Embed Size (px)
Citation preview
![Page 1: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/1.jpg)
: Anti-hypertensive
140mmHg 90mmHg
4000
- RA
1/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 2: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/2.jpg)
2
WHO/ISH
JNC7 JNC7[1][2]
2004 JSH2004 2009 1 JSH2009
JSH2009 CASE-J JIKEI-Heart JATOS
JSH2004 JSH2009 1 α
2 CKD
3 3
10
ADVANCE ARB
[3]
2/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 3: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/3.jpg)
9
Na+
Na+
Na+ Cl-
JNC7
ALLHAT ( ALLHAT
)
Cr 2.0
1/4
1/2
Cr 2.0
ADVANCE study ACE
β
Cr 2.0
[4]
ARB
◾◾◾
◾◾◾◾
3/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 4: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/4.jpg)
◾
Na+
Na+/K+/2Cl-
◾◾◾◾
Na+/K+
Na+
Na+ Na+/K+
K+
◾◾◾
: Calcium Channel Blocker, CCB
Ca
Ca2+
Ca2+
2008 L
N
CYP3A4
4/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 5: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/5.jpg)
CYP3A4 CCB
β
ARB
L N
L
1 10mg/10ml
2 10γ 50Kg 1γ 3ml/hr 2ml/hr
2 20ml/hr
0.5γ 1.5ml/hr
◾◾◾◾◾◾◾◾◾◾◾◾◾◾
5/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 6: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/6.jpg)
L D V
PSVT
1 50mg 3A 5% 1.5mg/ml
50Kg 1γ 3mg/hr 2ml/hr 1γ 5 15γ
1 5γ
◾
ACE
II ACE
II
ACE
II
ACE ARB
ARB
ACE
Ca
ARB ACEI
◾◾◾◾◾◾◾◾◾◾◾◾
II
: Angiotensin Receptor Blocker, ARB AT1
ARB Valsartan
ACE ARB
6/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 7: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/7.jpg)
ARB
PPARγ
ARB ACEI
ACEI ARB
◾◾◾◾◾◾◾
I
-
(Direct Renin
Inhibitor,DRI) Asp32 Asp215
24
ACE
◾
α
β α α1
α2 β β1-3
β1 β2
α
α α α1
α2
α2
β
7/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 8: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/8.jpg)
α1 α2
α
1 1 4mg 1 0.5mg
◾◾◾◾◾◾◾
β
α β
β1 β
β2
β1
β2 β1
β2 β2
β1 β2
β
β
β β1
ISA α
β1 Atenolol
Bisoprolol Carvedilol
Celiprolol ISA
8/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 9: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/9.jpg)
αβ
Carvedilol Metoprolol
Carvedilol
α
α1β β1
◾◾◾◾
α2
◾◾◾
◾◾
◾
◾
9/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
![Page 10: : Anti-hypertensive 140mmHg 90mmHg 4000 - RAsaigaiin.sakura.ne.jp/sblo_files/saigaiin/image/E9998DE59CA7E589A4E... · 2 WHO/ISH JNC7 JNC7 [1][2] 2004 JSH2004 2009 1 JSH2009 JSH2009](https://reader034.pdfslide.org/reader034/viewer/2022052007/601c6b3af5653210ab618dc8/html5/thumbnails/10.jpg)
10/10- Wikipedia
2018/03/29https://ja.wikipedia.org/wiki/%E9%AB%98%E8%A1%80%E5%9C%A7%E6%B2%...
