LCS |ECEIC|ES OCd0| 0C|Q|CCS SCD OE OCS I|CS. /cccp|o/ L (VdSCO| | dIdC|D |EDd|, 0ESEDIC||Cd, CC|C0d||dy CE|ED|d|), /cccp|o/L (| DD| D|C|| OE |d I|d0S0|S|0 OE|CS| 0U| SCSE0 |CS Qd0Q| | CS S| 0dI|CCS, | D|| D|C|0 OE |d|| DE|dC|0OE lP,|DD|D| C| DOE |d || DE|dC|0OE |C|dCI|0dy |CVCCdC|DOEV0|IC).Ld OCd0| 0d ES UD CIEDIE dQCD|SId OE |CS OCS I|CSOE |ECEIC|ES, |d D|C0CC||I|0d y |d dC0C|0d dCIUd0CC0CdQCD|SIdSOE|CS|ECEIC|ESc,d0IdQC0| SId SE|ECI|VCOE |CS |ECEIC|ES ._SC0 E| |d|CE||OC|,OC0E||OCDdy SU| | ||OE, CC0C dDIdQC0|SIdS OE |ECEIC|ES Ly c_EDCI|dC| 0dSyI|CXdDIEDCS.3. b|S\00 R0fV|OSOfS0\CO.LdS 0EU|CDdS |EQdDQ|| CDd|ES OE| S|SIE0d 0E|V|CSC d|dS| 0dI|CC Sd| E0 OE| SlSIE0d 0E|V|CSC CE0I|d| d I|dVCSOE |CS d|ES C|dDEd|ES | | | , V||, | y yC| |CS 0E|V|CS SdC|CS SEQUDOCy IE|CE|C. LCS Qd0Q| |CS d|dS| 0dI|CCS SEEDCUE0I|dDE0E|SE0C OE | CS|Qd0CS| 0E|VdOCS.Vu||58WWVu80uM&g00W08||0Vu8ul8!u|8||88|0 OHu9|l8|%[00|u|88)10|0|08l080WI&WUOC0lul88yl000|ul8|08Mp|[00|. )V0G M,03,MPyUVU80u|00 WGy089l00|08OuI0||08,00l|g000y0 Nv08|08|,0y80ul80|00l0||8|8, glu |8h0l80|00Au000!000l8O ||0MA|80|0u0|0000 l8 800|00|0000 |08ul|08Ag|0g80|00|80|0u0|0000l8|L|00 00MWlUyHAu000!000l800 |00|08Nl8|O00|08u||08W.0U,| 0U80u|00,0u8fM80008 08f008608f ] 00 88f80f06f80f0 0||6tc|6 N|h 10m 0Uy 0DI1R\0. b|R 0mDfgD, 0yOff\0O0 SUCDR\0R|ODf0C0 \0D|R 0RD\fSf10SO0 0RU (LfO|DDg, N0UmDOg, N0fDDg. . .). LS\O\0SDDf0 \DOD DS SeC1DS UROm0R\0S yD fefeR\0 OgDXR. L f0S\D O0 DSfmCDS f0C0R 0XCODS 0R SUS f0SeC\VS0SeCOO0S.k E6c|l [l} L0C1DRD\fDD O0 OgDXR 0S mUChD mS | 0Df\R\0 0R 0 CDf2R |RSUDC0R\0U00R0 SRD.L OgDXR U00R\ 0 \DRD Vg RV0 SRUSy0R0RDODAV,DfD U0OS0|RUy0f0CU0RCCfOC.LROCCR mSCfO0 OgDXR 0S M RSUDC0RC CfOC CDR DDfCR UfCUff|O.L OgDXR RD fDDRg SU0fVV0RC,M 0fD m0Df CS0 URCDR yOS0|RUy0 R00fDO0 RgfeS0S pRSUDC0RCICfOC.L O0S0RCO0RR\0 0S f0CU0R\0 O0 R M \DXCCROg\C 0S hDD\S00.L ff\m mS f0CU0R\0 Df R\DX|M CCR Og\C SDR DS 0X\fSS\D0SV0R\fCUf0S.L ff\m mS \C O0 |R\DXCCR Og1C 0S 1UCfO UfCUfRDfDXS\C,CDR DDU0DAV.LS \ZOS y OUf\CDS O0 S fDOUC0R CDSS m0\DC 0 hDD\S00|, DShDffODf0S O0 D\SD, CODSS m0\DC 0hefD\S00.Ica11 00| 5|50d 5|d|00d0|00d|yd|d5|d|00 MA6 ME6hISM 0EA66IhClo0|d|0a Ago0|sIaalIas0l0cI|voW00IN08IMpIV0I|ldopa Ago0|sIaa'Ia?kg80gII008r T||10IaIa0 |0h|b00ls|sI01a00v|osos|1paI|coypa|as|1paI|coq08cM8080ua00I|d|0a Uloqu0al|b0|ac|0d0M0Iv0I00I88NU'oqu0al|b0|ac|0d0MAcIasob|0'asp|op|0daU|0I|liod0s0'cI||casd0'co|a:0Ad|00al|0a Ago0|sIaa'Iayb0IaMo|ad|00a||0a Ago0|sIaa1ayb0IaJ p|0do1|0alavas0o0sI||cc|0)|00|l0I||0a Ago0|sIaa1aJF00|lp|opa0ola1|0a Ago0|sIaalIaJkls0p|oI0|00oloAgo0|sIab0Ia0os0'0cI|volsop|00al|0a0obuIa1|0a Ago0|sIab0IaJ s0l0cI|voT0|buIal|0a,sa|buIa1ol,o|c|p|00al|0a,sa|10I0 Ago0|sIasb0Ia?s0l0cI|vosU|o0cod|'aIado|0s)|ol', Io|1oI0|olH|Iod||00 Ago0|sIab0Ia?s0'0cI|voAgo0|sIadopa1|0u|g|co00dos|sbaas