Cyproterone Acetate and Epididymis 331

Der EinfluR von Cyproteronazetat auf die Spontan-Kontraktilitat des Ratten-Nebenhodens

Zusammenfassung Es wird uber in-vivo-Experimente zur Beeinflussung der Spontankontraktilitat des

Kattennebenhodens berichtet. Gegenuber einer Kontrollgruppe ergab sich nach 7-tatiger Applikation von Cyproteronazetat (5 mg tgl. pro Tier in Benzylbenzoat- und Rizinus- 01-Gemisch - 250-300 g Wistar-Ratten) keine Differenz; demgegenuber zeigte sich nach 11 Tagen Therapie ein Ruckgang der Amplitude und der Frequenz der Nebenho- denkontraktionen. Diese Aktivitaten horten nach 14 Tagen Applikation vollstandig auf.

References

Benoit, J. 1926. Recherches anatomiques, cytologiques et histophysiologiques sur les voies excr6-

Hib, J. 1976. Effects of autonomic drugs on epididymal contractions. Fertil. Steril. 27,951-956. Hib, J. and R.O. Ponzio. Efferent duct ligation, gonadectomy and testosterone replacement on

Neumann, F. 1974. Theoretical and experimental principles and clinical aplicatioris of the antian-

Neumann, F. and R. von Berswordt-Wallrabe. 1966. Effects of the androgen antagonist cyproterone

trices du testicule chez les mammif6res. Arch. Anat. Histol. l:.mbryol 5, 173-414.

epididyrnal contractility in the rat. J. Reprod. Fert. (in press).

drogens. Reproduccion 1, 303-335.

acetate on the testicular structure, spermatogenesis and accessory sexual glands of testosterone- treated adult hypophysectomized rats. J. Endocr. 35, 363-371.

Risley, P.L. 1959. Hormone effects of the in vivo contractile behaviour of the ductus epididymidis of the rat. Anat. Rec. 133, 329-330.

Acknowledgement: This research was supported by a grant from Programa Latinoamericano de Investigaciones en Reproducci6n Humana (PLAMIRH 1-1 -1-75) with the assistance of the Cor- poracion Centro Regional de Poblacih (Bogoti, Colombia). We are indebted to Schering Argentina S.A. for the provision of cyproterone acetate.

Address: Dr. J. HIB, Dr. R.O. PONZIO, Centro de Investigaciones en Reproducci6n - Paraguay 2155 - Piso 10, Buenos Aires, Argentina.

m Hook H d e w

Immunology of Human Reproduction, J.S. SCOTT and W.R. JONES (Eds.). 476 pages. Academic Press Inc. (London) Ltd. 1976. .€ 15,-

This is a very interesting book about the problems of the immunology in the field of reproduction. Scott and Jones (Editors) in collaboration with 1 1 contributors present all aspects especially for obstetricians and gynaecologists. This excellent organized book is a concentration of up-to-date knowledge which will give an introduction t o this extensive field, will provide the clinician with a broad view of the subject, and will give research immunologists an appreciation of the actual and potential contribution of immunology t o clinical practice. Good information for non-specialists with a glossa- ry a t the beginning. Good list of references t o each chapter. Very good get-up. Also for andrologists a very good information.

C. Schirren, Hamburg

andrologia 9 (1977)