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d l e H n o e h t 3 d r h t n o m h c a e f o y a d s r u h T s d n u o R d n a r G e n i c i d e M l a n o i t a l s n a r T d n a r e t n e C h c r a e s e R l a c i d e m o i B n o t g n i n n e P f o m a r g o r p l a n o i t a c u d e t n i o j A d n a t n e m p o l e v e d e h t t r o p p u s o t m u x e n i K . s e i r e v o c s i d g n i s i m o r p f o n o i t a z i l a i c r e m m o c t u o b a s t c a F d n a , s n o i t p m u s e r P , s h t y M r o f s n o i t a c i d n I l e v o N g n i t e g r a T s g u r D c i l o b a t e M 2 1 3 1 0 2 , 1 2 y r a u r b e F , T S C n o o n D . M , g n i m e l F r e d n a x e l A

Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

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Page 1: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

dleH no eht 3 dr htnom hcae fo yadsruhT

sdnuoR dnarG enicideM lanoitalsnarT dna retneC hcraeseR lacidemoiB notgninneP fo margorp lanoitacude tnioj A

dna tnempoleved eht troppus ot muxeniK.seirevocsid gnisimorp fo noitazilaicremmoc

tuoba stcaF dna ,snoitpmuserP ,shtyMrof snoitacidnI levoN gnitegraT

sgurD cilobateM

21 3102 ,12 yraurbeF ,TSC noon

D.M ,gnimelF rednaxelA

Page 2: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

2

dleifsmyeH .B nevetS

ytisebO tuoba stcaF dna ,snoitpmuserP ,shtyM

Page 3: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

yadoT• peed hcni dna ,hgih elim a ,ediw elim A

– htlaeh detaluger fo seirogetac lla redisnoCstcudorp

• gnidnatsrednu retteb a ot teg ot dnetnI dna evitatneverp eveihca ew woh tuoba

seipareht evitarotser *• taht ezisahpme ot tnaW siht tsuj ton si

ytisebo dna MD2T tuoba• gnitroppus rof sloot no hcuoT

seipareht evitatneverp fo tnempoleved 3

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44

stegraT noitalupoP citueparehT rof

:tnempoleveD

dna setebaiD eht era ytisebo

elbaifitnedi ylisae taht snoitalupop

yeht nehw taert ew.segats etal hcaer

ytisebO dna setebaiD

cilobateMemordnyS

erP -setebaiD

gnigA

ni ti ta kool s’teLyaw rehtona -

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55

ecnedive gnisaercnI eht ot stniop

fo ecnatropmi dna cilobatem

srotcaf lanoitirtun srotubirtnoc toor sa

fo sesuac tsom ot.ytilatrom

srotcaf ksir esehT ro detanimile eb nac

.deifidom

setebaiD

recnaC

gnigA

ytisebO

s'remiehzlAoidraC

ralucsavesaesiD

noisserpeD

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66

llac ew dluoc tahW fo noitalletsnoc siht

dna cilobatem lanoitirtun

hcihw ,sredrosid detegrat eb dluoc erom ro eno htiw

?seipareht

.…?tuoba woH

“ ytisebateM ”

setebaiD

recnaC

gnigA

ytisebO

s'remiehzlAoidraC

ralucsavesaesiD

noisserpeD

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7

24/trats/moc.sllahnwotenilno//:ptth

tuoba noitasrevnoC A ytisebateM

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8

?…emitemoSAMIXO

( )evitavired emixodima cinitocin gm 002 telbaT

SNOITACIDNI

AMIXO ot tcnujda na sa detacidni si ni esoculg doolb eht rewol ot teid/nimroftem

epyt htiw stneitap 2 esohw setebaid yb dellortnoc eb tonnac aimecylgrepyh

.ypareht dradnats

sutillem setebaid 2 epyt fo noitneverp rof.…emordnys cilobatem htiw elpoep ni

R

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9

?dedaeh ew era erehWAMIXO( cinitocin emixodima evitavired )

gm 006 dna gm 002 stelbaT

SNOITACIDNI

esoculg doolb eht rewol ot teid/nimroftem ot tcnujdA htiw stneitap ni D2T eb tonnac aimecylgrepyh esohw

.ypareht dradnats yb dellortnoc

,IM( stneve ralucsavoidrac esrevda rojam ni noitcudeR MD2T htiw elpoep ni )htaed dna ,ekorts

htiw elpoep ni sutillem setebaid 2 epyt fo noitneverPemordnys cilobatem

R

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01

fo gnitekraM rof syawhtaP yrotalugeRASU eht ni stcudorP htlaeH

sgurD

dooF

yrateiDtnemelppuS tcA C&DF

AEHSD

lacideMdooF

seciveD

scigoloiBlacinatoB

gurD

tcA SHP

tcA C&DF

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11

stcudorp htlaeh fo noitaluger ADF”esU dednetnI“ no desab si

• A dooF ro ,amora ,etsat rof yllaro demusnoc si.eulav evitirtun

• A tnemelppuS yrateiD tnemelppus ot nekat si dna erutcurts no stceffe ecudorp ot teid eht

ydob namuh eht fo noitcnuf• A gurD ,etagitim ,taert ,eruc ,esongaid ot desu si

.esaesid tneverp ro• A dooF lacideM yllaiceps a si detalumrof

dednetni tcudorp fo tnemeganam yrateid eht rof tneitap a deriapmi htiw ,tsegid ,tsegni ot yticapac

ro ,brosba ezilobatem yranidro .sffutsdoof

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detaluger ton era stcudorp htlaeh ynaM

21

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nac tnemelppus yrateid A“”.gurd a sa depoleved eb reven

• htym a si sihT• stcaF

– nicaiN napsaiN– agemO - stcudorp slio hsif 3

)APE+AHD( azavoL– lortarevseR sirtriS tcudorp

31

Page 14: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

esaesid a yrrac nac doof lacidem A“”.noitpircserp a eriuqer dna mialc

• eurt si sihT• :snoitpmuserP

– elbaiv a si etuor doof lacidem ehTyawhtap noitazilaicremmoc

– fo deriuqer si ecnedive fo level rewol A gurd rof naht stcudorp doof lacidem

stcudorp

41

• :htyM– tnailpmocnon a eciton ot ylekil ton si ADF

doof lacidem

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61

setaY divaDtnediserP

noitirtuN eraChtlaeH eltseNevirD elcriC deR 10801

34355 atosenniM ,aknotenniM GNINRAW RETTEL

eR NASFC : - CO - 01 - 40:setaY .rM raeD

ruoy deweiver )ADF( noitartsinimdA gurD dna dooF eht taht uoy esivda ot si sihT eht ta setisbew sesserdda tenretnI eltseN.www//:ptth - ,moc.noitirtuN

,moc.erotSnoitirtuNeltseN.www ptth dna rebmevoN ni moc.slaitnessedik.www//: etelpmoC yllanoitirtuN slaitnessE diK TSOOB ruoY .9002 ( knirD ,allinaV

lacidem" a sa setisbew ruoy no detomorp si )srovalf yrrebwartS dna ,etalocohC dna ",doof gnilebal eht a sa tcudorp eht tneserper setisbew ruoy no smialc

" fo noitidnoc lacidem eht rof doof lacidem …… eruliaf

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“ lacinilc mret trohS seiduts a elbane nac temnu sserdda ot tnemelppus yrateid

deen lacinilc ”.• dna noitpmuserp a si sihT

.htym a ylbaborp• :snoitpmuserP

– gnol dettimmoc emoceb lliw sremusnoCatad no desab tcudorp a fo sresu mret

– dna ecarbme lliw ytinummoc lacidem ehT.seipareht eseht dnemmocer

– eht retne ton lliw stcudorp gnitepmoCtekram

71

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poT ehT - ,dooF eht ni stnemelppuS labreH gnilleS setatS detinU eht ni lennahC tekraM ssaM dna ,gurD

1102 rof

81

Page 19: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

“ rof snoitacidni evorppa ylno nac ADF yb decarbme yllasrevinu era taht snoitidnoc

lacinilc eht ”.ytinummoc• :no desab htym a si sihT• :snoitpmuserP

– no desab eb tsum snoitacidni citueparehT gnidnatsrednu citsinahcem hguoroht

– wen yna troppus yllamrof ot sah ADA.ti tpoda ot ADF rof noitacidni cilobatem

91

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02

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12

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22

ESOPRUP sihT elbuod - owt ,lellarap ,dnilb - ecuder ot laitnetop eht etaulave lliw yduts mra

gnol dna ytilibarelot eht ,ksir ralucsavoidrac - fo eliforp ytefas mret razatilgela etuca tnecer htiw stneitap ni erac dradnats fo pot no obecalp ot derapmoc

eb lliw stneitaP .sutillem setebaid 2 epyt dna )SCA( emordnys yranoroc rehtie eviecer ot dezimodnar razatilgela .sesod laro sa yliad ecno obecalp ro

tnemtaert yduts no emit tub ,rucco stneve 059 tsael ta litnu tsal lliw yduts ehTsraey 5.2 tsael ta rof eb lliw .

htiW ydutS A razatilgelA yranoroC etucA tneceR a htiW stneitaP nisutilleM setebaiD 2 epyT dna emordnyS

Page 23: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet
Page 24: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet
Page 25: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

• slairt latovip nevird tnevE —2 esaercni tsoc - ;3 esahP rof X3

005$ fo egnar eht ni - noillim 007• emit dna tsoc eht neviG — siht

reviled tsum tnemtsevnitifeneb evitisop

• eb lliw atad lacoviuqe/lartueN .g.e( tekram eht yb dehsinup

aiteZ )

rof snoitacilpmI amrahP :

dedaol kcab si ksir llAdedaol tnorf si tnemtsevni tub

Page 26: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

“ tuohtiw stcudorp gurD fo noitisopmoc PI rettam eb tonnac

depoleved yllufsseccus ”.• :no desab snoitpmuserp a si sihT

– 01( SU eht ni ytivisulcxe tekram ’sraey 5 tnarraw ot tneiciffusni si UE eht ni sraey

tnemtsevni– eb tonnac stnetap noitalumrof dna esU

.dednefed ylgnorts

62

• :snoitpecxe ynam era ereht ,tuB– )egahpoculG( nimrofteM– )napsaiN( nicaiN– noos gnimoC -- sralimisoib

Page 27: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

ecnedive eht teg ew od woH?snoitacidni evitneverp rof

• retsaF• evisnepxe sseL• elbatiderc eroM

72

Page 28: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

eht fo tpecnoClairT elpmiS egraL

hgiHksir

rep %0.4 raey

*etar tneve

etaredoM:

rep %57.0*etar raey

ksiR VC hgiH

ksiR VC woL

lairT elpmiS egraL)TSL( hcaorppA

dehcirnE lanoitnevnoC)TCR( hcaorppA lairT

MD2T latoT noitalupoP

ta ksiR

000,5=N

000,52=N

001 - 002stneve ECAM

Page 29: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

ecudeR TSL eht naC woH T ?stluseR ot emi

noitamrofnI gurDnoitaicossA

gro.emohaid.www 92

dehcirnE lanoitnevnoC)TCR( hcaorppA lairT

lairT elpmiS egraL)TSL( hcaorppA

sraey 5.1

sraey 5.1

gurD no emiT sisylanAtnemtiurceR

raey 1 sraey 3.

sisylanAgurD no emiTtnemtiurceR

4- skeew 8

sraey 3.

Page 30: Held rd Thursda y of each month Translational …...OXIMA Where are we headed? ( nicotin ic amidoxim e deriva tive) Tablets 200 mg and 600 mg INDICATIONS Adjunct to metformin/diet

• era slairt ni etapicitrap ot seitinutroppO hguorht stneitap dna snaicisyhp ot dereffo

e dna setis desab bew elpitlum - .liam• ”setis“ lacinilc ynam sA ( 000,1 - eb nac )000,01

fo loop tsav a morf dedeen sa deretsiger1( snaicisyhp - .)etis rep stneitap 01

• era srotagitsevnI detiurcer dna deifilauq a ybbew elpmis - mrof desab

• yb llorne stneitaP pleh eht htiw ro ,enohp ,bewffats eciffo lacidem fo

• dengissA morf liam yb detubirtsid si gurdycamrahp lartnec

ecudeR TSL eht naC woH?emiT tnemtiurceR

noitamrofnI gurDnoitaicossA

gro.emohaid.www 03

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13

?ereht teg ew od woH

ASNEGORP R )lonerponeseR( gm 005 stelbaT

NOITACIDNIasnegorP fo sraey 04 snosrep rof detacidni si

efil gnisaercni fo snaem a sa redlo dna egaega gniwols dna naps - ni enilced detaler

.noitcnuf dna efil fo ytilauq